Article
Environmental Sciences
Qingyuan Guo, Xiao Chen, Kai Yang, Jianwei Yu, Feng Liang, Chunmiao Wang, Bairen Yang, Tianming Chen, Zhaoxia Li, Xuan Li, Cheng Ding
Summary: A study identified fishy odorants produced by four algae separated from Yanlong Lake and evaluated their contribution to fishy odor profile. It found that Cryptomonas ovate, Dinobryon sp., Synura uvella, and Ochromonas sp. were associated with fishy odor. Sixteen odorants were verified in the separated algae and were linked to fishy odor. The research provides a comprehensive understanding of controlling and managing fishy odor in drinking water.
Article
Physiology
Liyuan Sun, Xueqin Pan, Hongwei Li, Xinyang Zhang, Xincheng Zhao, Liwei Zhang, Long Zhang
Summary: This study identifies a panel of chemical cues that induce evident vomiting in locust nymphs and demonstrates the selective combinatorial coding strategy employed by palp olfactory receptor neurons (ORNs). Suppression or enhancement of specific odorant receptors can modulate the intensity of vomiting evoked by certain chemicals. The neural projection pathway involved in vomiting is also revealed.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rui Xu, Xiaojing Cong, Qian Zheng, Lun Xu, Mengjue J. Ni, Claire A. March, Hiroaki Matsunami, Jerome Golebiowski, Minghong Ma, Yiqun Yu
Summary: This study investigated the heterologous expression and functional assays of over 80 OR variants and chimeras. The results showed that the transmembrane domain 4 (TM4) and its interactions with neighboring residues play important roles in OR functional expression. Modifications in TM4 can rescue ORs that fail to reach the cell membrane. Additionally, modifications in MOR256-3 (Olfr124) were found to alter OR responses to odorants.
Article
Biochemistry & Molecular Biology
Alice Roche, Nathalie Mejean Perrot, Thierry Thomas-Danguin
Summary: In the field of odor perception, expert perfumers or flavorists create specific odor objects using mental combinations of odor qualities. This paper introduces an ontology to bridge the gap between molecular composition and odor perception and description.
Article
Environmental Sciences
Yipu Pei, Ning Liu, Shihua Liu, Hongyan Guan, Zhongbao Guo, Qiannan Li, Wei Han, Hanmei Cai
Summary: This study aimed to explore the evaluation method for odor concentration of coating products and its key influencing factors. By studying the recovery rate of different materials and the influences of sample curing and odor emission times on odor concentration, it was found that the odor concentration method more accurately and reliably discriminated coating products than the odor intensity method. Meanwhile, the key odorants in different coatings were determined using the odor activity value method.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Review
Cell Biology
Smija M. Kurian, Rafaella G. Naressi, Diogo Manoel, Ann-Sophie Barwich, Bettina Malnic, Luis R. Saraiva
Summary: Odor detection starts with the activation of odorant receptors in mature olfactory sensory neurons, and different odorants activate unique receptors, providing an explanation for perceiving different odors. Recent studies have found that antagonist interactions play an important role in the formation of combinatorial receptor code.
CELL AND TISSUE RESEARCH
(2021)
Article
Engineering, Electrical & Electronic
Hongchao Deng, Hidefumi Mitsuno, Ryohei Kanzaki, Shuhei Nomoto, Takamichi Nakamoto
Summary: Gas-phase odor biosensors based on cells expressing olfactory receptors (ORs) have favorable detection characteristics but suffer from nonlinearity, drift, and aging problems. This study developed a gas-phase odorant fast quantification method to speed up the quantification procedure. By controlling the stimulation duration and using curve fitting, an unknown odor intensity can be accurately quantified, overcoming nonlinearity issues. The biosensor response was calibrated based on known odor stimulations to address drift and aging problems. The fast quantification method was successfully achieved in 400 s, and its feasibility was verified on different odorants.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Daigo Terutsuki, Tomoya Uchida, Chihiro Fukui, Yuji Sukekawa, Yuki Okamoto, Ryohei Kanzaki
Summary: In this study, a fully autonomous small drone with a portable electroantennogram (EAG) based on silkmoth antennae was developed for real-time odorant concentration detection. Enhanced sensor directivity enabled the drone to recognize odor source locations without a wind direction sensor. This study proposes an efficient flight platform for detecting odorant molecules and localizing their sources.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Agricultural Engineering
Qian Zhu, Jingping Hu, Bingchuan Liu, Sha Liang, Keke Xiao, Wenbo Yu, Shushan Yuan, Jiakuan Yang, Huijie Hou
Summary: This study investigated the effects of adding tetraethylammonium (TEA), a potassium channel blocker, on the formation of mixed-cultured electroactive biofilms. The results showed that TEA decelerated biofilm formation but selectively enriched Geobacter over time, resulting in higher extracellular electron transfer efficiency. The analysis also indicated adaptive responses of electrogenic biofilms to electrical signaling disruption.
BIORESOURCE TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xin Zhang, Xiulin Lin, Hui Luo, Yuanxing Zhi, Xin Yi, Xiaoyan Wu, Wendi Duan, Ying Cao, Jianxin Pang, Shuwen Liu, Pingzheng Zhou
Summary: Potassium efflux mediated by the Kv1.3 channel plays a critical role in TLR3/4 activation, and pharmacological inhibition of Kv1.3 may be beneficial for treating autoimmune diseases and bacterial infections.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Engineering, Electrical & Electronic
Dani Prasetyawan, Takamichi Nakamoto
Summary: The main idea of odor reproduction is to replicate specific scents by mixing 'base odors'. Despite the complexity of our sense of smell, scientists have been trying to identify combinations of basic smell components that can mimic various scents. The range of reproducible scents depends on the selection of base odors.
IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING
(2023)
Review
Food Science & Technology
Lais Campelo Mendes, Gabriela Magnolia Melo Viana, Ana Leonor Abrahao Nencioni, Daniel Carvalho Pimenta, Emidio Beraldo-Neto
Summary: The scorpion family Buthidae includes arthropods whose venom contains diverse biomolecules, including neurotoxins that target ion channels in cell membranes. Disturbances in ion channel activity can lead to channelopathies, causing a range of diseases. Scorpion peptides offer potential as resources for developing drugs that specifically target ion channels. This review provides a comprehensive overview of ion channels, scorpion toxins, and potential areas for future research, emphasizing the significance of scorpion venom in discovering novel drugs for treating channelopathies.
Article
Biochemistry & Molecular Biology
Yu Peng, Dandan Zhao, Mo Li, Xin Wen, Yuanying Ni
Summary: Plant-based products produced from soy protein isolate (SPI) have higher sodium (Na) content compared to animal-based products. Alternative soy fractionation processes using KOH as a replacement for NaOH have been established to produce low-sodium soy protein fractions (SPFs). The application of KOH increases the protein content, water holding capacity (WHC), and thermal stability of SPFs, while reducing the yields and protein solubility. Overall, the use of KOH provides the possibility to develop low-sodium high-potassium soy protein ingredients for healthy soy-based foods.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Physiology
Sijian Wang, Biyao Wang, Dehao Shang, Kaige Zhang, Xu Yan, Xinwen Zhang
Summary: Ion channel proteins in astrocytes are strongly associated with neurodegenerative disorders by participating in oxidative stress, neuroinflammation, and pathological processes. Understanding these critical proteins and their signaling pathways may provide new therapeutic targets for neurodegenerative diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Woo Sung, Camden M. Driggers, Barmak Mostofian, John D. Russo, Bruce L. Patton, Daniel M. Zuckerman, Show-Ling Shyng
Summary: Regulation of pancreatic KATP channels involves complex interactions between their subunits and ligands. This study investigates the structural changes and ligand interactions associated with channel gating using cryo-EM data. The results show that pharmacological inhibitors and ATP can modulate the channel conformation and affect intra-subunit and inter-subunit interactions.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
G. Li, C. Chen, S. D. Laing, C. Ballard, K. C. Biju, R. L. Reddick, R. A. Clark, S. Li
Article
Neurosciences
K. C. Biju, Robert C. Evans, Kripa Shrestha, Daniel C. B. Carlisle, Jonathan Gelfond, Robert A. Clark
Article
Multidisciplinary Sciences
Cang Chen, Xiuhua Li, Guo Ge, Jingwei Liu, K. C. Biju, Suzette D. Laing, Yusheng Qian, Cori Ballard, Zhixu He, Eliezer Masliah, Robert A. Clark, Jason C. O'Connor, Senlin Li
SCIENTIFIC REPORTS
(2018)
Article
Neurosciences
Beverly S. Colley, Melissa A. Cavallin, K. C. Biju, David R. Marks, Debra A. Fadool
Article
Biochemistry & Molecular Biology
G. Li, K. C. Biju, X. Xu, Q. Zhou, C. Chen, A. J. Valente, W. He, R. L. Reddick, G. L. Freeman, S. S. Ahuja, R. A. Clark, S. Li
Article
Biochemistry & Molecular Biology
Archana Gaikwad, K. C. Biju, Vikas Barsagade, Yogesh Bhute, Nishikant Subhedar
JOURNAL OF CHEMICAL NEUROANATOMY
(2009)
Article
Biotechnology & Applied Microbiology
K. C. Biju, Qing Zhou, Guiming Li, Syed Z. Imam, James L. Roberts, William W. Morgan, Robert A. Clark, Senlin Li
Article
Neurosciences
K. C. Biju, Rene A. Santacruz, Cang Chen, Qing Zhou, Jiemin Yao, Sara L. Rohrabaugh, Robert A. Clark, James L. Roberts, Kimberley A. Phillips, Syed Z. Imam, Senlin Li
NEUROSCIENCE LETTERS
(2013)
Article
Neurosciences
Melissa Cavallin Johnson, K. C. Biju, Joshua Hoffman, Debra Ann Fadool
NEUROSCIENCE LETTERS
(2013)
Article
Multidisciplinary Sciences
Linlin Cong, Eric R. Muir, Cang Chen, Yusheng Qian, Jingwei Liu, K. C. Biju, Robert A. Clark, Senlin Li, Timothy Q. Duong
Article
Neurosciences
Eric R. Muir, K. C. Biju, Linlin Cong, William E. Rogers, Enrique Torres Hernandez, Timothy Q. Duong, Robert A. Clark
NEUROSCIENCE LETTERS
(2019)
Article
Endocrinology & Metabolism
K. C. Biju, Qiang Shen, Enrique Torres Hernandez, Michael J. Mader, Robert A. Clark
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Article
Behavioral Sciences
Kimberley A. Phillips, Corinna N. Ross, Jennifer Spross, Catherine J. Cheng, Alyssa Izquierdo, K. C. Biju, Cang Chen, Senlin Li, Suzette D. Tardif
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Neurosciences
K. C. Biju, David Ronald Marks, Thomas Gerald Mast, Debra Ann Fadool
JOURNAL OF COMPARATIVE NEUROLOGY
(2008)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)