Article
Neurosciences
Eva Schweickert de Palma, Tilman Guennewig, Michael Rullmann, Julia Luthardt, Mohammed K. Hankir, Philipp M. Meyer, Georg-Alexander Becker, Marianne Patt, Sarah Martin, Anja Hilbert, Matthias Blueher, Osama Sabri, Swen Hesse
Summary: This study investigated whether there is altered brain alpha 4 beta 2* nAChR availability in individuals with obesity compared to normal-weight healthy controls. The findings suggest the possibility of aberrant alpha 4 beta 2* nAChR availability in the key brain regions that regulate feeding behavior.
Article
Neurosciences
Nils Richter, Lara-Sophia David, Michel J. Grothe, Stefan Teipel, Markus Dietlein, Marc Tittgemeyer, Bernd Neumaier, Gereon R. Fink, Oezguer A. Onur, Juraj Kukolja
Summary: The study aimed to investigate if the extent of cholinergic deficit in non-demented AD patients could be predicted from the volume of cholinergic basal forebrain nuclei. Results showed that greater volumes of anterior basal forebrain nuclei and younger age were associated with a more significant cholinergic deficit in MCI due to AD. Further research is needed to explore if individual response to cholinomimetics can be inferred from these measures.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Yawen Wang, Minye Zhan, Alard Roebroeck, Peter De Weerd, Sriranga Kashyap, Mark J. Roberts
Summary: This study examines the feasibility of using MRI to locate the nucleus basalis of Meynert (nbM) in humans, and finds that current methods of mapping nbM may have limitations, especially when dealing with high resolution MRI data. By developing a new nbM mask and utilizing high spatial resolution data, more accurate and stable volume estimates can be obtained. Direct imaging of nbM appears to be feasible, but further development is necessary for standard (f)MRI scanning to allow such imaging.
Article
Biochemistry & Molecular Biology
Zhao-yi Chen, Yao-lian Yang, Mai Li, Lu Gao, Wei-min Qu, Zhi-li Huang, Xiang-shan Yuan
Summary: The cholinergic neurons in the nucleus basalis of Meynert (NBM) play a crucial role in cognition and are associated with various neurological disorders. This study used a transgenic mouse model and tracing techniques to investigate the neural connectivity of NBM cholinergic neurons. The results revealed specific inputs from the caudate putamen and the posterior limb of the anterior commissure, as well as widespread axon projections to the cortex mantle. Interestingly, while NBM cholinergic neurons received input projections from certain regions, they sparsely sent axon projections back to these areas. Furthermore, specific cortical regions received abundant inputs from the NBM but sent few outputs back. These findings provide important insights into the connectivity and function of cholinergic neurons in the NBM.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Clinical Neurology
Nicola J. Ray, Rachael A. Lawson, Sarah L. Martin, Hilmar P. Sigurdsson, Joanna Wilson, Brook Galna, Sue Lord, Lisa Alcock, Gordon W. Duncan, Tien K. Khoo, John T. O'Brien, David J. Burn, John-Paul Taylor, River C. Rea, Maurizio Bergamino, Lynn Rochester, Alison J. Yarnall
Summary: Free-water imaging can predict dopamine system degeneration in Parkinson's disease and enhance the sensitivity of traditional DTI metrics. However, it has not been applied to investigate cholinergic system degeneration. Free-water imaging, free-water-corrected DTI, and volumetry were used to extract structural metrics from the cholinergic basal forebrain and pedunculopontine nucleus in people with Parkinson's disease.
Article
Clinical Neurology
Milan Nemy, Martin Dyrba, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, Doreen Goerss, Michael T. Heneka, Stefan Hetzer, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris-Stephan Rauchmann, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike J. Spruth, Michael Wagner, Jens Wiltfang, Renat Yakupov, Maria Eriksdotter, Eric Westman, Olga Stepankova, Lenka Vyslouzilova, Emrah Duezel, Frank Jessen, Stefan J. Teipel, Daniel Ferreira
Summary: Nemy et al. investigate cholinergic white matter projections along the Alzheimer's disease continuum, finding that alterations in these pathways are present in individuals with subjective cognitive decline. These alterations precede the more widespread changes seen in mild cognitive impairment and Alzheimer's disease dementia. The study highlights the potential of using cholinergic white matter pathways as markers for the early stages of Alzheimer's disease.
Article
Medicine, General & Internal
Isaac Colvett, Anah Gilmore, Samuel Guzman, Aurelie Ledreux, Jorge E. Quintero, Dhanunjaya Rao Ginjupally, Julie A. Gurwell, John T. Slevin, Zain Guduru, Greg A. Gerhardt, Craig G. van Horne, Ann-Charlotte Granholm
Summary: Parkinson's disease is a severe neurological disease with no effective treatment. This study demonstrates that autologous transplantation of peripheral nerve tissue into the basal forebrain or midbrain can lead to improved clinical features, with no significant cell death or host-tissue reaction observed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Claire Andre, Marie-eve Martineau-Dussault, Veronique Daneault, Helene Blais, Sonia Frenette, Dominique Lorrain, Carol Hudon, Celyne Bastien, Dominique Petit, Alexandre Lafreniere, Cynthia Thompson, Jacques Montplaisir, Nadia Gosselin, Julie Carrier
Summary: This study investigated the associations between the volume of basal forebrain nuclei and REM sleep characteristics, and the impact of cognitive status on these links. The findings suggest that REM sleep disturbances may be an early manifestation of the degeneration of the basal forebrain cholinergic system, especially in participants with mild memory deficits.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Fangchen Zhu, Sarah Elnozahy, Jennifer Lawlor, Kishore V. Kuchibhotla
Summary: The study found that cholinergic signals from the basal forebrain relay auditory information to the auditory cortex. These signals are modulated by brain and behavioral states and provide repeated auditory representations across the cortical tonotopy. However, it remains unknown whether sensory cholinergic signals target the sensory cortex and how they relate to local functional topography.
NATURE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Franziska E. Hildesheim, Ralph H. B. Benedict, Robert Zivadinov, Michael G. Dwyer, Tom Fuchs, Dejan Jakimovski, Bianca Weinstock-Guttman, Niels Bergsland
Summary: NBM damage is associated with cognitive impairment in patients with multiple sclerosis, with diffusivity of NBM showing significant correlation with cognitive test results and ability to predict cognitive changes.
JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elisabetta Coppi, Federica Cherchi, Erica Sarchielli, Irene Fusco, Giulia Guarnieri, Pasquale Gallina, Renato Corradetti, Felicita Pedata, Gabriella B. Vannelli, Anna Maria Pugliese, Annamaria Morelli
Summary: This study characterized cholinergic effects in human NBM neurons, showing that acetylcholine can modulate ion channels by enhancing K currents, reducing Na currents, and activating different receptors. Spontaneous acetylcholine release from neuroblasts in the human fetal NBM may play a key role in brain development.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neuroimaging
Daniel H. Lench, Travis H. Turner, Emma Wetmore, Federico J. Rodriguez-Porcel, Gonzalo J. Revuelta
Summary: This study found that structural degeneration of the Nucleus Basalis of Meynert is associated with worsening cognitive symptoms in Parkinson's Disease patients during OFF periods, but does not affect their overall cognitive functioning in the ON-state.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Clinical Neurology
Muhammad Nazmuddin, Jan-Willem Van Dalen, Ronald J. H. Borra, Gilles N. Stormezand, Harm Jan van der Horn, Sygrid van der Zee, Jeffrey Boertien, Teus van Laar
Summary: The study found a loss of microstructural integrity of the NBM-WM tract in PIGD-PD patients, indicating that the loss of cholinergic projections in this PD subtype already presents in de novo PD patients. Furthermore, significant correlations between the severity of gait and posture issues and NBM-WM FA and MD were identified.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Neurosciences
Mihai Avram, Michel J. Grothe, Lena Meinhold, Claudia Leucht, Stefan Leucht, Stefan Borgwardt, Felix Brandl, Christian Sorg
Summary: Research suggests that patients with schizophrenia have lower volumes of cholinergic basal forebrain nuclei, which are associated with cognitive deficits, specifically in attention.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Chen-Pei Lin, Irene Frigerio, Baayla D. C. Boon, Zihan Zhou, Annemieke J. M. Rozemuller, Femke H. Bouwman, Menno M. Schoonheim, Wilma D. J. van de Berg, Laura E. Jonkman
Summary: Cognitive deficits in Alzheimer's disease, especially memory decline, are associated with cholinergic degeneration in the basal forebrain. This study used a combination of post-mortem in situ MRI and histopathology to investigate the pathophysiology of nucleus basalis of Meynert atrophy in Alzheimer's disease. The results showed that Alzheimer's disease donors had reduced volume and altered microstructural integrity of the nucleus basalis of Meynert, which was associated with decreased cholinergic cell density and damaged cortical projections, leading to cognitive deterioration.
Article
Neurosciences
Sara Touj, Sebastien Houle, Djamel Ramla, Renaud Jeffrey-Gauthier, Harumi Hotta, Gilles Bronchti, Maria-Grazia Martinoli, Mathieu Piche
Article
Neurosciences
Nobuhiro Watanabe, Harumi Hotta
FRONTIERS IN NEUROSCIENCE
(2017)
Article
Neurosciences
Harumi Hotta, Akiko Onda, Harue Suzuki, Philip Milliken, Arun Sridhar
FRONTIERS IN NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Jun Kamei, Hiroki Ito, Naoki Aizawa, Harumi Hotta, Toshio Kojima, Yasunori Fujita, Masafumi Ito, Yukio Homma, Yasuhiko Igawa
SCIENTIFIC REPORTS
(2018)
Article
Neurosciences
Harumi Hotta, Harue Suzuki, Kaori Limura, Nobuhiro Watanabe
FRONTIERS IN NEUROSCIENCE
(2018)
Article
Neurosciences
Nobuhiro Watanabe, Satoshi Sasaki, Kazuto Masamoto, Harumi Hotta
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Anatomy & Morphology
Harumi Hotta, Nobuhiro Watanabe
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2019)
Article
Physiology
Kaori Iimura, Harue Suzuki, Harumi Hotta
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2019)
Article
Endocrinology & Metabolism
Harumi Hotta, Harue Suzuki, Tomio Inoue, Mark Stewart
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Article
Biochemistry & Molecular Biology
Kaori Iimura, Nobuhiro Watanabe, Philip Milliken, Yee-Hsee Hsieh, Stephen J. Lewis, Arun Sridhar, Harumi Hotta
Article
Physiology
Nobuhiro Watanabe, Yoshihiro Noda, Taeko Nemoto, Kaori Iimura, Takahiko Shimizu, Harumi Hotta
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2020)
Article
Integrative & Complementary Medicine
Nobuhiro Watanabe, Kaori Iimura, Harumi Hotta
Summary: The study revealed that Ninjin'yoeito (NYT) can prevent a decrease in cerebral blood flow independently of vagal activity by cholinergic activation and enhance the cerebral blood flow response to somatosensory stimulation.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Physiology
Harumi Hotta, Kaori Iimura, Nobuhiro Watanabe, Kazuhiro Shigemoto
Summary: The study revealed that spinal and supraspinal somato-sympathetic nerve reflexes induced by contractions of skeletal muscles contribute to the maintenance of their own contractile force. In experiments with rats, transection of the lumbar sympathetic trunk, spinal cord, or dorsal roots resulted in a reduction of approximately 10% in tetanic force (TF) amplitude after 20 minutes.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2021)
Article
Anesthesiology
Ryota Tokunaga, Yukari Takahashi, Sara Touj, Harumi Hotta, Hugues Leblond, Fusao Kato, Mathieu Piche
Summary: Chronic widespread mechanical hypersensitivity in a rat model of chronic back pain can be attenuated by inhibiting GABAergic neurons of the right amygdala, indicating that this type of hypersensitivity is not maintained by chronic systemic inflammation. The amygdala plays a key role in pain perception and modulation, and targeting amygdala GABAergic neurons may be a potential intervention for patients with chronic back pain.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Immunology
Rie Hasebe, Kaoru Murakami, Masaya Harada, Nada Halaka, Hiroshi Nakagawa, Fuminori Kawano, Yoshinobu Ohira, Tadafumi Kawamoto, Fiona E. E. Yull, Timothy S. S. Blackwell, Junko Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, Nobuhiro Watanabe, Harumi Hotta, Toshihide Yamashita, Daisuke Kamimura, Yuki Tanaka, Masaaki Murakami
Summary: Local inflammation is spread to remote positions through sensory neuron-interneuron crosstalk using ATP. This neural pathway, known as the remote inflammation gateway reflex, may serve as a therapeutic target for inflammatory diseases with remote inflammation, such as rheumatoid arthritis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)