Review
Biochemistry & Molecular Biology
Henriett Butz
Summary: Pituitary neuroendocrine tumors (PitNET) are common intracranial neoplasms. Non-coding RNAs (ncRNAs) have emerged as potential biomarkers for PitNET due to their stability and tissue specificity. However, the origin of ncRNAs in PitNET and their causal involvement in the pathophysiology remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Mehdi Akhavan-Bahabadi, Bashdar Mahmud Hussen, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: This study identified differentially expressed genes (DEGs), including long non-coding RNAs (DElncRNAs) and microRNAs (DEmiRNAs), in non-functioning pituitary adenomas (NFPA) compared to normal samples. The study also assessed the relationship between these genes and important signaling pathways. The findings revealed dysregulated pathways and differential expression of several genes in NFPA.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Borbala Szabo, Kinga Nemeth, Katalin Meszaros, Lilla Krokker, Istvan Liko, Eva Saskoi, Krisztina Nemeth, Pal Tamas Szabo, Nikolette Szucs, Sandor Czirjak, Gabor Szaloki, Attila Patocs, Henriett Butz
Summary: This study revealed that aspirin can induce global DNA demethylation and consequential transcriptome changes in pituitary cells, leading to decreased cell proliferation and migration. Aspirin also regulates the activity of Tp53 and the expression of Pttg1, which are involved in cell cycle control. The findings suggest that aspirin may have potential beneficial effects in PitNET.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Antonio Bianchi, Sabrina Chiloiro, Antonella Giampietro, Simona Gaudino, Rosalinda Calandrelli, Ciro Mazzarella, Carmelo Caldarella, Mario Rigante, Marco Gessi, Liverana Lauretti, Laura De Marinis, Alessandro Olivi, Alfredo Pontecorvi, Francesco Doglietto
Summary: Growth hormone-secreting adenomas exhibit a wide range of behaviors and outcomes, from mild disease to aggressive neoplasms. Treatment for patients who do not respond to surgery or first-generation somatostatin receptor ligands may involve multiple surgical, medical, and radiation treatments. Currently, there are no markers that can predict the prognosis or aggressiveness of acromegaly. A multidisciplinary approach is necessary to tailor treatment for difficult/aggressive cases, including radiation therapy, chemotherapy, and emerging treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Xiao Yue, Fengming Lan, Weiping Liu
Summary: Serum exosomal circCCDC66 is abnormally elevated in PA patients and may serve as a promising biomarker for the diagnosis and predicting prognosis in PA.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Luigi Albano, Marco Losa, Lina Raffaella Barzaghi, Ajay Niranjan, Zaid Siddiqui, John C. Flickinger, Lawrence Dade Lunsford, Pietro Mortini
Summary: A systematic review and meta-analysis of outcomes of Gamma Knife radiosurgery for pituitary tumors over the past twenty years showed that it is safe and effective, with good tumor control and remission rates for both non-secreting and secreting tumors.
Review
Oncology
Soudeh Ghafouri-Fard, Atefe Abak, Bashdar Mahmud Hussen, Mohammad Taheri, Guive Sharifi
Summary: Non-coding RNAs have been shown to play a significant role in the pathogenesis of pituitary gland tumors and meningiomas. Further research is needed to explore their potential applications as biomarkers for diagnosis and treatment in these brain tumors.
Article
Endocrinology & Metabolism
Ashley J. Han, Elena V. Varlamov, Maria Fleseriu
Summary: This study characterized the clinical features and natural history of nonfunctioning pituitary microadenomas and found that they are generally benign. It suggests that the initial MRI follow-up interval for these tumors can be extended up to 3 years, unless there are specific concerns.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Mengqi Chang, Shenzhong Jiang, Xiaopeng Guo, Jun Gao, Peng Liu, Xinjie Bao, Ming Feng, Renzhi Wang
Summary: Exosomes are small vesicles that carry various molecules, including RNAs, and play important roles in cell communication and drug delivery. In this review, the impact of exosomal RNAs on pituitary adenoma and their potential as clinical therapies are discussed. Potential biomarkers and therapeutic applications of exosomes in pituitary adenoma are examined.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Xiaohai Liu, Congxin Dai, Xinjie Bao, Kan Deng, Yong Yao, Ming Feng, Mingchu Li, Ge Chen, Renzhi Wang
Summary: This study retrospectively analyzed the clinical and pathological characteristics of patients with refractory pituitary adenomas. The findings showed that refractory PAs are unresponsive to conventional treatments and have a poor prognosis. Tumor size, invasive rate, and tumor growth rate were significantly higher in refractory PAs. A TGR >2.2% per month, Ki-67 index >= 3%, and EGFR overexpression may be independent predictors of clinical refractoriness.
FRONTIERS IN ONCOLOGY
(2022)
Review
Genetics & Heredity
Lilla Krokker, Attila Patocs, Henriett Butz
Summary: The 14q32 miRNAs play a significant role in the tumorigenesis of endocrine organs and have potential as biomarkers in endocrine neoplasms. Different endocrine tumors exhibit distinct characteristics in the expression of 14q32 miRNAs, suggesting further research may aid in diagnosis and prognosis.
Article
Endocrinology & Metabolism
Limei Zheng, Xiaorong Yan, Chengcong Hu, Peng Zhang, Yupeng Chen, Qiaoyan Zheng, Liwen Hu, Mi Wang, Guoping Li, Ping Wu, Changzhen Jiang, Jing Tian, Sheng Zhang, Xingfu Wang
Summary: This study investigated the clinicopathologic features of pituitary adenoma with neuronal differentiation. The results revealed that mixed gangliocytoma-pituitary adenomas are rare tumors associated with endocrinopathies. It was found that PIT1-positive pituitary adenomas may have neural differentiation potential.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Neurosciences
Yuhang Zhou, Anke Zhang, Chaoyou Fang, Ling Yuan, Anwen Shao, Yuanzhi Xu, Danyang Zhou
Summary: Pituitary adenomas, or PitNETs, are commonly found in the anterior pituitary gland and can exhibit both benign and malignant characteristics. The tumor microenvironment, consisting of various cells, is significantly influenced by oxidative stress. While immunotherapies have shown promise in multiple cancers, their potential in PitNETs has yet to be fully explored. Modulating oxidative stress-regulated immune cells to suppress PitNETs using a combination of agents and the immune system is a promising therapeutic direction. This review analyzes the role of oxidative stress in PitNET cells and immune cells to elucidate the potential value of immunotherapy.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Cell Biology
Swalih P. Ahmed, Javier S. Castresana, Mehdi H. Shahi
Summary: Central nervous system tumors, including medulloblastoma and glioblastoma, are a leading cause of cancer-related death. Cell heterogeneity and genetic mutations result in treatment resistance. Circular RNAs play a role in cancer development processes. This study aims to uncover the relationship between GBM pathogenesis and circRNAs.
Review
Immunology
Ling Wang, Dingkai Xu
Summary: Pituitary adenoma (PA) is a common type of intracranial tumor that can be treated surgically or with medication. However, some PA cases show invasion and cannot be completely removed, and a small percentage eventually develop into pituitary carcinomas. Understanding the pathological mechanism of PA and developing targeted therapies are of great importance.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Pathology
Cumhur Kaan Yaltirik, Emin Oguzcan Yamaner, Oznur Suakar, Sezin Gurkan, Aydin Sav, Ugur Ture
Summary: Tanycytic ependymoma is a rare neuroectodermal tumor that originates from ependymoglial cells or tanycytes. This article reports a case of a 34-year-old male diagnosed with intradural-intramedullary tanycytic ependymoma at the C4-5 level, presenting with a 9-month history of neck pain, left arm pain, and finger numbness. The lesion was completely removed by surgery and histopathological examination revealed fascicles forming nebula-like whorling structures.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Medical Laboratory Technology
Laya Jose, Sidong Liu, Carlo Russo, Cong Cong, Yang Song, Michael Rodriguez, Antonio Di Ieva
Summary: A deep learning-based approach for automated classification of glioma histopathology images was proposed in this study. Two different deep neural network architectures were tested, and the multiclass method outperformed the ensemble method. The proposed method can assist in the diagnosis and classification of glioma histopathology images.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Chiara Siracusa, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Marek Postula, Salvatore De Rosa
Summary: Lack of timely intervention strategies for acute ischemic stroke due to limited understanding of underlying mechanisms. Circular RNAs involved in pathophysiological processes of ischemic stroke, providing potential therapeutic targets and clinical biomarkers.
Article
Neurosciences
Jennilee M. Davidson, Sharlynn S. L. Wu, Stephanie L. Rayner, Flora Cheng, Kimberley Duncan, Carlo Russo, Michelle Newbery, Kunjie Ding, Natalie M. Scherer, Rachelle Balez, Alberto Garcia-Redondo, Alberto Rabano, Livia Rosa-Fernandes, Lezanne Ooi, Kelly L. Williams, Marco Morsch, Ian P. Blair, Antonio Di Ieva, Shu Yang, Roger S. Chung, Albert Lee
Summary: This study reveals the role of cyclin F in regulating substrate solubility and its contribution to the pathogenesis of ALS and FTD. The ALS and FTD-associated protein p62 is identified as a substrate of cyclin F, and its aggregation is promoted by cyclin F expression. Mutations in cyclin F result in dysregulated p62 solubility and formation of p62 foci, which are associated with ALS and FTD pathogenesis.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Clinical Neurology
Miracle C. Anokwute, Veronica Preda, Antonio Di Ieva
Summary: This study reviewed the literature on multidisciplinary team meetings (MDTMs) in neurosurgical care and identified limiting factors that may introduce bias to patient care. Productive MDTMs were found to involve quaternary/tertiary referral centers, a nonhierarchical environment, regularly scheduled meetings, inclusion of nonmedical factors, and use of clinical guidelines and institutional protocols. However, the use of artificial intelligence to reduce bias was not described in the literature.
WORLD NEUROSURGERY
(2023)
Review
Medicine, General & Internal
Nadia Salerno, Giuseppe Panuccio, Jolanda Sabatino, Isabella Leo, Michele Torella, Sabato Sorrentino, Salvatore De Rosa, Daniele Torella
Summary: Tricuspid valve (TV) disease is highly prevalent and has received significant attention in recent years. Comprehensive knowledge of molecular and cellular mechanisms underlying TV development and disease is necessary for better understanding and treatment of tricuspid regurgitation patients. Scientific efforts are still needed to fully understand the etiopathogenesis of TV and TV-associated cardiomyopathy, and future advances may come from combining diagnostic imaging with molecular and cellular studies. Basic science research could provide the basis for innovative valve repair and regeneration using tissue-engineered heart valves.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Chiara Siracusa, Niccolo Vono, Maria Benedetta Morano, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Eleonora Cianflone, Marek Postula, Daniele Torella, Salvatore De Rosa
Summary: Despite improvements in diagnosis and treatment, ischemic stroke remains a challenge with significant morbidity and mortality. The identification of high-risk individuals, timely diagnosis, recognition of different clinical forms, treatment response assessment, and prognostic evaluation are unmet clinical needs. This article provides an overview of circular RNAs as potential biomarkers in stroke, aiming to gather comprehensive information on this promising class of molecules.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Nadia Salerno, Mariangela Scalise, Fabiola Marino, Andrea Filardo, Antonio Chiefalo, Giuseppe Panuccio, Michele Torella, Antonella De Angelis, Salvatore De Rosa, Georgina M. Ellison-Hughes, Konrad Urbanek, Giuseppe Viglietto, Daniele Torella, Eleonora Cianflone
Summary: A mouse model of non-ischemic dilated cardiomyopathy (DCM) was established by administering isoproterenol (ISO) and 5-fluorouracil (5-FU) to mice. This model is valuable for studying DCM due to its characteristic pathological and functional changes.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Clinical Neurology
Merve Aktan Suzgun, Elif Everest, Selin Kucukyurt, Melih Tutuncu, Ugur Uygunoglu, Ahmet Emre Eskazan, Ugur Ture, Herbert Budka, Aydin Sav, Aksel Siva
Summary: Erdheim-Chester disease is a syndrome characterized by histiocytic infiltration of various organs and systems in the body. When the disease only affects the central nervous system (CNS), it is challenging to diagnose due to the absence of systemic symptoms, leading to misdiagnosis and ineffective treatment choices.
Article
Chemistry, Multidisciplinary
Fabiola Boccuto, Salvatore De Rosa, Daniele Torella, Pierangelo Veltri, Pietro Hiram Guzzi
Summary: Chronic heart failure (CHF) is a prevalent and multifactorial condition with a significant burden on healthcare systems and public budgets worldwide. Artificial intelligence (AI) shows promise in assisting clinical decision-making by analyzing raw image data and electrocardiogram recordings. This article provides an overview of the current gaps and needs in CHF research and clinical management and introduces AI-powered tools that may address these gaps and needs.
APPLIED SCIENCES-BASEL
(2023)
Review
Medicine, General & Internal
Giuseppe Panuccio, Youssef S. Abdelwahed, Nicole Carabetta, Nadia Salerno, David Manuel Leistner, Ulf Landmesser, Salvatore De Rosa, Daniele Torella, Gerald S. Werner
Summary: Chronic total occlusions (CTO) in coronary angiographies present a significant challenge. This meta-analysis aimed to compare IVUS-guided and angiography-guided approaches in CTO-PCI. The study included five studies and 2320 patients with stable CAD and CTO. The results showed that routine use of IVUS did not significantly improve clinical outcomes in CTO-PCI, except for reducing stent thrombosis. Decisions in CTO-PCI should be individualized based on patient characteristics and supported by a multi-parametric approach.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Mehnaz Tabassum, Abdulla Al Suman, Eric Suero Molina, Elizabeth Pan, Antonio Di Ieva, Sidong Liu
Summary: Radiomics is a method of extracting quantitative features from medical images, providing more detailed and objective information about tumor features. Machine learning techniques can enhance tumor diagnosis, treatment response assessment, and patient prognosis prediction. However, practical application of radiomics in clinical settings still needs improvement.
Review
Pharmacology & Pharmacy
Mahsa Vaezzadeh, Ehsan Kachooei, Shivani Krishnamurthy, Preeti Manandhar, Annemarie Nadort, Gilles J. Guillemin, Antonio Di Ieva, Marina Santiago, Benjamin Heng, Anna Guller
Summary: Combination drug therapy is a promising strategy to improve treatment outcomes for glioblastoma patients. However, there is a lack of clarity in drug testing using 3D in vitro models of glioblastoma. This review explores the available literature on the application of temozolomide (TMZ) in 3D in vitro models of glioblastoma, providing a roadmap for future combination treatment research.
ADVANCED THERAPEUTICS
(2023)
Meeting Abstract
Endocrinology & Metabolism
Mariana Peduti Halah, Ana Carolina Maia Teodozio, Davi Casale Aragon, Paula Conde lamparelli Elias, Margaret de Castro, Ayrton Custodio Moreira, Sonir Roberto Rauber Antonini
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Meeting Abstract
Endocrinology & Metabolism
Ana Carolina Maia Teodozio, Mariana Peduti Halah, Davi Casale Aragon, Paula Lamparelli Elias, Margaret de Castro, Ayrton Custodio Moreira, Sonir Roberto Rauber Antonini
HORMONE RESEARCH IN PAEDIATRICS
(2023)
