Article
Biochemistry & Molecular Biology
Seong Shoon Yoon, Jaesuk Yun, Bong Hyo Lee, Hee Young Kim, Chae Ha Yang
Summary: Acupuncture at HT7 acupoint can regulate the brain reward function of rats and elevate ICSS thresholds. However, it does not affect the threshold-lowering effects produced by cocaine, indicating that it only effectively regulates the ICSS thresholds in drug-naive rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
F. Buehning, L. Miguel Telega, Y. Tong, J. Pereira, V. A. Coenen, M. D. Doeroessy
Summary: The study investigated the acute effects of MFB DBS on neuronal oscillations in different neuronal populations related to the pathophysiology of depression. MFB DBS differentially affected neuronal oscillations in the mPFC, NAc, and VTA across SD and FSL rats, with a significant increase in low gamma oscillations in the mPFC of FSL rats.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Fernando A. Tinoco Mendoza, Timothy E. S. Hughes, Rebecca Robertson, Lewis S. Crawford, Noemi Meylakh, Paul M. Macey, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson
Summary: The PAG is a critical region for pain-related responses and shows a crude somatotopy for contextually appropriate behavioral responses. Different regions in the PAG are activated by cutaneous and muscle pain. Using ultra-high field functional magnetic resonance imaging, it was found that the PAG exhibits different signal intensity changes in response to noxious stimuli. This suggests a preserved somatotopic organization in the PAG between animals and humans.
Article
Neurosciences
Tiago Bortolini, Bruno Melo, Rodrigo Basilio, Ronald Fischer, Roland Zahn, Ricardo de Oliveira-Souza, Brian Knutson, Jorge Moll
Summary: This study explores the intrinsic motivation of humans to bond with others and the role of reward circuitry in the anticipation and response to affiliative rewards. The findings suggest a general appetitive response in the Nucleus Accumbens to different types of rewards, while a more specific response is seen in the septo-hypothalamic region to affiliative rewards. The new task presented in this work allows for distinguishing between neural responses to affiliative and non-affiliative rewards.
Article
Neuroimaging
Tobias Bracht, Nicolas Mertse, Sebastian Walther, Karin Luedi, Sigrid Breit, Andrea Federspiel, Roland Wiest, Niklaus Denier
Summary: This study aimed to explore the associations between structural connectivity of the medial forebrain bundle (MFB), functional connectivity (FC) of the ventral tegmental area (VTA), anhedonia, and depression severity in patients with depression. The results showed reduced tract volume and number in the left supero-lateral branch (slMFB) in depression patients. Additionally, there was an increase in FC between the VTA and right medial prefrontal cortex (PFC) in these patients, and depression severity was associated with reduced tract volume and number in the left slMFB. Furthermore, reduced hedonic tone was associated with reduced tract volume and increased FC between the VTA and the PFC.
NEUROIMAGE-CLINICAL
(2022)
Article
Biochemistry & Molecular Biology
Peter Kiss, Eszter Banki, Balazs Gaszner, Daniel Nagy, Zsuzsanna Helyes, Endre Pal, Gyongyver Reman, Gabor Toth, Andrea Tamas, Dora Reglodi
Summary: Pituitary adenylate cyclase-activating peptide (PACAP) shows promising therapeutic effects in a rat model of streptozotocin-induced diabetic neuropathy. PACAP treatment can alleviate mechanical hyperalgesia, reduce morphological signs of neuropathy, and attenuate neuronal activation in pain processing centers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Tianye Jia, Chao Xie, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Christian Buechel, Erin Burke Quinlan, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Trevor W. Robbins, Jianfeng Feng
Summary: Using neural imaging techniques, a study explored the neural network underlying alcoholism onset in adolescents. It identified a network centered on the medial orbitofrontal cortex, with evidence of inhibitory and excitatory coregulation by this region over the dorsal periaqueductal gray. Additionally, the study found significant relationships between baseline excitatory coregulation in this network and impulsivity, supporting the role of negative urgency in alcohol dependence.
Article
Neurosciences
Jia Ryoo, Seahyung Park, Daesoo Kim
Summary: Animals have an innate motivation to explore unknown objects and environments. Photostimulation of a subset of medial preoptic area (MPA) neurons can increase exploration without causing place preference. Photoinhibition of these neurons does not lead to emotional changes, suggesting they can enhance innate exploration behavior.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yusuke Shibata, Airi Yoshimoto, Kotaro Yamashiro, Yuji Ikegaya, Nobuyoshi Matsumoto
Summary: In operant conditioning, reinforcement and extinction are driven by independent neural mechanisms. During the reinforcement period, nose-poke behaviors increase under both immediate and delayed conditions; however, in the extinction period, nose pokes are more persistent in the delayed condition compared to the immediate condition.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Irene Puig-Parnau, Soleil Garcia-Brito, Laia Vila-Soles, Andrea Riberas, Laura Aldavert-Vera, Pilar Segura-Torres, Elisabet Kadar, Gemma Huguet
Summary: Curative or fully effective treatments for Alzheimer's disease (AD) are currently unavailable. Electrical stimulation of deep brain areas is proposed as a therapeutic approach. Previous research shows that intracranial self-stimulation (ICSS) targeting the medial forebrain bundle (MFB) improves learning and memory in rats with memory impairment. Based on this, MFB could be a promising target for AD treatment.
Article
Neurosciences
Michael B. Pritz
Summary: The preoptic area and the hypothalamus are closely connected and essential for the survival of the species. By studying two species of crocodiles, a new classification system was developed which identified three rostrocaudal areas (preoptic, anterior, and tuberal) and four mediolateral zones (ependyma, periventricular, medial, and lateral). This simplified and applicable classification system avoids the complicated nomenclature used in traditional morphological studies of reptiles.
NEUROSCIENCE LETTERS
(2023)
Article
Biology
Justin N. Siemian, Miguel A. Arenivar, Sarah Sarsfield, Cara B. Borja, Lydia J. Erbaugh, Andrew L. Eagle, Alfred J. Robison, Gina Leinninger, Yeka Aponte
Summary: Functional imaging has shown that lateral hypothalamic parvalbumin-positive glutamatergic neurons play a crucial role in nociceptive processing. Modulating these neurons can alter pain-related behaviors and unpleasantness of noxious stimuli. Additionally, activating these neurons has been found to have synergistic antinociceptive effects with morphine and can restore morphine antinociception after developing tolerance.
Article
Biochemistry & Molecular Biology
Shuming An, Haiyan Sun, Miao Wu, Danfeng Xie, Su-Wan Hu, Hai-Lei Ding, Jun-Li Cao
Summary: The medial septum glutamatergic neurons exhibit higher activities during wakefulness and mainly promote wakefulness through the transition from NREM sleep to wakefulness. Activation of these neurons enhances wakefulness, while inactivation reduces wakefulness. Moreover, these neurons innervate the lateral hypothalamus glutamatergic neurons, which also promote wakefulness.
Article
Neurosciences
Joanne C. Damborsky, Jerrel L. Yakel
Summary: Cholinergic and GABAergic interactions impact HS GABA release in the MS/DBB, with carbachol and baclofen decreasing GABA release. Repetitive stimulation of HS fibers increases local GABA release, suggesting bidirectional modulation of GABA release in the MS/DBB with far-reaching implications for hippocampal-dependent learning and memory.
Article
Immunology
Rashmi Gamage, Ilaria Rossetti, Garry Niedermayer, Gerald Munch, Yossi Buskila, Erika Gyengesi
Summary: This study provides evidence of the significant impact of both aging and chronic glial activation on the cholinergic and microglial numbers and morphology. These effects result in cholinergic dysfunction, similar to what is seen in Alzheimer's disease (AD).
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Neurosciences
Gonzalo Alvarez-Bolado, Marco R. Celio
JOURNAL OF COMPARATIVE NEUROLOGY
(2016)
Article
Neurosciences
Alessandro Bilella, Gonzalo Alvarez-Bolado, Marco R. Celio
Article
Neurosciences
Federica Filice, Marco R. Celio, Alexandre Babalian, Walter Blum, Viktoria Szabolcsi
JOURNAL OF COMPARATIVE NEUROLOGY
(2017)
Article
Neurosciences
Viktoria Szabolcsi, Gioele W. Albisetti, Marco R. Celio
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Review
Cell Biology
Gonzalo Alvarez-Bolado
CELL AND TISSUE RESEARCH
(2019)
Article
Behavioral Sciences
Diana M. Roccaro-Waldmeyer, Franck Girard, Daniele Milani, Elisabetta Vannoni, Laurent Pretot, David P. Wolfer, Marco R. Celio
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Article
Anatomy & Morphology
Alexandre Babalian, Simone Eichenberger, Alessandro Bilella, Franck Girard, Viktoria Szabolcsi, Diana Roccaro, Gonzalo Alvarez-Bolado, Chun Xu, Marco R. Celio
BRAIN STRUCTURE & FUNCTION
(2019)
Article
Neurosciences
Elise Wattendorf, Birgit Westermann, Klaus Fiedler, Simone Ritz, Annetta Redmann, Joerg Pfannmoeller, Martin Lotze, Marco R. Celio
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
C. Gutierrez Herrera, F. Girard, A. Bilella, T. C. Gent, D. M. Roccaro-Waldmeyer, A. Adamantidis, M. R. Celio
NATURE COMMUNICATIONS
(2019)
Article
Clinical Neurology
Franck Girard, Michelle von Siebenthal, Fred P. Davis, Marco R. Celio
Article
Biochemistry & Molecular Biology
Xunlei Zhou, Pierre-Yves Risold, Gonzalo Alvarez-Bolado
Summary: In recent years, there has been a significant increase in genomic data related to hypothalamic development and structure, with particular attention given to the Lateral Zone. New information has highlighted the transcriptional diversity of lateral hypothalamic neurons, including both known and previously unknown types. Surprising discoveries include specific regions of the embryonic forebrain neuroepithelium generating unique LHA neurons, as well as evidence suggesting the presence of multiple types of bilingual lateral hypothalamic neurons expressing glutamate, GABA, and various neuropeptides.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)
Article
Psychiatry
Melike Kuecuekerden, Ute E. Schuster, Iris Roeckle, Gonzalo Alvarez-Bolado, Kerstin Schwabe, Herbert Hildebrandt
Summary: This study investigates the neurodevelopmental and behavioral consequences of St8sia2 deficiency in mice. The researchers found that impaired mammillary body connectivity leads to psychotic-like responses in St8sia2-deficient mice.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Anatomy & Morphology
Siri Leemann, Alexandre Babalian, Franck Girard, Fred Davis, Marco R. Celio
Summary: The PV2 cluster is a group of parvalbumin-positive neurons located in the ventromedial region of the periaqueductal gray (PAG). It has unique connections and gene expression patterns. PV2 receives inputs from the orbitofrontal cortex and ventrolateral hypothalamus, and projects to various regions involved in autonomic control. It expresses peptides and receptors, indicating its inhibitory nature. PV2 may play a role in regulating the activity of specific nuclei in the hypothalamus and PAG.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
