Article
Neuroimaging
Michael M. Francis, Tom A. Hummer, Emily Liffick, Jenifer L. Vohs, Nikki F. Mehdiyoun, Andrew C. Visco, Ziyi Yang, Richard J. Kovacs, Ying Zhang, Alan Breier
Summary: Evidence suggests that Fingolimod, approved for treating multiple sclerosis, may have potential therapeutic effects on the white matter deficits in schizophrenia by reducing circulating lymphocytes and improving microstructure. However, the impact on cognition and symptoms was not significant in this pilot study.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neurosciences
Aleksi J. Sihvonen, Paula Virtala, Anja Thiede, Marja Laasonen, Teija Kujala
Summary: This study utilized a hodological approach to investigate the relationships between structural white matter connectivity and reading skills and phonological processing. The findings revealed specific brain regions associated with reading skills and phonological processing, as well as structural connectivity anomalies in dyslexics.
Article
Clinical Neurology
Jakob Wasserthal, Klaus H. Maier-Hein, Peter F. Neher, Robert C. Wolf, Georg Northoff, John L. Waddington, Katharina M. Kubera, Stefan Fritze, Anais Harneit, Lena S. Geiger, Heike Tost, Dusan Hirjak
Summary: This study highlights the potential role of white matter microstructure alterations, specifically in the orbitofrontal cortex and superior frontal gyrus, in the pathogenesis of parkinsonism among patients with schizophrenia spectrum disorders. The findings suggest aberrant connectivity with fronto-parietal regions and striatum may play a significant role in the development of parkinsonism in patients with SSD.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Jiaxin Zeng, Wenjing Zhang, Yuan Xiao, Gui Fu, Lu Liu, Biqiu Tang, Na Hu, John A. Sweeney, Su Lui, Qiyong Gong
Summary: The study suggests that baseline neuroimaging changes may predict treatment response in schizophrenia patients. The related diffusion tensor imaging features demonstrate potential clinical applications.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Psychiatry
Nahrie Suk Kim, Tae Young Lee, Wu Jeong Hwang, Yoo Bin Kwak, Seowoo Kim, Sun-Young Moon, Silvia Kyungjin Lho, Sanghoon Oh, Jun Soo Kwon
Summary: The study found that in patients with first-episode psychosis, ToM strange story scores were positively correlated with the white matter integrity of the left cingulum and left SLF. This suggests that the left cingulum and SLF may constitute a neural basis for ToM deficits in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Qiuting Wen, Shannon L. Risacher, Linhui Xie, Junjie Li, Jaroslaw Harezlak, Martin R. Farlow, Frederick W. Unverzagt, Sujuan Gao, Liana G. Apostolova, Andrew J. Saykin, Yu-Chien Wu
Summary: The study explored the spatial pattern of tau-white matter (WM) associations across the whole brain and found a distinct spatial pattern resembling the typical propagation of tau pathology in Alzheimer's disease (AD). The association between tau and WM degeneration highlights the important role of WM alterations in the AD pathological cascade.
Article
Genetics & Heredity
Jingwen Yin, Xudong Luo, Qian Peng, Susu Xiong, Dong Lv, Zhun Dai, Jiawu Fu, Ying Wang, Yaxue Wei, Chunmei Liang, Xusan Xu, Dandan Zhang, Lulu Wang, Dongjian Zhu, Xia Wen, Xiaoqing Ye, Zhixiong Lin, Juda Lin, You Li, Jiafeng Wang, Guoda Ma, Keshen Li, Yajun Wang
Summary: The study found that polymorphisms within the MIR137 gene are associated with the risk of schizophrenia, especially in a Han Chinese population where a female-specific association was reported.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Steven L. Meisler, John D. E. Gabrieli
Summary: Reading involves a widely distributed brain network and white matter tracts play an important role in transmitting information between constituent network nodes. A study with a large dataset of 686 children found that while white matter FA increased with age, there were no significant correlations between overall reading abilities and tract FAs. However, higher FA in specific tracts was associated with better nonword reading skills in older children.
Article
Clinical Neurology
Marta Matrone, Georgios D. Kotzalidis, Andrea Romano, Alessandro Bozzao, Ilaria Cuomo, Francesca Valente, Chiara Gabaglio, Ginevra Lombardozzi, Giada Trovini, Emanuela Amici, Filippo Perrini, Simone De Persis, Felice Iasevoli, Sergio De Filippis, Andrea de Bartolomeis
Summary: By using brain imaging techniques and cognitive tests, specific alterations in glutamate levels and white matter integrity were identified in patients with treatment-resistant schizophrenia (TRS). TRS patients generally showed lower cognitive function, and symptom severity was positively correlated with glutamate levels.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Heather M. Clark, Nirubol Tosakulwong, Stephen D. Weigand, Farwa Ali, Hugo Botha, Nha Trang Thu Pham, Christopher G. Schwarz, Robert Reid, Matthew L. Senjem, Clifford R. Jack, Val J. Lowe, J. Eric Ahlskog, Keith A. Josephs, Jennifer L. Whitwell
Summary: This study found that impairments in swallowing function were associated with specific brain regions' reduced gray matter volumes and abnormal white matter integrity. The impairments in the oral and pharyngeal phases of swallowing corresponded to different regions of neuroanatomical impairment.
MOVEMENT DISORDERS
(2021)
Article
Medicine, General & Internal
Justyna Beresniewicz, Alexander R. Craven, Kenneth Hugdahl, Else-Marie Loberg, Rune Andreas Kroken, Erik Johnsen, Renate Gruner
Summary: The study utilized a longitudinal design and repeated PANSS questionnaire interviews to capture AVH fluctuations, finding significant widespread FA-value reduction in the AVH+ group compared to the AVH- group. The control group's FA values were between the two patient groups, with the AVH- group showing significantly higher leftward FA asymmetry than the AVH+ group in two clusters.
Article
Geriatrics & Gerontology
Wen-Xin Li, Jing Yuan, Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Shu-Yang Zhang, Zheng-Yu Jin, Li-Ying Cui, Fei-Fei Zhai, Yi-Cheng Zhu
Summary: This study aimed to investigate the global and topographic changes of white matter integrity and cortical structure related to cognitive impairments in a community-based population. The results showed that disrupted white matter integrity is associated with visuomotor processing speed, semantic memory, and executive function, while cortical surface area is related to cognitive scores. These findings contribute to a better understanding of the pathological process underlying cognitive impairments.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Bingxin Zhao, Tengfei Li, Yue Yang, Xifeng Wang, Tianyou Luo, Yue Shan, Ziliang Zhu, Di Xiong, Mads E. Hauberg, Jaroslav Bendl, John F. Fullard, Panagiotis Roussos, Yun Li, Jason L. Stein, Hongtu Zhu
Summary: The study identified common genetic variants influencing white matter microstructure and detected multiple associated loci, some of which were related to brain diseases. Additionally, genetic correlations were observed between white matter microstructure and a wide range of complex traits and diseases.
Article
Immunology
Aoife O'Donovan, Amber Bahorik, Stephen Sidney, Lenore J. Launer, Kristine Yaffe
Summary: The study found that increasing or high inflammation trajectories from early to mid adulthood are associated with worse brain health, as indexed by lower white matter volume and/or worse white matter integrity.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Behavioral Sciences
Vincent DeLuca, Toms Voits
Summary: Bilingualism has been found to delay age-related neurocognitive decline and influence white matter integrity. However, previous research has mainly focused on older adults and young adults, neglecting the middle-aged population. This study used DTI to examine the effects of bilingualism and degree of bilingual engagement on white matter integrity. The results showed that bilingualism, particularly higher engagement, can slow down the decline in white matter integrity associated with aging.
Review
Neurosciences
Ida E. Sonderby, Christopher R. K. Ching, Sophia I. Thomopoulos, Dennis van Der Meer, Daqiang Sun, Julio E. Villalon-Reina, Ingrid Agartz, Katrin Amunts, Celso Arango, Nicola J. Armstrong, Rosa Ayesa-Arriola, Geor Bakker, Anne S. Bassett, Dorret I. Boomsma, Robin Bulow, Nancy J. Butcher, Vince D. Calhoun, Svenja Caspers, Eva W. C. Chow, Sven Cichon, Simone Ciufolini, Michael C. Craig, Benedicto Crespo-Facorro, Adam C. Cunningham, Anders M. Dale, Paola Dazzan, Greig I. de Zubicaray, Srdjann Djurovic, Joanne L. Doherty, Gary Donohoe, Bogdan Draganski, Courtney A. Durdle, Stefan Ehrlich, Beverly S. Emanuel, Thomas Espeseth, Simon E. Fisher, Tian Ge, David C. Glahn, Hans J. Grabe, Raquel E. Gur, Boris A. Gutman, Jan Haavik, Asta K. Haberg, Laura A. Hansen, Ryota Hashimoto, Derrek P. Hibar, Avram J. Holmes, Jouke-Jan Hottenga, Hilleke E. Hulshoff Pol, Maria Jalbrzikowski, Emma E. M. Knowles, Leila Kushan, David E. J. Linden, Jingyu Liu, Astri J. Lundervold, Sandra Martin-Brevet, Kenia Martinez, Karen A. Mather, Samuel R. Mathias, Donna M. McDonald-McGinn, Allan F. McRae, Sarah E. Medland, Torgeir Moberget, Claudia Modenato, Jennifer Monereo Sanchez, Clara A. Moreau, Thomas W. Muhleisen, Tomas Paus, Zdenka Pausova, Carlos Prieto, Anjanibhargavi Ragothaman, Celine S. Reinbold, Tiago Reis Marques, Gabriela M. Repetto, Alexandre Reymond, David R. Roalf, Borja Rodriguez-Herreros, James J. Rucker, Perminder S. Sachdev, James E. Schmitt, Peter R. Schofield, Ana I. Silva, Hreinn Stefansson, Dan J. Stein, Christian K. Tamnes, Diana Tordesillas-Gutierrez, Magnus O. Ulfarsson, Ariana Vajdi, Dennis van 't Ent, Marianne B. M. van den Bree, Evangelos Vassos, Javier Vazquez-Bourgon, Fidel Vila-Rodriguez, G. Bragi Walters, Wei Wen, Lars T. Westlye, Katharina Wittfeld, Elaine H. Zackai, Kari Stefansson, Sebastien Jacquemont, Paul M. Thompson, Carrie E. Bearden, Ole A. Andreassen
Summary: The ENIGMA-CNV and 22q-ENIGMA WGs aim to investigate the effects of CNVs on brain structures, with findings showing differences in cognitive, neurodevelopmental, and neuropsychiatric traits as well as characteristic patterns of brain structural abnormalities. The genotype-first approach provides insights into the etiopathogenesis of brain disorders, and future directions include further understanding the impacts of CNVs on brain structure and behavior.
HUMAN BRAIN MAPPING
(2022)
Review
Psychology, Clinical
E. Frawley, M. Cowman, M. Lepage, G. Donohoe
Summary: This study aimed to evaluate the effectiveness of psychosocial interventions in improving functioning in early psychosis. The results indicated that psychosocial interventions, particularly when provided as part of a multi-component intervention model in community-based settings, are associated with significant improvements in social and occupational function. Different intervention approaches showed varying levels of effectiveness, with cognitive remediation training outperforming symptom-focused cognitive behavioural therapy interventions and multi-component interventions associated with the largest gains.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Genetics & Heredity
Joan Fitzgerald, Laura Fahey, Laurena Holleran, Pilib Broin, Gary Donohoe, Derek W. Morris
Summary: This study explored the genetic basis of cognitive resilience using education years as a proxy for past cognitive performance and processing speed as a measure of current cognitive performance. By conducting a GWAS-by-subtraction, the researchers identified 13 genetic loci associated with resilience. Functional analyses revealed enrichment in various brain regions and specific cell types. Furthermore, a Mendelian randomisation analysis showed a causal effect of white matter volume on cognitive resilience.
Review
Genetics & Heredity
Muhammad Kamran, Farhana Bibi, Asim Ur Rehman, Derek W. Morris
Summary: Major depressive disorder (MDD) is a common mental disorder characterized by symptoms associated with mood, pleasure and daily life activities. The pathogenesis of MDD is complex and not fully understood. Utilizing genetic data to understand the molecular mechanism of MDD, large genome-wide association studies have identified hundreds of loci, providing important information on the risk genes for MDD.
Article
Biochemistry & Molecular Biology
Niamh Ryan, Cathal Ormond, Yi-Chieh Chang, Javier Contreras, Henriette Raventos, Michael Gill, Elizabeth Heron, Carol A. Mathews, Aiden Corvin
Summary: This study investigates the genetic variants associated with Tourette Syndrome (TS) in a Costa Rican family through whole-genome sequencing analysis. The researchers identified rare variants that were not present in controls and were linked with risk haplotypes in the family. These variants are enriched in pathways related to locomotion and signal transduction, suggesting their role in TS risk. The study highlights the importance of investigating both coding and non-coding variants in understanding the genetic basis of TS.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Tom Burke, Christina Gleeson, Laurena Holleran, David Mothersill, Jessica Holland, Laura Costello, Ruan Kane, Declan P. McKernan, Derek W. Morris, John P. Kelly, Aiden P. Corvin, Brian P. Hallahan, Colm McDonald, Gary Donohoe
Summary: This study found that patients with schizophrenia have reduced white matter tract integrity in the corpus callosum, which is associated with social cognition deficits and severity of clinical symptoms.
Article
Psychiatry
Emma Frawley, Caroline Heary, Clio Berry, Matteo Cella, David Fowler, Til Wykes, Gary Donohoe
Summary: This study explores a psychosocial intervention combining cognitive remediation and social recovery therapy for early psychosis. Through qualitative research methods, four themes were identified and pragmatic feedback for improving the therapy was provided. The findings suggest that this intervention is acceptable and helpful for early psychosis patients.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Correction
Biochemistry & Molecular Biology
Sean R. McWhinney, Katharina Brosch, Vince D. Calhoun, Benedicto Crespo-Facorro, Nicolas A. Crossley, Udo Dannlowski, Erin Dickie, Lorielle M. F. Dietze, Gary Donohoe, Stefan Du Plessis, Stefan Ehrlich, Robin Emsley, Petra Furstova, David C. Glahn, Alfonso Gonzalez-Valderrama, Dominik Grotegerd, Laurena Holleran, Tilo T. J. Kircher, Pavel Knytl, Marian Kolenic, Rebekka Lencer, Igor Nenadic, Nils Opel, Julia-Katharina Pfarr, Amanda L. Rodrigue, Kelly Rootes-Murdy, Alex J. Ross, Kang Sim, Antonin Skoch, Filip Spaniel, Frederike Stein, Patrik Svancer, Diana Tordesillas-Gutierrez, Juan Undurraga, Javier Vaquez-Bourgon, Aristotle Voineskos, Esther Walton, Thomas W. Weickert, Cynthia Shannon Weickert, Paul M. Thompson, Theo G. M. van Erp, Jessica A. Turner, Tomas Hajek
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Megan Cowman, Emmet Godfrey, Talissa Walsh, Emma Frawley, David Fowler, Mario Alvarez-Jimenez, Karen O'Connor, Til Wykes, Max Birchwood, Gary Donohoe
Summary: This study conducted a systematic review and meta-analysis of functioning measures in psychosis. The results showed that more specific measures of social and occupational function were better at detecting changes over time and in response to treatment.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Genetics & Heredity
Muhammad Kamran, Aodan Laighneach, Farhana Bibi, Gary Donohoe, Naveed Ahmed, Asim Ur Rehman, Derek W. Morris
Summary: This study identifies associations between SORCS3 and various brain-related disorders and traits, and reveals that SNPs related to neurodevelopment and cognitive function are associated with SORCS3. The study also shows that the SORCS3 gene-set contributes significantly to the heritability of schizophrenia, bipolar disorder, intelligence, and education attainment. Furthermore, functional annotation reveals the enrichment of synapse-related ontologies in the SORCS3 gene-set.
Article
Behavioral Sciences
Emma Corley, Laura Fahey, Joan Fitzgerald, Laurena Holleran, Esther Walton, Derek W. W. Morris, Gary Donohoe
Summary: Cognitive ability is a powerful predictor of occupational achievement, quality of life, and physical health. However, little is known about how genetic variation, brain morphology, early life adversity, and education interact to explain this variation in cognition.
GENES BRAIN AND BEHAVIOR
(2023)
Article
Health Care Sciences & Services
Amy Joanne Lynham, Ian R. Jones, James T. R. Walters
Summary: This study developed a web-based cognitive assessment tool (CONCA) to measure the core cognitive domains affected in people with psychiatric disorders. The results showed that CONCA can provide a valid measure of cognitive ability (g) within 15 minutes and demonstrated associations with demographic characteristics and current depression and anxiety symptoms.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Cell Biology
Eduardo A. Maury, Maxwell A. Sherman, Giulio Genovese, Thomas G. Gilgenast, Tushar Kamath, S. J. Burris, Prashanth Rajarajan, Erin Flaherty, Schahram Akbarian, Andrew Chess, Steven A. McCarroll, Po-Ru Loh, Jennifer E. Phillips-Cremins, Kristen J. Brennand, Evan Z. Macosko, James T. R. Walters, Michael O'Donovan, Patrick Sullivan, Jonathan Sebat, Eunjung A. Lee, Christopher A. Walsh
Summary: This study suggests that somatic copy-number variants (sCNVs) may play a potential role in the risk of schizophrenia (SCZ). Early-developmental sCNVs were more common in SCZ cases, including recurrent somatic deletions in the NRXN1 gene. Additionally, recurrent intragenic deletions of the ABCB11 gene were observed in treatment-resistant SCZ cases.
Meeting Abstract
Medicine, General & Internal
Niamh Ryan, Cathal Ormond, Yi-Chieh Chang, Nelson Freimer, Javier Contreras, Henriette Raventos, Carol A. Mathews, Elizabeth Heron, Michael Gill, Aiden Corvin
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
E. Frawley, M. Cowman, M. Cella, D. Cohen, E. Ryan, B. Hallahan, C. Bowie, C. McDonald, D. Fowler, T. Wykes, G. Donohoe
Summary: This research trial aims to evaluate the feasibility and effectiveness of a novel psychosocial intervention for early psychosis, combining cognitive remediation training and cognitive behavioural therapy. The study aims to improve cognitive difficulties and social and occupational functioning in individuals with psychotic disorders.
PILOT AND FEASIBILITY STUDIES
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)