Article
Chemistry, Medicinal
Yu-Peng Zhou, Yang Sun, Kazue Takahashi, Vasily Belov, Nick Andrews, Clifford J. Woolf, Pedro Brugarolas
Summary: Neuropathic pain affects a significant portion of the adult population, and accurately monitoring biological changes is crucial for understanding its mechanisms and developing treatments. In this study, researchers developed two fluorinated derivatives of gabapentin and demonstrated their ability to bind to the alpha 2 delta-1 receptor, which is involved in neuropathic pain. Although these changes could not be visualized using PET, the study confirms the potential of alpha 2 delta-1 as a target for imaging neuropathic pain.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Liren Li, Liying Bai, Kangli Yang, Jian Zhang, Yan Gao, Mingjun Jiang, Yin Yang, Xuan Zhang, Li Wang, Xueli Wang, Yiming Qiao, Ji-Tian Xu
Summary: The study reveals that the upregulation of KDM6B induced by neuropathic pain demethylates H3K27me3, facilitating the binding of STAT3 with the IL-6 promoter, consequently leading to an increase in IL-6 expression in the DRG and dorsal horn which contributes to the development and maintenance of neuropathic pain. Targeting KDM6B may be a promising therapeutic strategy for the treatment of chronic pain.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Guadalupe Garcia, Carlos J. Martinez-Magana, Norma Oviedo, Vinicio Granados-Soto, Janet Murbartian
Summary: Previous studies have shown that L5/L6 spinal nerve ligation enhances the expression of anoctamin-1 in injured and uninjured dorsal root ganglia (DRG), while L5 spinal nerve transection does not. The role of bestrophin-1 in these conditions is still unknown.
Article
Biochemistry & Molecular Biology
Keun-Tae Park, Heejoon Jo, Bonglee Kim, Woojin Kim
Summary: Red ginger extract can prevent pain development induced by oxaliplatin and may do so by regulating the noradrenergic system.
Article
Biochemistry & Molecular Biology
Siqi Wei, Shuyang Chang, Yue Dong, Linping Xu, Xiaocui Yuan, Hong Jia, Jun Zhang, Lingli Liang
Summary: The study indicates that electro-acupuncture can alleviate neuropathic pain by inhibiting the AXL signaling pathway, and the combination of AXL inhibitor and electro-acupuncture may have a synergistic effect, providing a new strategy for clinical treatment of neuropathic pain.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Shiwu Guo, Zhiwen Song, Junsheng He, Gang Yin, Jianguo Zhu, Haifeng Liu, Lei Yang, Xubiao Ji, Xu Xu, Zhiyuan Liu, Jinbo Liu
Summary: This study investigates the role of aquaporin-4 (AQP4) and Akt pathways in the pathogenesis of neuropathic pain (NP). The results indicate that AQP4 is significantly upregulated in the spinal dorsal horn (SDH) and primarily expressed in astrocytes. Inhibition of AQP4 attenuates glial activation and anti-neuroinflammatory mechanisms, reducing the development and maintenance of NP. Similarly, inhibition of Akt suppresses AQP4 upregulation and astrocyte activation, alleviating NP in the early and late phases after spinal nerve ligation (SNL).
Article
Surgery
Chao Xu, TianYu Liu, YunPeng Zhang, Yi Feng
Summary: In this study, bioinformatics analysis was conducted to identify mechanisms for more effective treatments of neuropathic pain. Seven hub genes and potential targeting miRNA related to the pathogenesis of neuropathic pain were identified, expanding understanding of the mechanism and facilitating treatment development.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Immunology
Chia-En Wong, Chia-Ying Hu, Po-Hsuan Lee, Chi-Chen Huang, Han-Wei Huang, Chih-Yuan Huang, Hsin-Tien Lo, Wentai Liu, Jung-Shun Lee
Summary: This study investigated the therapeutic effect of sciatic nerve stimulation (SNS) on acute neuropathic pain (NP) and its underlying mechanism. The results showed that both 2 Hz and 20 Hz SNS could alleviate pain behavior and hyperactivation of pain conducting pathways, reduce neuroinflammation and inflammatory protein expression, suppress astrocytic gliosis and microglia activation, and enhance the activity of the descending pain modulation pathway.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Chemistry, Medicinal
Angel Zuniga-Romero, Quetzali Rivera-Plata, Jesus Arrieta, Francisco Javier Flores-Murrieta, Juan Rodriguez-Silverio, Juan Gerardo Reyes-Garcia, Juan Carlos Huerta-Cruz, Gustavo Ramirez-Martinez, Hector Isaac Rocha-Gonzalez
Summary: This study explored the participation of GPR55 and GPR119 in the processing of neuropathic pain and found that they could be useful targets to manage neuropathic pain disorders.
Article
Neurosciences
Kimberly Gomez, Alberto Vargas-Parada, Paz Duran, Alejandro Sandoval, Rodolfo Delgado-Lezama, Rajesh Khanna, Ricardo Felix
Summary: Voltage-gated Ca2+ channels play a crucial role in regulating cell processes and have been linked to neuropathic pain. Cdk5, a neuron-specific kinase, may phosphorylate Ca-v channels, altering their functional expression. Changes in Ca-v channels location and function in afferent fibers associated with Cdk5-mediated phosphorylation may contribute to nerve injury-induced allodynia.
Article
Biochemistry & Molecular Biology
Yonggang Xie, Zhen Li, Hongyu Xu, Jiahai Ma, Tao Li, Cunxian Shi, Jin Jin
Summary: This study reveals the regulatory role of transcription factor Sp1 in neuropathic pain (NP)-like behaviors after spinal nerve ligation (SNL) and the underlying mechanism. Sp1 promotes HDAC1 expression, which in turn promotes SOX10 expression. Downregulating Sp1 alleviates NP-like behaviors after SNL via the HDAC1/SOX10 axis.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Cell Biology
Tadayuki Ishibashi, Daichi Sueto, Yu Yoshikawa, Keisuke Koga, Ken Yamaura, Makoto Tsuda
Summary: This study identified an inhibitory interneuron subset in the spinal dorsal horn that is depolarized by noradrenaline (NA) and showed that alpha(1B)-adrenoceptors (ARs) and AAV-NpyP(+) neurons are critical targets for spinal NA and necessary for the therapeutic effect of duloxetine on neuropathic pain.
Article
Biochemistry & Molecular Biology
Yi-Hao Wang, Xiao Gao, Yu-Ru Tang, Yang Yu, Ming-jie Sun, Fu-qiang Chen, Yan Li
Summary: Accumulated evidence suggests that melatonin alleviates neuropathic pain by regulating pyroptosis through the NF-kappa B/NLRP3 signaling pathway. In a rat model of spinal nerve ligation, melatonin and NF-kappa B/NLRP3 inhibitors significantly reduced pain behaviors and suppressed inflammatory cytokines. Melatonin demonstrates potent analgesic and anti-inflammatory effects through preventing pyroptosis in neuropathic pain models.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Simin Tang, Huan Jing, Fuhu Song, Haicheng Huang, Wenjun Li, Guiling Xie, Jun Zhou
Summary: The study explores the role of microRNAs in neuropathic pain, specifically how miR-124 reverses NP by maintaining microglia quiescent, and miR-155 promotes NP by activating microglia. These findings provide insights for basic research and potential clinical treatments for neuropathic pain.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yoki Nakamura, Ayako Fukuta, Keita Miyashita, Fang Fang Zhang, Dengli Wang, Keyue Liu, Hidenori Wake, Kazue Hisaoka-Nakashima, Masahiro Nishibori, Norimitsu Morioka
Summary: The study demonstrates that increased HMGB1 around the injured sciatic nerve may induce nociceptive hypersensitivity through the activation of spinal microglia.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Neurosciences
Rebeca Vidal, Emilio Garro-Martinez, Alvaro Diaz, Elena Castro, Eva Florensa-Zanuy, Makoto M. Taketo, Angel Pazos, Fuencisla Pilar-Cuellar
MOLECULAR NEUROBIOLOGY
(2019)
Editorial Material
Psychiatry
Estela Salagre, Celso Arango, Francesc Artigas, Jose Luis Ayuso-Mateos, Miquel Bernardo, Josefina Castro-Fornieles, Julio Bobes, Manuel Desco, Lourdes Fananas, Ana Gonzalez-Pinto, Josep Maria Haro, Juan Carlos Leza, Peter J. Mckenna, Jose Javier Meana, Jose Manuel Menchon, Juan Antonio Mico, Tomas Palomo, Angel Pazos, Victor Perez, Jeronimo Saiz-Ruiz, Julio Sanjuan, Rafael Tabares-Seisdedos, Benedicto Crespo-Facorro, Miquel Casas, Elisabet Vilella, Diego Palao, Jose Manuel Olivares, Roberto Rodriguez-Jimenez, Eduard Vieta
REVISTA DE PSIQUIATRIA Y SALUD MENTAL
(2019)
Article
Clinical Neurology
Fuencisla Pilar-Cuellar, Elena Castro, Sylvie Bretin, Elisabeth Mocaer, Angel Pazos, Alvaro Diaz
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Article
Psychiatry
Fulgencio Ruso-Julve, Ana Pombero, Fuencisla Pilar-Cuellar, Nuria Garcia-Diaz, Raquel Garcia-Lopez, Maria Juncal-Ruiz, Elena Castro, Alvaro Diaz, Javier Vazquez-Bourgon, Agustin Garcia-Blanco, Emilio Garro-Martinez, Helena Pisonero, Alicia Estirado, Rosa Ayesa-Arriola, Juan Lopez-Gimenez, Federico Mayor, Elsa Valdizan, Javier Meana, Javier Gonzalez-Maeso, Salvador Martinez, Jose Pedro Vaque, Benedicto Crespo-Facorro
TRANSLATIONAL PSYCHIATRY
(2019)
Article
Neurosciences
Emilio Garro-Martinez, Rebeca Vidal, Albert Adell, Alvaro Diaz, Elena Castro, Josep Amigo, Raquel Gutierrez-Lanza, Eva Florensa-Zanuy, Laura Gomez-Acero, M. Mark Taketo, Angel Pazos, Fuen Pilar-Cuellar
MOLECULAR NEUROBIOLOGY
(2020)
Article
Immunology
Santiago Mora, Elena Martin-Gonzalez, Angeles Prados-Pardo, Joaquin Moreno, Maria Jose Lopez, Fuencisla Pilar-Cuellar, Elena Castro, Alvaro Diaz, Pilar Flores, Margarita Moreno
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Pharmacology & Pharmacy
Eva Florensa-Zanuy, Emilio Garro-Martinez, Albert Adell, Elena Castro, Alvaro Diaz, Angel Pazos, Karina S. Mac-Dowell, David Martin-Hernandez, Fuencisla Pilar-Cuellar
Summary: Recent evidence suggests that cannabidiol (CBD) has antidepressant properties in a neuroinflammatory model of depression, reducing inflammatory mediators and the activation of specific pathways.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Josep Amigo, Emilio Garro-Martinez, Rebeca Vidal Casado, Valerie Compan, Fuencisla Pilar-Cuellar, Angel Pazos, Alvaro Diaz, Elena Castro
Summary: The study investigated the influence of 5-HT(4)Rs on the response to antidepressant fluoxetine in mice subjected to chronic corticosterone administration. The results indicated that the absence of 5-HT4Rs did not affect the behavioral effects of chronic fluoxetine treatment in a depression and anxiety animal model. Additionally, chronic fluoxetine treatment increased BDNF mRNA expression and potentiated 5-HT1AR desensitization in the corticosterone model.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Emilio Garro-Martinez, Maria Neus Fullana, Eva Florensa-Zanuy, Julia Senserrich, Veronica Paz, Esther Ruiz-Bronchal, Albert Adell, Elena Castro, Alvaro Diaz, Angel Pazos, Analia Bortolozzi, Fuencisla Pilar-Cuellar
Summary: Knocking down mTOR expression in the infralimbic cortex of mice resulted in a robust depressive-like phenotype, as assessed in the forced swimming test and the tail suspension test, suggesting a causal relationship between mTOR expression in the IL cortex and depressive behaviors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Silvia Breviario, Julia Senserrich, Eva Florensa-Zanuy, Emilio Garro-Martinez, Alvaro Diaz, Elena Castro, Angel Pazos, Fuencisla Pilar-Cuellar
Summary: The study found that the activity and protein expression of MMP-9 are significantly elevated in brain areas relevant to depression, while nectin-3 levels are lower in these areas. The immobility time in the tail suspension test is positively correlated with cortical MMP-9 activity and negatively correlated with nectin-3 levels. These findings support the role of MMP-9 in the pathophysiology of depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)