Review
Medicine, General & Internal
Tzu-Hsin Huang, Ming-Chi Lai, Yu-Shiue Chen, Chin-Wei Huang
Summary: This review focuses on the fundamentals of DWI and its associated techniques, such as apparent diffusion coefficient, diffusion tensor imaging, and tractography, as well as their impact on epilepsy in terms of differential diagnosis, epileptic foci determination, and prognosis prediction.
Article
Clinical Neurology
Silvana Sarria-Estrada, Estevo Santamarina, Manuel Quintana, Deborah Pareto, Maria Sueiras, Cristina Auger, Manuel Toledo, Alex Rovira
Summary: This study analyzed MRI features in patients with status epilepticus (SE), finding abnormalities in over half of the patients. Longer SE duration and the presence of lateralized periodic discharges (LPDs) on EEG were associated with SE-related MRI abnormalities and the development of mesial temporal sclerosis (MTS).
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Ke Xu, Xiongfei Wang, Jian Zhou, Yuguang Guan, Tianfu Li, Guoming Luan
Summary: This study investigates the clinical discrepancies and predictors of anterior temporal lobectomy (ATL) in children and adults with temporal lobe epilepsy (TLE). Significant differences in clinical manifestations, MRI examinations, number of preoperative AEDs, and pathologies were observed between TLE children and adults. The early complete resection of MRI-detected epileptogenic focus in TLE children predicts favorable seizure outcome, while the concordance of MRI-detected focus with EEG-detected epileptogenic zone predicts favorable seizure outcomes in TLE adults.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Yuchao Jiang, Wei Li, Yingjie Qin, Le Zhang, Xin Tong, Fenglai Xiao, Sisi Jiang, Yunfang Li, Qiyong Gong, Dong Zhou, Dongmei An, Dezhong Yao, Cheng Luo
Summary: This study used T1-weighted and T2-weighted MRI to investigate the myelination changes in temporal lobe epilepsy (TLE) patients. The mSCN analysis showed decreased myelination in frontotemporal regions, amygdala, and thalamus in both patient groups compared to healthy controls. Left TLE patients also had lower myelination in left medial temporal regions. The findings suggest that myelination alterations in TLE are related to epileptic seizures.
HUMAN BRAIN MAPPING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felipe S. Furtado, Nathaniel D. Mercaldo, Thomas Vahle, Thomas Benkert, William R. Bradley, Lisa Ratanaprasatporn, Ravi Teja Seethamraju, Mukesh G. Harisinghani, Susanna Lee, Krista Suarez-Weiss, Lale Umutlu, Ciprian Catana, Kelsey L. Pomykala, Liran Domachevsky, Hanna Bernstine, David Groshar, Bruse R. Rosen, Onofrio Antonio Catalano
Summary: This study compared standard (STD-DWI) single-shot echo-planar imaging DWI and simultaneous multislice (SMS) DWI during whole-body positron emission tomography (PET)/MRI in terms of acquisition time, image quality, and lesion detection. The results showed that SMS-DWI shortened the acquisition time and maintained or improved the diagnostic yield in most anatomical regions. Therefore, SMS-DWI has important clinical application prospects in cancer staging and restaging.
EUROPEAN RADIOLOGY
(2023)
Article
Genetics & Heredity
Yishu Wang, Jing Peng, Shuwei Bai, Haojun Yu, Hong He, Chunxiang Fan, Yong Hao, Yangtai Guan
Summary: Temporal lobe epilepsy (TLE), the most common form of refractory epilepsy in adults, may require surgery to alleviate seizures. Research suggests that a mutation in the PIK3R2 gene may play a significant role in the development of TLE.
FRONTIERS IN GENETICS
(2021)
Article
Neuroimaging
Loxlan W. Kasa, Terry Peters, Seyed M. Mirsattari, Michael T. Jurkiewicz, Ali R. Khan, Roy A. M. Haast
Summary: This study evaluated the use of diffusion kurtosis imaging (DKI) to detect microstructural abnormalities in the temporal pole and its cortex in temporal lobe epilepsy (TLE) patients. The DKI measurements showed significant differences between lesional TLE patients and controls, particularly in the most temporopolar segment of the white matter bundles. There were also correlations between DKI measurements and disease duration in the temporopolar cortex. DKI has the potential to detect subtle microstructural alterations in the temporopolar cortex of TLE patients, which could improve our understanding of seizure generation and aid in surgical planning.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Georgios Mantziaris, Joshua Diamond, Stylianos Pikis, Farid M. El Hefnawi, Ghusn Al Sideiri, Francois-Louis Coupe, David Mathieu, Cheng-Chia Lee, Jaromir May, Roman Liscak, Selcuk Peker, Yavuz Samanci, Ajay Niranjan, L. Dade Lunsford, Jason P. Sheehan
Summary: SRS appears to be a safe and effective treatment option for surgically inaccessible, recurrent, and residual gangliogliomas. In this series, the 5-year progression-free survival rate after SRS was 85.6%.
JOURNAL OF NEUROSURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tsung-Tai Lin, Cheng-Chuan Hu, Yi-Chih Hsu, Chih-Chien Wang, Shih-Wei Chiang, Chao-Ying Wang, Wei-Chou Chang, Guo-Shu Huang
Summary: Using MRS technology, we found that divers with hip pain had increased water content, increased unsaturation index of lipids, and decreased total lipid fraction in the femoral heads. These findings suggest that dysbaric changes in the femoral heads can be detected using MRS.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Clinical Neurology
Hossein Sanjari Moghaddam, Mohammad Hadi Aarabi, Jafar Mehvari-Habibabadi, Roya Sharifpour, Bahram Mohajer, Neda Mohammadi-Mobarakeh, Seyed Sohrab Hashemi-Fesharaki, Kost Elisevich, Mohammad-Reza Nazem-Zadeh
Summary: The study demonstrates distinct patterns of hippocampal subfield atrophy in patients with left and right mesial temporal lobe epilepsy (mTLE), suggesting that the pathophysiology of epileptogenesis in left and right mTLE may be different.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Chloe Dumot, Georgios Mantziaris, Stylianos Pikis, Sam Dayawansa, Zhiyuan Xu, Yavuz Samanci, Gokce D. Ardor, Selcuk Peker, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdel Karim, Amr M. N. El-Shehaby, Reem M. Emad Eldin, Ahmed H. Elazzazi, Nuria Martinez Moreno, Roberto Martinez alvarez, Roman Liscak, Jaromir May, David Mathieu, Jean-Nicolas Tourigny, Manjul Tripathi, Akshay Rajput, Narendra Kumar, Rupinder Kaur, Piero Picozzi, Andrea Franzini, Herwin Speckter, Wenceslao Hernandez, Anderson Brito, Ronald E. Warnick, Juan Alzate, Douglas Kondziolka, Greg N. Bowden, Samir Patel, Jason P. Sheehan
Summary: Stereotactic radiosurgery (SRS) has been proposed as an alternative to resection for epilepsy control in patients with cerebral cavernous malformations (CCM) located in critical areas. This multicentric, retrospective study evaluated seizure control in patients with a solitary CCM and a history of at least one seizure prior to SRS. 47.7% of patients achieved Engel class I at the last follow-up.
JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao Zhang, Kai Xu, Haiyan Zhang, Jingyun Sha, Hongyu Yang, Houliang Zhao, Nan Chen, Kuncheng Li
Summary: This study investigated the recovery of the glymphatic system (GS) function in patients with temporal lobe epilepsy (TLE) after anterior temporal lobectomy (ATL) using diffusion tensor image analysis. The results revealed a significant decrease in GS function before surgery in TLE patients compared to healthy controls, but a significant increase after successful ATL. Furthermore, the GS index was significantly correlated with disease duration.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Grace Simmons, Matthew Gallitto, Albert Lee, Gordon Baltuch, Brett E. Youngerman, Tony J. C. Wang
Summary: Stereotactic radiosurgery (SRS) is a well-known treatment modality for malignant brain tumors. However, it can also be used to treat non-malignant functional disorders. This article provides a consolidated discussion of the application of SRS for functional ailments and serves as a reference for clinical practice.
PRACTICAL RADIATION ONCOLOGY
(2023)
Review
Clinical Neurology
Nadim Jaafar, Amar Bhatt, Alexandra Eid, Mohamad Z. Koubeissi
Summary: Some surgical failures after temporal lobe epilepsy surgery may be caused by the presence of extratemporal epileptogenic zones, particularly in the medial parietal lobe. Seizures originating from this area may not cause obvious symptoms before spreading to the temporal lobe.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
E-Nae Cheong, Ji Eun Park, Da Eun Jung, Woo Hyun Shim
Summary: The study found significant differences in radiomics features of extrahippocampal regions between epilepsy patients and healthy controls, which can aid in identifying MRI-negative temporal lobe epilepsy patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ali Sarrami-Foroushani, Mohsen Nasr Esfahany, Abbas Nasiraei Moghaddam, Hamidreza Saligheh Rad, Kavous Firouznia, Madjid Shakiba, Hossein Ghanaati, Iain David Wilkinson, Alejandro Federico Frangi
IRANIAN JOURNAL OF RADIOLOGY
(2015)
Review
Clinical Neurology
Micaela Mitolo, Annalena Venneri, Iain D. Wilkinson, Basil Sharrack
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Deirdre M. McGrath, Nishant Ravikumar, Iain D. Wilkinson, Alejandro F. Frangi, Zeike A. Taylor
MAGNETIC RESONANCE IN MEDICINE
(2016)
Article
Neurosciences
Philip S. J. Weston, Michael D. Hunter, Dilraj S. Sokhi, Iain D. Wilkinson, Peter W. R. Woodruff
Article
Behavioral Sciences
Tom F. D. Farrow, Jenny Burgess, Iain D. Wilkinson, Michael D. Hunter
Article
Clinical Neurology
Kwang-Hyuk Lee, Graham Pluck, Nicoletta Lekka, Andrew Horton, Iain D. Wilkinson, Peter W. R. Woodruff
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2015)
Article
Anesthesiology
Solomon Tesfaye, Dinesh Selvarajah, Rajiv Gandhi, Marni Greig, Pallai Shillo, Fang Fang, Iain D. Wilkinson
Article
Endocrinology & Metabolism
Dinesh Selvarajah, Thomas Cash, Adhithya Sankar, Lloyd Thomas, Jennifer Davies, Elaine Cachia, Rajiv Gandhi, Iain D. Wilkinson, Nicholas Wilkinson, Celia J. Emery, Solomon Tesfaye
DIABETES & VASCULAR DISEASE RESEARCH
(2014)
Article
Endocrinology & Metabolism
Dinesh Selvarajah, Iain D. Wilkinson, Michael Maxwell, Jennifer Davies, Adhithya Sankar, Elaine Boland, Rajiv Gandhi, Irene Tracey, Solomon Tesfaye
Article
Neurosciences
Yael Benn, Thomas L. Webb, Betty P. I. Chang, Yu-Hsuan Sun, Iain D. Wilkinson, Tom F. D. Farrow
FRONTIERS IN HUMAN NEUROSCIENCE
(2014)
Article
Neurosciences
Glyn P. Hallam, Thomas L. Webb, Paschal Sheeran, Eleanor Miles, Karen Niven, Iain D. Wilkinson, Michael D. Hunter, Peter W. R. Woodruff, Peter Totterdell, Tom F. D. Farrow
FRONTIERS IN HUMAN NEUROSCIENCE
(2014)
Article
Multidisciplinary Sciences
Elaine G. Boland, Dinesh Selvarajah, Mike Hunter, Yousef Ezaydi, Solomon Tesfaye, Sam H. Ahmedzai, John A. Snowden, Iain D. Wilkinson
Article
Multidisciplinary Sciences
Dinesh Selvarajah, Tom Cash, Jennifer Davies, Adithya Sankar, Ganesh Rao, Marni Grieg, Shillo Pallai, Rajiv Gandhi, Iain D. Wilkinson, Solomon Tesfaye
Review
Medicine, General & Internal
Stuart Currie, Nigel Hoggard, Ian J. Craven, Marios Hadjivassiliou, Iain D. Wilkinson
POSTGRADUATE MEDICAL JOURNAL
(2013)
Article
Multidisciplinary Sciences
Yael Benn, Ofer Bergman, Liv Glazer, Paris Arent, Iain D. Wilkinson, Rosemary Varley, Steve Whittaker
SCIENTIFIC REPORTS
(2015)