期刊
NEUROSURGERY
卷 69, 期 2, 页码 440-454出版社
OXFORD UNIV PRESS INC
DOI: 10.1227/NEU.0b013e318215a3b3
关键词
Brain diseases; Brain neoplasms; Gene expression regulation; MicroRNA; Nervous system RNA; Posttranscriptional; Untranslated RNA processing
The recent discovery of microRNAs (miRNAs) has caused the traditional central dogma of molecular biology to be rewritten. miRNAs are small, noncoding pieces of ribonucleic acid that exert control over gene expression at the posttranscriptional level. They appear to play important roles in the normal development and functioning of the nervous system and in disease states. To understand future diagnostic and therapeutic advances arising from the study of miRNAs, it is crucial that neurosurgeons understand what miRNAs are, how they function, and the role they play in diseases of the nervous system. This article serves as a basic introduction to miRNAs and their ever-expanding role in the neurological sciences.
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