期刊
NEUROSCIENCE LETTERS
卷 518, 期 2, 页码 92-95出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2012.04.060
关键词
EphA4; EphA4-Fc; Hippocampal neuron; Ischemia-reperfusion; Apoptosis
资金
- Shanxi Scholarship Council of China [200949]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [210029]
Hippocampal CA1 pyramidal neurons are sensitive to ischemic damage. However, the cellular and molecular mechanisms underlying neuronal cell death caused by ischemia-reperfusion (I/R) are not completely clear. Here, we report that the ephrinA/EphA cell-cell interaction signaling pathway plays an important role in the apoptosis of hippocampal CA1 pyramidal neurons induced by I/R. We found that the expression of ephrinA3 and EphA4 is increased in the CA1 region following transient forebrain ischemia. Blocking ephrinA3/EphA4 interaction by EphA4-Fc, an inhibitor of EphA4, attenuated apoptotic neuronal cell death, likely through the inhibition of caspase-3 activation. These results reveal a novel function of ephrin/Eph signaling in the regulation of apoptosis in CA1 pyramidal neurons after I/R. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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