Article
Behavioral Sciences
Sarah Martins Presti-Silva, Alice Laschuk Herlinger, Cristina Martins-Silva, Rita Gomes Wanderley Pires
Summary: Parkinson's disease is the second most common neurodegenerative disease worldwide. Current therapeutic approaches only provide relief for motor symptoms, but do not stop or prevent neurodegeneration. Rosmarinic acid, obtained from plants such as sage and rosemary, has antioxidant and anti-inflammatory properties and could be a potential additional therapy for neurodegenerative disorders. This study evaluated the neuroprotective effects of rosmarinic acid treatment in a murine model of Parkinson's disease.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Shin Jie Yong, Abhimanyu Veerakumarasivam, Wei Ling Lim, Jactty Chew
Summary: Recent research on lactoferrin has revealed its multifunctional roles as an antimicrobial protein, immunomodulatory agent, anticancer agent, and neuroprotective agent. This literature review focuses on lactoferrin's neuroprotective effects and mechanisms against Alzheimer's and Parkinson's diseases, highlighting the involvement of various cellular pathways and proteins. It also discusses the inconsistent findings related to the neuroprotective effects of lactoferrin against Alzheimer's disease.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Katherine E. Olson, Krista L. Namminga, Yaman Lu, Mackenzie J. Thurston, Aaron D. Schwab, Seymour de Picciotto, Sze-Wah Tse, William Walker, Jared Iacovelli, Clayton Small, Brian T. Wipke, R. Lee Mosley, Eric Huang, Howard E. Gendelman
Summary: Restoring the number and function of regulatory T cells through the use of lipid nanoparticles containing GM-CSF mRNA has shown promising results in preclinical Parkinson's disease models, with dose-dependent increases in Treg populations and neuroprotection seen after treatment. This approach represents a novel therapeutic strategy for neurodegenerative disorders by harnessing immune modulation to enhance adaptive immune function.
Review
Chemistry, Medicinal
Victor A. D. Holanda, Julia J. Didonet, Manara B. B. Costa, Adriano H. do Nascimento Rangel, Edilson D. da Silva, Elaine C. Gavioli
Summary: This study explores the role of the neuropeptide S (NPS) and its receptor (NPSR) system in Parkinson's disease (PD), suggesting that the NPS/NPSR system may be an emerging therapeutic strategy for alleviating motor and non-motor dysfunctions of PD and possibly slowing disease progression.
Article
Neurosciences
Urmila Maitra, John Conger, Mary Magdalene (Maggie) Owens, Lukasz Ciesla
Summary: Nature-derived bioactive compounds show potential as prevention and treatment options for chronic illnesses, including neurodegenerative diseases. However, their specific neuroprotective mechanisms remain unclear. Current therapies for neurodegeneration only provide symptomatic relief, calling for novel strategies. Using a Drosophila Parkinson's disease model, we identified flavones as neuroprotective compounds against environmental toxin-induced neurotoxicity, while other flavonoids failed to provide protection. Neuroprotection by flavones involves specific structural features and the involvement of Nrf2 and the IMD pathway. These findings highlight the potential of specific flavonoids for novel therapeutic interventions in neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Fatemeh Mamashli, Ali Akbar Meratan, Atiyeh Ghasemi, Nahal Obeidi, Bahram Salmani, Deyhim Atarod, Mitra Pirhaghi, Faezeh Moosavi-Movahedi, Mahya Mohammad-Zaheri, Mohammad Bagher Shahsavani, Zahra Habibi-Kelishomi, Bahram Goliaei, Mahdi Gholami, Ali Akbar Saboury
Summary: This study compared the neuroprotective effects of bulk and nano forms of propolis polyphenolic fraction (PFP) against Parkinson's disease models. The results showed that the nano form of PFP was more effective in reducing oxidative stress, improving antioxidant enzyme activity, and protecting animals from Parkinson's disease.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Rui-Fang Wang, Yan-Peng Li, Han-Yue Zhang, Sha-Sha Xu, Zhuo Wang, Xing-Min Han, Bao-Ping Liu
Summary: The purpose of this study was to evaluate the association between sleep benefit (SB) phenomenon in Parkinson's disease (PD) patients and dopamine transporter (DAT) expression levels in the striatum. The results showed significant differences in clinical variables, sleep scores, and striatum DAT expression levels between SB and nSB groups. The DAT expression level in the putamen could predict the occurrence of SB phenomenon in PD patients.
Article
Biochemistry & Molecular Biology
Tarek K. Motawi, Rawan H. Al-Kady, Sahar M. Abdelraouf, Mahmoud A. Senousy
Summary: This study investigated the neuroprotective effect of empagliflozin in a rat model of Parkinson's disease by targeting the endoplasmic reticulum (ER) stress pathway. The results showed that empagliflozin could mitigate ER stress, oxidative stress, astrocyte/microglial activation, and neuroinflammation, and improve motor function. These findings highlight the potential therapeutic impact of empagliflozin in Parkinson's disease.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Clinical Neurology
Gregory M. Pontone, Kate M. Perepezko, Jared T. Hinkle, Joseph J. Gallo, Stephen Grill, Jeannie -Marie Leoutsakos, Kelly A. Mills, Howard D. Weiss, Zoltan Mari
Summary: Anxiety associated with dopamine medication fluctuations is a significant problem for individuals with Parkinson's disease. This study aimed to determine whether a specific profile of fluctuating anxiety exists in PD patients and whether it is associated with other symptoms or characteristics. The findings revealed that 31% of participants experienced a worsening in anxiety during the off-dopamine medication state, indicating the potential need for targeted interventions for this subgroup.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Plant Sciences
Yu Zhang, Sheng Li, Liyan Hou, Mingyang Wu, Jianing Liu, Ruonan Wang, Qingshan Wang, Jie Zhao
Summary: Research found that SVHRSP, a single component extracted from scorpion venom, has neuroprotective effects in Parkinson's disease. The study further discovered that SVHRSP achieves neuroprotection by inhibiting microglia-mediated neuroinflammatory pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Francesco Agostini, Anna Masato, Luigi Bubacco, Marco Bisaglia
Summary: This article reviews the potential mechanisms and clinical applications of metformin in the treatment of Parkinson's disease. Studies have shown that metformin may exert neuroprotective effects by regulating cellular pathways such as autophagy, degradation of pathological proteins, and mitochondrial function. Epidemiological studies on the correlation between long-term metformin use and the risk of developing Parkinson's disease are also discussed. However, there is controversy regarding the results obtained from experimental models and clinical studies, and further research is needed to clarify the mechanisms and efficacy of metformin in the treatment of Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Raul Valdes, Alicia Armijo, Patricia Munoz, Kjell Hultenby, Andres Hagg, Jose Inzunza, Ivan Nalvarte, Mukesh Varshney, Bengt Mannervik, Juan Segura-Aguilar
Summary: The enzyme glutathione transferase M2-2 is shown to prevent the toxic effects of aminochrome by catalyzing its conjugation. It is released in exosomes from U373MG cells, providing a mechanism for intercellular transport of the enzyme. This mechanism may help astrocytes protect dopaminergic neurons against aminochrome-induced damage.
NEUROTOXICITY RESEARCH
(2021)
Article
Chemistry, Medicinal
Shiou-Shiow Farn, Kang-Wei Chang, Wan-Chi Lin, Hung-Man Yu, Kun-Liang Lin, Yu-Chin Tseng, Yu Chang, Chung-Shan Yu, Wuu-Jyh Lin
Summary: Novel PET tracer IPCAT-NOTA 24 was successfully synthesized with high radiochemical yield and specific activity, showing promising stability and binding affinity in biological studies.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Clinical Neurology
Han-Kyeol Kim, Myung Jun Lee, Han Soo Yoo, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyoo
Summary: This study established a temporal trajectory model for dopaminergic input in the striatal subregions in Parkinson's disease (PD), and found that its loss is sequential and correlated with motor severity. This model may be beneficial for evaluating individual disease progression.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Alejandro Quintero-Villegas, Sergio Ivan Valdes-Ferrer
Summary: 5-HT7 receptors are the most recently identified among serotonin receptors, and their role in neurodegenerative diseases is not fully understood. This review discusses the signaling pathways and cellular mechanisms involved in 5-HT7R activation, as well as the potential therapeutic implications of pharmacological interventions for 5-HT7R signaling in neurodegeneration.
MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)