Article
Clinical Neurology
Jimmy C. Yang, Katie L. Bullinger, Faical Isbaine, Abdulrahman Alwaki, Enrico Opri, Jon T. Willie, Robert E. Gross
Summary: CM deep brain stimulation (DBS) shows promise in treating drug-resistant generalized epilepsy and bifrontal epilepsy, with a significant reduction in seizure frequency observed in patients. Further studies are needed to explore the optimal use of CM DBS in different types of epilepsy and its impact on treatment outcomes.
JOURNAL OF NEUROSURGERY
(2022)
Article
Acoustics
Yi Huang, Peng Wen, Bo Song, Yan Li
Summary: This study numerically investigated the ultrasound wave propagation and energy distribution within brain tissues using customized single element focused ultrasound transducers (SEFT) targeting the hippocampus. The study found that ultrasound neuromodulation targeting the deep brain tissue of the hippocampus can be a potential alternative method to non-acoustic brain stimulation modalities.
Review
Behavioral Sciences
Xiaodong Liu, Fang Qiu, Lijuan Hou, Xiaohui Wang
Summary: Brain stimulation is a critical technique in neuroscience research and clinical application. Traditional techniques have limitations, but the development of second-generation brain stimulation offers great prospects for neuromodulation.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Andreas Horn, Martin M. Reich, Siobhan Ewert, Ningfei Li, Bassam Al-Fatly, Florian Lange, Jonas Roothans, Simon Oxenford, Isabel Horn, Steffen Paschen, Joachim Runge, Fritz Wodarg, Karsten Witt, Robert C. Nickl, Matthias Wittstock, Gerd-Helge Schneider, Philipp Mahlknecht, Werner Poewe, Wilhelm Eisner, Ann-Kristin Helmers, Cordula Matthies, Joachim K. Krauss, Gunther Deuschl, Jens Volkmann, Andrea A. Kuhn
Summary: This study retrospectively investigated the clinical results of deep brain stimulation (DBS) for cervical and generalized dystonia in 80 patients. The researchers modeled the optimal stimulation sites based on imaging and found that the optimal treatment for cervical dystonia involved modulation of the striatopallidofugal axis, while pallidothalamic bundles were responsible for optimal treatment of generalized dystonia. Additionally, the study showed a common network substrate in the form of connectivity to the cerebellum and somatomotor cortex for both types of dystonia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Abhijeet Gummadavelli, Dario J. Englot, Jason M. Schwalb, Chengyuan Wu, Jorge Gonzalez-Martinez, Joseph Niemat, Jason L. Gerrard
Summary: Neuromodulation has provided additional surgical treatment options for patients with medically refractory epilepsy, especially for those who are not candidates for resective surgery. DBS of the bilateral anterior nucleus of the thalamus has been proven to be a safe and effective treatment option for refractory focal epilepsy.
Article
Clinical Neurology
Seongyeon Kim, Yehhyun Jo, Geon Kook, Cristina Pasquinelli, Hyunggug Kim, Kipom Kim, Hyang-Sook Hoe, Youngshik Choe, Hyewhon Rhim, Axel Thielscher, Jeongyeon Kim, Hyunjoo Jenny Lee
Summary: By crossing two ultrasound beams of commercially available piezoelectric curved transducers, a dual-crossed transducer system achieved high axial resolution without the need for complex microfabrication. In vivo animal experiments demonstrated the high target specificity of the system, with a focal volume under 0.52 mm(3) and successful brain stimulation observed in wild-type mice.
Article
Pharmacology & Pharmacy
Shawn Zheng Kai Tan, Chi Him Poon, Ying-Shing Chan, Lee Wei Lim
Summary: The study identified the critical time point during memory consolidation stage to disrupt fear memory via prelimbic cortex deep brain stimulation. The disruption was partially modulated by the inactivation of the ventral hippocampus and the transient changes in ventral hippocampus dopamine (D-2) receptors expression upon prelimbic cortex deep brain stimulation. Wide-scale changes of various neurotransmitters and their metabolites in ventral hippocampus were also observed, confirming its important role in response to prelimbic cortex deep brain stimulation.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Clinical Neurology
Sarah Osou, Sonja Radjenovic, Lena Bender, Martin Gaal, Anna Zettl, Gregor Doerl, Eva Matt, Roland Beisteiner
Summary: This retrospective analysis showed that Transcranial Pulse Stimulation (TPS) can improve motor symptoms in Parkinson's disease (PD) patients and is safe to use. The findings should be considered in the context of placebo effects in non-invasive brain stimulation studies.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Martijn Figee, Patricio Riva-Posse, Ki Sueng Choi, Lucia Bederson, Helen S. Mayberg, Brian H. Kopell
Summary: This article reviews the efficacy of different deep brain stimulation (DBS) targets for treatment-resistant depression (TRD), discusses the networks involved in their therapeutic effects, and explores how this information can be used to improve targeting and programming of DBS for individual patients. The integration of these DBS network findings into the development of adaptive stimulation and optimal trial designs is also highlighted.
Article
Optics
Linli Shi, Ying Jiang, Fernando R. Fernandez, Guo Chen, Lu Lan, Heng-Ye Man, John A. White, Ji-Xin Cheng, Chen Yang
Summary: The development of a tapered fiber optoacoustic emitter (TFOE) has enabled high-precision ultrasound stimulation at a spatial resolution of 39.6 μm, allowing for optoacoustic activation of single neurons or subcellular structures. The TFOE technology also facilitates direct measurement of the electrical response of single neurons to acoustic stimulation, revealing cell-type-specific responses of excitatory and inhibitory neurons to acoustic stimulation. TFOE shows promise as a non-genetic technology for single-cell and sub-cellular modulation, shedding new insights into the mechanism of ultrasound neurostimulation.
LIGHT-SCIENCE & APPLICATIONS
(2021)
Article
Clinical Neurology
Anusha Allawala, Kelly R. Bijanki, Wayne Goodman, Jeffrey F. Cohn, Ashwin Viswanathan, Daniel Yoshor, David A. Borton, Nader Pouratian, Sameer A. Sheth
Summary: Deep brain stimulation (DBS) has shown inconsistent results in prior clinical trials for neuropsychiatric illnesses. An individualized intracranial investigation approach, combining behavioral assessments, is proposed to inform ideal DBS parameters for better treatment outcomes.
Article
Clinical Neurology
Wolf-Julian Neumann, Leon A. Steiner, Luka Milosevic
Summary: Deep brain stimulation is a neuromodulatory treatment that uses electrodes to deliver pulsatile electrical stimulation to disease-relevant brain regions, aiming to restore neurocircuit function. However, the mechanisms of deep brain stimulation and its effects on brain activity are not fully understood.
Review
Psychiatry
Amanda R. Arulpragasam, Mascha van 't Wout-Frank, Jennifer Barredo, Christiana R. Faucher, Benjamin D. Greenberg, Noah S. Philip
Summary: This article introduces a new emerging non-invasive neuromodulatory technology called low intensity focused ultrasound (LIFU). LIFU has the potential to deliver non-invasive and reversible deep brain neuromodulation at millimeter precision through acoustic sonication. Its spatial precision and non-invasive nature make it different from current technologies. Studies have shown that LIFU can safely modulate human brain activity. The novelty of this technique underscores the need for foundational papers to introduce it to the community.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Clinical Neurology
G. Darmani, T. O. Bergmann, K. Butts Pauly, C. F. Caskey, L. de Lecea, A. Fomenko, E. Fouragnan, W. Legon, K. R. Murphy, T. Nandi, M. A. Phipps, G. Pinton, H. Ramezanpour, J. Sallet, S. N. Yaakub, S. S. Yoo, R. Chen
Summary: Transcranial ultrasound stimulation (TUS) has the potential to alter neural circuits non-invasively in both animals and humans. Unlike other non-invasive brain stimulation methods, TUS can focus on both cortical and deep brain targets with unprecedented spatial resolution. The neuromodulatory effects of TUS are derived from the interaction of ultrasound waves with neuronal membranes, resulting in changes in excitability and firing rate. After years of research, TUS is now being applied in human studies and can be assessed using non-invasive brain mapping techniques. This review provides a comprehensive overview of the principles, mechanisms, effects, and potential applications of TUS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Jordan Lam, Justin Lee, Marcus Williams, Melanie Cohn, Melissa Wilson, Catherine Mark, Nasrin Esnaashari, Andrew Petkus, Jennifer Hui, Danielle Feigenbaum, Mark Liker, Charles Y. Liu, Brian Lee, Darrin J. Lee
Summary: The study evaluated the acute effects of theta frequency bilateral STN stimulation on executive function in Parkinson's disease patients, showing significant improvement in episodic category fluency compared to gamma frequency stimulation. However, there were no significant differences between stimulation frequencies in other tests.
Article
Multidisciplinary Sciences
William J. Tyler, Alyssa M. Boasso, Hailey M. Mortimore, Rhonda S. Silva, Jonathan D. Charlesworth, Michelle A. Marlin, Kirsten Aebersold, Linh Aven, Daniel Z. Wetmore, Sumon K. Pal
SCIENTIFIC REPORTS
(2015)
Article
Clinical Neurology
Bhaskar Paneri, Devin Adair, Chris Thomas, Niranjan Khadka, Vaishali Patel, William J. Tyler, Lucas Parra, Marom Bikson
Editorial Material
Engineering, Biomedical
Alexander Opitz, William J. Tyler
NATURE BIOMEDICAL ENGINEERING
(2017)
Article
Clinical Neurology
Marom Bikson, Bhaskar Paneri, Andoni Mourdoukoutas, Zeinab Esmaeilpour, Bashar W. Badran, Robin Azzam, Devin Adair, Abhishek Datta, Xiao Hui Fang, Brett Wingeier, Daniel Chao, Miguel Alonso-Alonso, Kiwon Lee, Helena Knotkova, Adam J. Woods, David Hagedorn, Doug Jeffery, James Giordano, William J. Tyler
Article
Neurosciences
William J. Tyler, Shane W. Lani, Grace M. Hwang
CURRENT OPINION IN NEUROBIOLOGY
(2018)
Article
Clinical Neurology
Jerel Mueller, Wynn Legon, Alexander Opitz, Tomokazu F. Sato, William J. Tyler
Article
Neurosciences
Wynn Legon, Tomokazu F. Sato, Alexander Opitz, Jerel Mueller, Aaron Barbour, Amanda Williams, William J. Tyler
NATURE NEUROSCIENCE
(2014)
Review
Clinical Neurology
Marom Bikson, Zeinab Esmaeilpour, Devin Adair, Greg Kronberg, William J. Tyler, Andrea Antal, Abhishek Datta, Bernhard A. Sabel, Michael A. Nitsche, Colleen Loo, Dylan Edwards, Hamed Ekhtiari, Helena Knotkova, Adam J. Woods, Benjamin M. Hampstead, Bashar W. Badran, Angel V. Peterchev
Article
Neurosciences
Joseph L. Sanguinetti, Stuart Hameroff, Ezra E. Smith, Tomokazu Sato, Chris M. W. Daft, William J. Tyler, John J. B. Allen
FRONTIERS IN HUMAN NEUROSCIENCE
(2020)
Article
Health Care Sciences & Services
Stephen T. Foldes, Amanda R. Jensen, Austin Jacobson, Sarah Vassall, Emily Foldes, Ann Guthery, Danni Brown, Todd Levine, William James Tyler, Richard E. Frye
Summary: The study provides preliminary evidence that transdermal electrical neuromodulation (TEN) is well-tolerated in individuals with Autism Spectrum Disorder (ASD) and can significantly improve anxiety symptoms. 57% of the participants responded positively to the treatment, showing a significant reduction in self-reported anxiety symptoms.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Neurosciences
Alexandra Evancho, William J. Tyler, Keith McGregor
Summary: This review examines exercise strategies and non-invasive neuromodulation techniques targeting neuroplasticity in rehabilitation for Parkinson's Disease, Traumatic Brain Injury, stroke, and Spinal Cord Injury. The review highlights the potential benefits of combining non-invasive neuromodulation with rehabilitation and identifies gaps in current literature and barriers to implementation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Proceedings Paper
Nanoscience & Nanotechnology
Grace M. Hwang, Shane W. Lani, Allan P. Rosenberg, Marina B. Congedo, William J. Tyler
MICRO- AND NANOTECHNOLOGY SENSORS, SYSTEMS, AND APPLICATIONS X
(2018)
Proceedings Paper
Nanoscience & Nanotechnology
William J. Tyler, Joseph L. Sanguinetti, Maria Fini, Nicholas Hool
MICRO- AND NANOTECHNOLOGY SENSORS, SYSTEMS, AND APPLICATIONS IX
(2017)
Review
Psychiatry
Maria Fini, William J. Tyler
INTERNATIONAL REVIEW OF PSYCHIATRY
(2017)
Review
Biochemistry & Molecular Biology
Jerel K. Mueller, William J. Tyler