期刊
NEUROSCIENCE LETTERS
卷 569, 期 -, 页码 89-93出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2014.03.074
关键词
Prefrontal cortex; Conditioned place avoidance; Acquisition; Expression; Pain emotion; Rats
资金
- NNSF [31271092, 30970959, 61033011, 31171067]
- Chinese Academy of Sciences Knowledge Innovation Project [KSCX2-EW-Q-18, YZ200944, KSCX2-YW-R-254, KSCX2-EW-J-8]
- NIH Fogarty International Center [R03 TW008038]
- Key Laboratory of Mental Health at the Institute of Psychology, Chinese Academy of Sciences, China
Conditioned place avoidance (CPA) paradigm has been used to investigate the affective component of pain. Although the anterior cingulate cortex (ACC) has been demonstrated to play an important role in the affective aspect of pain, whether the other prefrontal subdivisions are involved in pain-related aversion is unknown. The present study investigated the role of the prelimbic cortex (PL) and infralimbic cortex (IL) in the acquisition and expression of formalin-induced CPA (F-CPA) in rats. GABA(A) receptor agonist muscimol was bilaterally microinjected into PL/IL before or after the formalin-paired training, to explore the effect of temporary inactivation of PL/IL on the acquisition and expression of F-CPA, respectively. The results showed that inactivation of PL rather than IL impaired the acquisition and expression of F-CPA. Moreover, the PL inactivation did not block the acquisition of LiCl-induced CPA, suggesting that PL may be specifically implicated in the pain-emotion related encoding. These results indicate that PL but not IL is involved in the aversive dimension of pain. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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