Editorial Material
Medicine, Research & Experimental
Michael S. Beauchamp, William H. Bosking, Denise Oswalt, Daniel Yoshor
Summary: The study successfully implanted an electrode array with 96 penetrating electrodes in the visual cortex of a blind patient, allowing the patient to perceive visual patterns created by passing current through array electrodes. Penetrating electrodes require less current to create a visual percept compared to electrodes resting on the cortical surface, but patterned electrical stimulation often fails to produce the expected percept, necessitating further research to understand the relationship between stimulus and perception.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Engineering, Biomedical
Himanshu Bansal, Neha Gupta, Sukhdev Roy
Summary: The study reveals that ChRmine is a potential opsin for optogenetic retinal prostheses, with high light sensitivity and spatiotemporal resolution, capable of evoking high-frequency firing in neurons at low light intensities and providing single spike temporal resolution.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Hyeonhee Roh, Yanjinsuren Otgondemberel, Maesoon Im
Summary: This study systematically explored network-mediated responses that arise from various short pulses in both normal and degenerate retinas. The results showed that short pulses elicited strong network-mediated responses in both healthy and degenerate retinas. The response of ON RGCs was highly dependent on the current amplitude, while the response of OFF RGCs was more influenced by the number of stimuli.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
M. G. Peng, E. Iseri, A. Simonyan, P. Lam, T. Kim, S. Medvidovic, J. Paknahad, M. Machnoor, G. Lazzi, K. K. Gokoffski
Summary: Failure to direct axon regeneration to appropriate targets is a major barrier to restoring function after nerve injury. We demonstrate that a new class of asymmetric, charge balanced (ACB) waveforms are effective at directing retinal ganglion cell axon growth, in vitro, without compromising cell viability. This work can serve as a practical guideline for the potential deployment of electrical stimulation as a treatment strategy for nerve injury.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Laiming Jiang, Gengxi Lu, Yushun Zeng, Yizhe Sun, Haochen Kang, James Burford, Chen Gong, Mark S. Humayun, Yong Chen, Qifa Zhou
Summary: The authors demonstrate a flexible piezo-array for ultrasound-induced retinal stimulation, which has the potential to restore functional vision and enhance quality of life in blind individuals.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Physical
Stanisa Raspopovic, Giacomo Valle, Francesco Maria Petrini
Summary: Commercial prosthetic devices currently lack natural sensory feedback, leading to unphysiological movement and health issues for users. Restoring natural sensory feedback to amputees is a clinical need that has not been met. Various neurotechnological approaches have been proposed for developing optimal sensory feedback restoration devices for arm and leg amputees.
Article
Medicine, Research & Experimental
Daniel Palanker
Summary: Retinal prostheses offer hope for restoring vision in patients with photoreceptor atrophy. By stimulating surviving inner retinal neurons, they can introduce visual information. Depending on the type of implant, either subretinal or epiretinal, different neural cell types are targeted. Subretinal implants aim to preserve the natural retinal signal processing, while epiretinal implants focus on encoding visual information in spiking patterns. This review provides insights into the concepts, technologies, preclinical characterization, and clinical outcomes of prosthetic vision, as well as future developments.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Alessandro Bellapianta, Ana Cetkovic, Matthias Bolz, Ahmad Salti
Summary: Despite significant progress in modern medicine, millions of people with retinal dystrophies or age-related diseases still suffer from severe visual impairment. Reprogramming somatic cells into induced pluripotent stem cells and advancements in electronic retinal prosthesis technology offer promising opportunities for studying and treating these conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Multidisciplinary Sciences
Shan Jiang, Xiang Wu, Nicholas J. Rommelfanger, Zihao Ou, Guosong Hong
Summary: This review article provides an overview of recent advances in optical neuromodulation and its applications in addressing physical constraints of in vivo light delivery. The article presents the latest optical techniques for neuromodulation and explores new methods for minimal invasiveness and footprint.
NATIONAL SCIENCE REVIEW
(2022)
Article
Multidisciplinary Sciences
Cordelia Erickson-Davis, Helma Korzybska
Summary: Despite the approval and commercial availability of retinal implants for over 5 years, few data are available to answer basic questions about artificial vision outcomes. A study conducted in France and the UK with implant recipients of Argus II or IRIS II devices revealed that artificial vision is a highly specific, learned skill that requires bodily techniques, associative learning, and deductive reasoning to interpret surroundings. The percept does not transform over time, but recipients become better at interpreting the signals received through cognitive techniques.
Article
Engineering, Biomedical
Yanjinsuren Otgondemberel, Hyeonhee Roh, Shelley Fried, Maesoon Im
Summary: The study characterized the electrically-evoked network-mediated responses of ON-OFF direction-selective (DS) RGCs in rabbit and mouse retinas for the first time. Different species showed strong negative correlations between spike counts of electric responses and direction selective indices, with some distinct differences between DS cells. Proper animal model selection is crucial in prosthetic researches as species-dependent retinal circuits may result in different electric response features.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Audiology & Speech-Language Pathology
Ajmal A. Azees, Alex C. Thompson, Ross Thomas, Jenny Zhou, Patrick Ruther, Andrew K. Wise, Elise A. Ajay, David J. Garrett, Anita Quigley, James B. Fallon, Rachael T. Richardson
Summary: This study compares the spread of neural activity in the auditory midbrain during electrical and optical stimulation in the cochlea of mice with opsin-modified spiral ganglion neurons. Optogenetic stimulation results in reduced channel interaction and higher spatial precision compared to electrical stimulation, potentially increasing the number of independent channels in a cochlear implant and improving speech perception for recipients.
Article
Neurosciences
Hyeonhee Roh, Yanjinsuren Otgondemberel, Jeonghyeon Eom, Daniel Kim, Maesoon Im
Summary: This study investigates the electric response features of retinal ganglion cells (RGCs) in rd8 mice with retinal degeneration caused by Crb1 mutation. The results show that different types of RGCs have different electric response features in the early stage of RP, suggesting the importance of genotype- and RGC type-dependent analyses for retinal prosthetic research.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Xiaofan Su, Jiahui Guo, Meixuan Zhou, Jianpin Chen, Liming Li, Yao Chen, Xiaohong Sui, Heng Li, Xinyu Chai
Summary: The study proposed a computational modeling method to explore spatially selective retinal stimulation via temporally interfering electric fields. Results showed that temporal interference stimulation could gradually generate an increasingly localized high-intensity region on the retina, with the position of the convergent region modulated by regulating the current ratio of different electrode channels.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Engineering, Electrical & Electronic
Ziliang Zhou, Yicheng Yang, Jia Zeng, Xiaoxin Wang, Honghai Liu
Summary: This study focuses on exploring the parametric properties of electrotactile feedback using an electrical stimulation system and innovative measurement methods. The results show that the new bisection algorithm is more robust and achieves a 50% efficiency improvement, while individual differences and sensitivities can be quantified by the sensitivity index.
IEEE SENSORS JOURNAL
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)