Article
Biochemistry & Molecular Biology
Akina Osaki, Marie Aoyama, Masashi Mita, Kenji Hamase, Masato Yasui, Jumpei Sasabe
Summary: This study investigated the origin of D-serine in the mouse brain and found that besides the known source of D-serine through the enzymatic synthesis, there is an endogenous, SR-independent source of D-serine which may contribute to the baseline activity of NMDARs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Clinical Neurology
Xiance Ni, Hisashi Mori
Summary: This review discusses the role and metabolism of D-serine in the progression of Alzheimer's disease (AD). It highlights the involvement of A beta oligomers in NMDAR dysregulation, the role of D-serine in excitotoxicity, and the participation of D-serine and serine racemase (SR) in AD-related inflammatory pathological progression.
CURRENT ALZHEIMER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
E. Ploux, T. Freret, J-M Billard
Summary: As people age, communication and plasticity between neurons weaken, with NMDAr activation playing a crucial role in brain plasticity. D-serine may contribute to mechanisms of physiological cognitive aging.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2021)
Article
Medicine, Research & Experimental
Lang Huang, Jing Wang, Guanmei Liang, Yue Gao, Shi-Yang Jin, Jian Hu, Xiaoxue Yang, Jianpei Lao, Jinfa Chen, Zhou-Cai Luo, Cuixia Fan, Li Xiong, Xinhong Zhu, Tian -Ming Gao, Mei Zhong, Xinping Yang
Summary: Research on Htr3a knockout mice revealed autistic-like behaviors, impaired memory, and reduced susceptibility to seizures. The upregulation of NMDAR in PV+ interneurons plays a critical role in regulating GABAergic input and may be involved in the pathogenesis of autism associated with HTR3A deficiency. The NMDAR system could be a potential therapeutic target for autism.
Article
Biochemistry & Molecular Biology
Jean-Marie Billard, Thomas Freret
Summary: This study found that adding sAPP alpha significantly increased the activation of NMDAR in aged mice and rescued the deficit of long-term potentiation in these mice. The improvement of NMDAR in adult mice was also significantly increased with a higher concentration of sAPP alpha, but this effect was reduced in transgenic mice lacking the synthesizing enzyme serine racemase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xianzhe Yu, Binjie Zhang, Cailing Fan, Qianqian Yan, Shenglin Wang, Hui Hu, Qinxi Dong, Gengyu Du, Yanan Gao, Chaoyuan Zeng
Summary: D-amino acids are biologically significant, but their identification remains challenging due to their structural similarities. In this study, a chiral fluorescent probe was developed to specifically detect D-arginine and enable both quantitative and qualitative determination of its concentration and enantiomeric configuration.
Article
Neurosciences
Yanling Liang, Yuxin Ma, Jieqin Wang, Lei Nie, Xusheng Hou, Wenyu Wu, Xingmei Zhang, Yinghong Tian
Summary: This study investigated the role of leptin in neuropathic pain and found that leptin promotes neuropathic pain by enhancing NR2B-mediated currents and nNOS expression. The data suggest an important cellular link between the spinal effects of leptin and the extrasynaptic NMDAR-nNOS-mediated cellular mechanism of neuropathic pain.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Glenn Dallerac, Xia Li, Pierre Lecouflet, Nadege Morisot, Silvia Sacchi, Rachel Asselot, Thu Ha Pham, Brigitte Potier, David J. G. Watson, Staffan Schmidt, Gregoire Levasseur, Pascal Fossat, Andrey Besedin, Jean-Michel Rivet, Joseph T. Coyle, Ginetta Collo, Loredano Pollegioni, Jan Kehr, Micaela Galante, Kevin C. Fone, Alain M. Gardier, Thomas Freret, Angelo Contarino, Mark J. Millan, Jean-Pierre Mothet
Summary: The study reveals the crucial role of D-serine in regulating glutamatergic transmission in the prefrontal cortex through D1 and D3 receptors, which are essential components in the dopamine-glutamate dialogue. In vivo microdialysis showed that D1 and D3 receptors modulate extracellular levels and activity of D-serine in the PFC via the cAMP/PKA signaling cascade. Furthermore, D-serine is necessary for the cognitive enhancement by D3 receptor blockade, as demonstrated in novel object recognition memory test.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Oluwarotimi O. Folorunso, Theresa L. Harvey, Stephanie E. Brown, Cristina Cruz, Ellie Shahbo, Ismail Ajjawi, Darrick T. Balu
Summary: NMDARs play a crucial role in synaptogenesis and synaptic maturation during early postnatal weeks, with SR producing D-serine as a co-agonist essential for their activation. The expression of SR in the brain correlates with that of NMDARs, and varies across different brain regions and time points. These findings enhance our understanding of NMDAR function and its implications for the pathophysiology of neurodevelopmental disorders.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Editorial Material
Biochemistry & Molecular Biology
Herman Wolosker, Inna Radzishevsky
Summary: This study reveals a biochemical pathway for the synthesis of D-glutamate in mammalian cells mediated by promiscuous catalysis of the pyridoxal 5'-phosphate enzyme SDHL, advancing our knowledge on this less-studied D-amino acid in mammals. D-Amino acids may have unique roles in biochemistry, intercellular signaling, and potentially serve as disease biomarkers.
BIOCHEMICAL JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Dena Arizanovska, Jada A. Emodogo, Anna P. Lally, Caroline B. Palavicino-Maggio, Daniel J. Liebl, Oluwarotimi O. Folorunso
Summary: Bridging the gap between preclinical models and human manifestations of neurological and psychiatric disorders is crucial for understanding their underlying mechanisms and developing effective therapies. Cognitive and social impairments are common in these disorders and are often associated with sleep disturbances. Research has shown that glutamatergic gene variants are associated with the risk and frequency of psychiatric disorders. The role of D-serine, a key molecule in complex behaviors and implicated in various pathological conditions, is explored in this review.
Article
Multidisciplinary Sciences
Evan R. Semenza, Maged M. Harraz, Efrat Abramson, Adarsha P. Malla, Chirag Vasavda, Moataz M. Gadalla, Michael D. Kornberg, Solomon H. Snyder, Robin Roychaudhuri
Summary: D-cysteine, as an endogenous molecule in the mammalian brain, is involved in regulating the proliferation of neural progenitor cells and may play a role in NPC homeostasis during brain development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Dunlu Yuan, Jiaqing Li, Min Guo, Qing Yang, Jingjing Huang, Jingwen Nie, Ruomei Li, Qing Li
Summary: This study investigated the expression of fibroblast growth factor 23 (FGF23) and D-serine in maintenance hemodialysis (MHD) patients with hearing impairment, and explored the correlation between FGF23/D-serine and hearing impairment. The results showed that MHD patients with hearing impairment had significantly higher levels of FGF23 and D-serine compared to those with normal hearing and normal controls. Elevated FGF23 and D-serine were identified as risk factors for hearing impairment in end-stage renal disease (ESRD).
Article
Cell Biology
Brittney Yegla, Asha Rani, Ashok Kumar
Summary: Age-associated decrease in NMDAR-mediated synaptic function contributes to cognitive impairments. Enhancing NMDAR function via increased SR expression in middle age rats improves learning and synaptic transmission. Prefrontal SR upregulation can improve visual discrimination and increase NMDAR activity.
Article
Biology
Yaling Dai, Sinuo Wang, Minguang Yang, Peiyuan Zhuo, Yanyi Ding, Xiaoling Li, Yajun Cao, Xiaoqin Guo, Huawei Lin, Jing Tao, Lidian Chen, Weilin Liu
Summary: This study found that electroacupuncture treatment has protective effects on vascular cognitive impairment (VCI) by enhancing BOLD signal in the hippocampus and entorhinal cortex. The miR-219a gene plays a crucial role in regulating VCI, and inhibiting miR-219a can improve VCI and enhance learning and memory.
BIOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)