期刊
NEUROSCIENCE LETTERS
卷 473, 期 2, 页码 126-130出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2010.02.036
关键词
Septic encephalopathy; Hypothalamic-pituitary-adrenal axis; Corticosterone; ACTH
资金
- CNPq
- UNESC
- CAPES
Sepsis is characterized by a systemic inflammatory response of the immune system against an infection, presenting with hypothalamic-pituitary-adrenal (HPA) axis dysfunction, behavior alterations, and high mortality. In this study, we aimed to evaluate the effects of dexamethasone on mortality, anhedonia, circulating corticosterone and adrenocorticotropin hormone (ACTH) levels, body and adrenal gland weight, and aversive memory in sepsis survivor rats. Male Wistar rats underwent sham operation or cecal ligation and perforation (CLP) procedure. Rats subjected to CLP were treated with basic support and dexamethasone (at 0.2 and 2 mg/kg daily for 7 days after CLP, intraperitonially) or saline. After 10 days of sepsis procedure, it was evaluated aversive memory, sweet food consumption, and body and adrenal gland weight. Serum and plasma were also obtained. It was observed that low dose dexamethasone reverted anhedonia, normalized adrenal gland and body weight, corticosterone and ACTH levels, and decreased mortality and avoidance memory impairment, demonstrating that low doses of dexamethasone for moderate periods may be beneficial for sepsis treatment and its sequelae depressive-like parameters and memory impairment. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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