期刊
NEUROSURGERY
卷 63, 期 2, 页码 230-238出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1227/01.NEU.0000320440.85178.CC
关键词
coil embolization; intracranial aneurysm; thromboembolism; tirofiban
资金
- Korea Health 21 RD Project
- Ministry of Health and Welfare, Republic of Korea [A06-0171-B51004-06NI-06040B]
- BK (Brain Korea) 21
OBJECTIVE: Thromboembolism is one of the most common and serious complications associated with the endovascular embolization of intracranial aneurysms. We report our clinical experiences with intra-arterial tirofiban infusion during aneurysm embolization. METHODS: The clinical, radiological, and laboratory data of 24 patients harboring 25 aneurysms (25 procedures) who underwent intra-arterial tirofiban infusion for thromboembolism during the endovascular treatment of intracranial aneurysms were reviewed retrospectively. Thrombi or emboli were resolved by superselective intra-arterial tirofiban infusion via a microcatheter. RESULTS: The study cohort comprised 14 unruptured and 11 ruptured aneurysms. Intra-arterially infused tirofiban doses ranged from 0.2 to 1.0 mg (mean +/- standard deviation, 0.64 +/- 0.25 mg). Thromboemboli were resolved, and arteries were recanalized on all occasions except one: a case of distal middle cerebral artery embolism. No hemorrhagic complications related to intra-arterial tirofiban infusion occurred. CONCLUSION: Intra-arterial tirofiban delivery appears to be a safe and effective treatment modality when thromboembolism is encountered during the endovascular treatment of intracranial aneurysms.
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