Article
Neurosciences
Wei-Wei Zhang, Rong-Rong Li, Jie Zhang, Jie Yan, Qian-Hui Zhang, Zhi-An Hu, Bo Hu, Zhong-Xiang Yao, Hao Chen
Summary: Using in vivo multi-channel recording and optogenetics, researchers found that hippocampal interneurons exhibited conditioned stimulus (CS)-evoked sustained activity, which played a predictive role in the performance of conditioned eyeblink responses (CRs) in the early acquisition of trace eyeblink conditioning (tEBC). Optogenetic suppression of the sustained activity of hippocampal interneurons impaired the acquisition of tEBC, suggesting the crucial role of these interneurons in associative learning.
NEUROSCIENCE BULLETIN
(2021)
Review
Psychology, Biological
Wayson Maturana, Isabela Lobo, J. Landeira-Fernandez, Daniel C. Mograbi
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by cognitive decline and the presence of brain abnormalities. This review explores the impact of Alzheimer's disease on nondeclarative associative learning, such as eyeblink conditioning and fear conditioning. Evidence suggests that nondeclarative learning is also affected by Alzheimer's disease, but some forms may be relatively preserved. The findings have implications for understanding the effects of the disease on different types of memory.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Behavioral Sciences
Henk-Jan Boele, Sangyun Joung, Joanne E. Fil, Austin T. Mudd, Stephen A. Fleming, Sebastiaan K. E. Koekkoek, Ryan N. Dilger
Summary: By conducting eyeblink conditioning experiments on 3-week-old pigs, it has been demonstrated for the first time that young pigs have the potential to be a valuable behavioral tool in measuring neurodevelopment through cerebellar classical conditioning tasks.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Psychology, Biological
Matthew M. Campolattaro, Olga Lipatova, Katherine Horenstein
Summary: Research investigated the effect of electrolytic fornix lesions on trace and delay eyeblink conditioning in rats. Results showed that fornix lesions impaired trace conditioning but not delay conditioning. The findings indicate that trace eyeblink conditioning relies on the hippocampus and that neural pathways for delay and trace conditioning differ even when the cue composition is the same.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Mathematical & Computational Biology
Matthew Ricci, Junkyung Kim, Fredrik Johansson
Summary: The cerebellar Purkinje cell controls eyeblinks and can learn, remember, and reproduce the timing of stimuli in a classical conditioning paradigm. Previous models suggest that the perception of time is represented in upstream networks, but direct stimulation of the Purkinje cell during conditioning still results in a well-timed response. Furthermore, experimental findings indicate that the acquired Purkinje cell response is insensitive to variations in the temporal structure of probe stimulation, motivating the development of alternative models.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2023)
Article
Neurosciences
Rongrong Li, Weiwei Zhang, Jie Zhang, Haibo Zhang, Hui Chen, Zhian Hu, Zhongxiang Yao, Hao Chen, Bo Hu
Summary: This study investigates the role of hippocampal parvalbumin-expressing interneurons (PV-INs) in associative learning. The researchers found that PV-INs exhibited sustained activity during the early stage of learning, and this activity was correlated with the occurrence of conditioned responses. Suppression of PV-IN activity impaired the acquisition of associative learning, and disrupted hippocampal gamma band oscillation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Anna Sadnicka, Lorenzo Rocchi, Anna Latorre, Elena Antelmi, James Teo, Isabel Parees, Britt S. Hoffland, Kristian Brock, Katja Kornysheva, Mark J. Edwards, Kailash P. Bhatia, John C. Rothwell
Summary: This study aimed to examine the influence of dystonia on eyeblink conditioning and explore its relationship with sex, age, and dystonia subtypes. The results showed that isolated dystonia and its subtypes had similar eyeblink conditioning levels compared to the control group, and a wide range of variability was observed in both healthy individuals and dystonia patients. This finding suggests that there is no global cerebellar learning deficit in isolated dystonia.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Eric E. Abrahamson, Julia K. Kofler, Carl R. Becker, Julie C. Price, Kathy L. Newell, Bernardino Ghetti, Jill R. Murrell, Catriona A. McLean, Oscar L. Lopez, Chester A. Mathis, William E. Klunk, Victor L. Villemagne, Milos D. Ikonomovic
Summary: In a post-mortem study, it has been found that the amyloid PET radioligand Pittsburgh compound B (PiB) interacts poorly with cotton wool plaques, which are common in familial Alzheimer's disease but rare in sporadic Alzheimer's disease. This limited interaction may lead to an underestimation of total amyloid burden in patients with familial Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Heewon Bae, Kyu Hwan Shim, Jang Yoo, Young-Soon Yang, Seong Soo A. An, Min-Ju Kang
Summary: The etiology of early-onset Alzheimer's disease (EOAD) is linked to mutations in the APP, PSEN1, and PSEN2 genes, leading to alterations in the production of amyloid beta (A beta) species. A 64-year-old woman with memory decline and a family history of Alzheimer's dementia was found to have mutations in APP (rs761339914; c.G1651A; p.V551M) and PSEN2 (rs533813519; c.C505A; p.H169N). These mutations affect protein interactions and intramolecular processes, potentially influencing A beta production and causing synergistic effects when combined. Further functional studies are needed to understand the pathological effects of these double mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Jiang Chen, Jun-Sheng Chen, Song Li, Fengning Zhang, Jie Deng, Ling-Hui Zeng, Jun Tan
Summary: Decades of research have shown that amyloid-beta (Aβ) plays an undeniable role in the development of Alzheimer's disease (AD). However, the focus on the pathological effects of Aβ may overshadow the significance of its metabolic precursor, amyloid precursor protein (APP), in the occurrence and progression of AD. This review explores the various roles of APP in AD, including its structure, functions, enzymatic processing, and potential therapeutic approaches to targeting APP to ameliorate AD pathologies and halt disease progression.
Article
Cell Biology
Tobias A. Weber, Johan Lundkvist, Johanna Wanngren, Hlin Kvartsberg, ShaoBo Jin, Pia Larssen, Dan Wu, Daniel Oliveira, Karolina Minta, Gunnar Brinkmalm, Henrik Zetterberg, Kaj Blennow, Gunnar Nordvall, Bengt Winblad, Erik Portelius, Helena Karlstrom
Summary: The study demonstrates that gamma-secretase modulators selectively affect the production of Aβ, with a particular modulation on the Aβ-like proteins derived from EphA4.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Joseph R. Winer, Allison Morehouse, Laura Fenton, Theresa M. Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L. Baker, William J. Jagust, Matthew P. Walker
Summary: This study found that early-stage tau and Aβ deposition in Alzheimer's disease can impact sleep, with tau burden leading to worse objective sleep and Aβ burden associated with decreased self-reported sleep quality. Aβ deposition also predicts a mismatch between objective and subjective sleep evaluation, with individuals underestimating their sleep, which is further linked to worse executive function.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Richard J. Elsworthy, Marianne C. King, Alastair Grainger, Emily Fisher, James A. Crowe, Sarah Alqattan, Adele Ludlam, Eric J. Hill, Sarah Aldred
Summary: The study reveals the impact of PSEN1 gene mutations on AβPP processing and cellular redox status, demonstrating the potential of iPSC-derived neuron and astrocyte co-cultures as an early human model of fAD.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Javier Alvarez, Pilar Alvarez-Illera, Jaime Santo-Domingo, Rosalba I. Fonteriz, Mayte Montero
Summary: Alzheimer's disease is the leading cause of dementia, but its molecular mechanisms are still unclear. To overcome ethical limitations, animal models are used for research. The nematode Caenorhabditis elegans has proven to be an effective model for studying Alzheimer's disease, allowing for quick and cost-effective experiments.
Article
Biology
Rui Li, Qi Li, Xiaolei Chu, Lan Li, Xiaoyi Li, Juan Li, Zhen Yang, Mingjing Xu, Changlu Luo, Kui Zhang
Summary: This study establishes a behavioral model to investigate the role of the cerebellar cortex in associative learning and memory. The results show that successful conditioning can be achieved in certain experimental groups, suggesting the importance of the cerebellum in eyeblink conditioning.
OPEN LIFE SCIENCES
(2022)
Article
Neurosciences
Steven A. Connor, Ina Ammendrup-Johnsen, Allen W. Chan, Yasushi Kishimoto, Chiaki Murayama, Naokazu Kurihara, Atsushi Tada, Yuan Ge, Hong Lu, Ryan Yan, Jeffrey M. Ledue, Hirotaka Matsumoto, Hiroshi Kiyonari, Yutaka Kirino, Fumio Matsuzaki, Toshiharu Suzuki, Timothy H. Murphy, Yu Tian Wang, Tohru Yamamoto, Ann Marie Craig
Article
Neurosciences
Hajime Shishido, Yasushi Kishimoto, Nobuyuki Kawai, Yasunori Toyota, Masaki Ueno, Takashi Kubota, Yutaka Kirino, Takashi Tamiya
NEUROSCIENCE LETTERS
(2016)
Article
Cell Biology
Steven A. Connor, Ina Ammendrup-Johnsen, Yasushi Kishimoto, Parisa Karimi Tari, Vedrana Cvetkovska, Takashi Harada, Daiki Ojima, Tohru Yamamoto, Yu Tian Wang, Ann Marie Craig
Article
Clinical Neurology
Hajime Shishido, Masaki Ueno, Kana Sato, Masahisa Matsumura, Yasunori Toyota, Yutaka Kirino, Takashi Tamiya, Nobuyuki Kawai, Yasushi Kishimoto
BEHAVIOURAL NEUROLOGY
(2019)
Article
Multidisciplinary Sciences
Harumi Nakao, Yasushi Kishimoto, Kouichi Hashimoto, Kazuo Kitamura, Miwako Yamasaki, Kazuki Nakao, Masahiko Watanabe, Masanobu Kano, Yutaka Kirino, Atsu Aiba
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Hayate Tanigami, Mitsugu Yoneda, Yuki Tabata, Ryosuke Echigo, Yui Kikuchi, Maya Yamazaki, Yasushi Kishimoto, Kenji Sakimura, Masanobu Kano, Takako Ohno-Shosaku
Article
Neurosciences
Md Razib Hossain, Mostofa Jamal, Yu Tanoue, Daiki Ojima, Hiroo Takahashi, Takashi Kubota, Tuba M. Ansary, Asuka Ito, Naoko Tanaka, Hiroshi Kinoshita, Yasushi Kishimoto, Tohru Yamamoto
NEUROSCIENCE LETTERS
(2020)
Article
Multidisciplinary Sciences
Sho Kakizawa, Yasushi Kishimoto, Shinichiro Yamamoto, Kazuko Onga, Kunihiko Yasuda, Yoshiaki Miyamoto, Masahiko Watanabe, Ryuichi Sakai, Nozomu Mori
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Yasushi Kishimoto, Moritoshi Hirono, Ryuichiro Atarashi, Suehiro Sakaguchi, Tohru Yoshioka, Shigeru Katamine, Yutaka Kirino
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Masahisa Matsumura, Kana Sato, Takashi Kubota, Yasushi Kishimoto
Summary: This study investigated the effects of memantine on spatial and latent learning deficits in PS2Tg2576 mice, using Morris water maze and water-finding test for cognitive function assessment. The information provided can aid in the selection of animal models and behavioral paradigms for Alzheimer's disease research.
Article
Chemistry, Multidisciplinary
Hirofumi Konno, Hiroyuki Haga, Yasushi Kishimoto, Jun Takeda
Summary: The modeling of iron porphyrins is important in studying heme proteins. In this study, the dimerization of highly substituted iron(III) porphyrins was investigated. The introduction of phenyl groups inhibited the dimerization process, and the stability of iron(III) hydroxo complexes increased with the number of phenyl groups. The synthesis and proton equilibria of water-soluble porphyrin iron(III) complexes were also studied. The order of the dimerization reaction was determined, and it was found to follow a mechanism where two hydroxo complexes form a dihydroxo-bridged intermediate. These findings have significant implications for modeling heme protein reactions.
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2022)
Article
Cell Biology
Maria Harbers, Harumi Nakao, Takaki Watanabe, Kyoko Matsuyama, Shoichi Tohyama, Kazuki Nakao, Yasushi Kishimoto, Masanobu Kano, Atsu Aiba
Summary: mGluR1 and mGluR5 show complementary distributions in the central nervous system. The study on mGluR5-rescue mice suggests that mGluR5 functions comparably to mGluR1 in cerebellar Purkinje cells.
Article
Neurosciences
Kazuya Kuboyama, Yuki Shirakawa, Koji Kawada, Naoki Fujii, Daiki Ojima, Yasushi Kishimoto, Tohru Yamamoto, Maki K. Yamada
NEUROPSYCHOPHARMACOLOGY REPORTS
(2020)
Article
Multidisciplinary Sciences
Yasushi Kishimoto, Hajime Shishido, Mayumi Sawanishi, Yasunori Toyota, Masaki Ueno, Takashi Kubota, Yutaka Kirino, Takashi Tamiya, Nobuyuki Kawai
Article
Multidisciplinary Sciences
Yasushi Kishimoto, Ikuko Tsukamoto, Atsuko Nishigawa, Akiko Nishimoto, Yutaka Kirino, Yoshihisa Kato, Ryoji Konishi, Tokumi Maruyama, Norikazu Sakakibara
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)