期刊
NEUROSCIENCE RESEARCH
卷 76, 期 4, 页码 261-264出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2013.05.003
关键词
Parkinson's disease; Pain; 6-OHDA; Electronic von Frey test; Animal model
Some patients with Parkinson's disease (PD) suffer from pain before motor symptoms. To model this, we proposed to assess the mechanical hypersensitivity in an animal model of PD with a bilateral lesion of the nigrostriatal pathway. PD model was validated by a decrease of locomotor activity and a 76% dopamine cell loss in the substantia nigra pars compacta. PD animals displayed a decrease of mechanical thresholds, correlated with the degree of the dopamine lesion. This animal model displays nociceptive disorders as found in PD patients and could be useful to assess the effects of new antiparkinsonian drugs. (C) 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据