Article
Pharmacology & Pharmacy
Sergio M. Borghi, Sylvia K. D. Bussulo, Felipe A. Pinho-Ribeiro, Victor Fattori, Thacyana T. Carvalho, Fernanda S. Rasquel-Oliveira, Tiago H. Zaninelli, Camila R. Ferraz, Antonio M. B. Casella, Fernando Q. Cunha, Thiago M. Cunha, Rubia Casagrande, Waldiceu A. Verri Jr
Summary: Delayed-onset muscle soreness (DOMS) is caused by unaccustomed exercise with eccentric contractions, high intensity, or long duration. This study investigates the role of spinal cord neuroinflammation in DOMS and suggests that glial cells, NF kappa B, cytokines/chemokines, and oxidative stress play important roles in DOMS-induced central sensitization.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Balazs Sonkodi
Summary: Piezo2 channels play a critical role in proprioception. They can be transiently damaged during strenuous contractions, leading to impaired proprioception and reduced range of motion. This damage can also cause neuroinflammation and neuronal activation in the spinal cord, contributing to delayed onset muscle soreness.
Review
Chemistry, Medicinal
Mohammad Beba, Hamed Mohammadi, Cain C. T. Clark, Kurosh Djafarian
Summary: The study aimed to assess the effects of curcumin supplementation on exercise-induced muscle damage, muscle soreness, inflammation, muscle strength, and joint flexibility. The meta-analysis showed that curcumin supplementation significantly reduced creatine kinase activity, muscle soreness, and TNF-alpha concentration, and improved muscle strength and range of motion. However, no significant changes were found in IL-6 and IL-8 levels. Further high-quality studies are needed to evaluate the long-term effects and safety of curcumin supplementation.
PHYTOTHERAPY RESEARCH
(2022)
Article
Clinical Neurology
Enrico De Martino, Luisina Gregoret, Matteo Zandalasini, Thomas Graven-Nielsen
Summary: The peak alpha frequency (PAF) decreases during cutaneous pain, but there is limited research on PAF during movement-related muscle pain. Individuals with high pain sensitivity (HPS) exhibit a faster PAF response to muscle pain, while long-lasting movement-related pain can lead to a decrease in PAF, indicating a widespread change in cortical excitability independent of pain sensitivity.
Article
Physiology
Hugo Keriven, Alberto Sanchez-Sierra, Diego Minambres-Martin, Angel Gonzalez de la Flor, Guillermo Garcia-Perez-de-Sevilla, Diego Dominguez-Balmaseda
Summary: This study aimed to examine the effects of peripheral electromagnetic stimulation on markers of Delayed Onset Muscular Soreness (DOMS) in male professional soccer players. The results showed that the stimulation did not lead to significant improvements in lower limb power and strength, but it decreased peripheral sensitization in the leg muscles after eccentric exercise.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Chemistry, Medicinal
Wang Fang, Yasaman Nasir
Summary: The study identified that curcumin supplementation has a significant effect in reducing creatine kinase levels and muscle soreness index among adults after exercise-induced muscle damage. Subgroup analysis further demonstrated the efficacy of curcumin based on factors such as follow-ups after exercise, dose of curcumin, duration of studies, exercise type, train status, and study design. This suggests that curcumin may be a priority agent for exercise-induced muscle damage recovery interventions.
PHYTOTHERAPY RESEARCH
(2021)
Article
Physiology
Ning Que
Summary: This study compares the effects of kinesio taping (KT), vibration treatment (VT), and joint intervention (JI) on delayed-onset muscle soreness (DOMS) in college students. The results show that VT is better than KT in reducing pain, and the combined intervention is more effective than single interventions.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Balazs Sonkodi
Summary: The pathophysiology of delayed onset muscle soreness is not fully understood. Lactic acid, previously believed to be responsible, is now thought to have a smaller role. However, it appears that lactate plays an important role in the initiation of muscle soreness within the intrafusal space and can contribute to secondary damage in the extrafusal space by potentiating the role of bradykinin.
Article
Health Care Sciences & Services
Pavlos Angelopoulos, Anastasios Diakoronas, Dimitrios Panagiotopoulos, Maria Tsekoura, Panagiota Xaplanteri, Dimitra Koumoundourou, Farzaneh Saki, Evdokia Billis, Elias Tsepis, Konstantinos Fousekis
Summary: This study investigated the effects of cold-water immersion (CWI) and sports massage on delayed-onset muscle soreness (DOMS) in amateur athletes. The results showed that CWI improves pain sensation, and the combination of sports massage and CWI also leads to a significant reduction in pain. However, these interventions do not affect other important adaptations of DOMS.
Article
Sport Sciences
Sema Ozden, Ozge Ozalp, Rabia Tugba Kilic, Hayri Baran Yosmaoglu
Summary: DOMS in trunk muscles has a negative effect on respiratory function parameters, respiratory muscle strength, respiratory muscle endurance, and exercise capacity. After DOMS, there is a 4% to 7.5% decrease in respiratory function parameters, and a 6.6% decrease in respiratory muscle strength.
SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
(2023)
Article
Pharmacology & Pharmacy
Sergio M. Borghi, Tiago H. Zaninelli, Telma Saraiva-Santos, Mariana M. Bertozzi, Renato D. R. Cardoso, Thacyana T. Carvalho, Camila R. Ferraz, Doumit Camilios-Neto, Fernando Q. Cunha, Thiago M. Cunha, Felipe A. Pinho-Ribeiro, Rubia Casagrande, Waldiceu A. Verri
Summary: In this study, the researchers investigated the effect of pentoxifylline (Ptx) on delayed-onset muscle soreness (DOMS) in untrained mice exposed to intense acute swimming exercise. They found that Ptx treatment reduced mechanical hyperalgesia caused by intense acute swimming in a dose-dependent manner. Ptx also inhibited neutrophil recruitment, oxidative stress, and cytokine production in the muscle tissue and spinal cord, as well as reduced glial cell activation in the spinal cord. These findings suggest that Ptx can alleviate pain in DOMS by targeting peripheral and spinal cord mechanisms.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Balazs Sonkodi, Eva Pallinger, Tamas Radovits, Emese Csulak, Kinga Shenker-Horvath, Bence Kopper, Edit Buzas, Nora Sydo, Bela Merkely
Summary: The purpose of this study was to investigate the immunophenotypical characterization, with a focus on natural killer cells, of junior swimmers from the Hungarian National Swim Team before and after intense exercise. The findings showed an increase in the percentage of CD3(-)/CD56(+) natural killer cells and CD3(-)/CD56(dim+) NK cells, as well as a decrease in the percentage of CD3(+) T cells among lymphocytes after exercise. Additionally, a link between delayed-onset muscle soreness and imbalanced control of CD3(+)/CD56(+) NKT-like cells among lymphocytes was demonstrated for the first time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Xiali Xue, Yuerong Hao, Xinwei Yang, Chaoyang Zhang, Jie Xu, Xiaolei Wu, Zhongyi Deng, Ning Li
Summary: This study compared the effects of Kinesio Tape (KT) and Compression Sleeves (CS) on Delayed Onset Muscle Soreness (DOMS) and found that KT is more effective in reducing DOMS pain. Additionally, combining KT and CS can help alleviate DOMS pain, accelerate muscle strength recovery, and shorten the recovery time.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Cell Biology
Balazs Sonkodi, Zsolt Kopa, Peter Nyirady
Summary: Post orgasmic illness syndrome is a rare condition with unknown pathomechanism and uncertain treatment, characterized by symptoms lasting 2-7 days post ejaculation. Proposed primary injury includes acute compression proprioceptive axonopathy in the muscle spindle and mitochondrial impairment. Similarities to delayed onset muscle soreness exist, but differences arise from spermidine depletion-induced physiological responses. Longitudinally, cognitive and memory consequences are noted due to learning and memory-related primary injury.
Article
Orthopedics
Harold Akehurst, John E. Grice, Manuela Angioi, Dylan Morrissey, Filippo Migliorini, Nicola Maffulli
Summary: The study found that post-exercise whole-body vibration therapy can significantly reduce muscle soreness and tightness in elite athletes after eccentric exercise, contributing to decreased injury risk and improved performance. This treatment modality can be easily integrated into existing training regimes and may have implications for other multi-sprint sports.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
