Article
Neurosciences
Rubal Singla, Abhishek Mishra, Rupa Joshi, Phulen Sarma, Rohit Kumar, Gurjeet Kaur, Amit Raj Sharma, Ashish Jain, Ajay Prakash, Alka Bhatia, Bikash Medhi
Summary: In this study, the therapeutic efficacy of the GABA mimic homotaurine (HT) in ameliorating ASD symptoms was evaluated in an ASD rat model. The results showed that HT treatment improved core behavioral deficits, decreased oxidative stress and pro-inflammatory cytokines, increased anti-inflammatory cytokines, preserved cell density, and normalized gene expression. This suggests that HT may be a potential therapeutic agent for ASD.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Weiru Jiang, Toshikazu Kakizaki, Kazuyuki Fujihara, Shigeo Miyata, Yue Zhang, Takashi Suto, Daiki Kato, Shigeru Saito, Koji Shibasaki, Yasuki Ishizaki, Koji Isoda, Hideaki Yokoo, Hideru Obinata, Touko Hirano, Yoshiki Miyasaka, Tomoji Mashimo, Yuchio Yanagawa
Summary: GABA is a major neurotransmitter in the mammalian central nervous system. In this study, the functional roles of GAD65 and/or GAD67 were investigated using various kinds of GAD isoform(s)-deficient rats. The results showed that both GAD65 and GAD67 are involved in palate formation, while neither isoform is critical for abdominal wall formation.
Article
Neurosciences
Michael C. Holter, Lauren T. Hewitt, Kenji J. Nishimura, Sara J. Knowles, George R. Bjorklund, Shiv Shah, Noah R. Fry, Katherina P. Rees, Tanya A. Gupta, Carter W. Daniels, Guohui Li, Steven Marsh, David Michael Treiman, Michael Foster Olive, Trent R. Anderson, Federico Sanabria, William D. Snider, Jason M. Newbern
Summary: Many developmental syndromes are associated with genetic mutations affecting ERK/MAPK pathways, but the specific neurobiological effects of hyperactive signaling remain unclear. This study found that hyperactivation of MEK1 in GABAergic cortical interneurons led to abnormal neuronal development and functionality, resulting in deficits in inhibitory synapses, increased risk of seizures, and impaired behavioral responses. These findings shed light on the potential mechanisms underlying neurological deficits in ERK/MAPK-related syndromes.
Article
Clinical Neurology
Dongyu Liu, Kazuyuki Fujihara, Yuchio Yanagawa, Hajime Mushiake, Tomokazu Ohshiro
Summary: By recording EEG in knockout rats for Gad1, we found that GABA can both suppress and enhance SWD generation. Comparison between normal rats and Gad1 knockout rats revealed that SWD symptoms were more severe in Gad1 knockout rats, and the effects of valproate treatment differed in the two groups. Immunohistochemistry results indicated significantly reduced GABA immunoreactivity in the RTN neurons of Gad1 knockout rats.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Matthew T. Schmitz, Kadellyn Sandoval, Christopher P. Chen, Mohammed A. Mostajo-Radji, William W. Seeley, Tomasz J. Nowakowski, Chun Jimmie Ye, Mercedes F. Paredes, Alex A. Pollen
Summary: This study investigates the gene expression trajectories of inhibitory neurons (INs) in primates and mice during neurogenic period. Researchers find that while the initial classes of INs generated prenatally are largely conserved among mammals, there are contrasting developmental mechanisms for specifying evolutionarily novel cell types during prenatal development.
Article
Pharmacology & Pharmacy
Sang Wan Ryu, Yeo Ok Kim, Han-Byul Kim, Seog Bae Oh, Jeong Il Choi, Myung Ha Yoon
Summary: The recently identified molecule P7C3 has been found to have antinociceptive effects in tissue injury pain evoked by formalin injection, with involvement of the GABA system. P7C3 may increase GAD activity and GABA concentration in the spinal cord, leading to an antinociceptive effect against pain evoked by formalin injection.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Erika Bolneo, Pak Yan S. Chau, Peter G. Noakes, Mark C. Bellingham
Summary: The normal development and function of the central nervous system depend on a balance between excitatory and inhibitory neurotransmission. Down-regulated inhibitory signaling is associated with various neurological disorders. GABA is the primary inhibitory neurotransmitter in the mammalian forebrain and its down-regulated signaling is linked with multiple neurological diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Ranjithmenon Muraleedharan, Diana Nardini, Ronald Raymond Waclaw, Biplab Dasgupta
Summary: Reactive astrogliosis is characterized by a profound change in astrocyte phenotype in response to CNS injuries. This study presents a revised protocol for labeling reactive astrocytes in mouse brains and provides a staining protocol for quantitative measures of astrocyte reactivity.
Article
Neurosciences
Sharmila Venugopal, Zohal Ghulam-Jhelani, In Sook Ahn, Xia Yang, Martina Wiedau, Dwayne Simmons, Scott H. Chandler
Summary: Amyotrophic Lateral Sclerosis (ALS) involves pre-symptomatic abnormal motor neuron (MN) excitability and synaptic perturbations. In a mouse model for ALS, changes in GABA and glycine neurotransmitters were compared in different types of MNs. The results showed reduced GABA innervation in trigeminal jaw closer MNs and elevated GABA and glycine innervation in midbrain extraocular MNs. The study also found an increase in voltage-gated L-type Ca2+ currents in mutant MNs. These findings suggest adaptive responses to counter synaptic deficits in vulnerable MNs.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Developmental Biology
Shiona Biswas, C. Savio Chan, John L. R. Rubenstein, Lin Gan
Summary: The external globus pallidus (GPe) is crucial for controlling action, and changes in GPe neuron activity are associated with both passive and active body movements. Aberrant GPe neuron activity is linked to motor symptoms seen in Parkinson's Disease, Huntington's disease, and dystonia.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Neurosciences
Faez Siddiqi, Alexandria L. Trakimas, Donald J. Joseph, Margaret L. Lippincott, Eric D. Marsh, John H. Wolfe
Summary: Cortical interneurons are primarily derived from the medial and caudal ganglionic eminences during embryogenesis, with some contribution from the preoptic area, but a small population also originates from the lateral ganglionic eminence. Different populations of cells from various origins show both common and distinct lineage contributions towards the fate of cortical interneurons.
Article
Plant Sciences
Ghulam Khaliq, Sajid Ali, Shaghef Ejaz, Gholamreza Abdi, Yahya Faqir, Jiahua Ma, Mohammed Wasim Siddiqui, Asgar Ali
Summary: The effect of GABA treatment on papaya fruit stored at low temperatures was investigated. The treatment at 5 mM concentration inhibited chilling injury and enhanced antioxidant enzyme activities and defense system of the fruit.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Cell Biology
Joseph Salomone, Shenyue Qin, Temesgen D. Fufa, Brittany Cain, Edward Farrow, Bin Guan, Robert B. Hufnagel, Masato Nakafuku, Hee-Woong Lim, Kenneth Campbell, Brian Gebelein
Summary: The study investigates how Gsx homeodomain proteins gain DNA binding specificity by forming cooperative homodimers on different DNA sites. It also shows that the ratio of homodimer to monomer binding and Gsx protein levels define whether a gene is up-regulated or down-regulated. These findings provide a new paradigm for understanding how cooperative homeodomain transcription factor binding can increase target specificity and alter regulatory outcomes.
GENES & DEVELOPMENT
(2021)
Review
Behavioral Sciences
Hoda Ranjbar, Monavareh Soti, Moazamehosadat Razavinasab, Kristi A. Kohlmeier, Mohammad Shabani
Summary: TRP channels play a crucial role in the pathogenesis of ataxia, with their activity modulated by endogenous endocannabinoids. Targeting TRP channels, particularly TRPC channels, may offer a potential therapeutic approach for the management of ataxia.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Yuan Yu, Zhiwei Zeng, Danlin Xie, Renliang Chen, Yongqiang Sha, Shiying Huang, Wenjie Cai, Wanhua Chen, Wenjun Li, Rongqin Ke, Tao Sun
Summary: The authors used single-cell RNA sequencing and in situ sequencing to profile the interneuron origin and molecular diversity in the human fetal brain, demonstrating the complexity and logic behind the specification of diverse interneurons in humans.
NATURE NEUROSCIENCE
(2021)
Article
Neurosciences
Akihito Okabe, Chigusa Shimizu-Okabe, Akiko Arata, Shiro Konishi, Atsuo Fukuda, Chitoshi Takayama
Review
Neurosciences
Miho Watanabe, Atsuo Fukuda
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)
Article
Multidisciplinary Sciences
Hirotomo Saitsu, Miho Watanabe, Tenpei Akita, Chihiro Ohba, Kenji Sugai, Winnie Peitee Ong, Hideaki Shiraishi, Shota Yuasa, Hiroshi Matsumoto, Khoo Teik Beng, Shinji Saitoh, Satoko Miyatake, Mitsuko Nakashima, Noriko Miyake, Mitsuhiro Kato, Atsuo Fukuda, Naomichi Matsumoto
SCIENTIFIC REPORTS
(2016)
Article
Clinical Neurology
Tenpei Akita, Kazushi Aoto, Mitsuhiro Kato, Masaaki Shiina, Hiroki Mutoh, Mitsuko Nakashima, Ichiro Kuki, Shin Okazaki, Shinichi Magara, Takashi Shiihara, Kenji Yokochi, Kaori Aiba, Jun Tohyama, Chihiro Ohba, Satoko Miyatake, Noriko Miyake, Kazuhiro Ogata, Atsuo Fukuda, Naomichi Matsumoto, Hirotomo Saitsu
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2018)
Article
Neurosciences
Tianying Wang, Tatsuro Kumada, Toshitaka Morishima, Satomi Iwata, Takeshi Kaneko, Yuchio Yanagawa, Sachiko Yoshida, Atsuo Fukuda
Article
Neurosciences
Rongqing Chen, Akihito Okabe, Haiyan Sun, Salim Sharopov, Ileana L. Hanganu-Opatz, Sergei N. Kolbaev, Atsuo Fukuda, Heiko J. Luhmann, Werner Kilb
JOURNAL OF PHYSIOLOGY-LONDON
(2014)
Article
Multidisciplinary Sciences
Mitsuhiro Edamura, Gen Murakami, Hongrui Meng, Makoto Itakura, Ryuichi Shigemoto, Atsuo Fukuda, Daiichiro Nakahara
Article
Neurosciences
Tomonori Furukawa, Junko Yamada, Tenpei Akita, Yoshitaka Matsushima, Yuchio Yanagawa, Atsuo Fukuda
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Article
Neurosciences
Taizhe Qian, Rongqing Chen, Masato Nakamura, Tomonori Furukawa, Tatsuro Kumada, Tenpei Akita, Werner Kilb, Heiko J. Luhmann, Daiichiro Nakahara, Atsuo Fukuda
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Review
Neurosciences
Miho Watanabe, Atsuo Fukuda, Junichi Nabekura
FRONTIERS IN NEUROSCIENCE
(2014)
Review
Biochemistry & Molecular Biology
Masaru Ishibashi, Kiyoshi Egawa, Atsuo Fukuda
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Neurosciences
Atsuo Fukuda
NEUROSCIENCE RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Miho Watanabe, Takashi Ito, Atsuo Fukuda
Summary: Research shows that taurine plays important roles in anxiety-like behavior, hearing, muscular endurance, and maintenance of body weight in mice.
Article
Biochemistry & Molecular Biology
Yashuang Ping, Kenji Ohata, Kenji Kikushima, Takumi Sakamoto, Ariful Islam, Lili Xu, Hengsen Zhang, Bin Chen, Jing Yan, Fumihiro Eto, Chiho Nakane, Keizo Takao, Tsuyoshi Miyakawa, Katsuya Kabashima, Miho Watanabe, Tomoaki Kahyo, Ikuko Yao, Atsuo Fukuda, Koji Ikegami, Yoshiyuki Konishi, Mitsutoshi Setou
Summary: As an important neurotransmitter, glutamate functions in the majority of excitatory synapses in the human brain. The metabolic pathway of glutamate is complex, and the exact role of glutamate pool in neurons remains unclear. This study utilized Ttll1 and Ttll7 knockout mice to investigate the impact of tubulin polyglutamylation on neuronal behavior. Matrix-assisted laser desorption/ionization (MALDI) Imaging mass spectrometry (IMS) analysis revealed increased levels of glutamate in the brains of knockout mice, suggesting that tubulin polyglutamylation by TTLLs acts as a reservoir of glutamate in neurons and modulates other glutamate-related amino acids.
Article
Neurosciences
Daniel Althof, David Baehrens, Masahiko Watanabe, Noboru Suzuki, Bernd Fakler, Akos Kulik
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)