Review
Cell Biology
Jirong Lv, Xue Xiao, Mingxia Bi, Tingting Tang, Deao Kong, Meining Diao, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jiang
Summary: ATP-sensitive potassium channels (KATP channels) play a crucial role in linking the electrical activity of the cell membrane with cell metabolism. They have been found to be expressed in various cells and play important roles in neurodegenerative diseases. The KATP channel openers and inhibitors have protective effects on neurons by regulating neuronal excitability and neurotransmitter release, reducing abnormal protein aggregation and Ca2+ overload, and decreasing reactive oxygen species (ROS) production and microglia activation. However, KATP channels also exhibit dual effects in some cases.
AGEING RESEARCH REVIEWS
(2022)
Article
Neurosciences
Paulo S. Strazza, Daniela V. F. de Siqueira, Ricardo M. Leao
Summary: Cartwheel neurons in the dorsal cochlear nucleus are glycinergic interneurons that provide inhibition to fusiform neurons. Most of these neurons exhibit spontaneous firing, while a small fraction are quiet neurons. The quiet neurons have an outward conductance sensitive to tolbutamide, while active neurons can be affected by the K-ATP agonist diazoxide. The role of K-ATP channels in controlling the spontaneous firing of these neurons is revealed.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Cell Biology
Amit S. Korde, William F. Maragos
Summary: The research findings indicate that NMDA(m) activation modulates mitochondrial bioenergetics through both Ca2+-dependent and Ca2+-independent mechanisms.
Article
Pharmacology & Pharmacy
Daniela Vanessa F. de Siqueira, Paulo S. Strazza Jr, Nikollas M. Benites, Ricardo M. Leao
Summary: High doses of salicylate can induce tinnitus and the increased activity in the Dorsal Cochlear Nucleus is associated with tinnitus. It has been found that salicylate may regulate the spontaneous firing of cartwheel neurons by opening KATP channels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Robin Frobom, Erik Berglund, Craig A. Aspinwall, Weng-Onn Lui, Inga-Lena Nilsson, Catharina Larsson, Robert Branstrom
Summary: The study investigated the effects of three clinically established TKIs (imatinib, sunitinib, nilotinib) on KATP channel activity, revealing that these drugs can decrease KATP channel activity by interacting with the ATP-binding site on the channel. This interaction may contribute to some of the side effects associated with TKIs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biology
Sarah K. El-Meanawy, Holly Dooge, Allison C. Wexler, Anna C. Kosmach, Lara Serban, Elizabeth A. Santos, Francisco J. Alvarado, Timothy A. Hacker, Mohun Ramratnam
Summary: The mitochondrial splice variant of the sulfonylurea receptor (SUR2A-55) is associated with protection from myocardial ischemia-reperfusion (IR) injury, increased mitochondrial ATP sensitive K+ channel activity (mitoK(ATP)) and altered glucose metabolism. It was found that SUR2A-55 regulates ROMK to form an alternate mitoK(ATP). The cardio-protection from SUR2A-55 is associated with ROMK regulation, enhanced mitochondrial uncoupling, and increased glucose uptake.
Article
Cardiac & Cardiovascular Systems
Mark J. Specterman, Qadeer Aziz, Yiwen Li, Naomi A. Anderson, Leona Ojake, Keat-Eng Ng, Alison M. Thomas, Malcolm C. Finlay, Richard J. Schilling, Pier D. Lambiase, Andrew Tinker
Summary: This study investigated the effects of hypoxia on atrial electrophysiology in mice with global deletion of the K-ATP pore-forming subunits. The results showed that K-ATP blockade or absence resulted in atrial electrophysiological modifications at the cellular and tissue level. Furthermore, the global knockout of Kir6.2 prevented hypoxia-induced atrial path length shortening and arrhythmogenicity, suggesting a potential translational approach for treating ischemically driven atrial arrhythmia.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Iskra Cruz-Cruz, German Bernate-Obando, Carlos Larque, Rene Escalona, Rodolfo Pinto-Almazan, Myrian Velasco
Summary: Metabolic syndrome (MS) is a cluster of metabolic signs that increases the risk of developing type 2 diabetes and cardiovascular diseases. In the early stage of MS, a high-sugar diet can affect the pharmacological properties of K-ATP channels involved in insulin secretion.
Review
Cell Biology
Ivan Alquisiras-Burgos, Javier Franco-Perez, Moises Rubio-Osornio, Penelope Aguilera
Summary: Sulfonylurea receptor (SUR) is a regulatory subunit associated with ion channels. It exists in both long and short forms, but the structure and function of the short forms, especially SUR1, are not well understood. Evidence suggests that the short forms of SUR1 are fully functional and can interact with channels. Their expression may have therapeutic implications in conditions where ATP concentrations decrease, such as stroke and epilepsy.
NEURAL REGENERATION RESEARCH
(2022)
Review
Neurosciences
Amalie Clement, Sarah Louise Christensen, Inger Jansen-Olesen, Jes Olesen, Song Guo
Summary: Migraine is a leading cause of disability worldwide and has a significant impact on work and social life. Blocking the ATP-sensitive potassium channel may be a promising approach for migraine treatment. However, further research is needed to understand the potential side effects and effectiveness of this approach.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Yunmeng Bai, Zhuhe Liu, Tinglin Qian, Yu Peng, Huan Ma, Hong Hu, Guangqing Cheng, Haixia Wen, Lulin Xie, Dong Zheng, Qingshan Geng, Jigang Wang, Honghao Wang
Summary: This study used mouse models and single-nucleus RNA sequencing to investigate the impact of anti-NMDAR encephalitis on gene expression in hippocampal neurons. Significant changes were observed in excitatory neurons in the dentate gyrus, including genes related to ATP metabolism and biosynthetic regulation. These findings suggest potential targets for further research on the pathological process of anti-NMDAR encephalitis.
Article
Endocrinology & Metabolism
Conor McClenaghan, Novella Rapini, Domenico Umberto De Rose, Jian Gao, Jacob Roeglin, Carla Bizzarri, Riccardo Schiaffini, Eloisa Tiberi, Mafalda Mucciolo, Annalisa Deodati, Alessandro Perri, Giovanni Vento, Fabrizio Barbetti, Colin G. Nichols, Stefano Cianfarani
Summary: The study identified a previously uncharacterized KCNJ11 gene mutation that causes neonatal diabetes with developmental delay. The mutation reduces ATP inhibition, resulting in a significant gain-of-function in K-ATP channels and loss of sensitivity to sulfonylurea therapy in the patient.
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Elena B. Soboleva, Dmitry V. Amakhin, Denis S. Sinyak, Aleksey V. Zaitsev
Summary: Potassium ion channels play a crucial role in regulating epileptic seizures. The activation of SK channels and K-ATP channels is influenced by calcium ion influx and ATP level reduction, respectively. These channels can contribute to the maintenance of high-frequency firing during epileptic activity. In this study, we found that SK and K-ATP channels are involved in sustaining the high-frequency firing of principal neurons in the deep layers of the entorhinal cortex. While the blockade of K-ATP channels did not prevent epileptiform activity, it increased the duration of seizure-like events, suggesting their potential role in terminating seizures.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Editorial Material
Endocrinology & Metabolism
Colin G. Nichols, Nathaniel W. York, Maria S. Remedi
Summary: Secretion of insulin from pancreatic beta-cells is mainly controlled by ATP-sensitive potassium (K-ATP) channel activity. Genetic mutations that affect K-ATP channel activity can lead to hyperinsulinism or diabetes. Drugs that target K-ATP channels have shown therapeutic effects in related diseases. However, the role of K-ATP channel activity in the development of type 2 diabetes is still not well understood.
Article
Medicine, General & Internal
Meng-Ting Wang, Hsueh-Yi Pan, Ya-Ling Huang, Li-Wei Wu, Pin-Chun Wang, Yu-Juei Hsu, Tzu-Chieh Lin, Chenwei Lin, Jyun-Heng Lai, Chien-Hsing Lee
Summary: In patients with type 2 diabetes receiving metformin, the use of high-affinity sulfonylureas for blocking mitoKATP channels is associated with an increased risk of major adverse cardiovascular events, myocardial infarction, all-cause mortality, and severe hypoglycemia compared to low-affinity sulfonylureas.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)