Article
Biochemistry & Molecular Biology
Mariana I. Holubiec, Juan I. Romero, Claudia Urbainsky, Manuela Gellert, Pablo Galeano, Francisco Capani, Christopher Horst Lillig, Eva-Maria Hanschmann
Summary: Nucleoredoxin (Nrx), a member of the Thioredoxin protein family, plays a crucial role in redox-mediated signal transduction. It regulates cell differentiation and is essential for maintaining cell morphology. Nrx is involved in increasing the number of glial cells and replenishing neurons lost due to hypoxic insult. These regulatory changes are related to VEGF but not the Wnt/beta-catenin pathway.
Article
Developmental Biology
Elisabeth Kugler, Isabel Bravo, Xhuljana Durmishi, Stefania Marcotti, Sara Beqiri, Alicia Carrington, Brian Stramer, Pierre Mattar, Ryan B. MacDonald
Summary: Cell morphology is important for cell functions, especially for glial cells that rely on complex shape for neuron support. However, accurate and reproducible methods to quantify complex glial cell shape are lacking. To address this, the image analysis pipeline 'GliaMorph' was developed, enabling in-depth understanding of glial cell morphology in the developing and diseased retina.
Review
Cell Biology
Gregory J. Konar, Claire Ferguson, Zachary Flickinger, Matthew R. Kent, James G. Patton
Summary: The study has identified the genetic pathways and components required for retina regeneration, as well as the key regulatory events controlling the process. Muller glia are reprogrammed as adult retinal stem cells, while miRNAs are recognized as key gene regulatory molecules in controlling retina regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Isabella Palazzo, Lisa Kelly, Lindsay Koenig, Andy J. Fischer
Summary: In this study, the researchers investigated different cytokines, growth factors, cell signaling pathways, and damage paradigms that influence NFkB-signaling in the mouse retina. They found that exogenous TNF and IL1 beta can activate NFkB-signaling in Muller glia in undamaged retinas. They also discovered that TLR1/2 agonist indirectly activates NFkB-signaling in Muller glia, but this activation depends on the presence of microglia.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Isabella Palazzo, Levi J. Todd, Thanh V. Hoang, Thomas A. Reh, Seth Blackshaw, Andy J. Fischer
Summary: Muller glia (MG) in mammalian retinas are incapable of regenerating neurons after damage, whereas the MG in lower vertebrates regenerate functional neurons. Identification of cell signaling pathways and gene regulatory networks that regulate MG-mediated regeneration is key to harnessing the regenerative potential of MG. In this study, NFkB signaling was found to play a crucial role in regulating immune cell accumulation and suppressing the neurogenic potential of MG after damage. Inhibition of NFkB enhanced the reprogramming of MG into neuron-like cells. Additionally, TGF beta 2 signaling and suppression of NFI and Id transcription factors were coordinated with NFkB signaling to regulate MG-mediated regeneration.
Article
Cell Biology
Raquel Lourenco, Ana S. Brandao, Jorge Borbinha, Rita Gorgulho, Antonio Jacinto
Summary: This study demonstrates that Yap plays a crucial role in regulating Muller glia response to injury, promoting cell cycle reentry and progenitor cell formation, leading to the differentiation of new photoreceptors in zebrafish retina regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Ye Xie, Bo Chen
Summary: This article discusses the regenerative potential of Muller glia (MG) in the mouse retina, focusing on the progress made in the de novo regeneration of retinal neurons through the reprogramming of MG.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Elisabeth C. Kugler, John Greenwood, Ryan B. MacDonald
Summary: The neurovascular unit is a complex multi-cellular structure consisting of various cell types such as endothelial cells, neurons, glia, smooth muscle cells, and pericytes. While neurovascular coupling is a key function of the NVU, the unit's functionality extends beyond this coupling to include signaling, metabolism, and homeostasis across different components. Glial cells have gained increased attention within the NVU and play central roles in its functionality and disease pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Cuiping Zhou, Xiaoli Zhang, Yuxi Chen, Zihao Lin, Shuqiang Zhang, Zhiqiang Zhang, Lining Cao, Huaijin Guan, Jianfeng Lu, Hui Xu
Summary: Inflammation plays a complex and context-dependent role in retinal regeneration in fish. Different types of immune cells and levels of inflammatory cytokines are present in different retinal regeneration models. Proper levels of inflammation promote the reprogramming and cell cycle re-entry of Muller glia, while excessive inflammation suppresses cell proliferation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Susanne Buerger, Jie Meng, Annette Zwanzig, Mike Beck, Maik Pankonin, Peter Wiedemann, Wolfram Eichler, Jan Darius Unterlauft
Summary: The study demonstrates that both PEDF receptors, PEDF-R and LR, are co-expressed in RGC and R28 retinal precursor cells, and their expression is upregulated by VEGF and under hypoxic conditions. These receptors mediate the pro-survival effects of PEDF on RGC by enhancing the expression of anti-apoptotic and neuroprotective factors. This highlights the importance of both PEDF receptors for the viability of retinal neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Warren A. Campbell, Allen Tangeman, Heithem M. El-Hodiri, Evan C. Hawthorn, Maddie Hathoot, Sydney Blum, Thanh Hoang, Seth Blackshaw, Andy J. Fischer
Summary: A recent study on chick retinas found that fatty acid binding proteins (FABPs) are highly expressed and play a role in regulating the function of glial cells and microglia. Inhibition of FABPs leads to transitions of glial cells to reactive states and suppresses the formation of progenitor cells, while inhibition of fatty acid synthase (FASN) increases microglia proliferation and suppresses progenitor cell formation.
Review
Biochemistry & Molecular Biology
Jana Tureckova, Zuzana Hermanova, Valeria Marchetti, Miroslava Anderova
Summary: TRPV4 is a non-selective cation channel expressed in different cell types of the central nervous system. Activation of TRPV4 by various stimuli mediates Ca2+ influx into the cell and is involved in the modulation of neuronal excitability, control of blood flow, and brain edema formation. It is considered a potential therapeutic target for the treatment of cerebral ischemia, but its expression and function in different cell types need further study and evaluation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Whitney A. Thiel, Zachary Blume, Diana M. Mitchell
Summary: This study found that microglia are primarily responsible for the clearance of dying cells in the developing zebrafish retina, while Muller glia also have a limited role in this process. In the absence of microglia, Muller glia significantly increase their uptake of apoptotic cells, with several of these cells localized with the early phagosome/endosome marker Rab5. Additionally, lysosomal staining also increases in Muller glia in the absence of microglia. These findings highlight the phagocytic capacity and compensatory functions of Muller glia, and emphasize the need to consider the effects of microglial deficiency or depletion on other glial cell types.
Article
Cell Biology
Patrick Boyd, Leah J. Campbell, David R. Hyde
Summary: Zebrafish have the ability to regenerate lost neurons in the retina, which is mediated by Muller glia that divide and produce neuronal precursor cells. The early signals that induce this response are not well understood. Alternative ligands of the Ciliary neurotrophic factor receptor (CNTFR), such as Cardiotrophin-like cytokine factor 1 (Clcf1) and Cytokine receptor-like factor 1a (Crlf1a), are expressed in Muller glia of the light-damaged retina. These ligands are required for Muller glia proliferation in the damaged retina and have a neuroprotective effect. CLCF1/CRLF1 injection protects against rod photoreceptor cell death and induces rod precursor cell proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Michael W. Country, Michael G. Jonz
Summary: By studying the responses of goldfish and rainbow trout retinal cells to hypoxia, it was found that goldfish maintain [Ca2+](i) stably by using mitochondrial ATP-dependent K+ channels (mK(ATP)) to resist excitotoxicity, while rainbow trout experience a rapid increase in [Ca2+](i) during hypoxia, which can be life-threatening.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kirsten A. Wunderlich, Naoyuki Tanimoto, Antje Grosche, Eberhart Zrenner, Milos Pekny, Andreas Reichenbach, Mathias W. Seeliger, Thomas Pannicke, Maria-Thereza Perez
Article
Biochemistry & Molecular Biology
Lysann Wagner, Thomas Pannicke, Ina Frommherz, Katja Sauer, Ju Chen, Antje Grosche
NEUROCHEMICAL RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Juliane Voigt, Antje Grosche, Stefanie Vogler, Thomas Pannicke, Margrit Hollborn, Leon Kohen, Peter Wiedemann, Andreas Reichenbach, Andreas Bringmann
NEUROCHEMICAL RESEARCH
(2015)
Article
Neurosciences
B. -A. Berk, S. Vogler, T. Pannicke, H. Kuhrt, T. B. Garcia, P. Wiedemann, A. Reichenbach, J. Seeger, A. Bringmann
Article
Neurosciences
Silke Agte, Thomas Pannicke, Elke Ulbricht, Andreas Reichenbach, Andreas Bringmann
Review
Neurosciences
Thomas Pannicke, T. Ivo Chao, Miriam Reisenhofer, Mike Francke, Andreas Reichenbach
Article
Ophthalmology
Stefanie Vogler, Margrit Hollborn, Benjamin-Andreas Berk, Thomas Pannicke, Johannes Seeger, Peter Wiedemann, Andreas Reichenbach, Andreas Bringmann
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Stefanie Vogler, Antje Grosche, Thomas Pannicke, Peter Wiedemann, Andreas Reichenbach, Andreas Bringmann
NEUROCHEMICAL RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Stefanie Vogler, Thomas Pannicke, Margrit Hollborn, Matthias Kolibabka, Peter Wiedemann, Andreas Reichenbach, Hans-Peter Hammes, Andreas Bringmann
NEUROCHEMICAL RESEARCH
(2016)
Article
Neurosciences
Stefanie Vogler, Helge Winters, Thomas Pannicke, Peter Wiedemann, Andreas Reichenbach, Andreas Bringmann
NEUROSCIENCE LETTERS
(2016)
Article
Neurosciences
Lysann Wagner, Thomas Pannicke, Vanessa Rupprecht, Ina Frommherz, Cornelia Volz, Peter Illes, Johannes Hirrlinger, Herbert Jaegle, Veronica Egger, Philip G. Haydon, Frank W. Pfrieger, Antje Grosche
Article
Neurosciences
Thomas Pannicke, Lysann Wagner, Andreas Reichenbach, Antje Grosche
NEUROSCIENCE LETTERS
(2018)
Article
Biochemistry & Molecular Biology
Tarcyane Barata Garcia, Thomas Pannicke, Stefanie Vogler, Benjamin-Andreas Berk, Antje Grosche, Peter Wiedemann, Johannes Seeger, Andreas Reichenbach, Anderson Manoel Herculano, Andreas Bringmann
JOURNAL OF NEUROCHEMISTRY
(2014)
Article
Anatomy & Morphology
Christian Roski, Christiane Langrock, Nicole Koerber, Gunnar Habermann, Eberhard Buse, Andreas Reichenbach, Thomas Pannicke, Mike Francke
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2018)
Meeting Abstract
Ophthalmology
Miriam Reisenhofer, Thomas Pannicke, Andreas Reichenbach, Volker Enzmann
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)