期刊
NEUROSCIENCE RESEARCH
卷 62, 期 3, 页码 206-209出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2008.07.005
关键词
Parkinson's disease; Uridine; Docosahexaenoic acid; Dopamine; Tyrosine hydroxylase activity; Synapse
资金
- National Institutes of Health [MH-28783]
- Center for Brain Sciences and Metabolism Charitable Trust
- Turkish Academy of Sciences
Administering uridine-5'-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 clays after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may Partially restore dopaminergic neurotransmission in this model of Parkinson's disease. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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