Article
Chemistry, Multidisciplinary
Keke Hu, Emily Relton, Nicolas Locker, Nhu T. N. Phan, Andrew G. Ewing
Summary: SGs encapsulate ROS, predominantly H2O2, and may act as communicators of cellular stress, regulating cellular metabolism and stress responses to provide cytoprotection in pathological conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Behavioral Sciences
Ahmad Tarmizi Che Has
Summary: Status epilepticus is a neurological disorder with various neuropathological conditions and presentations. Animal models, particularly the chemically induced pilocarpine model, have been used to understand and replicate its manifestations. However, there are challenges in inducing the model, such as morbidity and mortality rates. Modifications, including dose fractionation and lithium-pilocarpine model, have been introduced to tackle these issues. Despite the drawbacks, this model has proven its relevance and has been improved since its discovery in 1983.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Efrat Shavit-Stein, Shani Berkowitz, Tal Davidy, Uri Fennig, Shani Guly Gofrit, Amir Dori, Nicola Maggio
Summary: This study evaluated the effects of thrombin pathway inhibition in a mice model of SE and found that thrombin is involved in memory impairment and cognitive dysfunction. Inhibiting the thrombin pathway can prevent cognitive impairment and reduce neuronal damage.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Asheebo Rojas, Radhika Amaradhi, Avijit Banik, Chunxiang Jiang, JuanMartin Abreu-Melon, Sarah Wang, Raymond Dingledine, Thota Ganesh
Summary: Pilocarpine-induced SE results in hippocampal neurodegeneration and persistent inflammation, while inhibiting the EP2 receptor with TG8-260 can significantly reduce neuroinflammation and gliosis following SE.
Article
Clinical Neurology
Matthew C. Walker
Summary: It is recognized that status epilepticus can cause neuronal damage through excessive activation of NMDA receptors, leading to neuronal death. The generation of free radicals and reactive oxygen and nitrogen species plays a key role in this process. Recent evidence suggests that NADPH oxidase, rather than mitochondria, is a prominent source of reactive oxygen species. Therapies targeting reactive oxygen species production or removal have shown neuroprotective and antiepileptogenic effects, with the combination of NADPH oxidase inhibition and increased endogenous antioxidants offering the greatest benefits.
Article
Biochemistry & Molecular Biology
Petr Fabera, Libor Uttl, Hana Kubova, Grygoriy Tsenov, Pavel Mares
Summary: LiCl/pilocarpine status epilepticus induces changes in ADK isoform expression and inhibiting ADK with 5-ITU affects hippocampal excitability. The study shows that SE leads to decreased excitability in immature rats 3 days after induction, followed by increased excitability after 20 days. 5-ITU demonstrates inhibitory effects on hippocampal excitability in SE rats. ADK isoforms also show altered expression levels in SE rats, indicating their involvement in hippocampal excitability and brain development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Zhongrui Liu, Ziting Zhu, Yan He, Qiyun Kang, Fei Li, Wenlong Zhang, Yuehua He, Yuwan Lin, Baoyi Huang, Mingshu Mo, Pingyi Xu, Xiaoqin Zhu
Summary: The novel H2S donor synthesized in this study has been shown to effectively reduce seizures in animal models and in vitro experiments by regulating microglial inflammatory response. This suggests that the novel H2S donor may have a new mechanism and potential therapeutic strategy for anti-seizures.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Andy Wai Kan Yeung, Nikolay T. Tzvetkov, Maya G. Georgieva, Iliyan V. Ognyanov, Karolina Kordos, Artur Jozwik, Toni Kuhl, George Perry, Maria Cristina Petralia, Emanuela Mazzon, Atanas G. Atanasov
Summary: This research analyzed the literature on neurodegenerative diseases associated with ROS, identifying the US as the major contributor, the 21st century as the main publication time, and China, South Korea, and India as emerging major contributors. The study primarily focused on diseases such as AD, PD, and ALS, with future research directions emphasizing mitochondrial dysfunction, autophagy, and nuclear factor 2 related factor 2.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Nagwa I. Shehata, Mai A. Abdelsamad, Hebat Allah A. Amin, Nermin A. H. Sadik, Amira A. Shaheen
Summary: This study aimed to evaluate the potential neuroprotective effects of ketogenic diet (KD) against neuronal disruptions induced by status epilepticus (SE). Results showed that KD could improve neurotransmitter balance, oxidative stress and inflammatory response, reduce neuronal damage, and preserve neuronal integrity.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Neurosciences
Doodipala Samba Reddy, Marcus Zaayman, Ramkumar Kuruba, Xin Wu
Summary: Status epilepticus (SE) is a medical emergency characterized by continuous seizure activity that leads to severe neuronal damage, morbidity, or death. The induction of SE can be caused by various triggers, such as chemoconvulsants like pilocarpine and organophosphates like DFP and soman. These agents share a common feature of cholinergic crisis leading to refractory SE, but their comparative profiles are still unclear. Results from this study revealed distinct convulsant and neuronal injury patterns following exposure to cholinergic agonists, OP pesticides, and nerve agents, highlighting the importance of understanding different SE models for the development of new anticonvulsant therapies.
Article
Immunology
Sree Lalitha Bojja, Bikash Medhi, Shashi Anand, Alka Bhatia, Rupa Joshi, Ranjana W. Minz
Summary: The study found that metformin can alleviate seizure-induced inflammation and neuronal degeneration, potentially mediated by the mTOR pathway.
INFLAMMOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mengying He, Mengyuan Wang, Tao Xu, Mengyao Zhang, Huaxing Dai, Chao Wang, Dawei Ding, Zhiyuan Zhong
Summary: Reactive oxygen species (ROS) act as important signaling molecules that can stimulate the immune system. ROS has emerged as a unique therapeutic strategy for malignant tumors because it can directly reduce tumor burden and induce immunogenic cell death (ICD) to trigger immune responses. However, immunosuppressive signals and dysfunction of immune cells within the tumor microenvironment (TME) often downplay the anti-tumor immune responses. Various strategies have been developed to enhance ROS-based cancer immunotherapy, such as combining with immune checkpoint inhibitors, tumor vaccines, and immunoadjuvants, which have shown promising results with limited side effects. This review introduces the concept of ROS-powered cancer immunotherapy, highlights innovative strategies to boost ROS-based cancer immunotherapy, and discusses challenges in clinical translation and future perspectives.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Cell Biology
Sheba M. J. MohanKumar, Abarna Murugan, Arunkumar Palaniyappan, Puliyur S. Mohankumar
Summary: Aging has profound effects on the brain, and changes in immune cells play an important role. Immunosenescence and Inflammaging contribute to a pro-inflammatory state in the brain, leading to detrimental changes in brain structure, function, and repair, resulting in a decline in central and neuroendocrine function.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Article
Physiology
Murilo E. Graton, Bruno H. S. H. Ferreira, Jessica A. Troiano, Simone. R. R. Potje, Gabriel. T. T. Vale, Ana Claudia M. S. Nakamune, Carlos R. Tirapelli, Francis. J. J. Miller, Valdecir. F. F. Ximenes, Cristina Antoniali
Summary: This study compared the effects of apocynin and protocatechuic acid on hypertensive rats and vascular cells. Both compounds showed antioxidant and free radical scavenging abilities, and were able to decrease oxidative stress damage. Additionally, they increased nitric oxide levels and reduced vascular constriction. Therefore, these compounds have potential therapeutic importance in the treatment of vascular diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Yingying Wang, Yingshuang Song, Qi Zhong, Yaqin Wu, Jiabao Zhuang, Fang Qu, Chun Xu
Summary: The study revealed that cyclic stretch induces inflammatory reaction and ROS production in human periodontal ligament cells (HPDLCs). The inflammatory reaction was inhibited by the antioxidant apocynin through blocking ROS production. Additionally, cyclic stretch also induced the expression of caspase-1 and NLRP3 inflammasome, which was inhibited by apocynin.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Erika R. Kinjo, Guilherme S. V. Higa, Bianca A. Santos, Erica de Sousa, Marcio V. Damico, Lais T. Walter, Edgard Morya, Angela C. Valle, Luiz R. G. Britto, Alexandre H. Kihara
SCIENTIFIC REPORTS
(2016)
Article
Neurosciences
Erika Reime Kinjo, Pedro Xavier Royero Rodriguez, Bianca Araujo dos Santos, Guilherme Shigueto Vilar Higa, Mariana Sacrini Ayres Ferraz, Christian Schmeltzer, Sten Rudiger, Alexandre Hiroaki Kihara
MOLECULAR NEUROBIOLOGY
(2018)
Review
Neurosciences
Lais Takata Walter, Guilherme Shigueto Vilar Higa, Juliane Midori Ikebara, Danila Vedovello, Felipe Scassi Salvador, Silvia Honda Takada, Erika Reime Kinjo, Benjamin J. Whalley, Marcia Aparecida Speranca, Alexandre Hiroaki Kihara
MOLECULAR NEUROBIOLOGY
(2018)
Article
Neurosciences
Erika Reime Kinjo, Guilherme Shigueto Vilar Higa, Erica de Sousa, Otavio Augusto Nocera Casado, Marcio Vinicius Damico, Luiz Roberto G. Britto, Alexandre Hiroaki Kihara
EXPERIMENTAL NEUROLOGY
(2013)
Article
Neurosciences
Lais Takata Walter, Guilherme Shigueto Vilar Higa, Christian Schmeltzer, Erica Sousa, Erika Reime Kinjo, Sten Ruediger, Dania Emi Hamassaki, Giselle Cerchiaro, Alexandre Hiroaki Kihara
EXPERIMENTAL NEUROLOGY
(2014)
Article
Immunology
Marina S. Hernandes, Joana C. D'Avila, Silvia C. Trevelin, Patricia A. Reis, Erika R. Kinjo, Lucia R. Lopes, Hugo C. Castro-Faria-Neto, Fernando Q. Cunha, Luiz R. G. Britto, Fernando A. Bozza
JOURNAL OF NEUROINFLAMMATION
(2014)
Article
Neurosciences
Guilherme Shigueto Vilar Higa, Erica de Sousa, Lais Takata Walter, Erika Reime Kinjo, Rodrigo Ribeiro Resende, Alexandre Hiroaki Kihara
MOLECULAR NEUROBIOLOGY
(2014)
Article
Multidisciplinary Sciences
Erika R. Kinjo, Guilherme S. V. Higa, Edgard Morya, Angela C. Valle, Alexandre H. Kihara, Luiz R. G. Britto
Article
Neurosciences
Jianxiong Jiang, Ying Yu, Erika Reime Kinjo, Yifeng Du, Hoang Phuong Nguyen, Ray Dingledine
Article
Neurosciences
Pedro Xavier Royero, Guilherme Shigueto Vilar Higa, Daiane Soares Kostecki, Bianca Araujo dos Santos, Cayo Almeida, Kezia Accioly Andrade, Erika Reime Kinjo, Alexandre Hiroaki Kihara
EXPERIMENTAL NEUROLOGY
(2020)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)