Article
Biochemistry & Molecular Biology
Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Dong
Summary: The aim of this study was to investigate the protective mechanism of geraniol against cerebral ischemia-reperfusion injury (CIRI). The results showed that geraniol effectively attenuated cerebral infarction and pathological injury, reduced ER-stress-related protein expression and apoptosis occurrence, and increased anti-apoptotic protein expression, suggesting a protective effect against CIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Zhenyang Guo, Xueting Yu, Shuang Zhao, Xin Zhong, Dong Huang, Runyang Feng, Peng Li, Zheyan Fang, Yiqing Hu, Zhentao Zhang, Mukaddas Abdurahman, Lei Huang, Yun Zhao, Xiangdong Wang, Junbo Ge, Hua Li
Summary: This study revealed an epigenetic mechanism associated with SIRT6 and Ero1α expression, and highlighted the therapeutic potential of targeting the SIRT6-HIF1α/p300-Ero1α axis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Juan Ignacio Elio Mariangelo, Carlos Alfredo Valverde, Leticia Vittone, Matilde Said, Cecilia Mundina-Weilenmann
Summary: This study found that blocking ER calcium efflux via the translocon can suppress ER stress and improve the mechanical performance and diastolic calcium handling of stunned myocardium. Therefore, modulation of translocon permeability may be a therapeutic approach to treat the functional abnormalities caused by ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Chao Yang, Zeng Wang, Yuanchang Hu, Shikun Yang, Feng Cheng, Jianhua Rao, Xuehao Wang
Summary: This study found that hyperglycemia can trigger the activation of endoplasmic reticulum stress-ATF6-CHOP signaling pathway, inhibit the activation of beta-catenin, and promote the formation of inflammation, leading to liver ischemia-reperfusion injury. However, the use of endoplasmic reticulum stress inhibitor PBA or deficiency of CHOP can partially alleviate this injury.
CELL DEATH DISCOVERY
(2022)
Article
Immunology
Shixia Zhang, Jilang Tang, Chen Sun, Nuannuan Zhang, Xiaqing Ning, Xueqin Li, Jiaqi Wang
Summary: Dexmedetomidine (DEX) protects the liver against ischemia-reperfusion injury (IRI) by reducing oxidative stress, endoplasmic reticulum stress (ERS), and apoptosis. DEX increases antioxidant activity and reduces oxidative damage in BRL-3A cells. It also inhibits MAPK signaling pathway activation and ERS to prevent cell apoptosis. Animal studies confirm that DEX alleviates histopathological injury and improves liver function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Xinming Li, Zongxin Cheng, Xiaohong Chen, Dejiang Yang, Huanhuan Li, Youqing Deng
Summary: This study found that Purpurogallin (PPG) has neuroprotective effects on cerebral ischemia/reperfusion (I/R) injury. PPG attenuates brain I/R damage by suppressing endoplasmic reticulum (ER) stress and neuroinflammation via inactivation of the TLR4/NF-kappa B pathway. PPG may be a potential candidate drug for treating cerebral I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Jingwen Chen, Yang Liu, Defeng Pan, Tongda Xu, Yuanyuan Luo, Wanling Wu, Pei Wu, Hong Zhu, Dongye Li
Summary: The study showed that estrogen inhibits ER stress and attenuates MI/R injury by upregulating SERCA2a. These findings provide a new potential target for therapeutic intervention and drug discovery in coronary heart disease.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Pharmacology & Pharmacy
Tengfang Lai, Yong Shen, Chengcai Chen, Bo Huang, Tongyuan Deng, Zhuangzhi Zhao, Zhuohua Zhang, Zhaohe Huang, Xingshou Pan
Summary: This study demonstrates the cardioprotective role of glycyrrhizic acid in myocardial ischemia-reperfusion injury may involve attenuation of endoplasmic reticulum stress-induced apoptosis and inflammation, potentially providing an alternative strategy for intervention of myocardial ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yazhou Guo, Chen Yang, Rong Guo, Ruijie Huang, Yongxia Su, Shuai Wang, Yezi Kong, Jianguo Wang, Chengjian Tan, Chonghui Mo, Chenchen Wu, Baoyu Zhao
Summary: The study revealed that MCT exhibits significant cytotoxicity on primary rat hepatocytes and induces ER stress, leading to apoptosis. Inhibiting ER stress or knocking down CHOP can partially alleviate cell apoptosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Ya-lin Zhu, Jie Huang, Xue-ying Chen, Jian Xie, Qing Yang, Jia-feng Wang, Xiao-ming Deng
Summary: SEI alleviates renal injury induced by ischemia reperfusion with anti-inflammatory, anti-endoplasmic reticulum stress, anti-oxidative, and anti-apoptotic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Shijia Su, Jiarui Wang, Jing Wang, Ruili Yu, Likang Sun, Yue Zhang, Lei Song, Weiling Pu, Yi Tang, Yingli Yu, Kun Zhou
Summary: In this study, it was found that GP-17 can prevent myocardial ischemia/reperfusion injury by inhibiting endoplasmic reticulum stress, reducing cell apoptosis, autophagy, and oxidative stress. GP-17 also regulates the balance of mitochondrial fusion and fission, protecting mitochondrial function and improving cardiac function.
PHYTOTHERAPY RESEARCH
(2022)
Article
Plant Sciences
Yingli Yu, Min Wang, Rongchang Chen, Xiao Sun, Guibo Sun, Xiaobo Sun
Summary: GP-17 provides cardioprotective effects by inhibiting myocardial apoptosis, reducing cardiac dysfunction, and improving contractile recovery. The study results demonstrate that GP-17 inhibits I/R-induced mitochondrial injury by delaying the onset of ER stress, which is controlled by the PI3K/AKT and P38 signaling pathways.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Shuai Liu, Yuxuan Hou, Chenxi Lu, Wenwen Yang, Ting Ji, Yang Yang, Zhibin Yu, Zhenxiao Jin
Summary: This study demonstrates that Claudin-5 plays a potential therapeutic role in acute myocardial ischemia reperfusion injury. Overexpression of Cldn5 improves cardiac function and reduces myocardial damage, while attenuating oxidative stress, inflammatory response, mitochondrial dysfunction, endoplasmic reticulum stress, energy metabolism disorder, and apoptosis. Knockdown of Cldn5 inhibits cell viability in HL-1 cardiomyocytes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Medicine, Research & Experimental
Yue Wang, Tao Liu, Guangming Jiao, Yingguang Lv, Chenxi Piao, Xiangyu Lu, Haiyang Ma, Hongbin Wang
Summary: The aim of this study was to investigate the therapeutic efficacy of exosomes from adipose-derived mesenchymal stem cells (ADSCs-exo) against hepatectomy combined with ischemia-reperfusion injury (IRI) and compare it with the effect of adipose-derived mesenchymal stem cells (ADSCs). The results showed that ADSCs-exo alleviated histopathological injuries and ultrastructural changes in the endoplasmic reticulum (ER), and significantly improved ALP, TP and CAT levels. The therapeutic effects of ADSCs-exo and ADSCs were similar, indicating that ADSCs-exo is a novel cell-free therapeutic approach for surgery-related liver injury.
Article
Biochemistry & Molecular Biology
Bingtian Xu, Jiangping Xu, Ningbo Cai, Mengfan Li, Lu Liu, Yunyun Qin, Xing Li, Haitao Wang
Summary: The PDE4 inhibitor Roflumilast has the potential to protect neurons from ischemic stroke-induced injury by activating the GSK3 beta/Nrf-2 signaling pathway and suppressing the IRE1 alpha/TRAF2/JNK pathway, reducing oxidative stress and apoptosis-related protein phosphorylation levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Qinghua Qiu, Xiao Wei, Li Zhang, Yanjiao Li, Mingren Qu, Kehui Ouyang
Summary: This study compared the effects of different types and inclusion levels of tea leaves and tea residue on rumen fermentation characteristics. The results showed that tea residue had higher crude protein and fiber content, while tea leaves had higher ether extract and crude ash content. There were interaction effects between feed type and inclusion level. Overall, the inclusion of tea residue and tea leaves had similar effects on rumen fermentation characteristics and methane production, but an inclusion level higher than 10% would inhibit rumen fermentation.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Biochemical Research Methods
Shuai He, Chufeng Gu, Tong Su, Chuandi Zhou, Thashi Lhamo, Deji Draga, Lili Yin, Qinghua Qiu
Summary: This study used network pharmacology to investigate the mechanisms of the Chinese herbal compound Lingqihuangban Granule (LQHBG) in treating diabetic retinopathy (DR), revealing potential targets and pathways. It showed the characteristics of multi-component, multi-target, and multi-pathway treatment of LQHBG and provided new ideas for further research.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Ophthalmology
Xiaomeng Li, Dawei Luo, Chufeng Gu, Thashi Lhamo, Deji Draga, Zhi Zheng, Qinghua Qiu
Summary: This study describes an improved technique for secondary intraocular lens (IOL) implantation in aphakic eyes with a constricted capsular bag. The results demonstrate that the two-steps capsular bag reopening method can be successfully performed in the majority of cases, resulting in stable IOL positioning and improved visual outcomes.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Zoology
Mengxue Sun, Yanjiao Li, Zhen Gao, Qinghua Qiu, Xianghui Zhao, Lanjiao Xu, Huan Liang, Ke Pan, Mingren Qu, Kehui Ouyang
Summary: The effects of different niacin treatments on low pH-induced goat rumen epithelial cells acidosis were investigated. Results showed that pre-treatment with low-concentration niacin could relieve subacute ruminal acidosis, and it could be added after symptoms appear. However, niacin had a negative role in the protection of acute ruminal acidosis.
PAKISTAN JOURNAL OF ZOOLOGY
(2023)
Article
Ophthalmology
Chuandi Zhou, Chufeng Gu, Bo Li, Yujie Wang, Yanan Hu, Xinping She, Ya Shi, Mingming Ma, Tao Sun, Qinghua Qiu, Ying Fan, Fenge Chen, Hong Wang, Kun Liu, Xiaodong Sun, Xun Xu, Zhi Zheng
Summary: This retrospective cohort study investigated the prevalence and predictors of retinal breaks reopening after vitrectomy with air tamponade in rhegmatogenous retinal detachment. The study found that 7.99% of patients experienced recurrent detachment, with new or missed retinal breaks and reopening of original tears being the main causes. It was also identified that the presence of retinal breaks ≥ 1.5 disc diameters and a shorter period for restricted activities were independent predictors for breaks reopening.
Article
Biotechnology & Applied Microbiology
Qinghua Qiu, Jiantong Zhang, Mingren Qu, Yanjiao Li, Xianghui Zhao, Kehui Ouyang
Summary: This study investigated the effects of four energy provision strategies on rumen fermentation characteristics, bacterial diversity, and community composition in Hu sheep. The results showed that the energy provision strategy had little impact on rumen fermentation characteristics, but heavily influenced bacterial diversity and community composition. This study provides important insights into rumen fermentation characteristics and bacterial community, and contributes to the optimization of energy provision strategies for Hu sheep.
BIOENGINEERING-BASEL
(2023)
Article
Ophthalmology
Chufeng Gu, Yujie Wang, Yan Jiang, Feiping Xu, Shasha Wang, Rui Liu, Wen Yuan, Nurbiyimu Abudureyimu, Ying Wang, Yulan Lu, Xiaolong Li, Tao Wu, Li Dong, Yuzhong Chen, Bin Wang, Yuncheng Zhang, Wen Bin Wei, Qinghua Qiu, Zhi Zheng, Deng Liu, Jili Chen
Summary: This study evaluates the performance of the Airdoc retinal artificial intelligence system (ARAS) in detecting multiple fundus diseases in primary healthcare settings. The study was conducted in Shanghai and Xinjiang, China, and included six primary healthcare settings. The accuracy, specificity, and negative predictive value of ARAS were high, but the sensitivity and positive predictive value varied for different abnormalities. There were significant differences in the spectrum of fundus diseases between Shanghai and Xinjiang.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Yi Zhao, Cui Ma, Qinghua Qiu, Xucong Huang, Xijier Qiaolongbatu, Han Qu, Jiaqi Wu, Guorong Fan, Zhenghua Wu
Summary: This study aimed to explore the substance basis and mechanisms of Shen-qi-wang-mo Granule (SQWMG) in treating retinal vein occlusion (RVO). Analysis of components in SQWMG identified 63 components, with ganoderic acids (GA) being the largest proportion. Potential targets of active components and RVO-related targets were obtained, revealing the key targets and pathways of SQWMG against RVO. Molecular docking and qPCR experiments validated the effects of SQWMG on targets and pathways. Additionally, key components were identified from rat serum after treatment with SQWMG.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Qinghua Qiu, Tanghui Long, Kehan Ouyang, Xiaowen Lei, Jingyun Qiu, Jian Zhang, Yanjiao Li, Xianghui Zhao, Mingren Qu, Kehui Ouyang
Summary: This study investigated the dynamic variations in fermentation characteristics, bacterial diversity, and community composition during the extended preservation time at two different temperatures. The results showed that the preservation temperature did not have a significant effect on the fermentation characteristics, bacterial diversity, and community composition. However, after 60 days of preservation, there were changes in the concentrations of various fermentation products. Bacterial richness and evenness were not affected by the preservation time, but the relative abundances of certain bacterial groups changed. This study suggests that the fermentation characteristics in rumen fluid may be altered after 60 days of preservation, while the bacterial community profile may change after 30 days. It is recommended to determine rumen fluid samples within 30 days for accurate results. This study provides valuable information for determining the practical time for rumen fluid determination and appropriate preservation conditions for in vitro fermentation testing.
FERMENTATION-BASEL
(2023)
Article
Ophthalmology
Shuai He, Zenan Lin, Qinghua Qiu
Summary: This case report describes a patient in which silicone oil accidentally entered Berger's space after vitrectomy. The study highlights the effective treatments and possible etiological mechanisms of this phenomenon.
Article
Biotechnology & Applied Microbiology
Xiangyu Zhang, Xiaowen Lei, Kehui Ouyang, Wenjing Zhang, Chanjuan Liu, Yanjiao Li, Qinghua Qiu, Yitian Zang, Mingren Qu, Ke Pan, Xianghui Zhao
Summary: Ferulic acid esterases can enzymatically break down hemicellulose to release ferulic acid. This study investigated a ferulic acid esterase from Lentinula edodes (LeFae) and its effects on wheat straw fermentation. LeFae showed optimal pH and temperature at pH 7.0 and 60°C, respectively, exhibited broad adaptability to temperature and pH, and had good thermal stability. LeFae enhanced wheat straw hydrolysis and inhibited microbial fermentation, reducing digestibility and affecting rumen microorganisms.
FERMENTATION-BASEL
(2023)
Article
Zoology
Jie Chen, Qinghua Qiu, Yanjiao Li, Xianghui Zhao, Lanjiao Xu, Xiaowen Xiong, Qingqi Wen, Mingren Qu, Kehui Ouyang
Summary: This study aimed to investigate the differences in energy levels on autophagy, adipogenic differentiation and fat metabolism between subcutaneous and visceral pre-adipocytes. The results showed that subcutaneous pre-adipocytes had higher proliferation rate, differentiation degree, and lipid accumulation than visceral pre-adipocytes. In the high-glucose group, autophagy marker genes and lipolysis protein expression in visceral pre-adipocytes were higher than that in subcutaneous pre-adipocytes, but adipogenesis transcriptional factors were lower. The low-glucose group increased autophagy and reduced the expression of adipogenesis transcriptional factors and lipolysis protein in both subcutaneous and visceral pre-adipocytes.
PAKISTAN JOURNAL OF ZOOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiao Wei, Kehui Ouyang, Tanghui Long, Zuogui Liu, Yanjiao Li, Qinghua Qiu
Summary: This study aimed to explore the dynamic variations of rumen fermentation characteristics and bacterial community composition during a 24 h in vitro fermentation. Results showed that gas production, concentrations of microbial crude protein, ammonia nitrogen, and individual volatile fatty acids (VFA), as well as total VFA and branched-chain VFA concentrations, were higher in R24 when compared with R12. Bacterial diversity analysis found that Shannon index and Simpson index were higher in R24, and obvious clusters were observed in rumen bacterial community between R12 and R24. Taxonomic analysis revealed differences in abundance of bacterial phyla and genera between R12 and R24, and correlation analysis showed associations between gas production and bacterial abundances, as well as between VFA production and bacterial abundances.
FERMENTATION-BASEL
(2022)
Article
Agriculture, Dairy & Animal Science
Guwei Lu, Yanjiao Li, Kang Mao, Yitian Zang, Xianghui Zhao, Qinghua Qiu, Mingren Qu, Kehui Ouyang
Summary: This study aimed to investigate the effects of transport treatment and dietary supplementation of rumen-protected (RP)-CrPyr on the meat quality, muscle energy metabolism, and hepatic gluconeogenesis of beef cattle. The results showed that dietary RP-CrPyr supplementation can increase muscle glycogen storage, energy supply, and hepatic gluconeogenesis, and improve meat quality and regulatory capacity of energy metabolism.
FRONTIERS IN ANIMAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Zhenzhen Zhao, Yumeng Zhang, Chaoyang Zhang, Jingting Zhang, Xueting Luo, Qinghua Qiu, Dawei Luo, Jingfa Zhang
Summary: The transition of choroidal pericytes into myofibroblasts plays a crucial role in subretinal fibrosis. Inhibiting the Smad2/3 and Akt/mTOR pathways can reduce cell proliferation, transition, and migration, thereby alleviating the severity of fibrosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
