Article
Multidisciplinary Sciences
Fabian A. Mikulasch, Lucas Rudelt, Viola Priesemann
Summary: This study introduces a new learning scheme based on voltage-dependent synaptic plasticity rules, which can learn efficient representations by locally balancing feedforward inputs. It overcomes the limitations of traditional Hebbian-like plasticity, particularly for complex high-dimensional inputs and inhibitory transmission delays. The results suggest the importance of dendritic excitatory-inhibitory balance and voltage-dependent synaptic plasticity in representation learning.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Joshua Orvis, Caroline B. Albertin, Pragya Shrestha, Shuangshuang Chen, Melanie Zheng, Cheyenne J. Rodriguez, Luke J. Tallon, Anup Mahurkar, Aleksey Zimin, Michelle Kim, Kelvin Liu, Eric R. Kandel, Claire M. Fraser, Wayne Sossin, Thomas W. Abrams
Summary: The gastropod mollusk Aplysia is an important model organism used in cellular and molecular neurobiological studies. By studying the improved transcriptome of the Aplysia nervous system, researchers can explore the evolution of cognitive capacity at the molecular level. Comparing Aplysia with the octopus, it was found that both have a similar complement of genes linked to neuronal function, but vertebrates have more isoforms of certain scaffold proteins. This analysis provides insights into the evolution of the synaptic proteome and suggests that synaptic proteins and plasticity evolved gradually.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Shuo Zhang, Kexin Guo, Hong Han, Haiyang Yu, Huanhuan Wei, Jiangdong Gong, Wentao Xu
Summary: This paper introduces a synaptic transistor that combines p-type and n-type semiconductor nanowires to emulate complex neural functions. By utilizing nanowires with different polarities, it is possible to simulate a variety of neural activities, providing important insights for the development of future neuromorphic electronics.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Alireza Ghadimi, Leon Amadeus Steiner, Milos Popovic, Luka Milosevic, Milad Lankarany
Summary: This study presents a computational predictive model for the dynamics of short-term synaptic plasticity (STP) induced by deep brain stimulation (DBS) at different frequencies. The model-based approach integrates multiple frequencies of DBS-like electrical stimulation as pre-synaptic spikes and infers the parameters of the TM model from the post-synaptic currents. By distinguishing between steady-state and transient responses, a dual optimization algorithm is developed to track the model parameters in two steps. The applicability of the method is confirmed through empirical data from rodent brain slices.
Article
Neurosciences
Jingjing Cheng, Xiaolin Ma, Chunlu Li, Rahim Ullah, Xiaoyu Wang, Jianmei Long, Zhenxin Yuan, Shuangshuang Liu, Junfen Fu, Zhong Chen, Yi Shen, Yu-Dong Zhou
Summary: Overconsumption of high-fat diet can lead to neuroadaptive responses in the brain's reward circuitry, contributing to eating disorders. This study reveals that high-fat diet consumption hinders the suppression of sucrose-seeking in mice triggered by threat cues. It is found that enhanced cue-triggered neuronal activity in the anterior paraventricular thalamus, resulting from microglia activation induced by high-fat diet, contributes to this compulsive sucrose-seeking behavior.
NATURE NEUROSCIENCE
(2022)
Review
Clinical Neurology
Carla Fernandez-Garcia, Mariana H. G. Monje, Victor Gomez-Mayordomo, Guglielmo Foffani, Rafael Herranz, Maria Jose Catalan, Mercedes Gonzalez-Hidalgo, Jorge Matias-Guiu, Fernando Alonso-Frech
Summary: This study evaluated the effectiveness of directional subthalamic stimulation in Parkinson's disease based on intraoperatively recorded beta oscillations. The results showed a strong correlation between clinical efficacy and beta activity, and selecting the contacts with the highest beta peaks improved the therapeutic window. Long-term follow-up showed similar improvements in both groups, validating the efficacy of directional stimulation guided by intraoperative beta oscillations.
Review
Neurosciences
Manisha Sinha, Rishikesh Narayanan
Summary: Neurons and glial cells have membranes that express ion channels, transporters, and receptors, which generate voltage fluctuations. The high frequency components of the voltage signal reflect neuronal activity, while the low frequency components, known as the local field potential (LFP), provide information about synaptic inputs. This review emphasizes the importance of considering active dendritic mechanisms in understanding the genesis and location-dependent dynamics of LFPs.
Article
Chemistry, Multidisciplinary
Yue Wang, Yiyue Zhu, Yayao Li, Yiqiang Zhang, Deren Yang, Xiaodong Pi
Summary: This research presents an optoelectronic synaptic device with dual modes and versatile synaptic plasticity based on optoelectronic integration. The device can mimic biological synapses in wavelength-selective synaptic plasticity and spike-rate-dependent plasticity with optical stimulation. A light-stimulated artificial neural network for digit recognition and image processing simulation are proposed to demonstrate the device's potential applications.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Electrical & Electronic
Rongqi Wu, Xiaochi Liu, Zhongwang Wang, Yumei Jing, Yahua Yuan, Kui Tang, Xianfu Dai, Aocheng Qiu, Hemendra N. Jaiswal, Jia Sun, Huamin Li, Jian Sun
Summary: This article demonstrates an ambipolar WSe2 synaptic FET with both electron and hole charge traps, exhibiting balanced excitation and inhibition. It achieves nearly zero asymmetry with low nonlinearity of 0.04 in long-term potentiation and depression (LTP/LTD). The proposed devices have great potential in high-accuracy neuromorphic computing applications.
IEEE ELECTRON DEVICE LETTERS
(2023)
Review
Neurosciences
Anna Konopka, Julie D. Atkin
Summary: DNA damage and repair play important roles in neural plasticity and may contribute to neurodegenerative diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Alessandra Federici, Giulio Bernardi, Irene Senna, Marta Fantoni, Marc O. Ernst, Emiliano Ricciardi, Davide Bottari
Summary: A brief period of monocular deprivation induces short-term plasticity of the adult visual system. The impact of MD on neural correlates of multisensory processes is assessed. Results reveal eye-specific changes in neural activities associated with visual and multisensory processes. MD increases excitability to visual events for the deprived eye and audio-visual and auditory input for the non-deprived eye.
Article
Biology
Kyle Aitken, Stefan Mihalas
Summary: This study investigates a network called the multi-plasticity network (MPN) that relies solely on synapse modulation during inference to process task-relevant information. The results show that the MPN outperforms recurrent neural networks (RNNs) on neuroscience-relevant tests and its computational capabilities in synaptic modulation are comparable to networks with recurrent connections.
Article
Biochemistry & Molecular Biology
Danying Wang, Kimron L. Shapiro, Simon Hanslmayr
Summary: This study provides evidence for the role of spike-timing-dependent plasticity (STDP) in human episodic memory, bridging the gap between animal in vitro studies and human memory behavior.
Article
Computer Science, Artificial Intelligence
Serkan Kiranyaz, Junaid Malik, Habib Ben Abdallah, Turker Ince, Alexandros Iosifidis, Moncef Gabbouj
Summary: The proposed Operational Neural Networks (ONNs) aim to improve learning performance over conventional Convolutional Neural Networks (CNNs) by searching for optimal operator sets based on synaptic plasticity. Elite ONNs configured with top-ranked operator sets achieved superior learning performance compared to GIS-based ONNs, widening the performance gap with CNNs even with few neurons and layers.
NEURAL COMPUTING & APPLICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Xianghong Zhang, Enlong Li, Rengjian Yu, Lihua He, Weijie Yu, Huipeng Chen, Tailiang Guo
Summary: This paper introduces a new type of multilevel photosensitive blending semiconductor optoelectronic synaptic transistor (MOST), which achieves 8 stable states and synaptic behaviors under illumination in the wavelength range of 480-800 nm. The optical decoder model based on MOST is successfully fabricated and applied in neural machine translation, significantly simplifying the structure of traditional systems and laying the foundation for breaking the bottleneck of machine translation.
SCIENCE CHINA-MATERIALS
(2022)
Article
Geriatrics & Gerontology
Bin Zhao, Yi Wang, Rui Liu, Xiao-Li Jia, Nan Hu, Xing-Wei An, Chen-Guang Zheng, Chong Chen, Hong-Tao Sun, Feng Chen, Jing-Jing Wang, Xiao-Hong Li
Summary: Rutaecarpine can mitigate high sucrose diet-induced hyperphosphorylation of AD-associated tau protein and cognitive impairment by inhibiting GSK-3 beta, suggesting its potential for therapeutic intervention of AD.
REJUVENATION RESEARCH
(2021)
Article
Clinical Neurology
Yaqing Li, Xi Xiao, Ling Wang, Qian Wang, Rong Liang, Chenguang Zheng, Jiajia Yang, Dong Ming
Summary: Sleeplessness can lead to a range of neuropsychiatric disorders in both juveniles and young adults. The effects of chronic sleep deprivation on anxiety-like behavior and cognitive function were evaluated in mice of different age groups, with findings suggesting that although similar behavioral outcomes were observed, the underlying molecular mechanisms may be different. Further research into the impact of sleep on mental health is warranted.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xue Dong, Kaibin Wang, Zechen Tang, Yaoyao Zhang, Wenbo Yi, Huaijun Xue, Chenguang Zheng, Wenjun Bu
Summary: This study investigated the phylogenetic relationships within Coreoidea, specifically looking at the families Coreidae and Alydidae, using mitochondrial genomes. The results suggest that both Coreidae and Alydidae are not monophyletic, and further study is needed to resolve the classification issues within these families.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Neurosciences
Yimeng Wang, Yang Bai, Xi Xiao, Ling Wang, Ganjiang Wei, Mingkun Guo, Xizi Song, Yutao Tian, Dong Ming, Jiajia Yang, Chenguang Zheng
Summary: This study found that low-intensity focused ultrasound stimulation (LIFUS) can improve social avoidance behavior in defeated mice. LIFUS achieves this effect by inhibiting activation of the inflammatory response, increasing neuronal excitation, and protecting the integrity of the neuronal structure.
Article
Evolutionary Biology
Xiao-Long Lin, Yan-Min Zhao, Li-Ping Yan, Wen-Bin Liu, Wen-Jun Bu, Xin-Hua Wang, Chen-Guang Zheng
Summary: Evolutionary analysis of Prodiamesinae has been challenging due to lack of information, and its phylogenetic relationship with Orthocladiinae is still uncertain. However, this study sequenced ten complete mitogenomes of Orthocladiinae sensu lato, revealing conservation in gene arrangement and nucleotide composition, as well as protein-coding genes under purifying selection. The findings suggest a re-classification of Orthocladiinae by incorporating Prodiamesinae as a subgroup.
Article
Evolutionary Biology
Xue Dong, Wenbo Yi, Chenguang Zheng, Xiuxiu Zhu, Shujing Wang, Huaijun Xue, Zhen Ye, Wenjun Bu
Summary: This study focused on species delimitation of five Leptocorisa species in China, especially the rice seed bugs complex. Genetic markers were used to distinguish between morphologically similar species, with nuclear SNP data proving to be effective in identifying separate species. Mitochondrial introgression resulting from hybridization was suggested as a likely explanation for mito-nuclear discordance between two taxa in the complex. This molecular evidence is crucial for further studies on the ecology and pest management of these important rice pests.
Article
Geriatrics & Gerontology
Faqi Wang, Qian Wang, Ling Wang, Jing Ren, Xizi Song, Yutao Tian, Chenguang Zheng, Jiajia Yang, Dong Ming
Summary: This study found that low-intensity focused ultrasound stimulation (LIFUS) applied to the bilateral medial prefrontal cortex improved working memory impairment in vascular dementia (VD) rats. This improvement may be associated with enhanced synaptic function, cerebral blood flow, and reduced neuroinflammation in the prefrontal cortex.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Entomology
Chen-Guang Zheng, Zheng Liu, Yan-Min Zhao, Yang Wang, Wen-Jun Bu, Xin-Hua Wang, Xiao-Long Lin
Summary: This study sequenced and analyzed the complete mitogenomes of seven Stenochironomus species and identified a synapomorphic gene rearrangement. It also found that the mitogenomes of Stenochironomus have a higher A+T bias. The study provides new insights into the mitochondrial gene order of Chironomidae and contributes to understanding synapomorphic gene rearrangements.
Article
Ecology
Xiao-Long Lin, Zheng Liu, Li-Ping Yan, Xin Duan, Wen-Jun Bu, Xin-Hua Wang, Chen-Guang Zheng
Summary: This study utilized comparative and phylogenetic analysis of the mitogenomes of Diamesinae to reveal their high conservation and practical utility for phylogenetic inference.
ECOLOGY AND EVOLUTION
(2022)
Article
Astronomy & Astrophysics
Rong Liang, Ling Wang, Shufan Sun, Chenguang Zheng, Jiajia Yang, Dong Ming
Summary: Long-term spaceflight can cause physical and psychological impairments. In this study, mice were exposed to simulated microgravity and social isolation, and it was found that this environment resulted in emotional and social barriers but also enhanced cognitive abilities.
LIFE SCIENCES IN SPACE RESEARCH
(2022)
Article
Neurosciences
Nan Zhu, Yiyuan Zhang, Xi Xiao, Yimeng Wang, Jiajia Yang, Laura Lee Colgin, Chenguang Zheng
Summary: This study found that hippocampal CA2 supports social memory and experiences increased slow gamma rhythms during social interactions. The coupling between CA2 and CA1 theta-slow gamma was enhanced during social exploration. Furthermore, CA1 slow gamma rhythms and sharp wave-ripples were associated with social memory retrieval.
COGNITIVE NEURODYNAMICS
(2023)
Article
Agronomy
Xiuxiu Zhu, Chenguang Zheng, Xue Dong, Haiguang Zhang, Zhen Ye, Huaijun Xue, Wenjun Bu
Summary: This study clarified the species boundary between M. cribraria and its closely related species and revealed the phylogeographical pattern and evolutionary history of M. cribraria. The results have important implications for the monitoring and management of this agricultural pest.
PEST MANAGEMENT SCIENCE
(2022)
Article
Plant Sciences
Yan-Fei Li, Shu-Jing Wang, Jia-Yue Zhou, Cui-Qing Gao, Chen-Guang Zheng, Huai-Jun Xue, Wen-Jun Bu
Summary: This study uses an integrative taxonomic approach to classify economically significant bean pests of the genus Chauliops. By employing morphological analyses, population genetic methods, and multiple molecular species delimitation methods, four new species are described, increasing the total number of Chauliops species in the area. Phylogenetic analysis and divergence time estimation reveal that speciation events in Chauliops are consistent with historical uplift events of the Qinghai-Tibet Plateau, suggesting that orogeny plays a key role in species diversification.
JOURNAL OF SYSTEMATICS AND EVOLUTION
(2022)
Article
Neurosciences
Rong Liang, Ling Wang, Xinyao Li, Xiaohui Liu, Haonan Chang, Qing Xu, Yue Wang, Dong Xu, Dong Liu, Jiajia Yang, Chenguang Zheng, Dong Ming
Summary: Studies have shown that spaceflight has emotional and social effects on astronauts. Identifying the neural mechanisms behind these effects is essential for targeted treatment and prevention. Repetitive transcranial magnetic stimulation (rTMS) has been found to improve neuronal excitability and treat psychiatric disorders like depression. In this study, the researchers investigated how rTMS affects the excitatory neuron activity in the medial prefrontal cortex (mPFC) in a simulated space complex environment (SSCE). They found that rTMS effectively improved the emotional and social impairments in mice exposed to SSCE, and enhanced the excitability of mPFC neurons. The study suggests that rTMS can reverse the mood and social impairment caused by SSCE by enhancing the suppressed mPFC excitatory neuronal activity.
Article
Neurosciences
Faqi Wang, Qiuquan Cai, Rongfang Ju, Sutong Wang, Lu Liu, Meiyi Pan, Ning Sun, Xiunan Wang, Ling Wang, Jiajia Yang, Chenguang Zheng, Dong Ming
Summary: Exploring new effective treatments for depression is of great social significance and clinical value. Low-intensity focused ultrasound stimulation (LIFUS) has been shown to have notable neuroprotective effects on depression, but little is known about how different strategies of LIFUS affect the therapeutic effect. The purpose of this study is to investigate the association between the effects of LIFUS on depression-like behaviors, intensity, and underlying mechanisms.
