Article
Pharmacology & Pharmacy
Marta Dymowska, Aleksandra Aksamit, Katarzyna Zielniok, Monika Kniotek, Beata Kaleta, Aleksander Roszczyk, Michal Zych, Filip Dabrowski, Leszek Paczek, Anna Burdzinska
Summary: Although both BM-MSCs and WJ-MSCs have the ability to interact reciprocally with macrophages, the source of MSCs could slightly but significantly modify the response under clinical settings. WJ-MSCs secreted significantly more IL-6 than BM-MSCs and showed higher responsiveness to M1-derived chemotactic signals.
Article
Cell Biology
Wu Duan, Huajie Zou, Nan Zang, Dongxia Ma, Bo Yang, Lin Zhu
Summary: Bone marrow adipose tissue (MAT) can have both local and systemic effects on metabolic homeostasis. The effects of metformin, a first-line drug for type 2 diabetes, on MAT and bone marrow mesenchymal stem cell (BM-MSC) differentiation are conflicting. In vivo and in vitro experiments showed that metformin increased MAT in mice tibia and promoted both osteogenic and lipogenic gene expression in mouse bone marrow. However, metformin inhibited lipogenesis and promoted osteogenesis of MSC in vitro. The increased MAT may be attributed to the filling of adipose tissue after metformin-induced apoptosis of bone marrow stromal cells.
Review
Cell Biology
Mohamad Mahjoor, Arshia Fakouri, Simin Farokhi, Hojjatollah Nazari, Hamed Afkhami, Fatemeh Heidari
Summary: The skin is essential for the innate and adaptive immune systems, but skin lesions can have undesirable consequences. Mesenchymal stromal cells (MSCs) are being increasingly used for skin wound treatment due to their advantages in promoting healing. The oxygen concentration has an impact on MSC biology, and expanding MSCs in a hypoxic environment can enhance their effectiveness.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Dragan Primorac, Martin Cemerin, Vid Matisic, Vilim Molnar, Marko Strbad, Lenart Girandon, Lucija Zenic, Miomir Knezevic, Stephen Minger, Denis Polancec
Summary: The COVID-19 pandemic has had a significant impact globally and the overaggressive immune reaction in response to the virus can lead to ARDS. Mesenchymal stromal cell therapy presents a potential treatment option for severe patients.
Article
Cell & Tissue Engineering
Joan C. Fitzgerald, Georgina Shaw, J. Mary Murphy, Frank Barry
Summary: This study analyzed the impact of five widely used culture media formulations on the biological attributes of human bone marrow-derived MSCs. The results showed significant differences in clonogenicity, proliferation, differentiation propensity, and immunomodulatory capacity in response to the composition of the culture medium. Surface marker expression profiles were also affected by the culture medium.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Yeonsil Yu, Se-Young Oh, Ha Yeong Kim, Ji-Young Choi, Sangmee Ahn Jo, Inho Jo
Summary: Our study found that the level of CCN1 increases as osteogenic differentiation progresses in tonsil-derived mesenchymal stem cells (TMSCs). We investigated how CCN1 is regulated through HDAC inhibition in TMSCs and their relationship with osteogenesis. Valproic acid (VPA), a well-known HDAC inhibitor, was found to inhibit TMSC proliferation and increase osteogenic differentiation, while decreasing adipogenesis and chondrogenesis. The effects of VPA on CCN1 were mediated through the stability of the CCN1 protein instead of gene expression. These findings demonstrate the potential of VPA as an inhibitor of HDAC1 to promote osteogenic differentiation in TMSCs.
Article
Pharmacology & Pharmacy
Valentina Cocce, Mara Bonelli, Silvia La Monica, Roberta Alfieri, Luisa Doneda, Eleonora Martegani, Giulio Alessandri, Costanza Annamaria Lagrasta, Aldo Gianni, Valeria Sordi, Francesco Petrella, Leda Roncoroni, Francesca Paino, Augusto Pessina
Summary: Malignant pleural mesothelioma, an asbestos-related tumor, has poor response to chemotherapy. Adult mesenchymal stromal cells derived from bone marrow or adipose tissue can be a good model for cell-based therapy, and using Paclitaxel-loaded mesenchymal stromal cells inhibits mesothelioma cell proliferation more effectively than Paclitaxel alone. In vivo studies using a minimal amount of 106 mesenchymal stromal cells loaded with Paclitaxel showed the same efficacy as systemic administration of Paclitaxel, supporting the use of mesenchymal stromal cells as a drug delivery system for solid tumors.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Chih-Yi Yang, Rita Jui-Hsien Lu, Ming-Kang Lee, Felix Shih-Hsian Hsiao, Ya-Ping Yen, Chun-Chun Cheng, Pu-Sheng Hsu, Yi-Tzang Tsai, Shih-Kuo Chen, I-Hsuan Liu, Pao-Yang Chen, Shau-Ping Lin
Summary: MSCs lacking DNMT3L exhibit reduced colony forming ability and impaired osteogenesis in vitro, with differentially regulated genes associated with bone morphology-related phenotypes. The observed defects are hypothesized to result from pre-deposited epigenetic signatures from DNMT3L-expressing progenitors, rather than a direct effect of missing DNMT3L in MSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Tacia Tavares Aquinas Liguori, Gabriel Romero Liguori, Joris A. van Dongen, Luiz Felipe Pinho Moreira, Martin Conrad Harmsen
Summary: The study explored the potential of using dECM hydrogels to load and release paracrine factors secreted by (mesenchymal) cells for cardiovascular regeneration therapy. Different trophic factors exhibited diverse release kinetics depending on the concentration of CMed in the hydrogel. Higher concentrations of hydrogel resulted in a greater release of inflammation-related cytokines and a reduced release of pro-regenerative TFs. The biologically active factors released by the hydrogel influenced cell behavior, indicating the potential of dECM hydrogels as a platform for cardiovascular regeneration.
BIOMEDICAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Tamara Kukolj, Jasmina Lazarevic, Ana Borojevic, Uros Ralevic, Dragana Vujic, Aleksandra Jaukovic, Nenad Lazarevic, Diana Bugarski
Summary: This study used Raman spectroscopy to investigate inter-individual differences between bone marrow mesenchymal stem cells (BM-MSCs). The results showed that despite similar biological characteristics, slight differences in the Raman spectra of BM-MSCs from each donor could be detected. Raman spectroscopy, as a label-free assay, has the potential to understand stem cell heterogeneity and sort cell populations with a similar biochemical background.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Krawczenko, Aleksandra Klimczak
Summary: MSCs, known for their regenerative and immunomodulatory properties, are typically isolated from bone marrow and adipose tissue. This review focuses on MSCs derived from adipose tissue and their secretome in regeneration processes, with a special emphasis on their contribution to angiogenic processes. Various clinical trials have been registered to explore the application of AT-MSCs and their secretome in treating different medical conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Mahnaz Babaahmadi, Behnoosh Tayebi, Nima Makvand Gholipour, Phillip Bendele, Jed Pheneger, Abolfazl Kheimeh, Amir Kamali, Mohammad Molazem, Hossein Baharvand, Mohamadreza Baghaban Eslaminejad, Ensiyeh Hajizadeh-Saffar, Seyedeh-Nafiseh Hassani
Summary: The therapy based on mesenchymal stromal cells (MSCs) has shown effectiveness and safety in treating rheumatoid arthritis (RA). Compared to high passage number bone marrow-derived clonal MSCs (BM-cMSCs), early passages of bone marrow-derived heterogeneous MSCs (BM-hMSCs) and Wharton jelly-derived MSCs (WJ-MSCs) had similar therapeutic effects. BM-cMSCs have the potential to establish cell banks for competitive cell-based therapy in treating RA.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Genetics & Heredity
Shuanglong Lu, Xiaohong Qiao
Summary: This study compared the differences in cell cycle, stemness, differentiative potencies, and immunomodulate capability between unlicensed and licensed human bone marrow-derived MSCs using single-cell RNA sequencing data. The results showed that licensed MSCs exhibited enhanced immunomodulate capability and altered differentiation potencies compared to unlicensed MSCs.
Article
Cell & Tissue Engineering
Angela W. Xie, Nicholas A. Zacharias, Bernard Y. K. Binder, William L. Murphy
Summary: This study compared MSC aggregates generated via three different methods and found differences in their structure and immunomodulatory phenotype under resting conditions and in response to inflammatory stimulus. The methods with faster aggregation kinetics formed aggregates with higher cell packing density and reduced ECM synthesis.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Cell & Tissue Engineering
Hadi Yari, Maria Mikhailova, Mahsa Mardasi, Mohsen Jafarzadehgharehziaaddin, Somayeh Shahrokh, Lakshmi Thangavelu, Hosein Ahmadi, Navid Shomali, Yoda Yaghoubi, Majid Zamani, Morteza Akbari, Samira Alesaeidi
Summary: Accumulating evidence suggests that the pleiotropic effects of mesenchymal stromal cells (MSCs) are mainly mediated by the releases of soluble paracrine mediators, rather than their differentiation competencies. MSC-derived exosomes hold great potential for the treatment of neurodegeneration-associated neurological diseases due to their unique immunomodulatory and regenerative attributes. These exosomes can cross the blood-brain barrier (BBB) and efficiently deliver their cargo to damaged brain tissue, influencing various biological processes in neurons, oligodendrocytes, and astrocytes.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Ju Youn Lee, Seung Hoon Han, Min Hee Park, Im-Sook Song, Min-Koo Choi, Eunsoo Yu, Cheol-Min Park, Hee-Jin Kim, Seung Hyun Kim, Edward H. Schuchman, Hee Kyung Jin, Jae-sung Bae
NATURE COMMUNICATIONS
(2020)
Article
Psychiatry
Andrea Vergallo, Simone Lista, Yuhai Zhao, Pablo Lemercier, Stefan J. Teipel, Marie-Claude Potier, Marie-Odile Habert, Bruno Dubois, Walter J. Lukiw, Harald Hampel
Summary: The study identified brain-enriched miRNAs in a cohort of cognitively normal individuals with subjective memory complaints. It investigated the impact of age, sex, and the APOE epsilon 4 allele on miRNA plasma concentrations and explored associations with brain metabolic uptake using PET imaging. The results suggest potential associations between miRNA concentrations and neuroimaging biomarkers of AD pathophysiology.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Cell Biology
Wan Yun Ho, Jer-Cherng Chang, Kenneth Lim, Amaury Cazenave-Gassiot, Aivi T. Nguyen, Juat Chin Foo, Sneha Muralidharan, Ashley Viera-Ortiz, Sarah J. M. Ong, Jin Hui Hor, Ira Agrawal, Shawn Hoon, Olubankole Aladesuyi Arogundade, Maria J. Rodriguez, Su Min Lim, Seung Hyun Kim, John Ravits, Shi-Yan Ng, Markus R. Wenk, Edward B. Lee, Greg Tucker-Kellogg, Shuo-Chien Ling
Summary: The protein TDP-43 influences cholesterol metabolism in oligodendrocytes by directly binding to mRNA of key regulators. Depletion of TDP-43 leads to reduced expression of SREBF2 and LDLR, resulting in lower cholesterol levels. Reintroducing SREBF2 or LDLR can reverse the effects of TDP-43 depletion on cholesterol levels.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Harald Hampel, John Hardy, Kaj Blennow, Christopher Chen, George Perry, Seung Hyun Kim, Victor L. Villemagne, Paul Aisen, Michele Vendruscolo, Takeshi Iwatsubo, Colin L. Masters, Min Cho, Lars Lannfelt, Jeffrey L. Cummings, Andrea Vergallo
Summary: Breakthroughs in molecular medicine have highlighted the significance of the amyloid-beta pathway in the pathophysiology of Alzheimer's disease. Established biochemical alterations of the A beta cycle serve as promising targets for the development of disease-modifying therapies. Research indicates a crucial role of A beta pathway dyshomeostasis in the dynamics of AD pathophysiology, supporting the development of A beta-targeting therapeutic strategies for early treatment of AD.
MOLECULAR PSYCHIATRY
(2021)
Editorial Material
Clinical Neurology
Kristiana Salmon, Matthew C. Kiernan, Seung H. Kim, Peter M. Andersen, Adriano Chio, Leonard H. van den Berg, Philip Van Damme, Ammar Al-Chalabi, Patricia Lillo, Jinsy A. Andrews, Angela Genge
Article
Multidisciplinary Sciences
Min Hee Park, Kang Ho Park, Byung Jo Choi, Wan Hui Han, Hee Ji Yoon, Hye Yoon Jung, Jihoon Lee, Im-Sook Song, Dong Yu Lim, Min-Koo Choi, Yang-Ha Lee, Cheol-Min Park, Ming Wang, Jihoon Jo, Hee-Jin Kim, Seung Hyun Kim, Edward H. Schuchman, Hee Kyung Jin, Jae-Sung Bae
Summary: Alzheimer's disease (AD) is a complex neurodegenerative disorder. KARI 201, identified as both an ASM inhibitor and a ghrelin receptor agonist, has shown potential in rescuing neuropathological features and improving memory function in AD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Jinsup Kim, Won Hyuk Lee, Seung Hyun Kim, Jae Yoon Na, Young-Hyo Lim, Seok Hyun Cho, Sung Ho Cho, Hyun-Kyung Park
Summary: This study demonstrated that utilizing the impulse-radio ultrawideband (IR-UWB) radar sensor technique can provide accurate estimates of anthropometric parameters, highly consistent with bioelectrical impedance analysis (BIA) results.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Jihyun Eom, Bugyeong Son, Seung Hyun Kim, Yongsoon Park
Summary: Intake of antioxidants, especially those derived from vegetables and legumes, has a beneficial effect on delaying disease progression and prolonging survival in patients with ALS.
Article
Clinical Neurology
Hyuk Sung Kwon, Yeonjae Park, Ji Hyun Kim, Seung Hyun Kim, Jae-Bum Jun, Sojeong Park, Dae Ryong Kang, Hojin Choi
Summary: This study investigated the prevalence of motor neuron diseases (MNDs) in gout patients and found that gout may have a protective effect against the risk of MNDs. The prevalence of MNDs, especially amyotrophic lateral sclerosis (ALS), was significantly lower in gout patients compared to the general population.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Young Nam Kwon, Mark Woodhall, Jung-Joon Sung, Kwang-Kuk Kim, Young-Min Lim, Hyunjin Kim, Jee-Eun Kim, Seol-Hee Baek, Byung-Jo Kim, Jin-Sung Park, Hung Youl Seok, Dae-Seong Kim, Ohyun Kwon, Kee Hong Park, Eunhee Sohn, Jong Seok Bae, Byung-Nam Yoon, Nam-Hee Kim, Suk-Won Ahn, Kyomin Choi, Jeeyoung Oh, Hyung Jun Park, Kyong Jin Shin, Sanggon Lee, Jinseok Park, Seung Hyun Kim, Jung Im Seok, Dae Woong Bae, Jae Young An, In Soo Joo, Seok-Jin Choi, Tai-Seung Nam, Sunyoung Kim, Ki-Jong Park, Ki-Han Kwon, Patrick Waters, Yoon-Ho Hong
Summary: This study aimed to evaluate the diagnostic accuracy of ELISA for anti-MuSK antibody in AChR antibody-negative generalized MG patients and investigate the clinical contexts for the diagnosis of MuSK MG. The results showed that the positive results of ELISA were mostly consistent with CBA and RIPA. The most common differential diagnosis was motor neuron disease. These findings are of great importance for the diagnosis of MuSK MG in clinical practice.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Min-Young Noh, Min-Soo Kwon, Ki-Wook Oh, Minyeop Nahm, Jinseok Park, Young-Eun Kim, Chang-Seok Ki, Hee Kyung Jin, Jae-sung Bae, Seung Hyun Kim
Summary: This study identified a key factor, microglial NCKAP1, that is associated with the functional characteristics and progression of rapidly progressive sporadic ALS. ALS patients with rapid progression showed defective phagocytosis and an exaggerated pro-inflammatory response in microglia. Decreased NCKAP1 expression in microglia was correlated with the progression of ALS, suggesting that it may be a potential therapeutic target.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Wonjae Sung, Hyuk Sung Kwon, Yeonjae Park, Seung Hyun Kim, Sojeong Park, Dae Ryong Kang, Hojin Choi
Summary: This study analyzed the prevalence of dementia among patients diagnosed with gout in South Korea and found a relatively low prevalence of dementia in patients with gout. The study also found that patients with both gout and dementia were more likely to be women, have a wide range of comorbidities, and be prescribed gout-related medications.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Multidisciplinary Sciences
Wan Yun Ho, Li-Ling Chak, Jin-Hui Hor, Fujia Liu, Sandra Diaz-Garcia, Jer-Cherng Chang, Emma Sanford, Maria J. Rodriguez, Durgadevi Alagappan, Su Min Lim, Yik-Lam Cho, Yuji Shimizu, Alfred Xuyang Sun, Sheue-Houy Tyan, Edward Koo, Seung Hyun Kim, John Ravits, Shi-Yan Ng, Katsutomo Okamura, Shuo-Chien Ling
Summary: In this study, researchers analyzed the miRNA repertoires in spinal cords and hippocampi from ALS-FUS mice to understand the role of FUS-dependent miRNA deregulation in ALS. They identified differentially expressed miRNAs between CNS regions and disease states. One up-regulated miRNA, miR-1197, was found to target the pro-survival pseudokinase Trib2. They also observed reduced TRIB2 expression in motor neurons derived from ALS patients. Stabilizing TRIB2 protein with a cancer drug improved the survival of human motor neurons, including those from a sporadic ALS patient. These findings suggest that profiling miRNAs can help uncover the molecular mechanisms underlying selective vulnerability in ALS, and TRIB2 may be a potential therapeutic target.
Review
Clinical Neurology
Su Min Lim, Minyeop Nahm, Seung Hyun Kim
Summary: The balance of proteins and RNA is crucial for maintaining brain structure and function, but aging, cellular stress, and genetic factors can disrupt this balance, leading to protein misfolding, aggregate deposition, and abnormal dynamics of ribonucleoprotein granules. These disruptions contribute to age-related neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS. The formation of pathogenic aggregates, including tau and alpha-synuclein, is linked to irreversible liquid-liquid phase separation (LLPS), suggesting chaperone/disaggregase as potential therapeutic targets. This review emphasizes the importance of understanding cell death mechanisms and ribostasis in diseases.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Letter
Clinical Neurology
Wonjae Sung, Young-Eun Kim, Seung Hyun Kim
JOURNAL OF CLINICAL NEUROLOGY
(2021)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
