Review
Immunology
Alexandra Jade Thawley, Luciana Peixoto Veneziani, Francisco Diego Rabelo-da-Ponte, Ingo Riederer, Daniella Areas Mendes-da-Cruz, Victorio Bambini-Junior
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by stereotyped behaviors, specific interests, and impaired communication skills. Elevated levels of pro-inflammatory cytokine IL-17A (IL-17) have been implicated as part of immune alterations in ASD. Studies using rodent models have shown the role of T-cell activation and IL-17 secretion in the pathogenesis of ASD. A systematic review of 28 studies on IL-17 levels in rodent models of ASD found that IL-17 levels were generally increased in different ASD models.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Julio Santos-Terra, Iohanna Deckmann, Gustavo Brum Schwingel, Andre Vinicius Contri Paz, Clarissa S. Gama, Victorio Bambini-Junior, Mellanie Fontes-Dutra, Carmem Gottfried
Summary: This study investigated histological parameters and interneuron sub-populations in the hippocampus of an autism animal model induced by VPA, showing the protective effect of RSV. The research also demonstrated long-term effects of prenatal exposure to ASD on hippocampal structure and associated proteins.
Article
Biochemistry & Molecular Biology
Julio Santos-Terra, Iohanna Deckmann, Giovanna Carello-Collar, Gustavo Della-Flora Nunes, Guilherme Bauer-Negrini, Gustavo Brum Schwingel, Mellanie Fontes-Dutra, Rudimar Riesgo, Carmem Gottfried
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by brain alterations and E/I imbalance. This study investigates the inhibitory components associated with ASD and suggests that prenatal treatment with resveratrol (RSV) may have preventive effects on ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Hui Lv, Xiao Gu, Xingyue Shan, Tailin Zhu, Bingke Ma, Hao-Tian Zhang, Victorio Bambini-Junior, Tiantian Zhang, Wei-Guang Li, Xiaoling Gao, Fei Li
Summary: By utilizing nanotechnology, the study found that bumetanide can effectively alleviate social deficits associated with autism spectrum disorder (ASD), specifically within the medial prefrontal cortex (mPFC) region. Furthermore, the therapeutic effect of bumetanide was found to be dependent on microglia targeting in the mPFC.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Erica Zamberletti, Tiziana Rubino, Daniela Parolaro
Summary: In recent years, there has been a renewed interest in the therapeutic potential of specific cannabinoids derived from the Cannabis sativa plant, particularly cannabidiol (CBD) and its propyl analogue cannabidivarin (CBDV), for the treatment of neurological diseases. CBDV has shown promising therapeutic potential for managing epilepsy and autism spectrum disorder, and further research is ongoing to explore its efficacy in these conditions.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Neurosciences
Miyuki Doi, Mengwei Li, Noriyoshi Usui, Shoichi Shimada
Summary: Recent advancements in sequencing technology have made it easier to analyze the entire human genome, enabling researchers to study the pathological mechanisms underlying Autism Spectrum Disorder (ASD). This review discusses the functions of ASD-associated genes as well as the analytical strategies and their strengths and weaknesses when studying cellular and animal models.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Ling Wang, Binquan Wang, Chunyan Wu, Jie Wang, Mingkuan Sun
Summary: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with increasing prevalence. The lack of diagnostic markers and targeted medications for treatment has urged multidisciplinary collaboration in studying the underlying mechanisms and developing precision therapies. This review explores various animal models and interdisciplinary studies to understand the behavioral pathology and neurobiological alterations in ASD. It also highlights the advancements in gene transcription, synaptic signaling, epigenetic modifications, brain-gut axis, immune inflammation, and neural loop abnormalities, providing a theoretical basis for future precision therapies. Additionally, existing therapy tactics, limitations, and challenges in translating multidisciplinary knowledge into clinical practice are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Zuzanna Lewandowska-Pietruszka, Magdalena Figlerowicz, Katarzyna Mazur-Melewska
Summary: This review examines the gut microbiota in children with autism spectrum disorder (ASD) and interventions targeting microbiota modulation. The findings suggest that ASD children have microbiota alterations related to behavioral and gastrointestinal abnormalities. Probiotics and microbiota transfer therapy show promise in alleviating symptoms. However, further research is needed to determine their efficacy, and comprehensive standardized studies are required to understand the complex mechanisms linking the gut microbiota to ASD. Nonetheless, these findings offer potential therapeutic avenues for improving the quality of life for individuals with ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jing Zheng, Fei Long, Xu Cao, Bo Xiong, Yu Li
Summary: KATNAL2 mutations are associated with ASD and other related NDDs. In this study, katnal2 null allele was generated in zebrafish using CRISPR/Cas9 technology, and the resulting zebrafish showed developmental and behavioral defects, providing an in vivo model for studying the mechanisms underlying ASD related to KATNAL2 mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Alan Patricio da Silva, Italla Maria Pinheiro Bezerra, Thaiany Pedrozo Campos Antunes, Matheus Paiva Emidio Cavalcanti, Luiz Carlos de Abreu
Summary: This study observed 16 children diagnosed with ASD who received ABA-based treatment, and found that there were improvements in their skill performance during the treatment period.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Jennifer Ferina, Melanie Kruger, Uwe Kruger, Daniel Ryan, Conor Anderson, Jenny Foster, Theresa Hamlin, Juergen Hahn
Summary: This study explored the use of artificial intelligence models to predict behavior episodes in individuals with autism spectrum disorder (ASD). By analyzing data on co-occurring conditions and environmental factors, the models were able to accurately predict the likelihood of behavior episodes. Environmental and gastrointestinal factors were found to be significant predictors in the population studied.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Neurosciences
Na Wang, Longbao Lv, Xiaoyi Huang, Mingqin Shi, Youwu Dai, Yuanyuan Wei, Bonan Xu, Chenyang Fu, Haoyu Huang, Hongling Shi, Yun Liu, Xintian Hu, Dongdong Qin
Summary: This review discusses the application of gene editing techniques in autism research, utilizing genetically modified animal models to validate the relationship between genetic risk factors and the development of autism, thus contributing to the development of gene therapies. Future research should focus on improving the validity of animal models and developing reliable DNA diagnostics and accurate prediction of the functional effects of gene mutations.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Editorial Material
Microbiology
Maude M. David
Summary: Autism spectrum disorder (ASD) is a complex disorder influenced by genetic and environmental factors. Studies have suggested a role of the gut microbiome in modulating ASD phenotype, but results remain inconsistent. Future research will require new experimental methodologies to better understand this relationship.
Article
Multidisciplinary Sciences
Masud Rabbani, Munirul M. Haque, Dipranjan Das Dipal, Md Ishrak Islam Zarif, Anik Iqbal, Amy Schwichtenberg, Naveen Bansal, Tanjir Rashid Soron, Syed Ishtiaque Ahmed, Sheikh Iqbal Ahamed
Summary: This study aimed to evaluate the behavioral patterns of children with ASD during and after the COVID-19 lockdown, and found that support in the areas of problematic behavior could mitigate future risks.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Joao Matheus Bremm, Marcus Michels, Bruna Duarte Rengel, Flavia Gobetti Gomes, Lucas Rosa Fraga, Maria Teresa Vieira Sanseverino
Summary: The study found an association between a variant on the SMAD3 gene and recurrent pregnancy loss, suggesting potential impact on key processes for gestation. These findings are novel and promising for the clinical management of this condition.
Article
Biochemistry & Molecular Biology
Francisca Fernanda Nunes Azevedo, Francisca Joseli Freitas de Sousa, Francisco Lucas Santos de Oliveira, Jaqueline Vieira Carletti, Geancarlo Zanatta
Summary: The study compared the ATP-binding pockets of PI3K alpha and mTOR using existing crystallographic structures and investigated their binding profiles and relative contributions in the presence of selective or dual inhibitors. The results showed that the most important interactions occurred within a range of 3-3.5 angstroms, with residues within this range contributing to 75-100% of the total calculated interaction energy. The study provides key information for understanding the molecular mechanisms of multi-target inhibition.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Microbiology
Ito Liberato, Leticia A. Lino, Juan K. D. Souza, Joao B. A. Neto, Livia G. A. Sa, Vitoria P. F. Cabral, Cecilia R. Silva, Bruno C. Cavalcanti, Manoel O. Moraes, Valder N. Freire, Hello V. N. Junior, Claudia R. Andrade
Summary: The antifungal activity of gallic acid against fluconazole-resistant Candida strains was evaluated, and its potential mechanism of action was determined.
FUTURE MICROBIOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
V. F. de Paula, M. I. F. Guedes, M. F. van Tilburg, I. G. P. Vieira, J. B. Silva, R. C. R. dos Santos, J. P. Echeverry, G. Costa, B. P. Silva, F. F. Maia, E. W. S. Caetano, V. N. Freire
Summary: UV-vis optical absorption measurements and Density Functional Theory (DFT) calculations were used to study the optical properties and electronic structure of ethanol solvated quercetin molecule and different hydrated forms of quercetin crystals. The results showed that anhydrous quercetin exhibited semiconductor behavior with a large direct bandgap, while hydrated forms had smaller indirect bandgaps and showed optical anisotropy.
JOURNAL OF SOLID STATE CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Victor L. B. Franca, Jackson L. Amaral, Yandara A. Martins, Ewerton W. S. Caetano, Kellen Brunaldi, Valder N. Freire
Summary: Atrazine, a widely used herbicide, has been found to cause persistent contamination of water and soil due to its high resistance to degradation. It is associated with fertility issues, increased risk of prostate cancer, and birth defects. This study characterizes the binding of atrazine to human serum albumin (HSA) and identifies the most likely binding sites and the amino acid residues involved in the binding interactions.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Valdir Ferreira de Paula Junior, Mauricio Fraga van Tilburg, Pablo Abreu Morais, Francisco Francine Maia Junior, Elza Gadelha Lima, Victor Tabosa dos Santos Oliveira, Maria Izabel Florindo Guedes, Ewerton Wagner Santos Caetano, Valder Nogueira Freire
Summary: In this study, the co-crystallized structures of the Zika virus protease NS2B-NS3 with two inhibitors were evaluated. The results suggest that quantum biochemistry methods hold promise for the design of novel inhibitors targeting NS2B-NS3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Bruno P. Silva, Antonio G. L. Costa, Mauricelio B. da Silva, Ambrosio M. Cunha, Regina C. R. Santos, Antoninho Valentini, Geancarlo Zanatta, Pedro de Lima-Neto, Ewerton W. S. Caetano, V. N. Freire
Summary: This study investigates the structural, electronic, and optical properties of DMF using density functional theory (DFT). The results show that the delta-sol correction method improves the estimation of the band-gap energy from DFT calculations. Additionally, simulations of a monolayer and crystal form of DMF demonstrate that intermolecular interactions decrease the electronic energy gap.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2022)
Article
Neurosciences
Mellanie Fontes-Dutra, Joseane Righes Marafiga, Julio Santos-Terra, Iohanna Deckmann, Gustavo Brum Schwingel, Bruna Rabelo, Rafael Kazmierzak de Moraes, Marilia Rockenbach, Mayara Vendramin Pasquetti, Carmem Gottfried, Maria Elisa Calcagnotto
Summary: Prenatal exposure to valproic acid (VPA) leads to autism spectrum disorder (ASD), but resveratrol (RSV) can prevent these impairments. This study found that prenatal VPA exposure reduced synaptic inhibition in the somatosensory area, resulting in behavioral and electroencephalogram changes. However, RSV prevented these synaptic inhibition alterations and improved behavioral and electroencephalogram abnormalities.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Chemistry, Physical
Naara Oliveira Santana Froes, Uchchhal Bandyopadhyay, Jonatas Martins Negreiro, Thiago de Sousa Fonseca, Fatima Miranda Nunes, Marcos Carlos de Mattos, Geancarlo Zanatta, Joao Victor de Melo Pereira, Celina de Jesus Guimaraes, Claudia do O. Pessoa, Bruno Poti e Silva, Eric Manoury, Maria Conceicao Ferreira Oliveira
Summary: This work reports the lipase mediated kinetic resolution of (±)-1, resulting in the formation of enantiopure (Rp)-1 and enantioenriched (Sp)-2. The lipase from Thermomyces lanuginosus was found to exhibit high enantioselectivity towards the acetylation of (Sp)-1, leading to the preferential formation of (Sp)-2. Both (Rp)-1 and (Sp)-2 showed low cytotoxicity and no selectivity against the tested cell lines.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Inorganic & Nuclear
Jose Barbosa Silva, Juan Pablo Echeverry, Regina Claudia Rodrigues dos Santos, Valdir Ferreira de Paula Jr, Maria Izabel Florindo Guedes, Bruno Poti e Silva, Antoninho Valentini, Ewerton Wagner Santos Caetano, Valder Nogueira Freire
Summary: This study presents the growth of monoclinic gamma-aminobutyric acid (GABA) crystals from an aqueous ethanol solution. The crystal structure was confirmed to be monoclinic with space group P21/c using X-ray diffraction analysis. Thermal stability and melting point of the GABA crystal were investigated. Experimental characterization and DFT calculations were performed to understand the optical properties of GABA crystals. The monoclinic GABA crystal was found to have an indirect band gap semiconductor behavior with a gap value of 5.02 eV and the highest optical absorption in the 5-6 eV energy range.
JOURNAL OF SOLID STATE CHEMISTRY
(2023)
Article
Biochemical Research Methods
Anja Conev, Mauricio Menegatti Rigo, Didier Devaurs, Andre Faustino Fonseca, Hussain Kalavadwala, Martiela Vaz de Freitas, Cecilia Clementi, Geancarlo Zanatta, Dinler Amaral Antunes, Lydia E. Kavraki
Summary: Proteins are dynamic macromolecules that play vital roles in cells, and understanding their conformational landscapes is crucial for understanding their function. Our new approach, EnGens, provides a unified framework for generating and analyzing representative protein conformational ensembles from available structural datasets. These representative ensembles can be used for various downstream tasks such as protein-ligand docking, protein dynamics modeling, and analysis of mutations.
BRIEFINGS IN BIOINFORMATICS
(2023)
Letter
Multidisciplinary Sciences
Bruno E. Soares, Beatriz Hoermanseder, Mellanie Fontes-dutra, Marianne Bello, Willams Oliveira, Luisa Maria Diele-viegas
Summary: Science in Brazil is highly productive and is supported by public universities and institutions. However, most Brazilian researchers work under low wages and without labor rights, which has been exacerbated during President Bolsonaro's term. Bolsonaro's neglect to pay the researchers' wages threatens the livelihood of 200,000 people and exposes them to the risk of poverty and deprives them of basic human rights.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2023)
Article
Biochemistry & Molecular Biology
Marina C. Leite, Fabiana Galland, Maria Cristina Guerra, Leticia Rodrigues, Jessica Taday, Priscila T. Monteforte, Hanko Hirata, Carmem Gottfried, Rosario Donato, Soraya Smaili, Carlos-Alberto Goncalves
Summary: The secretion of S100B by astrocytes is triggered by the increase in intracellular Ca2+, which is caused by the mobilization of Ca2+ from the endoplasmic reticulum. The widely used solvent DMSO acts as a secretagogue for S100B, promoting its secretion both in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Gustavo Brum Schwingel, Mellanie Fontes-Dutra, Barbara Ramos, Rudimar Riesgo, Victorio Bambini-Junior, Carmem Gottfried
Summary: This study investigated the effects of prenatal exposure to valproic acid (VPA) and the potential preventive effects of trans-resveratrol (RSV) on offspring development. The results showed that VPA exposure led to delays and height deficiencies in developmental milestones, while prenatal RSV treatment prevented these delays and enhanced morphometric characteristics in the offspring.
IBRO NEUROSCIENCE REPORTS
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
