期刊
NEUROSCIENCE LETTERS
卷 561, 期 -, 页码 1-6出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.12.025
关键词
Hippocampus; Long-term potentiation; Somatostatin; Apical dendrite; Basal dendrite; Rat
资金
- Leibniz Institute for Neurobiology
The cyclic neuropeptide, somatostatin, is widely expressed in mammalian brain and modulates hormone secretion and neurotransmission. The long-term potentiation (LTP) at Schaffer collateral synapses onto hippocampal CA1 pyramidal neurons has been intensively studied as a cellular model of learning and memory. The apical (stratum radiatum) and basal dendrites (stratum oriens) of CA1 pyramidal neurons differ in LTP induction and maintenance. Here the role of somatostatin in the modulation of LTP was investigated in rat hippocampus. Our results show that somatostatin enhances LTP in apical and basal dendrites. However, the activation conditions of the somatostatin system are different in these two compartments. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据