期刊
NEUROSCIENCE LETTERS
卷 521, 期 2, 页码 152-157出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2012.05.075
关键词
Anorexia nervosa; Bulimia nervosa; Anterior insula; Functional connectivity; Effective connectivity
资金
- Yonsei University College of Medicine [6-2009-0117]
The anterior insula has been proposed to play a crucial role in eating disorders. However, it is still poorly understood how the anterior insula is involved in anorexia nervosa (AN) and bulimia nervosa (BN), which are characterized by opposite motivational responses to food. We applied a cue-reactivity paradigm using blood oxygen level-dependent functional magnetic resonance imaging in women with AN (N=18) and BN (N=20) and age-matched healthy controls (N=20). We defined the left anterior insula as a region-of-interest and performed seed-based functional connectivity and effective connectivity MRI analysis. In response to food images compared to non-food images, both the AN group and BN group demonstrated increased activity in the left anterior insula. In the AN group, the left anterior insula demonstrated significant interactions with the right insula and right inferior frontal gyrus. In the BN group, the left anterior insula demonstrated significant interactions with the medial orbitofrontal cortex. The distinct patterns of functional and effective connectivity of the anterior insula may contribute to the different clinical features of AN and BN. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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