Article
Biochemistry & Molecular Biology
Nagwa I. Shehata, Mai A. Abdelsamad, Hebat Allah A. Amin, Nermin A. H. Sadik, Amira A. Shaheen
Summary: This study aimed to evaluate the potential neuroprotective effects of ketogenic diet (KD) against neuronal disruptions induced by status epilepticus (SE). Results showed that KD could improve neurotransmitter balance, oxidative stress and inflammatory response, reduce neuronal damage, and preserve neuronal integrity.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Neurosciences
Efrat Shavit-Stein, Shani Berkowitz, Tal Davidy, Uri Fennig, Shani Guly Gofrit, Amir Dori, Nicola Maggio
Summary: This study evaluated the effects of thrombin pathway inhibition in a mice model of SE and found that thrombin is involved in memory impairment and cognitive dysfunction. Inhibiting the thrombin pathway can prevent cognitive impairment and reduce neuronal damage.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Ahmad Tarmizi Che Has
Summary: Status epilepticus is a neurological disorder with various neuropathological conditions and presentations. Animal models, particularly the chemically induced pilocarpine model, have been used to understand and replicate its manifestations. However, there are challenges in inducing the model, such as morbidity and mortality rates. Modifications, including dose fractionation and lithium-pilocarpine model, have been introduced to tackle these issues. Despite the drawbacks, this model has proven its relevance and has been improved since its discovery in 1983.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Chemistry, Medicinal
Thiago S. Charret, Mariana T. M. Pereira, Vinicius D. B. Pascoal, Iscia Lopes-Cendes, Aislan Cristina Rheder Fagundes Pascoal
Summary: Research has shown that citral has inhibitory effects on status epilepticus in a rat model, increasing latency for seizure development, reducing neuronal death, and inhibiting overexpression of proinflammatory genes.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Biochemistry & Molecular Biology
Petr Fabera, Libor Uttl, Hana Kubova, Grygoriy Tsenov, Pavel Mares
Summary: LiCl/pilocarpine status epilepticus induces changes in ADK isoform expression and inhibiting ADK with 5-ITU affects hippocampal excitability. The study shows that SE leads to decreased excitability in immature rats 3 days after induction, followed by increased excitability after 20 days. 5-ITU demonstrates inhibitory effects on hippocampal excitability in SE rats. ADK isoforms also show altered expression levels in SE rats, indicating their involvement in hippocampal excitability and brain development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Benjamin Owen, Edyta Bichler, Morris Benveniste
Summary: This study investigates changes in synaptic transmission with progression of chronic epilepsy, finding that rats treated with pilocarpine show alterations in synaptic characteristics at different time points, possibly related to depletion of neurotransmitter vesicles.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
ManKin Choy, Ehsan Dadgar-Kiani, Greg O. Cron, Ben A. Duffy, Florian Schmid, Bradley J. Edelman, Mazen Asaad, Russell W. Chan, Shahabeddin Vahdat, Jin Hyung
Summary: Repeated seizure activity can cause long-term changes in brain dynamics and behavior. This study developed an optogenetic kindling model to investigate the brain-wide circuit dynamics resulting from repeated stimulation, and found that kindling induced widespread changes in brain activity and functional connectivity, as well as elevated anxiety. Furthermore, the study identified a novel mechanism of seizure propagation from the ipsilateral to the contralateral hemisphere.
Article
Neurosciences
F. A. Concepcion, N. A. Ekstrom, M. N. Khan O. O. Estes, N. P. Poolos
Summary: This study investigated the expression and phosphorylation of the intracellular protein Tau in a rat model of temporal lobe epilepsy. The results showed that although Tau expression levels had a modest reduction at two months post-seizure, they had returned to normal by four months. However, there was a significant decrease in phosphorylation levels at the S202/T205 locus. These findings suggest that Tau may play a different role in epilepsy compared to Alzheimer's disease.
Article
Biology
Turgay Cokyaman, Ozlem Oztopuz, Ozlem Coskun, Basak Buyuk, Hasan A. Kiraz, Sait Elmas
Summary: The study found that medical ozone can reduce oxidative damage, neuroinflammation, and neuronal injury caused by SE, contributing positively to neuroprotection.
Article
Clinical Neurology
Diogo Vila Verde, Till Zimmer, Alessandro Cattalini, Marlene F. Pereira, Erwin van Vliet, Giuseppe Testa, Vadym Gnatkovsky, Eleonora Aronica, Marco de Curtis
Summary: The study found that seizures during FncSE may worsen brain tissue damage, while glial cells are only transiently activated in regions far from the lesion, suggesting that seizure activity during FncSE without local pathogenic factors does not lead to long-lasting detrimental changes.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna A. Kovalenko, Maria V. Zakharova, Alexander P. Schwarz, Alexandra V. Dyomina, Olga E. Zubareva, Aleksey V. Zaitsev
Summary: This study analyzed the changes in gene expression of mGluR subtypes in different brain regions during the latent and chronic phases of a lithium-pilocarpine model of epilepsy. The results showed region- and phase-specific changes in expression, with increased mGluR5 mRNA levels and decreased expression of group III genes during the latent phase. Most of the changes in expression detected in the latent stage were absent in the chronic stage, except for reduced mGluR8 mRNA production in the hippocampus. The study suggested that agonists of group III mGluRs are the most promising targets for preventing epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Asheebo Rojas, Radhika Amaradhi, Avijit Banik, Chunxiang Jiang, JuanMartin Abreu-Melon, Sarah Wang, Raymond Dingledine, Thota Ganesh
Summary: Pilocarpine-induced SE results in hippocampal neurodegeneration and persistent inflammation, while inhibiting the EP2 receptor with TG8-260 can significantly reduce neuroinflammation and gliosis following SE.
Article
Veterinary Sciences
Patrick Roynard, Ann Bilderback, Curtis Wells Dewey
Summary: Ketamine 5 mg/kg IV bolus may be successful in treating RSE in dogs, but its efficacy in handling CS is limited. The incidence of adverse effects is low, but timing of administration should be carefully considered.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Cell Biology
Weixing Xu, Yue Wang, Xiuting Qi, Kunpeng Li, Li Zhou, Sha Sha, Xiaoli Wang, Chunfeng Wu, Yimei Du, Lei Chen
Summary: The study found that TRPV4 activation may increase the expression of Kv4.2 and KCHIP2 in the hippocampus, as well as the levels of I-A in hippocampal pyramidal neurons, which may serve as compensatory measures for hyperexcitability at the early stage of epilepsy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sarah S. El-Sayed, Mohammed F. El-Yamany, Hesham A. Salem, Ayman E. El-Sahar
Summary: The study investigated the modulatory effects of Vinpocetine (VNP) on neurobehavioral comorbidities via the mTOR signaling pathway in a lithium-pilocarpine (Li-Pil) rat model of seizures. VNP demonstrated a protective effect against Li-Pil-induced seizures and improved locomotor and cognitive abilities, while also exerting a neuroprotective action through inhibitory effects on hippocampal glutamate excitotoxicity, mTOR pathway, and inflammatory and apoptotic parameters.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Oncology
Li Feng, Yi Shu, Qian Wu, Tiantian Liu, Hongyu Long, Huan Yang, Yi Li, Bo Xiao
MOLECULAR MEDICINE REPORTS
(2017)
Article
Clinical Neurology
Yi Li, Liesl Matzka, Louise Maranda, Daniel Weber
Article
Neurosciences
Qian Wu, Weiting Tang, Zhaohui Luo, Yi Li, Yi Shu, Zongwei Yue, Bo Xiao, Li Feng
FRONTIERS IN CELLULAR NEUROSCIENCE
(2017)
Article
Medicine, Research & Experimental
Tian-Tian Liu, Yi Li, Yi Shu, Bo Xiao, Li Feng
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Article
Cell Biology
Weifan Yin, Song Ouyang, Yi Li, Bo Xiao, Huan Yang
Article
Immunology
Weifan Yin, Windy Allman, Song Ouyang, Yi Li, Jing Li, Premkumar Christadoss, Huan Yang
JOURNAL OF NEUROIMMUNOLOGY
(2013)
Article
Neurosciences
Yi Shu, Bo Xiao, Qian Wu, Tiantian Liu, Yang Du, Haiyun Tang, Si Chen, Li Feng, Lili Long, Yi Li
MOLECULAR NEUROBIOLOGY
(2016)
Article
Neurosciences
Q. Wu, Y. Li, Y. Shu, L. Feng, L. Zhou, Z. W. Yue, Z. H. Luo, Z. G. Wu, B. Xiao
Article
Neurosciences
Yi Li, Timothy P. Fitzgibbons, David D. McManus, Richard P. Goddeau, Brian Silver, Nils Henninger
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2019)
Article
Clinical Neurology
Yi Li, Sarah Tymchuk, John Barry, Srikanth Muppidi, Scheherazade Le
Summary: The study found that some patients with drug-resistant focal epilepsy may have immune-mediated causes, and proposed an APES score to help identify patients for immunological evaluation in the pre-surgical assessment of refractory focal epilepsy with unknown cause.
Article
Clinical Neurology
Yi Li, Dawn Eliashiv, Sara C. LaHue, Vikram R. Rao, Michael L. Martini, Fedor Panov, Joel M. Oster, June Yoshii-Contreras, Christopher T. Skidmore, Laura A. Kalayjian, David Millett, Kimford J. Meador
Summary: This study is the first report of RNS System-exposed pregnancies in WWE, with no major congenital malformations identified. All obstetric complications were within the expected range based on previously published data.
Review
Behavioral Sciences
Yi Li, Sai Zhang, Michael P. Snyder, Kimford J. Meador
Summary: Epilepsy is a common neurological condition that affects nearly 70 million people globally. Women with epilepsy face gender-specific challenges and precision medicine may offer tailored management solutions.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Yi Li, Liesl Matzka, Julie Flahive, Daniel Weber
Article
Anesthesiology
Yi Li, Pamela Flood, Susannah Cornes
A & A CASE REPORTS
(2015)
Article
Clinical Neurology
Yi Li, Raphael A. Carandang, Swetha Ade, Julie Flahive, Kate Daniello
NEUROLOGY-CLINICAL PRACTICE
(2020)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
