Article
Biochemistry & Molecular Biology
Vjekoslav Peitl, Antonia Puljic, Mislav Skrobo, Sergej Nadalin, Lidija Fumic Dunkic, Dalibor Karlovic
Summary: This study aimed to evaluate the effectiveness of clozapine in treating patients with treatment-resistant schizophrenia (TRS) and the efficacy of electroconvulsive therapy (ECT) augmentation of clozapine in patients with ultra-treatment-resistant schizophrenia (UTRS). The results suggest that both clozapine and ECT are effective treatment options for TRS and UTRS patients.
Article
Neurosciences
Marion Psomiades, Marine Mondino, Filipe Galvao, Nathalie Mandairon, Mikail Nourredine, Marie-Francoise Suaud-Chagny, Jerome Brunelin
Summary: This study found that the level of mature BDNF (mBDNF) is associated with the efficacy of electroconvulsive therapy (ECT) for patients with treatment-resistant depression. Patients with higher baseline mBDNF levels were more likely to achieve remission after ECT sessions.
Review
Psychiatry
Shakila Meshkat, Yazen Alnefeesi, Muhammad Youshay Jawad, Joshua D. Di Vincenzo, Nelson B. Rodrigues, Felicia Ceban, Leanna M. W. Lui, Roger S. McIntyre, Joshua D. Rosenblat
Summary: This synthesis study found that TRD treatments can affect peripheral BDNF levels, but changes in peripheral BDNF levels are not significantly associated with antidepressant effects.
PSYCHIATRY RESEARCH
(2022)
Review
Psychology, Developmental
Santiago Castaneda-Ramirez, Timothy D. Becker, Adriana Bruges-Boude, Charles Kellner, Timothy R. Rice
Summary: ECT has been shown to be a safe and effective treatment for mood disorders in child and adolescent populations, particularly in severe and treatment-refractory cases. However, further controlled studies are needed to confirm its efficacy and long-term effects.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Victor M. Tang, Daniel M. Blumberger, Alanah Throop, Shawn M. McClintock, Daphne Voineskos, Jonathan Downar, Yuliya Knyahnytska, Benoit H. Mulsant, Paul B. Fitzgerald, Zafiris J. Daskalakis
Summary: Continuation magnetic seizure therapy (MST) can sustain improvements in depressive symptoms for most participants without adverse cognitive effects. During the study period, MST showed good control of suicidal ideation and no significant changes in neurocognitive test scores were observed.
JOURNAL OF CLINICAL PSYCHIATRY
(2021)
Article
Psychiatry
Julia M. Lappin, Kimberley Davies, Maryanne O'Donnell, Ishan C. Walpola
Summary: This study aimed to understand the use of clozapine and electroconvulsive therapy (ECT) in individuals with treatment-resistant psychosis. The study found that the utilization of these treatments was low and clozapine trials were often terminated prematurely without adequate testing. The study suggests strategies should be implemented to optimize the use of clozapine therapy and ECT in clinical settings to improve the therapeutic effectiveness for treatment-resistant psychosis.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Hannah Benedictine Maier, Christoph Pollak, Nicole Moschny, Sermin Toto, Colin Schlatt, Christian K. Eberlein, Wolfgang Sperling, Johannes Kornhuber, Kai G. Kahl, Stefan Bleich, Alexandra Neyazi, Helge Frieling
Summary: Obesity and major depressive disorder often coexist, and body mass index (BMI) may play a role in antidepressant treatment response. This study found an association between BMI and remission in electroconvulsive therapy (ECT), but no association with glucose homeostasis or serum lipids. Further research with larger sample sizes and focusing on fat distribution is needed.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Article
Psychiatry
J. J. E. Rovers, P. Vissers, D. Loef, J. A. van Waarde, J. P. A. J. Verdijk, B. F. P. Broekman, A. C. M. Vergouwen, M. L. Oudega, E. van Exel, R. Coenen, D. S. Everaerd, I. Tendolkar, A. Dols, P. F. P. van Eijndhoven
Summary: This study investigates the association between treatment resistance and the outcome and course of electroconvulsive therapy (ECT) in major depressive disorder (MDD). The results showed that higher levels of treatment resistance were associated with smaller reductions in depression symptoms and lower chances of response. Furthermore, patients with lower treatment resistance required fewer ECT sessions and had fewer switches to bilaterally electrode placement, potentially reducing the risk of cognitive side effects.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Neurosciences
J. Douglas Steele, Tom Farnan, David M. M. Semple, Siwei Bai
Summary: Recent observational studies have found that the cognitive side-effects and therapeutic efficacy of electroconvulsive therapy (ECT) are associated with electric field-induced changes in brain structures. A specific fronto-medial electrode placement has been found to reduce electric fields in the hippocampi while increasing electric fields in the dorsal sagittal cortex. This finding is clinically relevant as it may help minimize side-effects and improve treatment outcomes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Giedre Valiuliene, Vladas Valiulis, Kastytis Dapsys, Aida Vitkeviciene, Giedrius Gerulskis, Ruta Navakauskiene, Arunas Germanavicius
Summary: Resistance to pharmacological treatment poses challenges for psychiatry, and brain stimulation techniques are often used as alternative treatments. This study analyzed the impact of neurotrophic and inflammatory factors on treatment-resistant psychiatric patients, finding that different brain stimulation therapies have varying effects on BDNF and TNF alpha concentrations.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Vivien L. Hajak, Goran Hajak, Christoph Ziegelmayer, Simone Grimm, Wolfgang Trapp
Summary: The study retrospectively analyzed safety protocols and patient files of 157 patients who received ECT treatment, finding a low incidence rate of serious pLTAEs at 0.097%, indicating that ECT is a relatively safe treatment when performed in a controlled environment. Overall, the beneficial risk profile of ECT performed in standard care of psychiatric hospitals suggests a more generous indication for this treatment method.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Pharmacology & Pharmacy
Amanda Tamman, Amit Anand, Sanjay J. Mathew
Summary: Treatment-resistant depression is a significant public health and societal concern. Electroconvulsive therapy (ECT) is the standard intervention, but there are concerns regarding its perception, feasibility, and tolerability. Intranasal esketamine has been approved as an alternative treatment to ECT. This review compares the safety, efficacy, and tolerability of ketamine and ECT and aims to improve treatment assignment for treatment-resistant depression. Ongoing comparative effectiveness trials of ECT and IV ketamine are awaited to guide clinicians and patients.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Psychiatry
Abhiram Narasimhan Purohith, Shalaka Anand Chatorikar, Samir Kumar Praharaj, Rajeshkrishna Panambur Bhandary, Podila Satya Venkata Narasimha Sharma
Summary: Maintenance electroconvulsive therapy may be a safe and effective treatment option for long-term management of treatment-resistant schizophrenia.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Nutrition & Dietetics
Agnieszka Mechlinska, Adam Wlodarczyk, Marta Gruchala-Niedoszytko, Sylwia Malgorzewicz, Wieslaw Jerzy Cubala
Summary: Depression is a common mental disorder worldwide, and treatment resistance is often observed. Ketamine, an antidepressant, is frequently used for treatment-resistant depression. Research suggests that a healthy diet can lower the risk of developing depression and support conventional treatment. This study aimed to evaluate the dietary habits of patients with treatment-resistant depression and analyze the impact of ketamine on their food intake. The results revealed disrupted eating habits in patients with treatment-resistant depression, and after ketamine administration, there was a significant reduction in the consumption of various nutrients compared to the control group.
Article
Multidisciplinary Sciences
Anish Mitra, Marcus E. Raichle, Andrew D. Geoly, Ian H. Kratter, Nolan R. Williams
Summary: This study investigates the relationship between directed brain activity, major depressive disorder (MDD), and the response to neurostimulation therapy. The findings suggest that directed signaling patterns in the anterior cingulate cortex (ACC) are potential biomarkers of MDD, as changes in ACC signaling predict improvement in depression symptoms and treatment response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Geriatrics & Gerontology
Laura Kananen, Mikko Hurme, Alexander Buerkle, Maria Moreno-Villanueva, Jurgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dolle, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm, Miriam Capri, Claudio Franceschi, Eline Slagboom, Duncan Talbot, Claude Libert, Jani Raitanen, Seppo Koskinen, Tommi Harkanen, Sari Stenholm, Mika Ala-Korpela, Terho Lehtimaki, Olli T. Raitakari, Olavi Ukkola, Mika Kahonen, Marja Jylha, Juulia Jylhava
Summary: Circulating cell-free DNA (cf-DNA) levels are associated with age, sex, smoking, physical activity, vegetable consumption, ageing phenotypes, and various biomarkers. Higher cf-DNA levels were found in men, especially middle-aged men and women who smoke, and older frail individuals. Inflammatory markers, metabolites, and antioxidant levels were correlated with cf-DNA levels. These findings have implications for future studies on the epidemiology and biological mechanisms of cf-DNA and its potential as a clinical marker.
Article
Endocrinology & Metabolism
Mika Ala-Korpela, Terho Lehtimaki, Mika Kahonen, Jorma Viikari, Markus Perola, Veikko Salomaa, Johannes Kettunen, Olli T. Raitakari, Ville-Petteri Makinen
Summary: This study tested whether cross-sectional modeling can distinguish slow vs accelerated aging in a human population. A machine learning model was trained to predict age and tested against longitudinal data. The results showed that the cross-sectional proxy failed to predict longitudinal observations, suggesting that differences in starting points may explain diverging aging rates.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Psychology, Clinical
Amanda Nurmi, Laura Pulkki-Raback, Pia Salo, Katja Pahkala, Markus Juonala, Nina Hutri-Kahonen, Mika Kahonen, Terho Lehtimaki, Eero Jokinen, Liisa Keltikangas-Jarvinen, Tomi P. Laitinen, Paivi Tossavainen, Leena Taittonen, Jorma S. A. Viikari, Olli T. Raitakari, Suvi P. Rovio
Summary: The study found that adverse childhood psychosocial factors are associated with midlife learning ability and memory. Specifically, poor self-regulatory behavior and social adjustment in childhood are related to poorer learning ability and memory 30 years later.
Article
Genetics & Heredity
Tiit Ord, Tapio Lonnberg, Valtteri Nurminen, Aarthi Ravindran, Henri Niskanen, Miika Kiema, Kadri Ounap, Maleeha Maria, Pierre R. Moreau, Pashupati P. Mishra, Senthil Palani, Jenni Virta, Heidi Liljenback, Einari Aavik, Anne Roivainen, Seppo Yla-Herttuala, Johanna P. Laakkonen, Terho Lehtimaki, Minna U. Kaikkonen
Summary: Coronary artery disease (CAD) is a global disease with significant genetic factors. By using single-cell and bulk RNA sequencing, this study explores the biological diversity of atherosclerosis-associated cell states and their contribution to CAD risk. The researchers identified disease-associated cell states, with Vcam1 thorn smooth muscle cells showing the highest contribution to CAD heritability. The findings provide insights into CAD risk mechanisms and have implications for precision medicine and tailored therapeutic interventions.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Peripheral Vascular Disease
Erika Kahonen, Satu Korpimaki, Markus Juonala, Mika Kahonen, Terho Lehtimaki, Nina Hutri-Kahonen, Olli T. Raitakari, Mika Kivimaki, Jussi Vahtera
Summary: Limited data is available on the association between neighbourhood deprivation and arterial stiffening. This study found that neighbourhood deprivation in childhood and adulthood predicts arterial stiffness indicated by pulse wave velocity (PWV). These findings suggest that neighbourhood deprivation and low adulthood socioeconomic status are independent risk factors for increased arterial stiffness in adulthood.
Article
Multidisciplinary Sciences
Qile Dai, Geyu Zhou, Hongyu Zhao, Urmo Vosa, Lude Franke, Alexis Battle, Alexander Teumer, Terho Lehtimaki, Olli T. Raitakari, Tonu Esko, Michael P. Epstein, Jingjing Yang
Summary: Most TWAS tools require individual-level eQTL reference data, making them not suitable for summary-level reference eQTL datasets. Hence, the development of TWAS methods that can utilize summary-level reference data is valuable. In this study, a TWAS framework called OTTERS is introduced, which adapts multiple polygenic risk score methods to estimate eQTL weights from summary-level data and performs omnibus TWAS. Both simulations and application studies demonstrate the practicality and power of OTTERS as a TWAS tool.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Havard Aanes, Oyvind Bleka, Pal Skage Dahlberg, Kristina Totland Carm, Terho Lehtimaki, Olli Raitakari, Mika Kahonen, Mikko Hurme, Veslemoy Rolseth
Summary: More than 1/4 of children globally lack documentation of their date of birth, emphasizing the need for biological methods to predict age. DNA methylation is the most promising biomarker for age assessment, but there is currently no epigenetic clock specifically designed for adolescents and young adults. A novel age predictor called PAYA, using 267 CpG methylation sites, shows potential for age assessment in this population, but further research is needed to test its robustness across different populations and environments.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Miikael Lehtimaki, Binisha H. H. Mishra, Coral Del-Val, Leo-Pekka Lyytikainen, Mika Kahonen, C. Robert Cloninger, Olli T. T. Raitakari, Reijo Laaksonen, Igor Zwir, Terho Lehtimaki, Pashupati P. P. Mishra
Summary: This study used an unsupervised machine learning method called PGMRA to discover the genotype-lipidome relations in a Finnish population. The researchers found 93 statistically significant lipidome-genotype relations, which contained a total of 5977 SNPs across 3164 genes. Twenty nine of these relations represented distinct subgroups with unique SNPs and participants. Pathway enrichment analysis identified 30 significantly enriched biological processes related to plasma lipid metabolism. These findings have implications for precision medicine research.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Juhani S. Koskinen, Ville Kyto, Markus Juonala, Jorma S. A. Viikari, Jaakko Nevalainen, Mika Kahonen, Terho Lehtimaki, Nina Hutri-Kahonen, Tomi P. Laitinen, Paivi Tossavainen, Eero Jokinen, Costan G. Magnussen, Olli T. Raitakari
Summary: This study examines the association between childhood and adult dyslipidemia and adult carotid atherosclerotic plaques, and found that childhood dyslipidemia, even if resolved by adulthood, is still a risk factor for adult carotid plaques.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Neurosciences
Simo-Pekko Salminen, Anssi Solismaa, Leo-Pekka Lyytikainen, Vesa Paavonen, Nina Mononen, Terho Lehtimaki, Esa Leinonen, Olli Kampman
Summary: This study examined the clustering of Cloninger's temperament dimensions and their association with single nucleotide polymorphisms (SNPs). The results showed that multiple SNPs from different genes were associated with different temperament clusters. Genetic risk scores (GRSs) were also found to be associated with individuals' temperament profiles. However, further research is needed to explore the clinical applicability of these clusters.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Psychiatry
Aino Saarinen, Liisa Keltikangas-Jarvinen, Henrik Dobewall, Elina Sormunen, Terho Lehtimaki, Mika Kahonen, Olli Raitakari, Jarmo Hietala
Summary: This study examined the influence of childhood family environment on the risk of developing mental disorders in adulthood. It found that frequent stress-prone life events increased the risk of non-affective psychotic disorders, while disadvantageous emotional family atmosphere slightly increased the risk of affective disorders. These results highlight the importance of individual and public health preventive measures, including family support interventions.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yordi van de Vegte, Ruben P. Eppinga, M. Yldau van der Ende, Yanick Hagemeijer, Yuvaraj V. Mahendran, Elias Y. Salfati, Albert E. Smith, Vanessa Tan, Dan V. Arking, Ioanna Ntalla, Emil A. Appel, Claudia Schurmann, Jennifer Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina U. Mononen, Kirsi F. Auro, Anne Jackson, Lawrence Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Mueller-Nurasyid, Carolina E. Roselli, Weihua Zhang, Marcus J. Kleber, Xiuqing Guo, Henry E. Lin, Francesca Pavani, Tessel Galesloot, Raymond E. Noordam, Yuri Milaneschi, Katharina Schraut, Marcel den Hoed, Frauke E. Degenhardt, Stella Trompet, Marten van den Berg, Giorgio Pistis, Yih-Chung S. Tham, Stefan L. Weiss, Xueling J. Sim, Hengtong M. Li, Peter van der Most, Ilja Nolte, Leo-Pekka R. Lyytikaeinen, M. Abdullah Said, Daniel Witte, Carlos M. Iribarren, Lenore S. Launer, Susan Ring, Paul de Vries, Peter P. Sever, Allan Linneberg, Erwin M. Bottinger, Sandosh Padmanabhan, Bruce Psaty, Nona Sotoodehnia, Ivana Kolcic, Delnaz D. Roshandel, Andrew O. Paterson, David F. Arnar, Daniel Gudbjartsson, Hilma Holm, Beverley T. Balkau, Claudia H. Silva, Christopher Newton-Cheh, Kjell Nikus, Perttu L. Salo, Karen A. Mohlke, Patricia Peyser, Heribert Schunkert, Mattias Lorentzon, Jari C. Lahti, Dabeeru C. Rao, Marilyn D. Cornelis, Jessica A. Faul, Jennifer Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie F. Waldenberger, Moritz Sinner, Konstantin E. Strauch, Graciela D. Delgado, Kent Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline de Graaf, Renee de Mutsert, Eco J. C. de Geus, Asa K. Johansson, Peter K. Joshi, Lars Lind, Andre W. Franke, Peter V. Macfarlane, Kirill Tarasov, Nicholas B. Tan, Stephan Felix, E-Shyong Q. Tai, Debra Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia P. Lindgren, Andrew T. Morris, Olli Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur J. Gudnason, Nicholas C. Timpson, Alanna B. Morrison, Patricia P. Munroe, David Strachan, Niels Grarup, Ruth J. F. R. Loos, Susan Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif J. Groop, Nicholas M. Wareham, Cornelia F. van Duijn, Mary J. Feitosa, Christopher O'Donnell, Mika Kaehoenen, Markus Perola, Michael Boehnke, Sharon L. R. Kardia, Jeanette Erdmann, Colin N. A. Palmer, Claes J. Ohlsson, David G. Porteous, Johan Eriksson, Claude Bouchard, Susanne Moebus, Peter R. Kraft, David Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kaeaeb, Annette C. Peters, John S. Chambers, Jaspal Kooner, Winfried I. Maerz, Jerome A. Rotter, Andrew Hicks, J. Gustav Smith, Lambertus A. L. M. O. Kiemeney, Dennis Mook-Kanamori, Brenda W. J. H. Penninx, Ulf F. Gyllensten, James Wilson, Stephen Burgess, Johan Sundstroem, Wolfgang Lieb, J. Wouter Jukema, Mark Eijgelsheim, Edward L. M. Lakatta, Ching-Yu Cheng, Marcus Doerr, Tien-Yin Wong, Charumathi J. Sabanayagam, Albertine Oldehinkel, Harriette Riese, Terho Lehtimaeki, Niek Verweij, Pim van der Harst
Summary: This study identifies new genetic variants associated with resting heart rate (RHR) and demonstrates that higher genetically predicted RHR is associated with a decreased risk of atrial fibrillation and ischemic stroke. Genome-wide analysis reveals multiple genetic variants in cardiomyocyte-related genes and provides insights into their electrocardiogram (ECG) signature. Mendelian randomization analyses indicate that higher genetically predicted RHR increases the risk of dilated cardiomyopathy, but reduces the risk of atrial fibrillation, ischemic stroke, and cardio-embolic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Matilda Hurskainen, Juho Tynkkynen, Markku Eskola, Terho Lehtimaki, Jussi Hernesniemi
Summary: This study aimed to investigate the risk factors for ischemic stroke (IS) after acute coronary syndromes (ACS). Based on a retrospective registry study of 8049 ACS patients, it was found that previous stroke, atrial fibrillation or flutter, and heart failure indicated by the Killip classification were the most significant risk factors for both early-onset and late-onset IS. Left ventricular ejection fraction and coronary artery disease severity were important risk factors for early-onset IS, while age and peripheral artery disease were important risk factors for late-onset IS. The CHA(2)DS(2)-VASc score and its components were strong predictors for both early-onset and late-onset IS.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Nicholas Matsumoto, Anil Kumar Saini, Pedro Ribeiro, Hyunjun Choi, Alena Orlenko, Leo-Pekka Lyytikainen, Jari O. Laurikka, Terho Lehtimaki, Sandra Batista, Jason H. Moore
Summary: In this paper, we compare the role of two commonly used parent selection methods in evolving machine learning pipelines in TPOT. Results show that lexicase selection leads to significantly faster convergence compared to NSGA-II. We also compare the exploration of the search space by these selection methods using a trie data structure.
GENETIC PROGRAMMING, EUROGP 2023
(2023)
Article
Biotechnology & Applied Microbiology
Pashupati P. Mishra, Binisha H. Mishra, Emma Raitoharju, Nina Mononen, Jorma Viikari, Markus Juonala, Nina Hutri-Kahonen, Mika Kahonen, Olli T. Raitakari, Terho Lehtimaki
Summary: Advanced integrative analysis of DNA methylation and transcriptomics data reveals the effects of smoke-induced epigenetic alterations on gene expression and biological processes, linking smoking and related diseases.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
