Article
Neurosciences
C'iana P. Cooper, Andrea T. Shafer, Nicole M. Armstrong, Sharyn L. Rossi, Jennifer Young, Christa Herold, Hong Gu, Yihong Yang, Elliot A. Stein, Susan M. Resnick, Peter R. Rapp
Summary: The study used rhesus monkeys as a model to investigate the effects of cognitive aging on gray matter volume through structural imaging and voxel-based morphometry, revealing age-related differences in volume changes in specific brain regions and their relationships with task performance. The results demonstrate age-dependent correlations between volume changes in different brain regions and task performance, indicating that the aged primate brain retains the ability for structural reorganization.
Article
Neurosciences
Alexandrine Morand, Shailendra Segobin, Gregory Lecouvey, Julie Gonneaud, Francis Eustache, Geraldine Rauchs, Beatrice Desgranges
Summary: This study found that older participants had lower gray matter volumes in several brain areas, but these did not correlate with TBPM performance. On the other hand, a decline in white matter integrity was correlated with TBPM performance, indicating a disconnection process that occurs in aging and contributes to cognitive decline.
Article
Psychiatry
Jingyi Long, Kun Qin, Yong Wu, Lu Li, Juan Zhou
Summary: This meta-analysis identified stable patterns of gray matter abnormalities in patients with first-episode bipolar disorder (FEBD), including increased gray matter volume in the cerebellum, posterior cingulate cortex, and striatum, as well as decreased gray matter volume in the medial superior frontal gyrus and gyrus rectus. However, no common abnormalities were found between unaffected individuals at familial risk and FEBD patients, suggesting that gray matter deficits may not represent a familial risk endophenotype of bipolar disorder.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Minrui Lv, Xiaolin Yang, Xi Zhou, Jiakuan Chen, Haihua Wei, Duanming Du, Hai Lin, Jun Xia
Summary: This study investigated the relationship between changes in cerebral cortex volume and clinical symptoms in iNPH patients. The findings suggest that the cerebellum also plays a significant role in the pathogenesis of iNPH.
FRONTIERS IN NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qihao Zhang, Chaofan Sui, Junghun Cho, Linfeng Yang, Tao Chen, Bin Guo, Kelly McCabe Gillen, Jing Li, Lingfei Guo, Yi Wang
Summary: The objective of this study was to analyze the different brain oxygen metabolism statuses in preeclampsia using magnetic resonance imaging and investigate the factors that affect cerebral oxygen metabolism in preeclampsia. By studying 49 women with preeclampsia, 22 pregnant healthy controls, and 40 non-pregnant healthy controls, it was found that the preeclampsia group had significantly higher brain oxygen extraction fraction (OEF) values compared to the control groups.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Neurosciences
Jiayan Liu, Yahui Lei, Yuyao Diao, Yamei Lu, Xingbo Teng, Qingting Chen, Lian Liu, Jingxiang Zhong
Summary: This study investigates the morphological alterations in gray matter volume (GMV) in form-deprivation myopia (FDM) rats using voxel-based morphometry (VBM) method. The results show that compared to the normal controls, the FDM group exhibits significantly decreased GMVs in the left primary visual cortex, left secondary visual cortex, right subiculum, right cornu ammonis, right entorhinal cortex, and bilateral molecular layer of the cerebellum, while significantly increased GMVs were found in the right dentate gyrus, parasubiculum, and olfactory bulb.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Clinical Neurology
Xinyue Zhang, Jun Zhou, Mengyuan Guo, Shirui Cheng, Yilin Chen, Nannan Jiang, Xinling Li, Shengjie Hu, Zilei Tian, Zhengjie Li, Fang Zeng
Summary: This study comprehensively summarizes and meta-analyzes voxel-based morphometric neuroimaging studies of migraine. The findings reveal gray matter alterations in multiple brain regions in migraine patients, which may be a consequence of repeated migraine attacks.
JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Shanshan Cao, Jiajia Nie, Jun Zhang, Chen Chen, Xiaojing Wang, Yuanyuan Liu, Yuting Mo, Baogen Du, Yajuan Hu, Yanghua Tian, Qiang Wei, Kai Wang
Summary: Our study found that CSVD patients with WMHs had reduced gray matter volume and functional connectivity in the cerebellum, which were associated with cognitive impairment. This suggests that the cerebellum may have a crucial role in modulating cognitive function in CSVD patients with WMHs.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Feifei Zhang, Song Wang, Yang Feng, Kun Qin, Huiru Li, Baolin Wu, Zhiyun Jia, Qiyong Gong
Summary: The study highlights the potential risk of exercise dependence (EXD) due to excessive exercise and the role of stress in its onset and development. The findings suggest that gray matter volume (GMV) in specific brain regions may mediate the relationship between stress and EXD, even after controlling for various factors such as sex, age, and psychological conditions.
HUMAN BRAIN MAPPING
(2021)
Article
Psychiatry
Heng Shao, Na Li, Meiling Chen, Jie Zhang, Hui Chen, Minjun Zhao, Jingjing Yang, Jian Xia
Summary: This study used MRI to analyze the gray matter volume differences in patients with late-life depression with insomnia, patients with late-life depression only, and a healthy control group. The results showed that the late-life depression with insomnia group had worse anxiety and sleep quality compared to the late-life depression group. The analysis of brain structure revealed significant differences in gray matter volume in the anterior lobe of the cerebellum among the three groups, suggesting a possible link between insomnia and anxiety.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neuroimaging
Xiaoxi Ji, Hui Wang, Minwei Zhu, Yingjie He, Hong Zhang, Xiaoguang Chen, Wenpeng Gao, Yili Fu
Summary: The study revealed bilateral loss in the pons and left part of the midbrain in patients with mild Alzheimer's disease (AD-M) compared to the normal control group. There was also greater loss in the left midbrain in the AD-M group compared to those with very mild AD (AD-VM). This is the first VBM study providing evidence of early brainstem alterations in Alzheimer's disease.
BRAIN IMAGING AND BEHAVIOR
(2021)
Review
Clinical Neurology
Alessandro Miola, Nicola Meda, Giulia Perini, Fabio Sambataro
Summary: Around one-third of patients with major depressive disorder do not see significant improvement in their symptoms even after adequate treatment with two different antidepressant medications. This condition, known as treatment-resistant depression (TRD), severely impacts the quality of life of millions of people worldwide, leading to long-lasting interpersonal problems and social costs. A systematic review of neuroimaging studies indicates that frontal, cerebellar, and brainstem functions may be involved in the pathophysiology of TRD, although the heterogeneity and limitations of the available literature restrict the generalizability of the findings.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Geriatrics & Gerontology
Richard Agren, Amar Awad, Patric Blomstedt, Anders Fytagoridis
Summary: Comparison of cerebellar lobule volumes between ET patients and HCs using automated segmentation revealed smaller volumes in ET patients, opposing the hypothesis of localized atrophy in cerebellar motor areas in ET. However, the possibility of cerebellar pathophysiology in ET was not ruled out. Further prospective investigations using alternative neuroimaging modalities may help elucidate the pathophysiology of ET and guide diagnostic and therapeutic approaches.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Hernan C. Kulsgaard, Jose I. Orlando, Mariana Bendersky, Juan P. Princich, Luis S. R. Manzanera, Alberto Vargas, Silvia Kochen, Ignacio Larrabide
Summary: The study proposed to refine the findings of single subject VBM using SVM technique, which successfully reduced the false positive detections while maintaining the true positive findings. This method has the potential to assist radiologists and clinicians in manual analysis and increase the usability of SS-VBM for image reading.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Computer Science, Interdisciplinary Applications
Gabriel Solana-Lavalle, Roberto Rosas-Romero
Summary: This study proposes a new method for classifying 3-D MRI scans as an assisting tool for Parkinson's disease diagnosis, using separate experiments for men and women due to gender differences in disease prevalence. High detection performance was achieved, with men showing 99.01% accuracy and women showing 96.97% accuracy in classification experiments, highlighting the effectiveness of the proposed approach.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Clinical Neurology
Fenglian Zheng, Yuxin Li, Zhizheng Zhuo, Yunyun Duan, Guanmei Cao, Decai Tian, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Haiqing Li, Yongmei Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Xuemei Han, Sven Hallar, Frederik Barkhof, Yaou Liu
Summary: In a study involving 752 participants, it was found that MS patients had significantly lower hippocampal volume, FA, and MD compared to NMOSD patients and healthy controls, but no abnormal ALFF or DC were identified in any group. Hippocampal subfields were affected in both diseases, but some subfield volumes were significantly lower only in MS patients.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Neurosciences
Xiaodi Sun, Xinjun Suo, Xianyou Xia, Chunshui Yu, Yan Dou
Summary: This study demonstrates that DMF is a potential therapeutic option for Alzheimer's disease (AD) through its antioxidant, anti-inflammatory, anti-apoptotic, and other anti-AD effects by activating the Nrf2 pathway.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Genetics & Heredity
Meng Wang, Ke Hu, Lingzhong Fan, Hao Yan, Peng Li, Tianzi Jiang, Bing Liu
Summary: This study investigated the role of MRI and PRS in predicting antipsychotic medication treatment outcomes in schizophrenia. The results showed that combining MRI with PRS can provide superior prognostic performance, and PRS plays a certain role in predictions. Gray matter volume, amplitude of low-frequency fluctuation, and surface curvature were found to be important features in the predictions.
FRONTIERS IN GENETICS
(2022)
Article
Neurosciences
Yue Cui, Haibin Huang, Jinquan Gao, Tianzi Jiang, Chen Zhang, Shan Yu
Summary: Hematological and biochemical blood traits are linked to brain structural characteristics in macaques, forming interactive networks. Different subnetworks of the brain are correlated with specific blood indices, revealing previously unknown relationships in brain structural organization.
Article
Neurosciences
Haixia Long, Ming Fan, Qiaojun Li, Xuhua Yang, Yujiao Huang, Xinli Xu, Ji Ma, Jie Xiao, Tianzi Jiang
Summary: This study investigates the effects of sex on aggression subscales, gray matter volume, and functional connectivity of each insula subregion, as well as the correlation between aggression subscales and gray matter volume and functional connectivity. The study finds that sex significantly influences physical aggression, anger, and hostility, as well as the gray matter volume of all insula subregions and the functional connectivity of specific subregions. Mediation analysis reveals that the gray matter volume of bilateral dorsal agranular insula mediates the association between sex and physical aggression, and the functional connectivity between left dorsal dysgranular insula and left medial orbital superior frontal gyrus mediates the relationship between sex and anger. These findings highlight the neural mechanism underlying sex differences in aggression subscales and emphasize the important role of the insula in aggression differences between males and females.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemistry & Molecular Biology
Feng Liu, Jiayuan Xu, Lining Guo, Wen Qin, Meng Liang, Gunter Schumann, Chunshui Yu
Summary: Individual differences in human brain structure, function, and behavior can be explained by genetic variations, environmental exposures, and their interactions. While genetic variants associated with brain imaging phenotypes have been identified, the environmental exposures related to these phenotypes are largely unknown. This study proposes that research in environmental neuroscience should focus on understanding the associations between lifetime environmental exposures and brain imaging phenotypes, as well as identifying cumulative environmental effects and their vulnerable age windows.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Jingchun Liu, Caihong Wang, Wen Qin, Hao Ding, Yanmin Peng, Jun Guo, Tong Han, Jingliang Cheng, Chunshui Yu
Summary: Subcortical ischemic stroke can cause long-lasting changes in the cerebral cortex. This study investigated the relationship between cortical structural changes, motor recovery, lesion location, and early impairment of specific subsets of fibers in the corticospinal tract (CST) in patients with subcortical stroke. The findings revealed different patterns of cortical structural changes in patients with partial and complete recovery, which were associated with lesion location and impairment of specific CST fiber subsets.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Rui Zhao, Qian Su, Yingchao Song, Qingqing Yang, Sijia Wang, Juan Zhang, Wen Qin, Chunshui Yu, Meng Liang
Summary: Pain is subjective, and each individual has a unique pattern of brain responses to pain stimuli. These individual differences in brain activations are associated with an individual's awareness and vigilance towards pain.
Article
Neurosciences
Huaigui Liu, Wei Li, Nana Liu, Jie Tang, Lixin Sun, Jiayuan Xu, Yuan Ji, Yingying Xie, Hao Ding, Zhaoxiang Ye, Chunshui Yu, Wen Qin
Summary: Evidence suggests that dysregulation of the dopamine (DA) system and dysfunction of the prefrontal cortex (PFC) may contribute to the development of schizophrenia. However, the relationship between DA genes, PFC morphology, and schizophrenia is still not fully understood. In this study, we analyzed brain gene expression data and structural magnetic resonance imaging data to identify specific PFC subregions that are associated with the expression profiles of DA genes. We found that some PFC subregions showed abnormal increases in gray matter volume covariance with other brain regions in schizophrenia patients. Furthermore, our analysis of postmortem expression data revealed reduced coexpression of DA genes between the middle frontal gyrus and hippocampus in schizophrenia patients, with these genes being implicated in brain functions related to working memory, reward processing, speech production, and episodic memory.
Article
Neurosciences
Wenshuang Zhu, Feng Liu, Jilian Fu, Wen Qin, Kaizhong Xue, Jie Tang, Yong Zhang, Chunshui Yu
Summary: This study identified 903 clinically sensitive genes and 633 clinically insensitive genes associated with ALFF alterations in MDD. The sensitive genes were enriched for cell differentiation and development, while the insensitive genes were enriched for ion transport and synaptic signaling.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Jingchun Liu, Caihong Wang, Wen Qin, Jun Guo, Tong Han, Jingliang Cheng, Chunshui Yu
Summary: Subcortical stroke leads to structural changes in multiple areas of the cerebral cortex. The location of the lesion affects the pattern of cortical thickness changes. Motor outcomes and impairment of the corticospinal tract are correlated with cortical thickness in specific gyri. The longitudinal dataset shows gradual changes in cortical thickness and area in regions with structural reorganization.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neuroimaging
Ling Wang, Yi Ji, Hao Ding, Qin Tian, Ke Fan, Dapeng Shi, Chunshui Yu, Wen Qin
Summary: The study used arterial spin labeling (ASL) to investigate abnormal cerebral blood flow (CBF) in patients with Leber's hereditary optic neuropathy (LHON) and its associations with disease duration and neuro-ophthalmological impairment. The results showed differences in brain regions of LHON patients, including the left sensorimotor and bilateral visual areas. LHON patients had lower CBF in the bilateral calcarine compared to healthy controls. Chronic LHON patients also showed lower CBF in the left middle frontal gyrus, sensorimotor cortex, and temporal-partial junction. Disease duration and neuro-ophthalmological impairments were found to affect the metabolism of non-visual areas.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
