期刊
NEUROSCIENCE LETTERS
卷 463, 期 2, 页码 158-161出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.07.047
关键词
Amyloid beta (A beta); Curcumin; Prefrontal Cortical neuron; Bcl(2); Caspase-3
资金
- Ministry of Science and Technology of China [2006CB500706]
- National Science Foundation of China [30670658]
- NSFC Dean's Research [30701138]
- Minzu University 985 [cun985-3-3]
The present study explored the effect of curcumin against amyloid beta (A beta)-induced toxicity on cultured rat primary prefrontal cortical neurons. The results showed that administration of 10 mu M of curcumin induced significantly protection against 20 mu M of A beta(25-35)-induced toxicity on the cultured rat primary prefrontal cortical neurons tested by MTT and TUNEL assays. We further examined the involvements of the apoptotic or anti-apoptotic proteins in curcumin protection against A beta(25-35)-induced cytotoxicity on cultured neurons and found that the content of apoptotic protein caspase-3 was increased and the content of anti-apoptotic factor Bcl(2) was decreased significantly after A beta(25-35) treatments, while administration of curcumin significantly inhibited the A beta(25-35)-induced increases in the content of caspase-3 and inhibited the A025-35-induced decreases in the content of Bcl2 tested by Western blot. The results suggest that curcumin protects cultured rat primary prefrontal cortical neurons against A beta-induced cytotoxicity, and both Bcl2 and caspase-3 are involved in the curcumin-induced protective effects. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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