Article
Clinical Neurology
Marta Gonzalez-Sepulveda, Joan Compte, Thais Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Nuria Penuelas, Marina Lorente-Picon, Annabelle Parent, Jordi Romero-Gimenez, Joana M. Cladera-Sastre, Ariadna Laguna, Miquel Vila
Summary: Neurons that accumulate the highest levels of neuromelanin with age are also the most susceptible to degeneration in Parkinson's disease. Using a neuromelanin-producing rat model, Gonzalez-Sepulveda, Compte et al. show that slowing down age-dependent neuromelanin production can help prevent Parkinson's disease-like features.
Review
Cell Biology
Samir Kumar Beura, Abhishek Ramachandra Panigrahi, Pooja Yadav, Sunil Kumar Singh
Summary: Parkinson's disease is a common neurodegenerative disease characterized by motor and non-motor dysfunctions. Platelets play an important role in Parkinson's disease and may be a target for treatment.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Vandana Zaman, Kelsey P. Drasites, Ali Myatich, Ramsha Shams, Donald C. Shields, Denise Matzelle, Azizul Haque, Narendra L. Banik
Summary: In this study, the researchers found that the activation of calpain-1 and calpain-2 in a nigrostriatal pathway has different effects on glial activation and neuronal survival in the Parkinson's disease (PD) model. They also found that attenuating calpain-2 may be important in reducing the loss of substantia nigra (SN) neurons in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Toshiharu Nagatsu, Akira Nakashima, Hirohisa Watanabe, Shosuke Ito, Kazumasa Wakamatsu
Summary: Parkinson's disease is an aging-related neurodegenerative disease characterized by movement disorders and deficiency of dopamine. Lewy bodies and abnormal accumulation of neuromelanin are the histopathological hallmarks of Parkinson's disease, leading to cell death of dopamine neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Vignayanandam Ravindernath-Jayashree Muddapu, Karthik Vijayakumar, Keerthiga Ramakrishnan, V. Srinivasa Chakravarthy
Summary: Parkinson's disease is caused by the progressive loss of dopaminergic cells in the substantia nigra pars compacta, possibly linked to metabolic deficiency. L-DOPA treatment for PD may have toxic effects on neurons. A proposed computational model aims to investigate the mechanism behind neurodegeneration and offer insights for therapeutic development.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Tushar Kamath, Evan Z. Macosko
Summary: Parkinson's disease is characterized by the death of dopaminergic neurons in the substantia nigra. Recent advances in genomic profiling have identified specific pathways and genetic variants involved in the susceptibility of dopaminergic neurons in Parkinson's disease. This provides new opportunities for understanding and developing therapies for this complex disorder.
MOVEMENT DISORDERS
(2023)
Review
Endocrinology & Metabolism
Vandana Zaman, Donald C. Shields, Ramsha Shams, Kelsey P. Drasites, Denise Matzelle, Azizul Haque, Narendra L. Banik
Summary: Parkinson's disease is a neurodegenerative disorder linked to the loss of dopaminergic neurons in the substantia nigra. The disease's etiology is still unclear, but interactions between external and internal factors may play a crucial role in its onset and progression. Research in animal models and post-mortem human tissue has identified cellular and molecular changes in the diseased brain, indicating complex interactions between different glial cell types and molecular pathways.
METABOLIC BRAIN DISEASE
(2021)
Article
Clinical Neurology
Ada Ledonne, Mariangela Massaro Cenere, Emanuela Paldino, Vincenza D'Angelo, Sebastian Luca D'Addario, Nicolas Casadei, Annalisa Nobili, Nicola Berretta, Francesca R. Fusco, Rossella Ventura, Giuseppe Sancesario, Ezia Guatteo, Nicola Biagio Mercuri
Summary: Prolonged overexpression of alpha-synuclein has detrimental effects on the structural and functional properties of substantia nigra pars compacta dopamine neurons, including compromised soma and dendritic arborization, increased firing activity, and altered ion channel function.
MOVEMENT DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Xingxing Jian, Guihu Zhao, He Chen, Yanhui Wang, Jinchen Li, Lu Xie, Bin Li
Summary: This study utilized transcriptomics analysis to identify several hub DEGs between PD patients and normal controls, showing high correlations among these genes. A Cox model with an eight-gene signature was constructed to predict PD progression and survival successfully in an independent dataset, highlighting the clinical significance of these findings.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Cell Biology
Takuya Hikima, Christian R. Lee, Paul Witkovsky, Julia Chesler, Konstantin Ichtchenko, Margaret E. Rice
Summary: Research suggests that somatodendritic dopamine release in the substantia nigra pars compacta autoinhibits the neuron that releases it.
Article
Biochemistry & Molecular Biology
Jessica IChi Lai, Alessandra Porcu, Benedetto Romoli, Maria Keisler, Fredric P. P. Manfredsson, Susan B. B. Powell, Davide Dulcis
Summary: This study investigated the mechanism of how nicotine-induced dopamine (DA) plasticity protects substantia nigra (SN) neurons against nigrostriatal damage in Parkinson's disease (PD). The results showed that chronic nicotine treatment led to upregulation of transcription factor Nurr1 and DA-synthesizing enzyme tyrosine hydroxylase (TH) in GABAergic neurons in the SN. Nicotine also reduced the number of alpha-synuclein-expressing neurons and rescued motor deficits in PD mice. Importantly, the activation of GABA neurons and Nurr1 overexpression were sufficient to mimic nicotine-mediated dopamine plasticity. This study provides insights into developing new strategies for neurotransmitter replacement in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Kathleen Carmichael, Rebekah C. Evans, Elena Lopez, Lixin Sun, Mantosh Kumar, Jinhui Ding, Zayd M. Khaliq, Huaibin Cai
Summary: This review focuses on a distinct group of dopamine-producing neurons, which show significant loss in Parkinson's disease patients. These neurons can be easily identified by selective expression of ALDH1A1 and play a crucial role in regulating movement intensity. The study summarizes the connectivity and functionality of these neurons, as well as the mechanisms regulating their activity and their implications for potential Parkinson's disease treatment.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Cell Biology
Hao Yu, Xiaojie Liu, Bixuan Chen, Casey R. Vickstrom, Vladislav Friedman, Thomas J. Kelly, Xiaowen Bai, Li Zhao, Cecilia J. Hillard, Qing-Song Liu
Summary: The selective CB2 agonist GW842166x has protective effects against 6-OHDA-induced loss of dopamine neurons and associated motor deficits in mice, potentially through modulation of dopamine neuron firing activity. The neuroprotective effects of GW842166x were prevented by the CB2 receptor antagonist AM630, indicating a CB2-dependent mechanism. Electrophysiological recordings suggest that GW842166x may reduce dopamine neuron vulnerability to 6-OHDA by decreasing action potential firing and associated calcium load.
Review
Biochemistry & Molecular Biology
Ezia Guatteo, Nicola Berretta, Vincenzo Monda, Ada Ledonne, Nicola Biagio Mercuri
Summary: This article focuses on the functional properties of nigral dopaminergic neurons and summarizes the shared or unique features of neuronal dysfunction in different stages of PD animal models, with the goal of illustrating the functional modifications occurring in these neurons during disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Xishun Ma, Tongxia Li, Lizhen Du, Tongliang Han
Summary: Parkinson's disease is a common nervous system disease with motor retardation and resting tremor as its main manifestations. Early diagnosis of Parkinson's disease is difficult, but transcranial sonography has been widely used for its diagnosis and treatment. This article reviews the recent advances in the study of Parkinson's disease using transcranial sonography.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Alberto J. Espay, Joaquin A. Vizcarra, Luca Marsili, Anthony E. Lang, David K. Simon, Aristide Merola, Keith A. Josephs, Alfonso Fasano, Francesca Morgante, Rodolfo Savica, J. Timothy Greenamyre, Franca Cambi, Tritia R. Yamasaki, Caroline M. Tanner, Ziv Gan-Or, Irene Litvan, Ignacio F. Mata, Cyrus P. Zabetian, Patrik Brundin, Hubert H. Fernandez, David G. Standaert, Marcelo A. Kauffman, Michael A. Schwarzschild, S. Pablo Sardi, Todd Sherer, George Perry, James B. Leverenz
Article
Toxicology
Briana R. De Miranda, Marco Fazzari, Emily M. Rocha, Sandra Castro, J. Timothy Greenamyre
TOXICOLOGICAL SCIENCES
(2019)
Article
Toxicology
Vivek Lawana, Se Young Um, Jean-Christophe Rochet, Robert J. Turesky, Jonathan H. Shannahan, Jason R. Cannon
TOXICOLOGICAL SCIENCES
(2020)
Article
Neurosciences
Emily M. Rocha, Briana R. De Miranda, Sandra Castro, Robert Drolet, Nathan G. Hatcher, Lihang Yao, Sean M. Smith, Matthew T. Keeney, Roberto Di Maio, Julia Kofler, Teresa G. Hastings, J. Timothy Greenamyre
NEUROBIOLOGY OF DISEASE
(2020)
Article
Pharmacology & Pharmacy
Tauqeerunnisa Syeda, Rachel M. Foguth, Emily Llewellyn, Jason R. Cannon
Article
Computer Science, Interdisciplinary Applications
Brian Z. Bentz, Sakkarapalayam M. Mahalingam, Daniel Ysselstein, Paola C. Montenegro, Jason R. Cannon, Jean-Christophe Rochet, Philip S. Low, Kevin J. Webb
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Review
Biochemistry & Molecular Biology
Tauqeerunnisa Syeda, Jason R. Cannon
Summary: Alzheimer's disease is a major public health crisis due to cognitive symptoms and lack of curative treatments, with most cases occurring after age 65 and implicating environmental factors in disease pathogenesis. Environmental neurotoxicants have been linked to neurodegenerative disorders, but the biochemical and molecular basis of AD-relevant environmental neurotoxicity remains poorly understood. More research is needed to determine whether BACE1 is a critical mediator of AD-related neurotoxicity, but existing evidence suggests that BACE1 is altered by environmental risk factors associated with AD pathology.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Neurosciences
Vivek Lawana, Se Young Um, Rachel M. Foguth, Jason R. Cannon
Review
Chemistry, Medicinal
Tauqeerunnisa Syeda, Jason R. Cannon
Summary: This review summarizes and critically evaluates previous studies on HAAs-induced neurotoxicity and the potential neurotoxic effects of HAAs. The available studies provide strong evidence that HAAs may impact neurological function and addressing the adverse neurological outcomes is crucial.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Review
Chemistry, Medicinal
Josephine M. Brown-Leung, Jason R. Cannon
Summary: Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants found in the environment and living organisms, including humans. They have the potential to cause neurotoxicity and have been linked to ADHD, Parkinson's disease, and Alzheimer's disease. Studies suggest that PFAS disrupt neurotransmission in the brain, particularly affecting dopamine and glutamate systems.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Toxicology
Shreesh Raj Sammi, Tauqeerunnisa Syeda, Kendra D. Conrow, Maxwell C. K. Leung, Jason R. Cannon
Summary: Organophosphate (OP) pesticides, like CPF, have irreversible neurotoxic effects on dopaminergic neurons. CPF reduces mitochondrial content and is associated with specific genes, cyp-35A2 and cyp-35A3. Mitochondria may be a common target for all OP pesticide parent compounds.
TOXICOLOGICAL SCIENCES
(2023)
Article
Food Science & Technology
Soyol Enkh-Amgalan, Josephine M. Brown-Leung, Tauqeerunnisa Syeda, Rachel M. Nolan, Jason R. Cannon, Julia A. Chester
Summary: This study investigated the effects of the PD-related neurotoxicant PQ on binge-like alcohol drinking and striatal monoamines in mice bred for high alcohol preference. It found that PQ decreased alcohol drinking and ventral striatal DOPAC levels in male mice but not in females.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Regina F. Fernandez, Emily S. Wilson, Victoria Diaz, Jonatan Martinez-Gardeazabal, Rachel Foguth, Jason R. Cannon, Shelley N. Jackson, Brian P. Hermann, Jeffrey B. Eells, Jessica M. Ellis
Summary: Deleting the 6th isoform of long-chain acyl-CoA synthetase (ACSL6) in mice alters dopamine metabolism and regulation of light entrainment, suggesting that DHA metabolism mediated by ACSL6 plays a crucial role in dopamine neuron biology.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Chemistry, Medicinal
Medjda Bellamri, Kyle Brandt, Kari Cammerrer, Tauqeerunnisa Syeda, Robert J. J. Turesky, Jason R. R. Cannon
Summary: Animal fat and iron-rich diets increase the risk of Parkinson's disease. Heterocyclic aromatic amines (HAAs), including harman and norharman, formed in cooked meats, suggest a connection between red meat consumption and PD.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Review
Chemistry, Analytical
Briana R. R. De Miranda, J. Timothy Greenamyre
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2020)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)