Review
Biochemistry & Molecular Biology
Wu Jeong Hwang, Tae Young Lee, Nahrie Suk Kim, Jun Soo Kwon
Summary: This review highlights the role of estrogen and estrogen signaling in psychiatric disorders, emphasizing their impact on brain functions and neuroprotection. The potential therapeutic use of estrogen in treating psychiatric disorders is explored, along with disruptions in estrogen signaling and their implications for pathophysiologies in these disorders. Insights from this review suggest potential novel treatment strategies involving estrogen and its signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chad R. Johnson, Brian D. Kangas, Emily M. Jutkiewicz, Jack Bergman, Andrew Coop
Summary: This article discusses the significant role of the cholinergic system in CNS disorders and recent advances in drug design targeting mAChRs. Despite challenges, progress has been made in developing functionally selective orthosteric and allosteric ligands with limited side effects for the treatment of diseases like Alzheimer's and schizophrenia.
Article
Clinical Neurology
Shahram Bahrami, Guy Hindley, Bendik Slagsvold Winsvold, Kevin S. O'Connell, Oleksandr Frei, Alexey Shadrin, Weiqiu Cheng, Francesco Bettella, Linn Rodevand, Ketil J. Odegaard, Chun C. Fan, Matti J. Pirinen, Heidi M. Hautakangas, Anders M. Dale, Srdjan Djurovic, Olav B. Smeland, Ole A. Andreassen
Summary: Migraine shows a certain level of shared genetic basis with bipolar disorder, depression, and schizophrenia, with some shared genetic loci. It is less polygenic compared to mental disorders and shares variants with intelligence and educational attainment. Specific loci were identified that are jointly associated with migraine and depression, as well as with migraine and schizophrenia, implicating shared molecular mechanisms and highlighting candidate migraine genes for further research.
Article
Psychiatry
Xiaoyan Li, Xi Su, Jiewei Liu, Huijuan Li, Ming Li, Wenqiang Li, Xiong-Jian Luo
Summary: The study identified 53 significant risk genes for depression through a transcriptome-wide association study, with 7 of them showing associations in two independent brain expression datasets. Pathway enrichment analysis revealed biologically pathways relevant to depression. Further mechanistic study and functional characterization of the risk genes may facilitate the diagnostics and therapeutics for depression.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Nutrition & Dietetics
Ting Liu, Kunhong Deng, Ying Xue, Rui Yang, Rong Yang, Zhicheng Gong, Mimi Tang
Summary: Depression is one of the most common mental diseases, but its understanding is insufficient. The relationship between carnitine and depression has been confirmed in multiple studies, and the level of acylcarnitines can serve as biomarkers for depression, while supplementing acetyl-L-carnitine is beneficial for the treatment of depression.
FRONTIERS IN NUTRITION
(2022)
Article
Psychiatry
Aidin Abbaspour, Masoud Bahreini, Sherafat Akaberian, Kamran Mirzaei
Summary: The study found that most patients with psychiatric disorders were affected by ineffective parenting styles. Despite the involvement of several bio-psycho-social factors in the development of psychiatric disorders, the crucial roles of parents, especially mothers, should not be ignored. It was suggested that parents and parental bonding were important and fundamental factors for mental health promotion.
Article
Psychiatry
Tuyen T. Le, Joshua D. Di Vincenzo, Kayla M. Teopiz, Yena Lee, Danielle S. Cha, Leanna M. W. Lui, Nelson B. Rodrigues, Roger C. Ho, Bing Cao, Kangguang Lin, Flora Nasri, Hartej Gill, Orly Lipsitz, Mehala Subramaniapillai, Rodrigo B. Mansur, Joshua D. Rosenblat, Roger S. McIntyre
Summary: Psychotic depression is a severe subtype of major depressive disorder with high relapse and mortality rates. Ketamine may be an alternative pharmacotherapy, but its efficacy and safety in patients with psychotic depression have not been established.
PSYCHIATRY RESEARCH
(2021)
Article
Health Care Sciences & Services
Dror Ben-Zeev, Ayesha Chander, Justin Tauscher, Benjamin Buck, Subigya Nepal, Andrew Campbell, Guy Doron
Summary: This study conducted a fully remote randomized waitlist-controlled trial of CORE, a smartphone intervention for people with serious mental illness (SMI). Results showed that CORE was highly usable and acceptable, with significant reductions in psychiatric symptoms and disability levels, as well as improvements in recovery and self-esteem.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Psychiatry
Sophie-Kathrin Kirchner, Michael Lauseker, Kristina Adorjan, Heike Anderson-Schmidt, Ion-George Anghelescu, Bernhardt T. Baune, Monika Budde, Udo Dannlowski, Detlef E. Dietrich, Andreas J. Fallgatter, Peter Falkai, Christian Figge, Katrin Gade, Urs Heilbronner, Lena Hiendl, Georg Juckel, Janos L. Kalman, Farahnaz Kloehn-Saghatolislam, Carsten Konrad, Fabian U. Lang, Mojtaba Oraki Kohshour, Sergi Papiol, Daniela Reich-Erkelenz, Jens Reimer, Eva Z. Reininghaus, Sabrina K. Schaupp, Max Schmauss, Andrea Schmitt, Eva Christina Schulte, Simon Senner, Carsten Spitzer, Thomas Vogl, Joerg Zimmermann, Alkomiet Hasan, Thomas G. Schulze, Fanny Senner
Summary: This study comprehensively evaluates the association of sociodemographic, clinical, personality, and quality of life related factors with medication adherence by analyzing data from the PsyCourse study. The results show that never having used illicit drugs, the number of prescribed antipsychotics, the personality trait conscientiousness, and the environmental domain of quality of life have the strongest association with medication adherence.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Bhupendra Khobragade, Vikas Sharma, Smita N. Deshpande
Summary: The cognitive effects of tobacco use among women with schizophrenia, bipolar disorder, or depression have not been extensively studied. However, a study found that female tobacco users in these groups demonstrated poorer cognitive functioning and smoking may exacerbate cognitive dysfunction associated with major mental illnesses among women.
PSYCHIATRY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Nina Vindegaard Sorensen, Beate Holmelund Frandsen, Sonja Orlovska-Waast, Terkild Brink Buus, Niels Odum, Rune Haubo Christensen, Michael Eriksen Benros
Summary: This study systematically evaluated the circulating immune cells in blood and cerebrospinal fluid (CSF) from patients with unipolar depression compared to healthy controls. The findings suggest that patients with depression have higher overall leukocyte count, higher neutrophil count, higher monocyte count, and significant alterations in lymphocyte subsets. These immune cell alterations may be related to depression severity.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Clinical
Deepiksana Keerthy, Joht Singh Chandan, Juste Abramovaite, Krishna Margadhamane Gokhale, Siddhartha Bandyopadhyay, Ed Day, Steven Marwaha, Matthew R. Broome, Krishnarajah Nirantharakumar, Clara Humpston
Summary: This study investigates the relationship between cannabis exposure and the risks of mental illness diagnoses or treatment and finds that cannabis exposure is associated with an increased risk of developing mental health disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Anton Shkundin, Angelos Halaris
Summary: This review article comprehensively discusses the significance of single nucleotide polymorphisms (SNPs) in the brain-derived neurotrophic factor (BDNF) and BDNF antisense RNA (BDNF-AS) genes in psychiatric conditions, specifically focusing on their associations with depression, schizophrenia, and bipolar disorder. The variations in these genes, as well as their interactions with environmental factors and other genes, can alter brain structure and function, shaping vulnerability to mental health disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Wedad Alhassen, Siwei Chen, Marquis Vawter, Brianna Kay Robbins, Henry Nguyen, Thant Nyi Myint, Yumiko Saito, Anton Schulmann, Surya M. Nauli, Olivier Civelli, Pierre Baldi, Amal Alachkar
Summary: The study found that cilia genes play an important role in the pathogenesis of psychiatric disorders, with dysfunction potentially contributing to multiple disorders. Notably, cilia GPCRs genes and transition zone proteins were particularly affected in schizophrenia. This research provides new insights into the pathophysiology of these disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)