Article
Biology
Rolina K. Al-Wassia, Omar Iskanderani
Summary: In this study, the survival, local control, and treatment outcomes of 24 patients with brain metastases treated with SRS were evaluated based on radiological imaging. The results showed that some patients had no recurrence after SRS treatment, while those with recurrence experienced a decrease in lesion enhancement, size, or both. The overall survival rate was 16.7%, and there was a significant association between radiological findings and tumor recurrence.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongye Chen, Siyuan Qin, Weili Zhao, Qizheng Wang, Ke Liu, Peijin Xin, Huishu Yuan, Hongqing Zhuang, Ning Lang
Summary: This study aimed to develop response prediction models for patients with spinal metastases undergoing stereotactic body radiotherapy (SBRT) by extracting radiomics features from MRI using machine learning algorithms. The results showed that the MRI-based radiomics models have valuable predictive capability for treatment outcomes in these patients.
INSIGHTS INTO IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongye Chen, Qizheng Wang, Guangjin Zhou, Ke Liu, Siyuan Qin, Weili Zhao, Peijin Xin, Huishu Yuan, Hongqing Zhuang, Ning Lang
Summary: This study aimed to establish a prediction model for pain response after stereotactic body radiotherapy (SBRT) in patients with spinal metastases by analyzing conventional MRI, DCE-MRI, and clinical features. The results showed that the number of treated lesions, pretreatment pain score, Karnofsky performance status score, Bilsky grade, and DCE-MRI quantitative parameter K-trans were independent predictors of post-SBRT pain response in patients with spinal metastases. The predictive model had good discrimination performance with a C-index of 0.806.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Frenzel, Hannes-Friedrich Ulbrich, Hubertus Pietsch
Summary: The study compared the effects of repeated injections of two macrocyclic Gd-based contrast agents on rabbits, showing no significant differences in Gd concentrations in the brain between the two agents. Gd concentrations in the cerebellum and cerebrum decreased after 12 weeks, with the excreted Gd still present in urine in the intact complex form.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Oncology
Dominik Oft, Manuel Alexander Schmidt, Thomas Weissmann, Johannes Roesch, Veit Mengling, Siti Masitho, Christoph Bert, Sebastian Lettmaier, Benjamin Frey, Luitpold Valentin Distel, Rainer Fietkau, Florian Putz
Summary: There is insufficient understanding of the natural course of volumetric regression in brain metastases after stereotactic radiotherapy (SRT) and optimal volumetric criteria for the assessment of response and progression in radiotherapy clinical trials for brain metastases are currently unknown. Volumetric regression post-SRT does not occur at a constant rate but is most pronounced in the first 6 weeks to 3 months. A cutoff of >= 20% regression for the volumetric definition of response at 3 months post-SRT was predictive for subsequent control whereas the currently proposed definition of >= 65% was not.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
J. A. Crouzen, A. L. Petoukhova, M. L. D. Broekman, M. Fiocco, U. J. Fisscher, J. H. Franssen, C. G. M. Gadellaa-van Hooijdonk, M. Kerkhof, M. Kiderlen, M. E. Mast, C. M. van Rij, R. Nandoe Tewarie, M. A. E. van de Sande, P. P. G. van der Toorn, R. Vlasman, M. J. Vos, N. C. M. G. van der Voort van Zyp, R. G. J. Wiggenraad, L. M. Wiltink, J. D. Zindler
Summary: A multicenter prospective randomized study aims to compare the incidence of adverse local events in patients with brain metastases using fractionated stereotactic radiosurgery (fSRS) versus stereotactic radiosurgery (SRS) in one or three fractions. The study aims to reduce the risk of radionecrosis and improve the effectiveness of brain metastases treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hesheng Wang, Jinyu Xue, Tanxia Qu, Kenneth Bernstein, Ting Chen, David Barbee, Joshua S. Silverman, Douglas Kondziolka
Summary: Radiomic features from planning MR images and dose maps were used to predict local failure after SRS for brain metastases. A logistic regression model with automatic feature selection achieved a ROC AUC of 0.82 on 5-fold CV, with 83% sensitivity and 70% specificity for predicting local failure. Ten radiomic features significantly associated with treatment outcomes were selected for the model.
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Zhiyuan Xu, Reed Mullen, Juan Alzate, Kenneth Bernstein, Douglas Kondziolka, Zhishuo Wei, Ajay Niranjan, L. Dade Lunsford, Roman Liscak, Jaromir May, Cheng-chia Lee, Huai-che Yang, Francois-Louis Coupe, David Mathieu, Kimball Sheehan, Darrah Sheehan, Joshua D. Palmer, Haley K. Perlow, Selcuk Peker, Yavuz Samanci, Jennifer Peterson, Daniel M. Trifiletti, Matthew J. Shepard, Shahed Elhamdani, Rodney E. Wegner, Herwin Speckter, Wenceslao Hernandez, Ronald E. Warnick, Jason Sheehan
Summary: This retrospective study showed that stereotactic radiosurgery (SRS) is an effective treatment option for intraventricular metastases (IVMs), with a comparable local control rate to SRS for parenchymal brain metastases. However, careful follow-up is needed to detect leptomeningeal spread and hydrocephalus in patients with IVMs.
Review
Oncology
Raees Tonse, Martin C. Tom, Minesh P. Mehta, Manmeet S. Ahluwalia, Rupesh Kotecha
Summary: In modern times, brain metastasis requires multi-modal management and interdisciplinary care. Traditionally, treatment strategies have focused on local treatments alone due to limited efficacy of cytotoxic chemotherapy. However, with the availability of molecular-based therapies with central nervous system penetration, individualized selection of tailored systemic therapies can now be used alongside local treatments. Moreover, the introduction of immune checkpoint inhibitors has further revolutionized the management of brain metastasis patients.
Article
Clinical Neurology
Adomas Bunevicius, Karen Lavezzo, Leah Shabo, Jesse McClure, Jason P. Sheehan
Summary: The study evaluated the quality of life in patients treated with stereotactic radiosurgery for brain metastases, finding that the quality of life remained largely stable post-treatment. Factors such as the patient's RPA class, upfront whole-brain radiation therapy, and the number of intracranial lesions were identified as independent predictors of post-treatment quality of life deterioration. Additionally, a lower pre-treatment quality of life was associated with shorter survival independently of other clinical and demographic variables.
JOURNAL OF NEUROSURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeemin Seo, Changmok Lim, Kye Young Lee, Young-Cho Koh, Won-Jin Moon
Summary: The study determined the optimal delay time for contrast-enhanced T1-weighted imaging in patients with brain metastases, primary brain tumors, and meningiomas. The best timing for imaging was 5-7 minutes after gadobutrol injection.
BMC MEDICAL IMAGING
(2022)
Article
Clinical Neurology
Stylianos Pikis, Adomas Bunevicius, Cheng-Chia Lee, Huai-Che Yang, Brad E. Zacharia, Roman Liscak, Gabriela Simonova, Manjul Tripathi, Narendra Kumar, David Mathieu, Remi Perron, Selcuk Peker, Yavuz Samanci, Jason Gurewitz, Kenneth Bernstein, Douglas Kondziolka, Ajay Niranjan, L. Dade Lunsford, Nikolaos Mantziaris, Jason P. Sheehan
Summary: This multicenter study evaluated the safety and efficacy of stereotactic radiosurgery (SRS) in the management of intracranial prostate cancer metastases. The results showed that SRS was a safe, well-tolerated, and effective treatment option for these patients.
JOURNAL OF NEUROSURGERY
(2022)
Article
Oncology
Angela Barillaro, Mara Caroprese, Laura Cella, Anna Viggiano, Francesca Buccelli, Chiara Daponte, Chiara Feoli, Caterina Oliviero, Stefania Clemente, Antonio Farella, Manuel Conson, Roberto Pacelli
Summary: Brain metastases are severe events in patients with solid tumors. Stereotactic radiation therapy is an effective treatment for brain metastases, but it may lead to radiation necrosis, which can impact patient's quality of life. Prompt recognition and treatment are necessary for managing radiation necrosis.
Article
Clinical Neurology
Yuping Derek Li, Andrew T. Coxon, Jiayi Huang, Christopher D. Abraham, Joshua L. Dowling, Eric C. Leuthardt, Gavin P. Dunn, Albert H. Kim, Ralph G. Dacey, Gregory J. Zipfel, John Evans, Eric A. Filiput, Michael R. Chicoine
Summary: Neoadjuvant SRS, as a new treatment paradigm, shows the potential for improved outcomes compared with postoperative SRS, mitigating the limitations of the latter.
NEUROSURGICAL FOCUS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nathan Torelli, David Papp, Jan Unkelbach
Summary: This study investigates the potential of spatiotemporal fractionation schemes to reduce the healthy brain's received biological dose in the treatment of brain metastases (BMs). The spatiotemporal fractionation schemes involve partial hypofractionation in the metastases and more uniform fractionation in the healthy brain. A constrained approach to spatiotemporal fractionation (cSTF) is proposed for patients with multiple brain metastases, which is more robust against uncertainties. The results show that spatiotemporal fractionation schemes can effectively reduce the healthy brain's biological dose.
Letter
Clinical Neurology
Andrea Franzini, Luca Attuati, Maurizio Fornari, Franco Servadei, Pierina Navarria, Piero Picozzi
ACTA NEUROCHIRURGICA
(2020)
Letter
Clinical Neurology
Andrea Cardia, Irene Zerbetto, Delia Cannizzaro, Piero Picozzi, Maurizio Fornari, Paolo Levi Setti, Franco Servadei
JOURNAL OF NEUROSURGICAL SCIENCES
(2020)
Article
Clinical Neurology
Adomas Bunevicius, Rithika Kormath Anand, Mohanad Suleiman, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Marco Perez Caceres, David Mathieu, Cheng-chia Lee, Huai-che Yang, Piero Picozzi, Andrea Franzini, Luca Attuati, Herwin Speckter, Jeremy Olivo, Samir Patel, Christopher P. Cifarelli, Daniel T. Cifarelli, Joshua D. Hack, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Kareem R. Fakhoury, Chad G. Rusthoven, Ronald E. Warnick, Jason Sheehan
Summary: SRS provides durable tumor control and acceptable rates of vision preservation in perioptic meningiomas. A prescription dose of >= 12 Gy is associated with improved tumor control, while a dose to the optic apparatus of >= 10 Gy and tumor progression are associated with post-SRS visual decline.
Article
Oncology
Ramon F. Barajas, Letterio S. Politi, Nicoletta Anzalone, Heiko Schoder, Christopher P. Fox, Jerrold L. Boxerman, Timothy J. Kaufmann, C. Chad Quarles, Benjamin M. Ellingson, Dorothee Auer, Ovidiu C. Andronesi, Andres J. M. Ferreri, Maciej M. Mrugala, Christian Grommes, Edward A. Neuwelt, Prakash Ambady, James L. Rubenstein, Gerald Illerhaus, Motoo Nagane, Tracy T. Batchelor, Leland S. Hu
Summary: The article discusses the molecular and pathophysiologic characteristics of PCNSL, as well as critically reviewing the use of PET and MRI in diagnosis and treatment of PCNSL. Recommendations on standardized imaging practices are provided, along with ideal and minimum standard protocols for 3T and 1.5T MR systems to facilitate widespread adoption.
Review
Clinical Neurology
Andrea Franzini, Maria Pia Tropeano, Simone Olei, Mario De Robertis, Zefferino Rossini, Luca Attuati, Davide Milani, Federico Pessina, Elena Clerici, Pierina Navarria, Piero Picozzi
Summary: Trigeminal neuralgia in patients with multiple sclerosis is challenging to manage, often treated with Gamma Knife radiosurgery. This study evaluated the safety, efficacy, and durability of GKRS for TN in MS patients, finding short-term pain control was effective but long-term control was limited. Repeat GKRS was found to be safe and effective in prolonging pain relief.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Sonia Francesca Calloni, Marianna Perrotta, Luisa Roveri, Pietro Panni, Anna del Poggio, Paolo Quintiliano Vezzulli, Massimo Filippi, Andrea Falini, Nicoletta Anzalone
Summary: The study showed that CE-MRA is a reliable tool for ruling out intracranial pathology associated with supraortic steno-occlusive disease and also reduces examination time. In cases of suspicion of dissection, a T1-weighted sequence should be added to detect the presence of subacute vessel wall hematoma.
NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
Andrea Franzini, Zefferino Rossini, Shayan Moosa, Maria Pia Tropeano, Davide Milani, Luca Attuati, Elena Clerici, Pierina Navarria, Federico Pessina, Piero Picozzi
Summary: Medial thalamotomy using stereotactic radiosurgery (SRS) is effective for select patients with treatment-resistant pain and remarkably safe when modern radiation delivery platforms are used. More studies are warranted to shed light on differences in patient responses.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Adomas Bunevicius, Stylianos Pikis, Rithika Kormath Anand, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Tomas Chytka, Roman Liscak, Marco Perez Caceres, David Mathieu, Cheng-Chia Lee, Huai-Che Yang, Piero Picozzi, Andrea Franzini, Luca Attuati, Herwin Speckter, Jeremy Olivo, Samir Patel, Christopher P. Cifarelli, Daniel T. Cifarelli, Joshua D. Hack, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Kareem R. Fakhoury, Chad G. Rusthoven, Ronald E. Warnick, Jason Sheehan
Summary: The study found that SRS treatment for clinoid meningiomas can achieve good tumor control and visual preservation in the majority of patients. A higher radiosurgical prescription dose is associated with better tumor control, while radiation dose to the optic apparatus of >= 10 Gy and pre-existing visual impairment increase the risk of visual deterioration.
ACTA NEUROCHIRURGICA
(2021)
Letter
Clinical Neurology
Andrea Franzini, Elena Clerici, Pierina Navarria, Federico Pessina, Piero Picozzi
CHILDS NERVOUS SYSTEM
(2021)
Article
Clinical Neurology
Adomas Bunevicius, Jungeun Ahn, Sarah Fribance, Selcuk Peker, Batu Hergunsel, Darrah Sheehan, Kimball Sheehan, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Tomas Chytka, Roman Liscak, Roberto Martinez Alvarez, Nuria Martinez Moreno, Anne-Marie Langlois, David Mathieu, Cheng-Chia Lee, Huai-Che Yang, Manjul Tripathi, Ronald E. Warnick, Herwin Speckter, Camilo Albert, Piero Picozzi, Andrea Franzini, Luca Attuati, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Caleb E. Feliciano Valls, Carlos H. Carbini, Samir Patel, Jason Sheehan
Summary: The study shows that SRS treatment provides durable local control for patients with olfactory groove meningiomas, with an acceptable safety profile, and allows preservation or improvement of olfactory function in the majority of patients.
Article
Oncology
Eric J. Lehrer, Jason Gurewitz, Kenneth Bernstein, Dev Patel, Douglas Kondziolka, Ajay Niranjan, Zhishuo Wei, L. Dade Lunsford, Timothy D. Malouff, Henry Ruiz-Garcia, Samir Patel, Phillip A. Bonney, Lindsay Hwang, Cheng Yu, Gabriel Zada, David Mathieu, Claire Trudel, Rahul N. Prasad, Joshua D. Palmer, Brianna M. Jones, Sonam Sharma, Kareem R. Fakhoury, Chad G. Rusthoven, Christopher P. Deibert, Piero Picozzi, Andrea Franzini, Luca Attuati, Cheng-Chia Lee, Huai-Che Yang, Manmeet S. Ahluwalia, Jason P. Sheehan, Daniel M. Trifiletti
Summary: The occurrence of symptomatic radiation necrosis (RN) in patients with renal cell carcinoma (RCC) brain metastases treated with immune checkpoint inhibitors (ICIs) and stereotactic radiosurgery (SRS) is relatively low, with most events being grade 1 to 3 and managed by medical means. Concurrent therapy with ICI/SRS does not appear to increase the risk of RN. Efforts to improve dose conformality may be the most successful strategy for mitigating RN in single-fraction SRS.
Review
Clinical Neurology
Andrea Franzini, Elena Clerici, Pierina Navarria, Piero Picozzi
Summary: Gamma Knife radiosurgery (GKRS) can be used to treat drug-resistant cluster headache (CH). The outcomes of studies on GKRS for CH are inconsistent, and the ideal target and treatment parameters are unclear. This systematic review evaluates the safety and efficacy of GKRS for drug-resistant CH, showing high short-term pain reduction rates but controversial long-term results.
NEUROSURGICAL REVIEW
(2022)
Article
Biotechnology & Applied Microbiology
Michela Destito, Aldo Marzullo, Riccardo Leone, Paolo Zaffino, Sara Steffanoni, Federico Erbella, Francesco Calimeri, Nicoletta Anzalone, Elena De Momi, Andres J. M. Ferreri, Teresa Calimeri, Maria Francesca Spadea
Summary: This study aimed to investigate whether radiomics features can improve outcome prediction in patients with Primary Central Nervous System Lymphoma (PCNSL). By extracting and selecting radiomics features from normalized MR images and using machine learning models for survival prediction, better performance was achieved compared to current clinical prognostic factors. These results indicate that radiomics features can improve prognosis stratification of PCNSL patients and pave the way for further study on their potential role in treatment choice.
BIOENGINEERING-BASEL
(2023)
Article
Clinical Neurology
David T. Asuzu, Adomas Bunevicius, Rithika Kormath Anand, Mohanad Suleiman, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdel Karim, Amr M. N. El-Shehaby, Reem M. Emad Eldin, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Marco Perez Caceres, David Mathieu, Cheng-Chia Lee, Huai-Che Yang, Piero Picozzi, Andrea Franzini, Luca Attuati, Herwin Speckter, Jeremy Olivo, Samir Patel, Christopher P. Cifarelli, Daniel T. Cifarelli, Joshua D. Hack, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Kareem R. Fakhoury, Chad G. Rusthoven, Ronald E. Warnick, Jason P. Sheehan
Summary: This international multicenter study found that the majority of patients with meningiomas in direct contact with the anterior optic pathways achieved tumor control and preservation of visual function when treated with SRS.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
I. Jonathan Pomeraniec, Zhiyuan Xu, Cheng-Chia Lee, Huai-Che Yang, Tomas Chytka, Roman Liscak, Roberto Martinez-Alvarez, Nuria Martinez-Moreno, Luca Attuati, Piero Picozzi, Douglas Kondziolka, Monica Mureb, Kenneth Bernstein, David Mathieu, Michel Maillet, Akiyoshi Ogino, Hao Long, Hideyuki Kano, L. Dade Lunsford, Brad E. Zacharia, Christine Mau, Leonard C. Tuanquin, Christopher Cifarelli, David Arsanious, Joshua Hack, Ronald E. Warnick, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Herwin Speckter, Samir Patel, Dale Ding, Darrah Sheehan, Kimball Sheehan, Svetlana Kvint, Love Y. Buch, Alexander R. Haber, Jacob Shteinhart, Mary Lee Vance, Jason P. Sheehan
Summary: Stereotactic radiosurgery (SRS) is an effective treatment for pituitary adenomas, but the mechanism of delayed endocrine deficits is not well understood. This multicenter study aimed to evaluate radiation tolerance and identify predictors of delayed hypopituitarism after SRS for these tumors. The study found that tumor control was achieved in a high percentage of patients, but a significant number developed new loss of pituitary function, with certain factors such as tumor type, age, and radiation dose playing a role.
JOURNAL OF NEUROSURGERY
(2022)
