期刊
NEUROSCIENCE LETTERS
卷 468, 期 3, 页码 300-302出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.11.019
关键词
PACAP; ADCYAP1; Major depressive disorder; Depression; Single nucleotide polymorphism
资金
- Japanese Ministry of Health, Labor and Welfare [H18-kokoro-005, H19-kokoro-002]
- Japanese Ministry of Education, Culture, Sports, Science and Technology [18689030]
- JST
- MEXT [18023045]
- Japan Foundation for Neuroscience and Mental Health
- Grants-in-Aid for Scientific Research [18689030, 18023045] Funding Source: KAKEN
Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1) is a neuropeptide with neurotransmission modulating activity. The associations of the PACAP gene with schizophrenia and hippocampal volume have been reported. We recently reported depression-like behavior in the forced swimming test in PACAP deficient mice. Here we examined a possible association between the PACAP gene and major depressive disorder (MDD) in 637 patients and 967 controls and found that a genetic variant in the gene was associated with MDD. The present results suggest that PACAP signaling might contribute to the pathogenesis of MDD. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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