期刊
NEUROSCIENCE LETTERS
卷 549, 期 -, 页码 63-68出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.06.002
关键词
Paeonol; Diabetic encephalopathy; Cognition deficits; Anti-apoptosis; Neuropathological changes
资金
- Education Department of Shaanxi Province [12JK1019]
- Creative Scientific Research Projects for postgraduate student in Jiangsu General Colleges [CXLX12-0328]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Natural Science Foundation of China [81202906]
Diabetic encephalopathy (DE) has been characterized by the impaired cognition and the abnormalities of neurochemistry and neurostructure. The study was conducted to evaluate the neuroprotective effect of paeonol on STZ-induced DE rats. Paeonol of 25, 50, 100 mg/kg (p.o.) could decrease the latency time and path length, and enhance significantly the spent time in the target quadrant and platform crossings in Morris water maze test. The treatment with paeonol could also increase significantly Na+-K+-ATP enzyme and ChAT activities, as well as decreasing significantly AchE activity in hippocampal tissue. Immunohistochemistry and TUNEL staining showed that paeonol could attenuate apoptosis of neurons and caspase 3 expression, improve two neurotrophic factors BDNF and IGF expressions, and also ameliorate A beta deposition in the hippocampus and cerebral cortex. In conclusion, the present study demonstrated diabetic rats treated with paeonol could ameliorate the cognition deficits. These findings indicated paeonol might act as a beneficial agent for the prevention and treatment of DE. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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