Review
Neurosciences
Jaya Dilip Badadhe, Hyeonhee Roh, Byung Chul Lee, Jae Hun Kim, Maesoon Im
Summary: Globally, there are over 2.2 billion visually impaired individuals, and ultrasound stimulation can serve as a non-invasive alternative approach to restore vision. Recent studies have demonstrated that ultrasound stimulation can successfully modulate retinal/brain neuronal activities without causing any damage to nerve cells. The superior penetration depth and high spatial resolution of focused ultrasound can open new avenues in neuromodulation research.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Ophthalmology
Matthew M. Harper, Nickolas Boehme, Laura M. Dutca, Michael G. Anderson
Summary: This study examined the influence of genetic background on the retinal ganglion cell (RGC) response to blast-mediated traumatic brain injury (TBI) in mice. It found significant differences in RGC response between different genetic backgrounds, indicating a strong dependency of RGC response on genetic factors.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Giovanni Luca Romano, Lucia Gozzo, Oriana Maria Maurel, Serena Di Martino, Valentina Riolo, Vincenzo Micale, Filippo Drago, Claudio Bucolo
Summary: The topical ocular administration of FLX was found to have a neuroprotective effect in a mouse model of acute retinal damage, as it counteracted the damage of retinal ganglion cells and preserved retinal function. FLX treatment also reduced the production of pro-inflammatory molecules elicited by retinal injury. Further studies are needed to support the use of FLX as a neuroprotective agent in retinal degenerative diseases.
Article
Immunology
Elodie Reboussin, Juliette Buffault, Francoise Brignole-Baudouin, Annabelle Reaux-Le Goazigo, Luisa Riancho, Celine Olmiere, Jose-Alain Sahel, Stephane Melik Parsadaniantz, Christophe Baudouin
Summary: This study demonstrated the neuroprotective and immunomodulatory effects of MSCs on RGCs in an ex vivo neuroretina explant model. However, co-culture with MSCs led to explant edema and the formation of an epiretinal membrane-like phenotype. The use of MSC secretome may offer the beneficial effects of MSCs without their potential adverse effects through paracrine signaling.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Supraja G. Varadarajan, Fei Wang, Onkar S. Dhande, Phung Le, Xin Duan, Andrew D. Huberman
Summary: The wiring of visual circuits involves signaling between retinal axons and postsynaptic targets. Damage to these connections from the eye to the brain can result in vision loss. This study shows that enhancing neural activity in the postsynaptic visual target neurons promotes axon regeneration and target reinnervation, leading to the restoration of optomotor function. Targeted activation of retinorecipient neuron subsets is sufficient to promote axon regeneration. These findings highlight the importance of postsynaptic neuronal activity in neural circuit repair and the potential for restoring damaged sensory inputs through proper brain stimulation.
Article
Biochemistry & Molecular Biology
Sven Schnichels, Maximilian Schultheiss, Patricia Klemm, Matthias Blak, Thoralf Herrmann, Marion Melchinger, Karl-Ulrich Bartz-Schmidt, Marina Loescher, Guenther Zeck, Martin Stehphan Spitzer, Jose Hurst
Summary: This study investigated the neuroprotective effects of Cyclosporine A (CsA) on rat retinas, showing that a concentration of 9 μg/mL CsA had significant neuroprotective effects on retinal ganglion cells under hypoxic conditions without negative effects. Further in vivo studies are warranted to explore the potential of local CsA treatment for hypoxic retinal diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Chen Gong, Runze Li, Gengxi Lu, Jie Ji, Yushun Zeng, Jiawen Chen, Chifeng Chang, Junhang Zhang, Lily Xia, Deepthi S. Rajendran Nair, Biju B. Thomas, Brian J. Song, Mark S. Humayun, Qifa Zhou
Summary: The optic nerve is a crucial pathway for visual information transmission, and its damage can result in vision loss. This study proposes a novel model using low-frequency ring-transducer ultrasound stimulation to establish a direct connection between visual input and the visual cortex, providing a potential non-invasive therapeutic method for restoring vision in optic nerve-impaired patients.
BIOENGINEERING-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Stefania Vernazza, Francesco Oddone, Sara Tirendi, Anna Maria Bassi
Summary: Glaucoma is a neurodegenerative disease that causes damage to retinal ganglion cells and results in permanent vision loss. While Intra Ocular Pressure (IOP) is the main therapeutic target, other pathological conditions and neuroprotective therapeutic approaches also play important roles in the disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Maren-Christina Blum, Alexander Hunold, Benjamin Solf, Sascha Klee
Summary: Ocular current stimulation (oCS) with weak current intensities has shown positive effects on retinal nerve cells, potentially providing a treatment option for neurodegenerative ocular diseases. Studies indicate that oCS can influence the activity of retinal ganglion cells, with a need for further research into its applications and effects.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Federica Conti, Giovanni Luca Romano, Chiara Maria Eandi, Mario Damiano Toro, Robert Rejdak, Giulia Di Benedetto, Francesca Lazzara, Renato Bernardini, Filippo Drago, Giuseppina Cantarella, Claudio Bucolo
Summary: The study demonstrated that brimonidine effectively protected the function of RGCs in mouse eyes and regulated the inflammatory biomarkers induced by retinal ischemia reperfusion injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Alessio Canovai, James R. Tribble, Melissa Joe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte, Pete A. Williams
Summary: Retinal ganglion cells require regulated metabolism and functional mitochondria to maintain ATP levels and cell viability. Alterations in metabolism and mitochondrial processes are early indicators of optic neuropathies. PQQ, a quinone cofactor, has potential neuroprotective effects and can affect cellular and mitochondrial metabolism, but its mechanisms need to be further studied.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Kathy Beirne, Thomas J. Freeman, Malgorzata Rozanowska, Marcela Votruba
Summary: The study utilized aged mice models to investigate the therapeutic potential of photobiomodulation (PBM) for retinal ganglion cell (RGC) degeneration. Results showed that in vivo 670 nm light pretreatment inhibited RGC dendropathy, indicating the potential of PBM as a treatment for diseases involving RGC degeneration. Additionally, the study revealed a potential molecular mechanism priming the retina to resist future oxidative insult, suggesting a promising direction for further research and treatment development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Jing Zhao, Graydon B. Gonsalvez, Barbara A. Mysona, Sylvia B. Smith, Kathryn E. Bollinger
Summary: In this study, the absence of S1R within optic nerve head astrocytes was found to have a negative effect on the growth and survival of retinal ganglion cells. The data suggest that S1R may enhance ganglion cell survival via glia-mediated mechanisms.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Sangjun Lee, Jimin Park, Jinuk Kwon, Dong Hwan Kim, Chang-Hwan Im
Summary: A new electrode montage with multiple electrodes was proposed in this study for the effective delivery of electric fields to the posterior retina, leading to a more effective stimulation of the posterior retina compared to conventional tES with a pair of electrodes.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Faraz Sadrzadeh-Afsharazar, Alexandre Douplik
Summary: This study investigated the use of Non-Invasive Transcranial Alternating Current Stimulation (NITACS) to induce and map phosphenes in healthy individuals. The study identified optimal stimulation parameters for reliable phosphene induction without skin irritation or pain. The findings suggest that NITACS can be a valuable tool for studying the relationship between facial stimulation location and phosphene localization, and raise questions about the origin of phosphenes generated through NITACS.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Environmental Sciences
Nina Vitalievna Sayapina, Tatyana Anantolievna Batalova, Alexander Alexandrovich Sergievich, Mikhail Anatolievich Shtarbergb, Eugeny Alexandrovich Borodin, Pavel Pavlovich Khoroshikh, Vladimir Victorovich Chaika, Vladimir Valerievich Kodintsev, Alexey Anatolievich Vedyagin, Ilya Vladimirovich Mishakov, Antonis Vakis, Petra Henrich-Noack, Aristidis M. Tsatsakis, Ayse Basak Engin, Kirill Golokhvast
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2017)
Review
Cell Biology
Petra Henrich-Noack, Elena G. Sergeeva, Bernhard A. Sabel
NEURAL REGENERATION RESEARCH
(2017)
Review
Toxicology
Ayse Basak Engin, Dragana Nikitovic, Monica Neagu, Petra Henrich-Noack, Anca Oana Docea, Mikhail I. Shtilman, Kirill Golokhvast, Aristidis M. Tsatsakis
PARTICLE AND FIBRE TOXICOLOGY
(2017)
Article
Neurosciences
Hans-Ulrich Demuth, Rick M. Dijkhuizen, Tracy D. Farr, Mathias Gelderblom, Karen Horsburgh, Costantino Iadecola, Damian D. Mcleod, Dominik Michalski, Tim H. Murphy, Josune Orbe, Willem M. Otte, Gabor C. Petzold, Nikolaus Plesnila, Georg Reiser, Klaus G. Reymann, Maria A. Rueger, Dorothee Saur, Sean I. Savitz, Stephan Schilling, Neil J. Spratt, Renee J. Turner, Raghu Vemuganti, Denis Vivien, Manuel Yepes, Marietta Zille, Johannes Boltze
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2017)
Article
Neurosciences
Mira Chamoun, Elena G. Sergeeva, Petra Henrich-Noack, Shaobo Jia, Lisa Grigartzik, Jing Ma, Qing You, Frederic Huppe-Gourgues, Bernhard A. Sabel, Elvire Vaucher
Article
Engineering, Chemical
Xiwei Zhang, Enqi Zhang, Lisa Grigartzik, Petra Henrich-Noack, Werner Hintz, Bernhard A. Sabel
CHEMIE INGENIEUR TECHNIK
(2018)
Article
Biochemistry & Molecular Biology
Muhammad Kamran Khalid, Muhammad Asad, Petra Henrich-Noack, Maxim Sokolov, Werner Hintz, Lisa Grigartzik, Enqi Zhang, Alexander Dityatev, Berend van Wachem, Bernhard A. Sabel
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Multidisciplinary Sciences
Petra Henrich-Noack, Elena G. Sergeeva, Torben Eber, Qing You, Nadine Voigt, Juergen Koehler, Sebastian Wagner, Stefanie Lazik, Christian Mawrin, Guihua Xu, Sayantan Biswas, Bernhard A. Sabel, Christopher Kai-Shun Leung
SCIENTIFIC REPORTS
(2017)
Article
Pharmacology & Pharmacy
Qing You, Talea Hopf, Werner Hintz, Stefan Rannabauer, Nadine Voigt, B. van Wachem, Petra Henrich-Noack, Bernhard A. Sabel
JOURNAL OF DRUG TARGETING
(2019)
Review
Ophthalmology
Bernhard A. Sabel, Luisa Lehnigk
Summary: Chronic emotional stress may be a possible cause of glaucoma, affecting not only intraocular pressure but also vascular dysregulation in the eye and brain. In addition to standard therapy, stress reduction through relaxation techniques may be beneficial for patients.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2021)
Article
Neurosciences
Zheng Wu, Jiahua Xu, Andreas Nuernberger, Bernhard A. Sabel
Summary: Interactions between modules in brain functional connectivity networks are crucial for visual processing. Neuromodulation with rtACS can enhance visual recovery and improve the stability of functional connectivity networks.
Article
Engineering, Biomedical
B. A. Sabel, A. Kresinsky, L. Cardenas-Morales, J. Haueisen, A. Hunold, M. Dannhauer, A. Antal
Summary: Phosphene threshold measurements were used as surrogate markers to investigate the relationship between phosphene thresholds evoked by transcranial alternating current stimulation (tACS) and current density estimates generated by head model-based computer simulations. Results showed that lower phosphene thresholds were associated with higher simulated current levels in unilateral montages of the model head, with the F7-F8 montage having the lowest phosphene threshold.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Psychology, Experimental
Galina V. Paramei, Ophelie Favrod, Bernhard A. Sabel, Michael H. Herzog
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)