Article
Biochemistry & Molecular Biology
Bongki Cho, Seung-Jun Yoo, So Yeon Kim, Chang-Hun Lee, Yun-Il Lee, Seong-Ryong Lee, Cheil Moon
Summary: In this study, divergently modified peptide analogs derived from EPO showed potent neuroprotective effects against oxidative stress without inducing cell proliferation. One of the peptides, ML1-h3, exhibited unique binding potency to EPOR and inhibited neuronal death and brain injury under hypoxic stress.
Article
Neurosciences
Jonas Blixt, Yutong Song, Michael Wanecek, Eli Gunnarson
Summary: Erythropoietin (EPO) has neuroprotective effects in models of central nervous system injury such as traumatic brain injury (TBI) and ischemic stroke. Previous studies have shown that EPO can preserve astrocyte function and decrease brain edema in TBI. In this study, the effects of EPO on astrocytes in an in vitro model of ischemia were explored, and it was found that EPO increased glutamate uptake, restored intracellular acidification, and increased lactate release, suggesting its potential contribution to neuroprotection in ischemic stroke and brain ischemia secondary to TBI.
Article
Biochemistry & Molecular Biology
Zamzam Awida, Sahar Hiram-Bab, Almog Bachar, Hussam Saed, Dan Zyc, Anton Gorodov, Nathalie Ben-Califa, Sewar Omari, Jana Omar, Liana Younis, Jennifer Ana Iden, Liad Graniewitz Visacovsky, Ida Gluzman, Tamar Liron, Bitya Raphael-Mizrahi, Albert Kolomansky, Martina Rauner, Ben Wielockx, Yankel Gabet, Drorit Neumann
Summary: This study demonstrates that EPOR in the monocytic lineage is at least partially responsible for the effect of EPO on bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Longfei Wu, Di Wu, Jian Chen, Chunhua Chen, Tianqi Yao, Xiaoduo He, Yanqin Ma, Xinglong Zhi, Renyu Liu, Xunming Ji
Summary: Intranasal administration of SA reduced infarct volume, occupancy effect, and diffusion limitation in the lesion, leading to significantly improved neurological outcomes in a rhesus monkey ischemic stroke model over a 28-day observation period.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Chemistry, Multidisciplinary
C. R. DeJulius, A. Bernardo-Colon, S. Naguib, J. R. Backstrom, T. Kavanaugh, M. K. Gupta, C. L. Duvall, T. S. Rex
Summary: The study compared two polymeric microparticle formulations for sustained release of EPO-R76E, demonstrating their potential therapeutic benefits in treating optic nerve injuries.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Hematology
Huan Zhang, Shihui Wang, Donghao Liu, Chengjie Gao, Yongshuai Han, Xinhua Guo, Xiaoli Qu, Wei Li, Shijie Zhang, Jingyu Geng, Linlin Zhang, Avital Mendelson, Karina Yazdanbakhsh, Lixiang Chen, Xiuli An
Summary: The study demonstrates the expression of EpoR beyond erythroid cells with dynamic changes during erythropoiesis. EPO injection selectively promotes proliferation of EpoR-expressing cells and induces erythroid lineage bias during hematopoiesis.
Article
Chemistry, Medicinal
Jinghui Wang, Yuhua Zhang, Meifeng Zhang, Si Sun, Yang Zhong, Lei Han, Yitong Xu, Dong Wan, Junhui Zhang, Huifeng Zhu
Summary: This study investigates the feasibility of catalpol intranasal administration and its protective effect on acute cerebral ischemia in rats. The results showed that catalpol intranasal administration was safe and feasible, with good brain targeting. Additionally, catalpol intranasal administration could reduce brain injury through anti-oxidative and anti-apoptotic mechanisms, providing a potential for drug administration in the acute stage of cerebral ischemia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Nanoscience & Nanotechnology
Junzhuo Wang, Ying Tan, Yang Dai, Ke Hu, Xi Tan, Shaoli Jiang, Guannan Li, Xinlin Zhang, Lina Kang, Xiaojian Wang, Biao Xu
Summary: This study explores the therapeutic effects of endothelial cell-derived extracellular vesicles combined with a hydrogel for nasal administration on myocardial ischemia-reperfusion injury. The combination of extracellular vesicles and hydrogel has shown promising results in improving cardiac function and reducing the infarct area.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Immunology
Zhongnan Yang, Lei Yan, Huixia Cao, Yue Gu, Pan Zhou, Mingyue Shi, Guodong Li, Xiaojing Jiao, Na Li, Xiangnan Li, Kai Sun, Fengmin Shao
Summary: The study showed that erythropoietin (EPO) can alleviate diffuse alveolar hemorrhage (DAH) by reducing macrophage recruitment and promoting phenotype switch, suggesting its potential as a therapeutic agent for DAH. Further research is needed to validate the direct target of miR-494-3p in regulating JAK2/STAT3 signaling transduction.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Felix Marius Blaesius, Johannes Greven, Weijun Guo, Eftychios Bolierakis, Zhizhen He, Cavan Luebke, Tim-Philipp Simon, Frank Hildebrand, Klemens Horst
Summary: This study provides the first evidence that multiple trauma and traumatic hemorrhage can alter protein concentrations in bone, indicating the need for further research on the impact of these injuries on the hypoxia transcriptome.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Oncology
Yajing Zhang, Senyu Wang, Songtao Han, Yangchun Feng
Summary: This study conducted a pan-cancer analysis of erythropoietin receptor (EPOR) using bioinformatics methods and found that EPOR expression varies in different cancers, with correlations to prognosis, miRNAs, and tumor immunity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell & Tissue Engineering
Martina Rauner, Marta Murray, Sylvia Thiele, Deepika Watts, Drorit Neumann, Yankel Gabet, Lorenz C. Hofbauer, Ben Wielockx
Summary: High levels of erythropoietin (Epo) can be harmful to bone health in adult organisms, and EpoR in osteoprogenitor cells plays a crucial role in regulating osteoblast function and osteoblast-mediated osteoclastogenesis.
Review
Biochemistry & Molecular Biology
Yi-Fen Lai, Ting-Yi Lin, Yi-Hao Chen, Da-Wen Lu
Summary: Glaucoma, the second leading cause of blindness worldwide, can result in irreversible vision loss. The disease is complex, with various factors contributing to its development, such as ischemia, oxidative stress, neurotropic factor deprivation, and neuron excitotoxicity. Erythropoietin (EPO), a hormone that stimulates erythropoiesis in response to hypoxia, has been found to have neuroprotective effects and may be a potential treatment for rescuing retinal ganglion cells in glaucoma. This article explores the relationship between EPO and glaucoma and summarizes preclinical experiments using EPO, offering a different perspective on the incurability of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Physical
Yue Jiang, Xueting Pan, Tao Yu, Hai Wang
Summary: The existence of the blood-brain barrier (BBB) poses challenges for drug delivery to the central nervous system (CNS). Intranasal administration has emerged as an alternative method for delivering drugs to the brain by bypassing the BBB. This review focuses on the mechanisms, properties, and strategies of intranasal nanosystems for brain-targeted drug delivery. Despite promising results in animal models and clinical applications, significant challenges need to be overcome for the translation of these nanosystems into clinics. The future prospects of intranasal drug delivery nanosystems are discussed, aiming to provide insights and guidance for effective neurological disease treatment.
Review
Pharmacology & Pharmacy
Yuanyuan Ma, Zhiyuan Zhou, Guo-Yuan Yang, Jing Ding, Xin Wang
Summary: This review provides comprehensive information on the treatment of ischemic stroke with erythropoietin (EPO) and its derivatives. It covers the structure, function, pre-clinical studies, clinical trials, and therapeutic mechanisms of EPO, including its role in suppressing inflammation. The advanced studies on the therapy using EPO derivatives are also discussed. The findings of this review are valuable for basic researchers and clinicians in accelerating the clinical applications of EPO and its derivatives in ischemic stroke.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Martha Catalina Rivera-Carvantes, Jose Jaime Jarero-Basulto, Alfredo Ignacio Feria-Velasco, Carlos Beas-Zarate, Monica Navarro-Meza, Mariana Berenice Gonzalez-Lopez, Graciela Gudino-Cabrera, Julio Cesar Garcia-Rodriguez
Article
Oncology
M. A. Quezada-Ramirez, R. Castaneda-Arellano, G. Perez-Sanchez, J. Hernandez-Soto, J. Segovia
EXPERIMENTAL CELL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Martha Catalina Rivera-Cervantes, Rolando Castaneda-Arellano, Ruben Dario Castro-Torres, Graciela Gudino-Cabrera, Alfredo I. Feria y Velasco, Antoni Camins, Carlos Beas-Zarate
JOURNAL OF MOLECULAR NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
R. J. Macias-Velez, L. Fukushima-Diaz de Leon, C. Beas-Zarate, M. C. Rivera-Cervantes
JOURNAL OF MOLECULAR NEUROSCIENCE
(2019)
Review
Pharmacology & Pharmacy
Monica E. Urena-Guerrero, Jose L. Castaneda-Cabral, Martha C. Rivera-Cervantes, Rafael J. Macias-Velez, Jose J. Jarero-Basulto, Graciela Gudino-Cabrera, Carlos Beas-Zarate
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Neurosciences
Irene Guadalupe Aguilar Garcia, Judith Marcela Duenas-Jimenez, Luis Castillo, Laura Paulina Osuna-Carrasco, Braniff De La Torre Valdovinos, Rolando Castaneda-Arellano, Jose Roberto Lopez-Ruiz, Carmen Toro-Castillo, Mario Trevino, Gerardo Mendizabal-Ruiz, Sergio Horacio Duenas-Jimenez
FRONTIERS IN NEURAL CIRCUITS
(2020)
Review
Neurosciences
Lilia Carolina Leon-Moreno, Rolando Castaneda-Arellano, Jorge David Rivas-Carrillo, Sergio Horacio Duenas-Jimenez
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Article
Neurosciences
Lilia Carolina Leon-Moreno, Rolando Castaneda-Arellano, Irene Guadalupe Aguilar-Garcia, Maria Fernanda Desentis-Desentis, Elizabeth Torres-Anguiano, Coral Estefania Gutierrez-Almeida, Luis Jesus Najar-Acosta, Gerardo Mendizabal-Ruiz, Cesar Rodolfo Ascencio-Pina, Judith Marcela Duenas-Jimenez, Jorge David Rivas-Carrillo, Sergio Horacio Duenas-Jimenez
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Review
Chemistry, Medicinal
Jose J. Jarero-Basulto, Martha C. Rivera-Cervantes, Deisy Gasca-Martinez, Francisco Garcia-Sierra, Yadira Gasca-Martinez, Carlos Beas-Zarate
Article
Behavioral Sciences
Quetzalli D. Angeles-Lopez, Lucia Garcia-Lara, Nicolas Aguirre-Pineda, Rolando Castaneda-Arellano, Guillermo Elizondo-Azuela, Francisca Perez-Severiano, Jose Segovia
Summary: The lack of AhR reduces neurological damage and behavioral deterioration in a mouse model of Huntington's disease, suggesting that pharmacological modulation of AhR could be a potential therapeutic target for HD.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Cell Biology
Walter Angel Trujillo-Rangel, Leonel Garcia-Valdes, Miriam Mendez-del Villar, Rolando Castaneda-Arellano, Sylvia Elena Totsuka-Sutto, Leonel Garcia-Benavides
Summary: Ischemia-reperfusion (I-R) injury, caused by restoring blood flow to ischemic tissues or organs, involves various signaling pathways and molecular targets. These discoveries are important as they help reduce oxidative stress-induced damage and play a crucial role in resolving I-R.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Oncology
Coral Estefania Gutierrez-Almeida, Anne Santerre, Lilia Carolina Leon-Moreno, Irene Guadalupe Aguilar-Garcia, Rolando Castaneda-Arellano, Sergio Horacio Duenas-Jimenez, Judith Marcela Duenas-Jimenez
Summary: The study found that GPER is expressed in glioblastoma C6 cells and modulates cell proliferation and apoptosis. GPER agonists E2 and G1 promote cell proliferation, while the antagonist G15 reduces cell proliferation and promotes apoptosis.
Review
Neurosciences
Cornelio-Martinez Sergio, Castaneda-Arellano Rolando
Summary: Erythropoietin is a cytokine that regulates erythroid cell formation in the bone marrow and is also expressed in various organs and tissues, including the Nervous System, where it plays a role in tissue protection. In the Central Nervous System, Erythropoietin is primarily expressed by astrocytes, while neurons mainly express Erythropoietin receptors. Studies have shown that Erythropoietin has neuroprotective effects and is involved in various signaling pathways.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Review
Chemistry, Medicinal
Jose J. Jarero-Basulto, Yadira Gasca-Martinez, Martha C. Rivera-Cervantes, Monica E. Urena-Guerrero, Alfredo I. Feria-Velasco, Carlos Beas-Zarate
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
