Article
Neurosciences
Ming-Huan Yu, Qin Yang, You-Peng Zhang, Jia-Hui Wang, Ren-Jian-Zhi Zhang, Zhi-Gang Liu, Xiao-Cheng Liu
Summary: This study investigated the effect of the cannabinoid agonist WIN55, 212-2 on brain injury in a rat model of deep hypothermic circulatory arrest (DHCA) in cardiac surgery. The results showed that WIN55, 212-2 attenuated histopathological injury of the hippocampus, reduced levels of proinflammatory cytokines, and increased levels of superoxide dismutase (SOD). WIN55, 212-2 also regulated the expression of apoptotic-related protein caspase-3 and cannabinoid receptor CB1R in the hippocampus. Therefore, WIN55, 212-2 administration alleviates DHCA-induced hippocampal injury through a CB1R-dependent mechanism.
Article
Biochemistry & Molecular Biology
Min-Jeong Kim, Eun-Sang Hwang, Kwan Joong Kim, Sungho Maeng, Ho Jin Heo, Ji-Ho Park, Dae-Ok Kim
Summary: This study found that EGCG can alleviate scopolamine-induced learning and memory impairments and improve brain function. This may be achieved through mechanisms such as improving cholinergic function and reducing oxidative stress.
Article
Agriculture, Multidisciplinary
Zhiqiang Lu, Xiaomeng Xu, Dongmei Li, Na Sun, Songyi Lin
Summary: The study found that SCP improved behavioral performance and regulated the disorder of the cholinergic system in mouse models in a dose-dependent manner. High-dose SCP repaired damaged neuronal cells, enhanced the Nissl body number, increased the unsaturated lipid level, and activated the long-term potentiation (LTP) pathway in both mouse and rat hippocampus.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Joowon Kim, Hyeyeon Kang, Young-Beom Lee, Boyoung Lee, Doyun Lee
Summary: This study examined the behavior of mice in the Y-maze through quantitative analysis, while systematically varying the arm visit threshold, and evaluated the effect of acute social isolation on spatial working memory. The results showed that 24-hour social isolation significantly reduced spontaneous alternation rate and the memory of recently visited arms faded away faster in the socially isolated mice. However, other behavioral factors were comparable, indicating a specific impairment of short-term memory.
SCIENTIFIC REPORTS
(2023)
Article
Food Science & Technology
Ebrahim Rajab, Michael B. Keogh, Ashang L. Laiva, Fatima Al Hannan, Maryam Fateel, Fatema Abdulwahab, Fatema Al Madhoob, Bassam AlHamer, Samar Y. Ghazzal, Abdulla Dawaishan, Sadiq Mahdi, Abdulrahman Qareeballa, Sayed M. Almosawi, Faisal Falamarzi, Khalifa ElMusharaf, Amer Kamal
Summary: The study showed that GA supplementation can prevent cognitive decline in type 2 diabetes. Rats with diabetes supplemented with GA had shorter latency in the water maze, higher expression of PGC-1 alpha and a trend for greater ATBP protein expression in the hippocampus.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Nutrition & Dietetics
Ning Ding, Hanxiu Meng, Chao Wu, Wallace Yokoyama, Hui Hong, Yongkang Luo, Yuqing Tan
Summary: This study found that whey protein hydrolysate has the potential to improve cognitive degeneration. Interventions with whey protein hydrolysate improved cognitive abilities and reduced the levels of A beta(1-42) in the brain tissue and serum of mice. It also alleviated neuronal damage in the hippocampus and altered the abundance of gut microbe related to Alzheimer's disease.
Article
Pharmacology & Pharmacy
Ghada A. A. Omran, Eman S. H. Abd Allah, Sherine Ahmed Mohammed, Doaa M. M. El Shehaby
Summary: This study evaluated the effects of sub-chronic administration of synthetic cannabinoid WIN55, 212-2 on animal behavior and sex differences in mice. The results showed that WIN55, 212-2 had dose and gender-dependent effects on anxiety symptoms and locomotor activity in mice, with lesser effects in females. Additionally, WIN55, 212-2 affected GABA and glutamate levels significantly, with greater impact on females. Histopathological and CB1 immunohistochemistry analysis revealed no significant biochemical alterations, but increased CB1 receptor expression in female brains.
BMC PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
Horea Stefan Szedlacsek, David Bajusz, Rodica Aura Badea, Andreea Pop, Constantin Catalin Bica, Lilla Ravasz, Daniel Mittli, Dominik Matyas, Georgiana Necula-Petrareanu, Cristian V. A. Munteanu, Ildiko Papp, Gabor Juhasz, Lucian Hritcu, Gyorgy Miklos Keseru, Stefan Eugen Szedlacsek
Summary: Cognitive impairment and learning ability in the brain are directly tied to synaptic plasticity, with AMPAR internalization being linked to the activity of the STEP enzyme. Inhibitors designed to target this process have shown promise in restoring memory deficits and improving anxiety and depression symptoms.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Shima Kouhnavardi, Maureen Cabatic, M. Carmen Manas-Padilla, Marife-Astrid Malabanan, Tarik Smani, Ana Cicvaric, Edison Alejandro Munoz Aranzalez, Xaver Koenig, Ernst Urban, Gert Lubec, Estela Castilla-Ortega, Francisco J. Monje
Summary: Cortisol is a steroid hormone that affects the central nervous system and plays important roles in brain neuronal synaptic plasticity and emotional and behavioral responses. Dysregulation of cortisol is associated with conditions such as Alzheimer's Disease, chronic stress, anxiety, and depression. The effects of cortisol on hippocampal functions and the mechanisms involved in fine-tuning synaptic responses are poorly understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Sara Gazmeh, Maryam Azhir, Leila Elyasi, Mehrdad Jahanshahi, Emsehgol Nikmahzar, Seyed Behnamedin Jameie
Summary: The study found that Apelin-13 can alleviate scopolamine-induced passive avoidance memory impairment and neuronal loss in rats, possibly through regulating hippocampal synaptic protein levels.
METABOLIC BRAIN DISEASE
(2022)
Article
Environmental Sciences
Ali H. Abu Almaaty, Rehab M. Mosaad, Mohamed K. Hassan, Elham H. A. Ali, Ghada A. Mahmoud, Hassan Ahmed, Nahla Anber, Saad Alkahtani, Mohamed M. Abdel-Daim, Lotfi Aleya, Seddik Hammad
Summary: The study evaluated the therapeutic effects of Urtica dioica extracts on memory dysfunction, amnesia, and oxidative stress induced by scopolamine. The results demonstrated that Urtica dioica extracts, particularly nettle root, significantly improved memory deficits and monoamine levels, showing antioxidative stress effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biology
Garrett J. Blair, Changliang Guo, Shiyun Wang, Michael S. Fanselow, Peyman Golshani, Daniel Aharoni, Hugh T. Blair
Summary: This study found that place cells in the hippocampus of rats undergo remapping during the memory of aversive events, indicating that reorganization of hippocampal population codes may play a role in storing memories for aversive events.
Article
Cell Biology
Jinxia Yuan, Guoliang Yuan
Summary: This study investigates the role and mechanism of miRNA-212 in heart failure. The results suggest that miRNA-212 promotes cardiomyocyte hypertrophy by targeting and inhibiting the expression of TCF7L2 gene.
MEDIATORS OF INFLAMMATION
(2022)
Article
Nutrition & Dietetics
Ga-Young Choi, Hyun-Bum Kim, Jae-Min Cho, Inturu Sreelatha, In-Seo Lee, Hee-Seok Kweon, Sehyun Sul, Sun Ae Kim, Sungho Maeng, Ji-Ho Park
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline. Umbelliferone (UMB) is a compound known for its various beneficial properties, including antioxidant and anti-inflammatory effects. Studies have shown that UMB can improve cognitive impairment and enhance learning and memory in AD.
Article
Food Science & Technology
Jingru Zheng, Yuanhong Gao, Jie Ding, Na Sun, Songyi Lin
Summary: The study shows that Antarctic krill peptides can repair scopolamine-induced memory impairment by enhancing SOD activity and ACh level while reducing AChE and MDA levels in hippocampal neurons.
Article
Clinical Neurology
Mahsa Naeeni Davarani, Ali Arian Darestani, Peyman Hassani-Abharian, Salar Vaseghi, Mohammad-Reza Zarrindast, Mohammad Nasehi
Summary: This study investigated the effect of RehaCom on cognitive functions in patients with multiple sclerosis (MS). The results showed that RehaCom treatment improved attention, response control, processing speed, working memory, visuospatial skills, and executive functions in MS patients.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Biochemistry & Molecular Biology
Mitra-Sadat Sadat-Shirazi, Setareh Nouri Zadeh-Tehrani, Ardeshir Akbarabadi, Azarakhsh Mokri, Bahar Taleb Zadeh Kasgari, Mohammad-Reza Zarrindast
Summary: Exercise was found to improve the effect of parental morphine exposure on the offspring's morphine reinforcing effect, potentially through modulation of dopamine receptors, opioid receptors, and Delta FosB levels.
Article
Physiology
Farzan Fathalizade, Matin Baghani, Fatemeh Khakpai, Soheila Fazli-Tabaei, Mohammad-Reza Zarrindast
Summary: The study found that there is an interaction between the histaminergic and GABAergic systems in the modulation of anxiety in mice, suggesting their significant roles in the neurobiology of anxiety behavior.
EXPERIMENTAL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mahshid Ebrahimnejad, Paniz Azizi, Vahide Alipour, Mohammad-Reza Zarrindast, Salar Vaseghi
Summary: This article reviews the conflicting effects of exercise on memory in rodents and discusses the underlying mechanisms. The role of neurotransmitter systems and their interaction with brain-derived neurotrophic factor (BDNF) in modulating exercise effects on memory is highlighted. The article suggests further investigation into the specific effects of different types of exercise on neurotransmitter systems and emphasizes their importance in memory modulation.
NEUROCHEMICAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Salar Vaseghi, Shirin Arjmandi-Rad, Maliheh Eskandari, Mahshid Ebrahimnejad, Gita Kholghi, Mohammad-Reza Zarrindast
Summary: This review study discusses the role of serotonergic receptors in modulating the sleep-wake cycle, learning, and memory function, as well as the effects of sleep deprivation on memory function and its potential interaction with serotonin. There is inconsistency in the pattern of serotonergic function in sleep deprivation and it appears that serotonin may not have a definitive role in the effects of sleep deprivation on memory function. Factors such as the type of serotonergic agents, doses of drugs, and the regulation of serotonergic receptors during memory tasks training are important considerations in the effects of serotonergic signaling on sleep, memory, and sleep deprivation-induced memory impairments.
PHARMACOLOGICAL REPORTS
(2022)
Review
Neurosciences
Mitra-Sadat Sadat-Shirazi, Mahsa Sadeghi-Adl, Ardeshir Akbarabadi, Ghorbangol Ashabi, Azarakhsh Mokri, Mohammad-Reza Zarrindast
Summary: Drug addiction is a chronic relapsing disorder that poses a global problem, influenced by genetics and environmental factors. Recent research has emphasized the role of epigenetics in the intergenerational and transgenerational inheritance of drug addiction. Studies have shown that parental exposure to drugs of abuse (opioids, cocaine, nicotine, alcohol, and cannabis) before conception alters offspring phenotype and impacts neurochemical and neurostructural changes in the brain. This paper reviews the effects of parental drug exposure before gestation in animal models.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Neurosciences
Masoumeh Kourosh-Arami, Alireza Komaki, Mohammad-Reza Zarrindast
Summary: This article summarizes the importance of dopamine in learning and memory, particularly its role in spatial learning and memory. Through the study of dopamine system signaling, it explores the relationship between dopamine and various types of memory, such as reward signaling, working memory, long-term plasticity, and memory consolidation. It also analyzes memory impairment in dopamine-related neurological disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Neurosciences
Fatemeh Khakpai, Yasaman Issazadeh, Niloofar Rezaei, Mohammad-Reza Zarrindast
Summary: The involvement of the opioidergic system in the anxiolytic and antinociceptive responses induced by cholestasis was investigated. The results suggest that cholestasis and addiction can impact anxiety and pain behaviors, with mu-opioid receptors playing a key role in the anxiolytic and analgesic effects induced by cholestasis. Additionally, coadministration of morphine and tramadol can enhance these effects in both cholestatic and addicted mice.
Article
Behavioral Sciences
Naghmeh Saadati, Maryam Bananej, Fatemeh Khakpai, Mohammad -Reza Zarrindast, Hengameh Alibeik
Summary: This study evaluated the effects of co-treatment of orexin agents and citalopram on depression-like behavior and BDNF expression in the prefrontal cortex (PFC) of sleep-deprived male mice. It was found that sleep deprivation increased depression-like behavior while decreasing BDNF expression. Citalopram showed an antidepressant effect, which was potentiated by an orexin antagonist and reversed by orexin-1. The study suggests that the orexin system interacts with citalopram to modulate depression-like behavior in sleep-deprived mice.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Neurosciences
Shirin Arjmandi-Rad, Mohammad-Reza Zarrindast, Sina Shadfar, Mohammad Nasehi
Summary: Sleep deprivation can have both positive and negative effects on memory, depending on the duration. Long-term sleep deprivation impairs spatial learning and memory, decreases antioxidant activity, and increases inflammation. On the other hand, short-term sleep deprivation slightly improves spatial memory and significantly enhances antioxidant activity. Further studies are needed to explore the potential therapeutic effects of sleep deprivation on memory function, oxidative stress, and inflammation.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Genetics & Heredity
Parisa Rahimpour, Mohammad Nasehi, Mohammad -Reza Zarrindast, Solmaz Khalifeh
Summary: This study aimed to assess the effects of sleep deprivation (SD) and luteolin on spatial learning and memory. The results showed that luteolin dose-dependently restored SD-induced spatial memory impairment, possibly through modulating the levels of heat shock protein 70 and heat shock protein 90.
Review
Endocrinology & Metabolism
Salar Vaseghi, Ali Mostafavijabbari, Mohammad-Sadegh Alizadeh, Reza Ghaffarzadegan, Gita Kholghi, Mohammad-Reza Zarrindast
Summary: This review article discusses the intricate roles of sleep deprivation (SD) in modulating depression. The inconsistent effects of SD on depression have been studied for decades, with a focus on SD duration. However, the inconsistent role of SD seems to be more complicated, and other factors such as brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), serotonin, cortisol, and tumor necrosis factor-alpha (TNF-alpha) are involved. It was concluded that SD has inconsistent effects on BDNF, VEGF, serotonin, and cortisol levels. The diurnal rhythm of BDNF is significant in the modulatory role of SD in depression. VEGF is important in blood-brain barrier permeability which affects depression. Furthermore, there is a negative correlation between cortisol and BDNF, modulating depression. TNF-alpha regulates sleep/wake cycle and increases blood-brain barrier permeability, resulting in depressive behavior. Future studies should focus on these mechanisms/factors to better understand the complex roles of SD in modulating depression.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Gita Kholghi, Vahide Alipour, Maede Rezaie, Mohammad-Reza Zarrindast, Salar Vaseghi
Summary: Sleep deprivation has negative effects on cognitive functions, but some studies suggest it may improve cognitive functions. This study investigated the effects of 4-hour and 24-hour sleep deprivation, as well as mild short-term and moderate long-term treadmill exercise, on spatial memory performance and oxidative and antioxidant markers in rats. The results showed that 24-hour sleep deprivation and long-term moderate treadmill exercise had negative effects on memory and oxidative status. However, both treadmill exercise protocols reversed the negative effects of sleep deprivation on memory and oxidative stress.
NEUROCHEMICAL RESEARCH
(2023)
Article
Psychology, Biological
Sakineh Alijanpour, Zahra Ghasemzadeh, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindast
Summary: Evidence suggests that the amygdala endocannabinoid system plays a role in pain processing and mediates the antinociceptive effects of harmaline.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Medicine, Research & Experimental
Vahide Alipour, Ramin Shabani, Mohammad-Reza Zarrindast, Farhad Rahmani-Nia, Mohammad Nasehi
Summary: This study found that moderate exercise can improve stereotypical behaviors in rats with ASD, providing an effective treatment option for ASD.
GALEN MEDICAL JOURNAL
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
