Article
Clinical Neurology
Chao Ma, Haoyu Zhu, Shikai Liang, Fei Liang, Jidian Sun, Yupeng Zhang, Chuhan Jiang
Summary: This study compared the efficacy of traditional endovascular therapeutic approaches and the pipeline embolization device (PED) in treating distal cerebral circulation aneurysms. The study found that PED can provide similar rates of occlusion and complications compared to traditional endovascular therapeutic approaches. Rigorous patient selection and proper planning should be undertaken to reduce treatment-related complications.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Huijian Ge, Xiheng Chen, Kai Liu, Yang Zhao, Longhui Zhang, Peng Liu, Yuhua Jiang, Hongwei He, Ming Lv, Youxiang Li
Summary: This study aimed to investigate the clinical and angiographic outcomes of Pipeline embolization device (PED) treatment of large or giant basilar artery (BA) aneurysms and examine associated factors. The results showed that PED treatment is effective and can achieve a satisfactory long-term occlusion rate, but treatment complications are not negligible. Aneurysm size is the strongest predictor of perioperative complications and poor clinical outcome.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Linggen Dong, Chao Wang, Xiheng Chen, Mingtao Li, Tong Li, He Liu, Yang Zhao, Ran Duan, Weitao Jin, Yukun Zhang, Yang Wang, Ming Lv
Summary: This study developed a nomogram to predict persistent aneurysm filling after pipeline embolization device (PED) treatment, providing a practical approach for neurointerventionalists to evaluate treatment effectiveness and change their strategies.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Samuel J. Cler, David C. Lauzier, Arindam R. Chatterjee, Joshua W. Osbun, Christopher J. Moran, Akash P. Kansagra
Summary: This study characterized the timeline of aneurysm occlusion following treatment with the Pipeline embolization device (PED) using real-world variability in timing of angiographic follow-up. Larger aneurysms demonstrated a longer median time to occlusion and lower rate of aneurysm occlusion, while the number of PEDs deployed or the use of adjunctive coiling did not affect the time line or likelihood of aneurysm occlusion.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Samuel J. Cler, David C. Lauzier, Arindam R. Chatterjee, Joshua W. Osbun, Christopher J. Moran, Akash P. Kansagra
Summary: This study utilized real-world variability in timing of angiographic follow-up to characterize the time line of aneurysm occlusion following treatment with the Pipeline embolization device (PED). The findings showed that larger aneurysms had a longer median time to occlusion and lower rate of occlusion, but the number of PEDs deployed or the use of adjunctive coiling did not affect the time line or likelihood of aneurysm occlusion. The median time to observed occlusion of aneurysms treated with a PED was 7.5 months.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Weiying Zhong, Hong Kuang, Ping Zhang, Xinjian Yang, Bin Luo, Aisha Maimaitili, Yuanli Zhao, Donglei Song, Sheng Guan, Hongqi Zhang, Yang Wang, Donghai Wang, Wandong Su, Yunyan Wang
Summary: The study retrospectively analyzed the experience of PED treatment in 38 patients with ruptured intracerebral aneurysms and found that PED is a feasible and effective approach to prevent rebleeding and achieve aneurysm occlusion, but it comes with a substantial risk of periprocedural hemorrhage and ischemic complications in acute ruptured IAs. Adjunctive coiling during treatment may increase the risk of procedure-related stroke.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Sandeep Muram, Muneer Eesa, Brooke L. Belanger, Mohammed Almekhlafi, Mayank Goyal, William Morrish, John H. Wong, Santiago Gomez-Paz, Yosuke Akamatsu, Mohamed M. Salem, Timothy M. Robinson, Justin M. Moore, Ajith J. Thomas, Christopher S. Ogilvy, Alim P. Mitha
Summary: The study revealed that oversizing the stent and poor wall apposition can lead to aneurysm recurrence after PED placement due to elongation. A novel parameter based on two-dimensional imaging, the ML/NL ratio, was found to be significantly larger in nonoccluded aneurysms, suggesting it could predict aneurysm occlusion after PED placement.
WORLD NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Li Li, Bu-Lang Gao, Qiao-Wei Wu, Tian-Xiao Li, Qiu-Ji Shao, Kai-Tao Chang
Summary: The endovascular performance of the Pipeline Classic embolization device (PED Classic) and PED Flex device (PED Flex) in treating intracranial aneurysms was investigated. Fifty-three patients were treated with PED Classic and 118 patients were treated with PED Flex. Procedure time, contrast dosage, fluoroscopy time, and perioperative complications were analyzed. The study found that the PED Flex device may offer a safer and easier treatment option for intracranial aneurysms compared to the PED Classic device, despite some serious complications that still need to be addressed.
Article
Clinical Neurology
Dachao Wei, Dingwei Deng, Siming Gui, Wei You, Junqiang Feng, Xiangyu Meng, Xiheng Chen, Jian Lv, Yudi Tang, Ting Chen, Peng Liu
Summary: This study used machine learning methodology to establish a model for predicting in-stent stenosis (ISS) after Pipeline embolization device (PED) placement. Six predictors of ISS were identified, and the elastic net (ENT) model showed the best predictive performance. This model has the potential to improve patient outcomes in the treatment of intracranial aneurysms.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Yuhui Ling, Jie Liu, Liyun Zhou, Xiuzhi Xiang, Peiming Wang
Summary: Flow diverters, such as the pipeline embolization device (PED), have shown to be effective in the retreatment of recanalized aneurysms following stent-assisted coiling embolization.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Chaim M. Feigen, Juan Vivanco-Suarez, Kainaat Javed, Joseph M. Dardick, Ryan Holland, Alan Mendez-Ruiz, Santiago Ortega-Gutierrez, Neil Haranhalli, David J. Altschul
Summary: This study compared safety and efficacy profiles of Pipeline Embolization Device or Pipeline Flex versus Surpass Streamline flow diverters in treating aneurysms, and found that the deployment of Surpass Streamline was more technically challenging.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Samuel J. Cler, David C. Lauzier, Arindam R. Chatterjee, Joshua W. Osbun, Christopher J. Moran, Akash P. Kansagra
Summary: The study compared the real-world efficacy and safety of Pipeline embolization device (PED) use in on-label and off-label aneurysm treatments, finding no significant difference in complete aneurysm occlusion rates between the two groups but a higher risk of ischemic stroke in off-label treatments. Other clinical and procedural complications, as well as long-term functional status, were comparable between the on-label and off-label groups.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Justin M. Cappuzzo, Andre Monteiro, Maritza N. Taylor, Muhammad Waqas, Ammad A. Baig, Faisal Almayman, Jason M. Davies, Kenneth Snyder, Adnan H. Siddiqui, Elad Levy
Summary: This study reports the initial results of using the PED-Shield for intracranial aneurysm treatment in a series of US patients. The device showed excellent performance and no major complications. A literature review revealed that most studies were conducted in Europe and South America, with only a few US case reports available.
WORLD NEUROSURGERY
(2022)
Article
Surgery
Junlin Lu, Yang Zhao, Hongqi Zhang, Tianxiao Li, Donglei Song, Sheng Guan, Aisha Maimaitili, Yunyan Wang, Wenfeng Feng, Yang Wang, Jieqing Wan, Guohua Mao, Huaizhang Shi, Xinjian Yang, Jianmin Liu, Yuanli Zhao
Summary: This study found that operator experience has a significant impact on the complication and poor outcome rates of PED treatment. It also showed that a learning curve of 40 cases is required to achieve reproducibility in terms of complications and functional results. Furthermore, the study found that major complications and poor outcomes significantly decrease after the first 20 procedures. CUSUM analysis can serve as a useful tool for monitoring and assessing surgical performance.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Clinical Neurology
Hyun Sik Kim, Young Dae Cho, Dong Hyun Yoo, Noah Hong, Chang Hwan Pang, Kang Min Kim, Sung Ho Lee, Won-Sang Cho, Hyun-Seung Kang, Jeong Eun Kim, Moon Hee Han
Summary: This study evaluated the technical aspects and procedural outcomes of coil embolization in 36 patients with 72 kissing aneurysms. The results indicated that properly conducted single-stage coil embolization is a safe and effective method for treating such lesions.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Cameron G. McDougall, Robert F. Spetzler, Joseph M. Zabramski, Shahram Partovi, Nancy K. Hills, Peter Nakaji, Felipe C. Albuquerque
JOURNAL OF NEUROSURGERY
(2012)
Article
Clinical Neurology
Robert F. Spetzler, Cameron G. McDougall, Felipe C. Albuquerque, Joseph M. Zabramski, Nancy K. Hills, Shahram Partovi, Peter Nakaji, Robert C. Wallace
JOURNAL OF NEUROSURGERY
(2013)