Article
Behavioral Sciences
Alexander Weiss, Vanessa A. D. Wilson, William D. Hopkins
Summary: By testing the association between rearing methods and a specific genotype with autism-related phenotypes in chimpanzees, this study found that the phenotype is moderately heritable and chimpanzees reared by their mothers had lower scores. Chimpanzees with an indel deletion genotype had higher scores, but the interaction between genotype and rearing was unexpected based on previous work.
Article
Neurosciences
Krzysztof M. Wilczynski, Aleksandra Stasik, Lena Cichon, Aleksandra Augusciak-Duma, Malgorzata Janas-Kozik
Summary: Autism spectrum disorders (ASD) are a heterogeneous group of disorders that affect every population. Its pathogenesis involves the interaction of genetic and environmental factors. Social communication deficits are the main symptom of ASD, which lead to difficulties in everyday functioning.
Article
Neurosciences
Bo Zhou, Xiaoli Zheng, Yunhua Chen, Xuehui Yan, Jinggang Peng, Yibu Liu, Yi Zhang, Lei Tang, Min Wen
Summary: AVP can significantly improve the social interaction disorder of VPA-induced autism model by modulating the vasopressin pathways. Transcriptome sequencing results showed significant impairments in the nervous system developmental processes in the VPA-induced autism model group compared to the normal group. Pathway enrichment analysis showed dysregulation in the PI3K/AKT and Wnt pathways in the VPA-induced autism model group. AVP treatment improved deficits in oligodendrocyte development and function and enriched pathways related to NOTCH, mitogen-activated protein kinase, and focal adhesion signaling pathways.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Bernard Crespi, Tanya Procyshyn, Mika Mokkonen
Summary: Hormones play a crucial role in coordinating bodily systems with cognition, affect, and behavior, influencing social interactions such as cooperation, competition, isolation, and loneliness. While the adaptive functions of oxytocin and testosterone have been extensively studied, a unified theory for understanding the adaptive functions of arginine vasopressin remains underdeveloped. This article proposes and evaluates the hypothesis that arginine vasopressin mediates adaptive variation in social and sociosexual salience, attention, and behavior in situations involving cooperation with conflict or competition.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Pei-Liang Wu, Xiao Chun Ling, Eugene Yu-Chuan Kang, Kuan-Jen Chen, Nan-Kai Wang, Laura Liu, Yen-Po Chen, Yih-Shiou Hwang, Chi-Chun Lai, Shun-Fa Yang, Wei-Chi Wu
Summary: The study found that TIMP-2 gene polymorphisms are associated with the risk and severity of retinopathy of prematurity (ROP). Individuals with rs12600817 gene polymorphism are more likely to develop ROP and have a higher risk. Individuals with rs2889529 gene polymorphism are correlated with the treatment response of ROP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Hiroki Tanaka, Kuniyuki Nishina, Qiulu Shou, Hidehiko Takahashi, Masamichi Sakagami, Tetsuya Matsuda, Miho Inoue-Murayama, Haruto Takagishi
Summary: This study shows the association between genetic mutations in three genes associated with human sociality and individuals' aversion to inequity. The participants took part in five economic game experiments and their behavioral responses were used to calculate the level of disadvantageous inequity aversion and advantageous inequity aversion. The study found that there was an association between the AVPR1A gene mutation and advantageous inequity aversion, suggesting the important role of AVPR1A in aversion when individuals' gain is greater than that of others.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Peripheral Vascular Disease
Yexiu Sun, Ying Guo, He Xu, Ji Zhao, Di Wu, Jianwei Hu, Dandan Wang, Lei Wu, Hao Peng, Hongmei Li
Summary: This study aimed to investigate the relationship between AVP gene polymorphism and plasma copeptin concentration with the occurrence of hypertension in pregnancy. The results showed that higher plasma copeptin and AVP gene variants are associated with the occurrence of gestational hypertension and preeclampsia with chronic hypertension. The detection of copeptin and AVP gene in the early second trimester improves the predictive ability of traditional factors for gestational hypertension and preeclampsia with chronic hypertension.
JOURNAL OF HYPERTENSION
(2023)
Article
Behavioral Sciences
Xiao-E Cai, Jiao Le, Xiao-Jing Shou, Gao-Wa Wu-Yun, Xiao-Xi Wang, Song-Ping Han, Ji-Sheng Han, Keith M. Kendrick, Rong Zhang
Summary: Children with autism exhibit reduced attention to social paired with nonsocial stimuli compared to typically developing children. Using eye-tracking we show this difference is due to typically developing rather than autistic boys being more influenced by how interesting competing nonsocial objects are. On the other hand, reduced time looking at the eyes in autistic relative to typically developing boys is unaffected by nonsocial object salience. Time spent viewing social stimuli is associated with cognitive development and blood levels of oxytocin.
Article
Neurosciences
Akie Toya, Masahide Fukada, Eiko Aoki, Tohru Matsuki, Masashi Ueda, Shima Eda, Yoshio Hashizume, Akio Iio, Shigeo Masaki, Atsuo Nakayama
Summary: NLGN4X has been identified as the causative gene for familial nonsyndromic autism. Its function is not fully understood due to the lack of a similar gene in rodents. Recent studies have shown that NLGN4 is abundantly expressed in the cerebral cortex, mainly at excitatory synapses. However, the detailed histological distribution of NLGN4, which may be important for its relationship with autistic phenotypes, has not been clarified.
Article
Immunology
Xiaohua Liang, Jian Wang, Yongshi Liu, Lin Wei, Feng Tian, Jianyong Sun, Guoliang Han, Yan Wang, Chao Ding, Zhaolei Guo
Summary: SNPs of COX/PGE2 pathway-related genes are associated with an elevated risk of lung cancer, providing new clues for understanding the pathogenesis and personalized treatment of the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Aeseul Kim, Sun Mi Gu, Haemiru Lee, Dong Eun Kim, Jin Tae Hong, Jaesuk Yun, Hye Jin Cha
Summary: This study found that exposure to Ketamine and NMDA receptor antagonists during pregnancy can lead to psychosis-like behaviors in offspring, such as hyperlocomotion and reduced prepulse inhibition. Additionally, it was discovered that these drugs can increase the expression levels of Avpr1a in the striatum, and overexpression of Avpr1a inhibits PPI. Furthermore, the study showed that Ketamine and methoxetamine treatment can increase GAD67 and GABA levels in the striatum of offspring, causing GABAergic neuronal dysfunction and abnormalities in sensorimotor gating.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Marcos Calderon, Manuel J. More, Gustavo A. Gutierrez, Federico Abel Ponce de Leon
Summary: The project aimed to develop an alpaca single nucleotide polymorphism (SNP) microarray to improve the economic benefits and quality of life for small farm producers. The incorporation of molecular marker technology overcame current limitations for genetic improvement programs.
Article
Multidisciplinary Sciences
Ishtiaque Ahammad, Tabassum Binte Jamal, Arittra Bhattacharjee, Zeshan Mahmud Chowdhury, Suparna Rahman, Md Rakibul Hassan, Mohammad Uzzal Hossain, Keshob Chandra Das, Chaman Ara Keya, Md Salimullah
Summary: GRIN2A is a gene encoding NMDA receptors in the central nervous system, playing a crucial role in synaptic transmission, plasticity, and excitotoxicity. Variants in this gene, particularly the I463S variant, are predicted to have deleterious effects on protein structure and function. Bioinformatics tools were used to assess the impact of these variants, providing valuable insights for future research on GRIN2A-related diseases.
Article
Multidisciplinary Sciences
Yaxin Xu, Wentao Xue, Hongwei Gao, Jiabo Cui, Lingzhi Zhao, Chongge You
Summary: Studies have shown that TLRs gene polymorphisms may play a significant role in HBV and HCV infections, with certain SNPs affecting disease progression and prognosis. However, the exact mechanism of action still requires further exploration.
Review
Genetics & Heredity
Marcello Scala, Eleonora A. Grasso, Giuseppe Di Cara, Antonella Riva, Pasquale Striano, Alberto Verrotti
Summary: Reelin, a protein important for brain development and function, has been associated with autism spectrum disorders (ASD). Genetic variations in the RELN gene, specifically GCC repeats and single nucleotide polymorphisms (SNPs), have been suggested to influence brain development and predispose individuals to ASD. This review critically analyzes the available evidence supporting the link between Reelin deficiency and ASD.
FRONTIERS IN GENETICS
(2022)
Article
Clinical Neurology
Hyun-Jeong Lee, Eun-Hee Kim, Mi-Sun Yum, Tae-Sung Ko, Hyo-Won Kim
BRAIN & DEVELOPMENT
(2018)
Article
Pediatrics
Hyo-Won Kim, Eun-Jin Park, Ji-Hoon Kim, Vitharon Boon-Yasidhi, Jariya Tarugsa, Alexis Reyes, Stella Manalo, Yoo-Sook Joung
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2018)
Review
Psychiatry
Kukju Kweon, Je Sik Yoon, Kee Jeong Park, Seon-Ok Kim, Jin-Ho Choi, Hyo-Won Kim
PSYCHIATRY INVESTIGATION
(2018)
Article
Psychiatry
Sung Woo Joo, Hyo-Won Kim
PSYCHIATRY INVESTIGATION
(2018)
Review
Neurosciences
Kukju Kweon, Hyo-Won Kim
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2019)
Editorial Material
Gastroenterology & Hepatology
Harin Kim, Hyo-Won Kim, Kee Jeong Park
LIVER TRANSPLANTATION
(2021)
Article
Psychiatry
Taeyeop Lee, Kee Jeong Park, Seung-Hyun Shon, Seonok Kim, Hyo-Won Kim
Summary: This study aimed to evaluate the diagnostic stability and developmental trajectories of autism spectrum disorder (ASD) and intellectual disability (ID), and to determine baseline clinical characteristics that affect future diagnosis. The results showed that a subset of children lost their diagnosis of ASD or ID at follow-up, and such diagnostic change was significantly more common in ID compared to ASD. Baseline autism symptomatology was related to ASD at follow-up, and baseline adaptive and visuo-motor function was related to ID at follow-up.
PSYCHIATRY INVESTIGATION
(2022)
Article
Psychology, Developmental
Taeyeop Lee, Hyeji Lee, Soowhee Kim, Kee Jeong Park, Joon-Yong An, Hyo-Won Kim
Summary: This study aimed to investigate the genetic variations that contribute to the early neurodevelopmental outcomes in developmental disabilities (DDs). Through exome sequencing, it was found that the improvement group, compared to the non-improvement group, had a lower number of risk variants in known DD genes and haploinsufficient genes, as well as an overall lower number of putative risk variants. These findings provide a preliminary basis for developing a sequencing analysis model that predicts clinical outcomes.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Psychiatry
Taeyeop Lee, Seonok Kim, Jichul Kim, Kee Jeong Park, Hyo-Won Kim
Summary: This study examined the efficacy of the mobile-based cognitive training program DoBrain for children with developmental disabilities (DDs) compared to general educational apps. The results showed that DoBrain did not have a superior effect on overall cognitive development, regardless of the presence of DD. Careful monitoring of the negative effects of mobile-based cognitive training programs is necessary.
PSYCHIATRY INVESTIGATION
(2022)
Article
Psychology, Developmental
Taeyeop Lee, Hyunjung Park, Jeong-Min Ryu, Namkug Kim, Hyo-Won Kim
Summary: This study aimed to assess the association between media-based exposure to nonsuicidal self-injury (NSSI) and emergency department (ED) visits due to self-harm in Korea. The results showed a significant increase in ED visits due to self-harm, especially in adolescents and young adults, following the exposure to NSSI. Responsible media reporting and guidelines are important in preventing further increase in self-harm. Evaluation: 8 out of 10 points for importance.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Jeonghwan Lee, Jangho Park, Jukab Lee, Joon-Ho Ahn, Chang Sun Sim, Kukju Kweon, Hyo-Won Kim
Summary: Aircraft noise was found to be associated with night waking while road traffic noise showed no significant association with sleep. High levels of aircraft noise in the high-NS group were associated with high degrees of bedtime resistance. In terms of heart rate variability, no significant difference was observed between groups.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Harin Kim, Jeong Min Ryu, Hyo-Won Kim
JOURNAL OF KOREAN MEDICAL SCIENCE
(2020)
Article
Medicine, General & Internal
Jung Won Kim, Hyo-Won Kim, Duk-Soo Moon, Yun Shin Lim, Christopher J. McDougle, Yamini Jagannath Howe
JOURNAL OF KOREAN MEDICAL SCIENCE
(2019)
Article
Psychiatry
Han-Sung Lee, Yejin Kwon, Seung-Hyun Shon, Kee Jeong Park, Hyo-Won Kim
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2019)
Meeting Abstract
Clinical Neurology
Kukju Kweon, Eun-soon Shin, Yeon Ho Joo, Hyo-Won Kim
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
