Review
Clinical Neurology
Martje E. van Egmond, Tjerk J. Lagrand, Gintaute Lizaitiene, Marenka Smit, Marina A. J. Tijssen
Summary: Adult-onset dystonia can be acquired, inherited or idiopathic. Recent advances in neuroimmunology and genetic diagnostics have increased our understanding of the disease. To ensure early diagnosis and prevent unnecessary investigations, a new five-step diagnostic approach has been designed. The approach focuses on early identification of treatable forms of dystonia, both acquired and genetic. This novel diagnostic method can aid clinicians in deciding when to perform additional tests, including genetic testing, and facilitate timely treatment.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Eva Ntanasi, Maria Maraki, Mary Yannakoulia, Maria Stamelou, Georgia Xiromerisiou, Mary H. Kosmidis, Efthimios Dardiotis, Georgios Hadjigeorgiou, Paraskevi Sakka, Antonios Gargalionis, Kostas Patas, Stylianos Chatzipanagiotou, Socrates Charisis, Leonidas Stefanis, Nikolaos Scarmeas
Summary: The study found an association between frailty and prodromal PD and PD, suggesting that frailty may impact the likelihood of older individuals developing these conditions, and indicating common characteristics or underlying mechanisms among them.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Clinical Neurology
Grace A. Bailey, Emily K. Hubbard, Alfonso Fasano, Marina A. J. Tijssen, Timothy Lynch, Kirstie N. Anderson, Kathryn J. Peall
Summary: Sleep and circadian rhythm disturbances are central features of many movement disorders, with implications for early disease detection. Medication for motor symptoms can impact sleep, highlighting the importance of addressing sleep disturbances for improved quality of life. Shared underlying mechanisms between motor and sleep pathophysiology warrant further investigation for better understanding and management of movement disorders.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Grace A. Bailey, Anna Rawlings, Fatemeh Torabi, William Owen Pickrell, Kathryn J. Peall
Summary: This study reveals a higher rate of psychiatric diagnoses and prescriptions in individuals diagnosed with idiopathic dystonia compared to controls. There may be a bidirectional relationship between idiopathic dystonia and psychiatric disorders, particularly mood disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Editorial Material
Clinical Neurology
Alessandro Dinoto, Enrico Marcuzzo, Vanessa Chiodega, Francesco Dall'Ora, Sara Mariotto, Michele Tinazzi
Summary: This study found that serum neurofilament light chain (NfL) levels are similar in patients with functional motor disorders (FMDs) and healthy controls, indicating the lack of neuroaxonal damage. These results have important implications for pathogenesis and clinical practice, suggesting that serum NfL may serve as a promising diagnostic biomarker to differentiate functional and structural neurological disorders.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Sanjay Pandey, Juho Joutsa, Raja Mehanna, Aparna Wagle Shukla, Federico Rodriguez-Porcel, Alberto J. Espay
Summary: Poststroke movement disorders (PSMDs) are a common cause of secondary movement disorders. However, there are many knowledge gaps in terms of clinical definitions, stroke symptom latencies, and biomarkers for vulnerability for or resilience against developing PSMDs. After summarizing the existing evidence, a roadmap for future research is proposed to fill these gaps and resolve the related controversies. Further research is needed in the phenomenology, classification, diagnostic criteria, and pathophysiology of PSMDs, as well as the development of treatment guidelines.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
V Montano, D. Orsucci, V Carelli, C. La Morgia, M. L. Valentino, C. Lamperti, S. Marchet, O. Musumeci, A. Toscano, G. Primiano, F. M. Santorelli, C. Ticci, M. Filosto, A. Rubegni, T. Mongini, P. Tonin, S. Servidei, R. Ceravolo, G. Siciliano, Michelangelo Mancuso
Summary: The study reviewed the prevalence and clinical features of movement disorders in adults with primary mitochondrial diseases of the Italian Collaborative Network of Mitochondrial Diseases. It emphasizes the importance of considering a mitochondrial etiology in the diagnostic flowchart of a movement disorder.
JOURNAL OF NEUROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ritwik Ghosh, Souvik Dubey, Shambaditya Das, Julian Benito-Leon
Summary: Dystonic storm is a neurological emergency characterized by sustained/intermittent involuntary muscle contractions resulting in painful twisting movements and abnormal postures. This article describes a case of a dystonic storm in an 11-year-old girl with Japanese encephalitis, who had a good clinical recovery with invasive ventilation and drug therapy.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Neurosciences
Arrin Brooks, Alastair T. Hoyt
Summary: DBS has established itself as an effective surgical treatment for movement disorders, but in the United States, a majority of patients still undergo staged surgeries. A study suggests that implanting a complete DBS system in a single procedure may be an effective and well-tolerated option.
Article
Clinical Neurology
Xin-Yi Xie, Guo-zhen Lin, Qiang Huang, Chun-Bo Li, Mark Hallett, Valerie Voon, Ru-jing Ren, Sheng-di Chen, Gang Wang
Summary: The survey found that Chinese clinicians consider atypical movement disorders, multiple somatizations, and emotional disturbance to be essential for the diagnosis of functional movement disorders (FMD). However, lack of guidelines, physician knowledge, and training often limit their ability to manage patients with FMD. Efforts are needed to promote related research and establish practice guidelines in China in the future.
Review
Neurosciences
Chun-Hwei Tai, Sheng-Hong Tseng
Summary: Deep brain stimulation (DBS) is an effective treatment for various movement disorders, but some disorders do not respond well to current DBS therapy. Recent studies have suggested that cerebellar DBS may be beneficial for these non-responsive movement disorders. This article reviews the clinical data of cerebellar DBS, including indications, surgical targets, programming details, and outcomes, and discusses the potential mechanism of action. The study of new DBS targets in the cerebellum is important for a comprehensive treatment of movement disorders.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Health Care Sciences & Services
Valentina Varalta, Paola Poiese, Serena Recchia, Barbara Montagnana, Cristina Fonte, Mirko Filippetti, Michele Tinazzi, Nicola Smania, Alessandro Picelli
Summary: This study investigated the effects of consecutive physiotherapy and cognitive rehabilitation on cognitive, motor, and psychological aspects in Parkinson's disease patients. Results showed that patients who received consecutive training performed better in functional mobility and memory tasks, supporting the hypothesis that consecutive physiotherapy plus cognitive rehabilitation may be more beneficial than physiotherapy alone.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Xian Qiu, Yuhan Wang, Zhengyu Lin, Yunhao Wu, Wenying Xu, Yiwen Wu, Bomin Sun, Keyoumars Ashkan, Chencheng Zhang, Dianyou Li
Summary: The study evaluated patient preferences and satisfaction with rechargeable and non-rechargeable batteries for IPGs after DBS treatment. Most patients were satisfied with the treatment and implanted device, with economic factors influencing their choice of battery. Confidence in recharging the battery was high among patients with r-IPGs, but more training sessions may be needed to improve understanding of the process.
FRONTIERS IN NEUROLOGY
(2021)
Review
Neurosciences
Alessandro Stefani, Mariangela Pierantozzi, Silvia Cardarelli, Lucrezia Stefani, Rocco Cerroni, Matteo Conti, Elena Garasto, Nicola B. Mercuri, Carmine Marini, Patrizia Sucapane
Summary: Magnetic Resonance-guided Focused Ultrasound (MRgFUS) is an effective micro-lesioning approach for pharmaco-resistant tremors, with potential applications in the treatment of Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. It can also be used to temporarily open the blood-brain barrier, providing opportunities for drug delivery and cognitive improvement.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Maximilian U. Friedrich, Hazem Eldebakey, Jonas Roothans, Philipp Capetian, Andreas Zwergal, Jens Volkmann, Martin Reich
Summary: This study investigated the combined vestibular, ocular motor and postural syndrome induced by deep brain stimulation in a patient with Parkinson's disease. The results showed that stimulation of the INC region could lead to various symptoms, including ocular tilt reaction, body lateropulsion, and torsional nystagmus. The study also found that the symptom-associated tissue activation overlapped with the dorsal ZI and the ipsilateral vestibulothalamic tract.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)