Article
Radiology, Nuclear Medicine & Medical Imaging
Otto M. Henriksen, Adam E. Hansen, Aida Muhic, Lisbeth Marner, Karine Madsen, Soren Moller, Benedikte Hasselbalch, Michael J. Lundemann, David Scheie, Jane Skjoth-Rasmussen, Hans S. Poulsen, Vibeke A. Larsen, Henrik B. W. Larsson, Ian Law
Summary: This study compared the diagnostic yield of dynamic contrast-enhanced (DCE) perfusion MRI and O-(2-[F-18]-fluoroethyl)-L-tyrosine ([F-18]FET) PET in patients with recurrent high-grade gliomas. The results showed that DCE BV imaging had good overall diagnostic accuracy, but lower than [F-18]FET PET. Combining both techniques can improve specificity and risk stratification of the lesions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Clinical Neurology
Akihiro Inoue, Takanori Ohnishi, Shohei Kohno, Shiro Ohue, Masahiro Nishikawa, Satoshi Suehiro, Shirabe Matsumoto, Saya Ozaki, Mana Fukushima, Mie Kurata, Riko Kitazawa, Seiji Shigekawa, Hideaki Watanabe, Takeharu Kunieda
Summary: GBM largely caused by GSCs that cannot be fully removed during surgery; Met-PET imaging helps identify areas with infiltrating GSCs and active tumor cells; aggressive surgical excision including Met-positive areas at TNR 1.4 is recommended for maximum resection of GBMs.
NEUROSURGICAL REVIEW
(2021)
Article
Clinical Neurology
Zhan Xue, Lu Kong, Shuyu Hao, Yu Wang, Guijun Jia, Zhen Wu, Wang Jia, Junting Zhang, Liwei Zhang
Summary: The combined application of sodium fluorescein and neuronavigation techniques showed satisfactory tumor visualization in brain glioma resection surgery, with higher consistency in the brainstem group compared to the supratentorial group. A half dose of sodium fluorescein was found to be sufficient for pediatric patients. Overall, this combined approach may lead to better clinical outcomes for glioma patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marie Hautiere, Delphine Vivier, Donovan Pineau, Caroline Denis, Dimitri Kereselidze, Amaury Herbet, Narciso Costa, Victor Goncalves, Erwan Selingue, Benoit Larrat, Jean Philippe Hugnot, Franck Denat, Didier Boquet, Charles Truillet
Summary: This study demonstrates the potential of [Zr-89]Zr-xiRA63 in specifically targeting ETA+ tumors, which raises the possibility of detecting and treating ETA+ GSCs, thereby improving the management of GBM patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Clinical Neurology
Robert C. Subtirelu, Eric M. Teichner, Arjun Ashok, Chitra Parikh, Sahithi Talasila, Irina-Mihaela Matache, Ahab G. Alnemri, Victoria Anderson, Osmaan Shahid, Sricharvi Mannam, Andrew Lee, Thomas Werner, Mona-Elisabeth Revheim, Abass Alavi
Summary: This review discusses the mechanisms, challenges, and potential integration of dendritic cell vaccinations in the treatment of glioblastoma.
FRONTIERS IN NEUROLOGY
(2023)
Article
Oncology
David Sipos, Zoltan Laszlo, Zoltan Toth, Peter Kovacs, Jozsef Tollar, Akos Gulyban, Ferenc Lakosi, Imre Repa, Arpad Kovacs
Summary: This study investigated the added value of FDOPA PET in radiotherapy planning for GBM and found that FDOPA PET resulted in larger tumor volumes compared to MRI, but most recurrences still occurred within the prescribed dose level.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yuji Muraoka, Yukihiro Yoshida, Kazuo Nakagawa, Kimiteru Ito, Hirokazu Watanabe, Tetsuo Narita, Shun-ichi Watanabe
Summary: This retrospective study found that combining the maximum standardized uptake value and consolidation-to-tumor ratio from a high-resolution computed tomography scan can improve the predictive accuracy for noninvasive lung cancer, leading to better selection of patients for sublobar resection.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Multidisciplinary Sciences
Ou Yamaguchi, Kyoichi Kaira, Ichiro Naruse, Yukihiro Umeda, Takeshi Honda, Satoshi Watanabe, Kosuke Ichikawa, Kazunari Tateishi, Norimitsu Kasahara, Tetsuya Higuchi, Kosuke Hashimoto, Shun Shinomiya, Yu Miura, Ayako Shiono, Atsuto Mouri, Hisao Imai, Kunihiko Iizuka, Tamotsu Ishizuka, Koichi Minato, Satoshi Suda, Hiroshi Kagamu, Keita Mori, Ichiei Kuji, Nobuhiko Seki
Summary: This study aimed to investigate the clinical relevance of F-18-FDG PET/CT compared to CT in predicting the response to PD-1 blockade in the early phase. The results showed that metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Thomas Pyka, Iwona Krzyzanowska, Axel Rominger, Claire Delbridge, Bernhard Meyer, Tobias Boeckh-Behrens, Claus Zimmer, Jens Gempt
Summary: Static and dynamic FET-PET and MRS are useful for grading and prognostication in gliomas. Multimodal imaging improves discrimination and characterization of gliomas. PET parameters are correlated with overall survival, and the inclusion of MRS in the analysis is also useful for survival prediction.
Review
Biochemistry & Molecular Biology
Felix Neumaier, Boris D. D. Zlatopolskiy, Bernd B. Neumaier
Summary: In this review titled "Prospects and challenges for the application of mutated IDH PET probes in gliomas", the authors summarize the rationale behind the development of mutated IDH PET probes, describe their potential applications beyond IDH status assessment, and highlight potential challenges in tracer development. The authors also compile the major chemical classes of mutated IDH-selective inhibitors that have been described to date, briefly consider possible strategies for radiolabeling of the most promising candidates, and assess the suitability of radiolabeled analogs of mutated IDH inhibitors for PET imaging in gliomas.
Article
Chemistry, Organic
Aaron Schuell, Lisa Grothe, Eduardo Rodrigo, Thomas Erhard, Siegfried R. Waldvogel
Summary: A novel electrosynthetic approach for the synthesis of aryl dibenzothiophenium salts, including the metal-free, electrochemical formation of a C-S bond under ambient conditions, has been reported. The broad applicability of this method has been demonstrated with 14 examples, achieving isolated yields of up to 72%, including nitrogen-containing heterocycles. The resulting sulfonium salts can serve as precursors for the synthesis of [F-18]fluoroarenes found in PET tracer ligands.
Article
Oncology
Maxwell W. G. Miner, Heidi Liljenback, Jenni Virta, Semi Helin, Olli Eskola, Petri Elo, Jarmo Teuho, Kerttu Seppala, Vesa Oikonen, Guangli Yang, Andrea Kindler-Roehrborn, Heikki Minn, Xiang-Guo Li, Anne Roivainen
Summary: This study investigated the imaging capabilities of three PET imaging compounds in orthotopic BT4C gliomas in BDIX rats and compared two imaging systems. Results indicated that [F-18]FGln may offer improved imaging compared to [C-11]Met and [F-18]FDG, with similar end-result ratios between Inveon and Molecubes camera systems. Pharmacokinetic modeling suggested both reversible and irreversible uptake play an important role in the uptake of [F-18]FGln in BDIX rat pharmacokinetics.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Oncology
Hannah M. Linden, David A. Mankoff
Summary: [F-18]fluoroestradiol (FES) PET is an FDA-approved imaging biomarker that predicts clinical benefit of endocrine therapy and measures target activity in drug development. A recent study showed that tumor heterogeneity of expression predicts clinical benefit, and serial FES monitoring can assess estrogen receptor blockade and posttreatment release.
CLINICAL CANCER RESEARCH
(2023)
Review
Medicine, General & Internal
Dan L. Li, Marvin W. Kronenberg
Summary: Coronary artery disease is a major global health concern with noninvasive imaging tests playing a crucial role in its diagnosis and management. Myocardial perfusion imaging, along with other noninvasive tests such as stress echocardiography, coronary computed tomography angiography, and cardiac magnetic resonance imaging, have been widely used for evaluating ischemia and myocardial viability. The accuracy and clinical significance of these tests are essential in guiding risk stratification and revascularization decisions.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shuangshuang Song, Leiming Wang, Hongwei Yang, Yongzhi Shan, Ye Cheng, Lixin Xu, Chengyan Dong, Guoguang Zhao, Jie Lu
Summary: FET PET and DSC-PWI are non-invasive predictors for glioma grades and IDH mutation status. The combination of CBV with FET PET can improve the differentiation of IDH-mutated astrocytomas and IDH-wildtype glioblastomas.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Jean Regis, Constantin Tuleasca, Noemie Resseguier, Romain Carron, Anne Donnet, Jean Gaudart, Marc Levivier
JOURNAL OF NEUROSURGERY
(2016)
Article
Clinical Neurology
M. Messerer, G. Cossu, P. Pasche, C. Ikonomidis, C. Simon, E. Pralong, M. George, M. Levivier, R. T. Daniel
Review
Clinical Neurology
M. Messerer, B. Richoz, G. Cossu, F. Dhermain, A. F. Hottinger, F. Parker, M. Levivier, R. T. Daniel
Article
Neurosciences
Jean Regis, Constantin Tuleasca, Noemie Resseguier, Romain Carron, Anne Donnet, Shoji Yomo, Jean Gaudart, Marc Levivier
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2016)
Article
Neurosciences
Marc Vander Ghinst, Mathieu Bourguignon, Maxime Niesen, Vincent Wens, Sergio Hassid, Georges Choufani, Oveildco Jousmaki, Riitta Hari, Serge Goldman, Xavier De Tiege
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Jeroen Van Schependom, Diego Vidaurre, Lars Costers, Martin Sjogard, Marie B. D'hooghe, Miguel D'haeseleer, Vincent Wens, Xavier De Tiege, Serge Goldman, Mark Woolrich, Guy Nagels
HUMAN BRAIN MAPPING
(2019)
Article
Neurosciences
Lars Costers, Jeroen Van Schependom, Jorne Laton, Johan Baijot, Martin Sjogard, Vincent Wens, Xavier De Tiege, Serge Goldman, Miguel D'Haeseleer, Marie Beatrice D'hooghe, Mark Woolrich, Guy Nagels
HUMAN BRAIN MAPPING
(2020)
Article
Neurosciences
Lars Costers, Jeroen Van Schependom, Jorne Laton, Johan Baijot, Martin Sjogard, Vincent Wens, Xavier De Tiege, Serge Goldman, Miguel D'Haeseleer, Marie Beatrice D'hooghe, Mark Woolrich, Guy Nagels
Summary: This study found that MS patients showed a smaller maximum theta power increase in the right hippocampus between 0 and 400 ms compared to healthy subjects, and this increase value correlated negatively with reaction time on the task in MS. The results provide evidence of the influence of hippocampal dysfunction on working memory performance in MS.
HUMAN BRAIN MAPPING
(2021)
Article
Oncology
Corentin Martens, Olivier Debeir, Christine Decaestecker, Thierry Metens, Laetitia Lebrun, Gil Leurquin-Sterk, Nicola Trotta, Serge Goldman, Gaetan Van Simaeys
Summary: Recent research on dynamic amino acid positron emission tomography (PET) in gliomas has shown potential for extracting key features with the use of principal component analysis (PCA) to better understand intra-tumor heterogeneity. The PCA model outperforms traditional pharmacokinetic modeling in distinguishing characteristic dynamic uptake behaviors within the tumor.
Article
Radiology, Nuclear Medicine & Medical Imaging
Celine Mathey, Caroline Keyzer, Didier Blocklet, Gaetan Van Simaeys, Nicola Trotta, Simon Lacroix, Bernard Corvilain, Serge Goldman, Rodrigo Moreno-Reyes
Summary: This study found that F-18-FCH PET/CT performs better than C-11-MET PET/CT in detecting and localizing abnormal parathyroid tissue in patients with pHPT when Tc-99m-MIBI SPECT results are negative or inconclusive.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Odile Feys, Pierre Corvilain, Alec Aeby, Claudine Sculier, Niall Holmes, Matthew Brookes, Serge Goldman, Vincent Wens, Xavier De Tiege, Florence Christiaens
Summary: This study compared the effectiveness of cryogenic and on-scalp MEG in detecting and localizing focal interictal epileptiform discharges (IEDs) in children with epilepsy. The results showed that on-scalp MEG had higher IED amplitudes and signal-to-noise ratios compared to cryogenic MEG, and the localization value was similar between the two modalities.
Article
Oncology
Corentin Martens, Antonin Rovai, Daniele Bonatto, Thierry Metens, Olivier Debeir, Christine Decaestecker, Serge Goldman, Gaetan Van Simaeys
Summary: This research proposed a deep learning-based approach to address problems in glioma growth models. By training deep neural networks, it is possible to reconstruct the cell-density distribution of the tumor and accurately evaluate model parameters. This approach has significant potential application value for glioma characterization and therapy planning.
Article
Radiology, Nuclear Medicine & Medical Imaging
Corentin Martens, Laetitia Lebrun, Christine Decaestecker, Thomas Vandamme, Yves-Remi Van Eycke, Antonin Rovai, Thierry Metens, Olivier Debeir, Serge Goldman, Isabelle Salmon, Gaetan Van Simaeys
Summary: This study uses a 3D-printed slicer for stereotactic histological analysis of an unoperated brain with glioblastoma, revealing limitations of conventional MRI in deriving glioma cell density maps and emphasizing the need for other initialization methods for reaction-diffusion models in clinical practice.
Letter
Clinical Neurology
Pasquale Scoppettuolo, Noemie Ligot, Myriam Remmelink, Isabelle Delpierre, Serge Goldman, Gilles Naeije, Frederic Vandergheynst
JOURNAL OF CLINICAL NEUROLOGY
(2021)
Article
Clinical Neurology
N. Verburg, F. W. A. Hoefnagels, F. Barkhof, R. Boellaard, S. Goldman, J. Guo, J. J. Heimans, O. S. Hoekstra, R. Jain, M. Kinoshita, P. J. W. Pouwels, S. J. Price, J. C. Reijneveld, A. Stadlbauer, W. P. Vandertop, P. Wesseling, A. H. Zwinderman, P. C. De Witt Hamer
AMERICAN JOURNAL OF NEURORADIOLOGY
(2017)