期刊
NEUROSCIENTIST
卷 21, 期 3, 页码 290-305出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858414537560
关键词
functional connectivity; structural connectivity; module; rich club; graph theory; connectome
资金
- National Key Basic Research Program of China [2013CB837300, 2014CB846102]
- National Science Fund for Distinguished Young Scholars [81225012]
- Natural Science Foundation of China [81030028, 11328501, 11275027, 81322021]
- Beijing Funding for Training Talents (YH), the Beijing Nova Program [Z121110002512032]
- CERS-China Equipment and Education Resources System [CERS-1-52]
- Fundamental Research Funds for the Central Universities [2012CXQT01]
Relating the brain's structural connectivity (SC) to its functional connectivity (FC) is a fundamental goal in neuroscience because it is capable of aiding our understanding of how the relatively fixed SC architecture underlies human cognition and diverse behaviors. With the aid of current noninvasive imaging technologies (e.g., structural MRI, diffusion MRI, and functional MRI) and graph theory methods, researchers have modeled the human brain as a complex network of interacting neuronal elements and characterized the underlying structural and functional connectivity patterns that support diverse cognitive functions. Specifically, research has demonstrated a tight SC-FC coupling, not only in interregional connectivity strength but also in network topologic organizations, such as community, rich-club, and motifs. Moreover, this SC-FC coupling exhibits significant changes in normal development and neuropsychiatric disorders, such as schizophrenia and epilepsy. This review summarizes recent progress regarding the SC-FC relationship of the human brain and emphasizes the important role of large-scale brain networks in the understanding of structural-functional associations. Future research directions related to this topic are also proposed.
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