Article
Biochemistry & Molecular Biology
Marrit Putker, David C. S. Wong, Estere Seinkmane, Nina M. Rzechorzek, Aiwei Zeng, Nathaniel P. Hoyle, Johanna E. Chesham, Mathew D. Edwards, Kevin A. Feeney, Robin Fischer, Nicolai Peschel, Ko-Fan Chen, Michael Vanden Oever, Rachel S. Edgar, Christopher P. Selby, Aziz Sancar, John S. O'Neill
Summary: CRY proteins are considered essential components of the cellular clock mechanism, but studies show that circadian rhythms can still exist in the absence of CRY, albeit with variable expression and shorter periods. The classic circadian hallmarks like temperature compensation and period determination by specific activities are maintained even without CRY-mediated feedback repression. The sustained PER2 protein rhythms and circadian variation in protein stability suggest a post-translational core mechanism for biological clocks.
Article
Chemistry, Medicinal
Yong Uk Jeong, Hyo-Eon Jin, Hye Young Lim, Goyeong Choi, Hansol Joo, Bohun Kang, Ga-Hyun Lee, Kwang-Hyeon Liu, Han-Joo Maeng, Sooyoung Chung, Gi Hoon Son, Jong-Wha Jung
Summary: Non-ethoxypropanoic acid-type inhibitors were developed as potent enhancers of E-box-mediated transcription, showing promising metabolic and pharmacokinetic profiles. These inhibitors directly bound to both CRY1 and 2, and exhibited significant effects on molecular circadian rhythmicity as circadian clock-enhancers.
Article
Biochemistry & Molecular Biology
Yu-Sheng Lin, Ming-Lung Tsai, I-Chang Hsieh, Ming-Shien Wen, Chao-Yung Wang
Summary: Recent studies suggest that cryptochromes play an essential role in atherosclerosis by regulating the circadian rhythm of LDLR mRNA in bone marrow-derived cells, which affects lipid uptake and foam cell formation in macrophages. Therapeutic targeting of cryptochromes in macrophages may have implications for treating atherosclerosis.
Article
Biochemistry & Molecular Biology
David C. S. Wong, Estere Seinkmane, Aiwei Zeng, Alessandra Stangherlin, Nina M. Rzechorzek, Andrew D. Beale, Jason Day, Martin Reed, Sew Y. Peak-Chew, Christine T. Styles, Rachel S. Edgar, Marrit Putker, John S. O'Neill
Summary: The study suggests that CRY proteins play a crucial role in maintaining protein and osmotic homeostasis against daily perturbation instead of causing large-scale daily variation in proteome composition. CRY-deficient cells show differences in temporal variation compared to wild-type cells and are more susceptible to proteotoxic stress.
Article
Gastroenterology & Hepatology
Sebastian Larion, Caleb A. Padgett, Joshua T. Butcher, James D. Mintz, David J. Fulton, David W. Stepp
Summary: Nonalcoholic fatty liver disease (NAFLD) is related to the disruption of the liver's biological clock, and nobiletin can improve NAFLD by restoring the biological clock. The study suggests that nobiletin reduces hepatic lipid accumulation and alleviates steatosis in obesity.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Review
Physiology
Xunwen Xue, Yasser F. Ali, Wanrong Luo, Caorui Liu, Guangming Zhou, Ning-Ang Liu
Summary: The Earth's natural magnetic field plays a crucial role in regulating circadian rhythms and health, while the hypomagnetic field of outer space, the Moon, and Mars poses challenges to astronauts' physiological and behavioral well-being. Studies have shown that the hypomagnetic field disrupts circadian rhythms and contributes to various health issues such as sleep disorders and metabolic diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xinyu Zhao, Shu Huang, Peng Zhang, Xue Qiao, Yu Liu, Miren Dong, Qilin Yi, Lingling Wang, Linsheng Song
Summary: This study identified the role of EsCry in regulating the expression of cytokines in Chinese mitten crab, showing that it negatively regulates TNF and IL-16 through inhibiting their transcription factors LITAF and ILF.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Urology & Nephrology
Lina K. Sciesielski, Matthias Felten, Laura Michalick, Karin M. Kirschner, Georgia Lattanzi, Charlotte L. J. Jacobi, Thomas Wallach, Veronika Lang, Dominic Landgraf, Achim Kramer, Christof Dame
Summary: The generation of circadian rhythms is cell-autonomous and relies on a transcription/translation feedback loop controlled by a family of circadian clock transcription factors. The study found that circadian erythropoietin regulation in the normoxic adult murine kidney is transcriptionally controlled by master circadian activators CLOCK/BMAL1, and repressors CRY1/CRY2, which may have implications for kidney physiology and disease, laboratory diagnostics, and anemia therapy.
KIDNEY INTERNATIONAL
(2021)
Article
Neurosciences
Yukie Shirakawa, Sachi N. N. Ohno, Kanae A. A. Yamagata, Eriko Kuramoto, Yoshiaki Oda, Takahiro J. J. Nakamura, Wataru Nakamura, Mitsutaka Sugimura
Summary: This study aimed to elucidate the rhythm of expression of clock gene in the trigeminal ganglion of mice to understand the mechanism of circadian regulation in the same area. The results showed distinct circadian oscillations of clock gene expression in the trigeminal ganglion. The conclusion is that the trigeminal ganglion is responsible for relay of sensory inputs and temporal gating through autonomous circadian oscillations.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Yoshiaki Oda, Nana N. Takasu, Sachi N. Ohno, Yukie Shirakawa, Mitsutaka Sugimura, Takahiro J. Nakamura, Wataru Nakamura
Summary: The study found that Cry1 deficiency affects the length and stability of circadian rhythms, while a single allele of Cry2 deficiency affects the circadian rhythm. Cry1(+/-) mice showed similar circadian rhythms to wild-type mice.
NEUROSCIENCE LETTERS
(2022)
Article
Multidisciplinary Sciences
Mieka Rinsky, Eviatar Weizman, Hiba Waldman Ben-Asher, Gal Eyal, Bokai Zhu, Oren Levy
Summary: Studying the gene expression patterns in different coral morphs, symbiotic and aposymbiotic, exposed to different light conditions, this study found circadian and circatidal cycles of gene expression in the coral Euphyllia paradivisa. The results suggest the existence of an endogenous clock in E. paradivisa, which can oscillate independently from the symbiotic algae's clock.
Article
Biochemistry & Molecular Biology
Hui Tian, Yanwen Jiao, Mingyue Guo, Yilin Wang, Ruiqi Wang, Cao Wang, Xiongbiao Chen, Weiming Tian
Summary: In this study, we discovered the involvement of klf7 in regulating circadian rhythm. Knocking down klf7 disrupted circadian rhythm and led to autism-like behavior. We also observed downregulation of the Clock gene and disturbance of its downstream rhythm genes in the brain of klf7 knockout mice. Melatonin, a circadian regulation drug, was able to regulate the expression of rhythm genes in klf7 knockout cells and rescue the autistic behavior of klf7 knockout mice.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Laura Carrero, Desiree Antequera, Ignacio Alcalde, Diego Megias, Lara Ordonez-Gutierrez, Cristina Gutierrez, Jesus Merayo-Lloves, Francisco Wandosell, Cristina Municio, Eva Carro
Summary: Alzheimer's disease, characterized by disrupted circadian rhythm and retinal pathology, is more prevalent in female individuals. The study found severe circadian rhythm disturbances and retinal pathological hallmarks in female APP/PS1 mice, along with A beta deposits in retinal layers. Reduced expression of aquaporins in the retinal tissue suggests that abnormal A beta transport contributes to retinal degeneration in the early stages of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Shigehiro Ohdo, Satoru Koyanagi, Naoya Matsunaga
Summary: This article provides a critical summary of literature reports on the rationale/mechanisms for time-dependent dosing differences in therapeutic outcomes and safety, the molecular pathways underlying biological rhythms, and the possibility of pharmacotherapy based on intra- and inter-individual variabilities from the viewpoints of the clock genes.
JOURNAL OF CONTROLLED RELEASE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Michael J. Rust
Summary: The study on circadian clock suggests that it can function even in non-growing cells using minimal components from cyanobacteria. The findings indicate the potential evolution of the circadian clock to adapt to different cellular conditions.
Article
Genetics & Heredity
Daisuke Ogino, Taeko Hashimoto, Motoshi Hattori, Noriko Sugawara, Yuko Akioka, Gen Tamiya, Satoshi Makino, Kentaro Toyota, Tetsuo Mitsui, Kiyoshi Hayasaka
JOURNAL OF HUMAN GENETICS
(2016)
Article
Genetics & Heredity
Junpei Tanigawa, Haruka Mimatsu, Seiji Mizuno, Nobuhiko Okamoto, Daisuke Fukushi, Koji Tominaga, Hiroyuki Kidokoro, Yukako Muramatsu, Eriko Nishi, Shota Nakamura, Daisuke Motooka, Noriko Nomura, Kiyoshi Hayasaka, Tetsuya Niihori, Yoko Aoki, Shin Nabatame, Masahiro Hayakawa, Jun Natsume, Keiichi Ozono, Taroh Kinoshita, Nobuaki Wakamatsu, Yoshiko Murakami
Article
Endocrinology & Metabolism
Kiyoshi Hayasaka, Chikahiko Numakura, Mitsunori Yamakawa, Tetsuo Mitsui, Hisayoshi Watanabe, Hiroaki Haga, Masahide Yazaki, Hiromasa Ohira, Yasuo Ochiai, Toshiyuki Tahara, Tamio Nakahara, Noriyo Yamashiki, Takahiro Nakayama, Takashi Kon, Hiroshi Mitsubuchi, Hiroshi Yoshida
JOURNAL OF INHERITED METABOLIC DISEASE
(2018)
Article
Genetics & Heredity
Yuichiro Miura, Tatsuya Watanabe, Toshihiko Uchida, Tatsuro Nawa, Naobumi Endo, Taichi Fukuzawa, Ryuji Ohkubo, Junji Takeyama, Ayako Sasaki, Kiyoshi Hayasaka
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2019)
Article
Endocrinology & Metabolism
Chikahiko Numakura, Gen Tamiya, Masao Ueki, Tomoo Okada, Shun-ichi Maisawa, Kanako Kojima-Ishii, Jun Murakami, Reiko Horikawa, Daisuke Tokuhara, Koichi Ito, Masanori Adachi, Takahiro Abiko, Tetsuo Mitsui, Kiyoshi Hayasaka
JOURNAL OF INHERITED METABOLIC DISEASE
(2019)
Article
Pediatrics
Ayako Sasaki, Yumiko Kishikawa, Reisuke Imaji, Yu Fukushima, Yukiko Nakamura, Yutaka Nishimura, Megumi Yamada, Yoichi Mino, Tetsuo Mitsui, Kiyoshi Hayasaka
PEDIATRICS INTERNATIONAL
(2019)
Article
Endocrinology & Metabolism
Yoriko Watanabe, Chikahiko Numakura, Toshiyuki Tahara, Kaori Fukui, Takuji Torimura, Yuji Hiromatsu, Ken Tomotsune, Mitsunori Yamakawa, Kiyoshi Hayasaka
DIABETES RESEARCH AND CLINICAL PRACTICE
(2020)
Article
Clinical Neurology
Aoi Hino, Jiro Terada, Hajime Kasai, Hikaru Shojima, Keiko Ohgino, Ayako Sasaki, Kiyoshi Hayasaka, Koichiro Tatsumi
JOURNAL OF CLINICAL SLEEP MEDICINE
(2020)
Review
Endocrinology & Metabolism
Kiyoshi Hayasaka
Summary: Citrin deficiency is a hereditary disorder caused by SLC25A13 mutations, affecting the energy metabolism of hepatocytes. MCT supplementation therapy is recommended for NICCD and CTLN2 patients to provide energy, promote lipogenesis, and improve ammonia detoxification.
JOURNAL OF INHERITED METABOLIC DISEASE
(2021)
Article
Genetics & Heredity
Tetsuo Mitsui, Satoshi Makino, Gen Tamiya, Hiroko Sato, Yuki Kawakami, Yoshitaka Takahashi, Toru Meguro, Hiroko Izumino, Yosuke Sudo, Ikuo Norota, Kuniaki Ishii, Kiyoshi Hayasaka
Summary: The study reveals the significant role of ALOX12 in platelet aggregation and calcium signaling, suggesting that defects in ALOX12 could lead to abnormal platelet aggregation. A heterozygous c.1946A > G ALOX12 mutation may be a disease-causing mutation contributing to inherited bleeding diathesis.
JOURNAL OF HUMAN GENETICS
(2021)
Article
Genetics & Heredity
Miyako Kanno, Mitsuyoshi Suzuki, Ken Tanikawa, Chikahiko Numakura, Shu-ichi Matsuzawa, Tetsuya Niihori, Yoko Aoki, Yoichi Matsubara, Satoshi Makino, Gen Tamiya, Satoshi Nakano, Ryo Funayama, Matsuyuki Shirota, Keiko Nakayama, Tetsuo Mitsui, Kiyoshi Hayasaka
Summary: PILBD is a heterogeneous disorder classified into syndromic and non-syndromic categories. In a family with dominantly inherited PILBD, a pathogenic variant CACYBP/SIP p.E177Q was found, leading to enhanced degradation of beta-catenin and delayed intrahepatic bile duct maturation. This discovery suggests that accurate regulation of beta-catenin concentration is crucial for bile duct development.
JOURNAL OF HUMAN GENETICS
(2022)
Article
Genetics & Heredity
Satoko Miyatake, Eriko Koshimizu, Atsushi Fujita, Hiroshi Doi, Masaki Okubo, Taishi Wada, Kohei Hamanaka, Naohisa Ueda, Hitaru Kishida, Gaku Minase, Atsuhiro Matsuno, Minori Kodaira, Katsuhisa Ogata, Rumiko Kato, Atsuhiko Sugiyama, Ayako Sasaki, Takabumi Miyama, Mai Satoh, Yuri Uchiyama, Naomi Tsuchida, Haruka Hamanoue, Kazuharu Misawa, Kiyoshi Hayasaka, Yoshiki Sekijima, Hiroaki Adachi, Kunihiro Yoshida, Fumiaki Tanaka, Takeshi Mizuguchi, Naomichi Matsumoto
Summary: We developed a diagnostic method for repeat expansion diseases that is faster, more accurate, and more comprehensive compared to conventional methods.
NPJ GENOMIC MEDICINE
(2022)
Article
Urology & Nephrology
Taeko Hashimoto, Yutaka Harita, Keiichi Takizawa, Seiya Urae, Kiyonobu Ishizuka, Kenichiro Miura, Shigeru Horita, Daisuke Ogino, Gen Tamiya, Hideki Ishida, Tetsuo Mitsui, Kiyoshi Hayasaka, Motoshi Hattori
KIDNEY INTERNATIONAL REPORTS
(2019)
Meeting Abstract
Pediatrics
Ayako Sasaki, Kiyoshi Hayasaka
PEDIATRIC PULMONOLOGY
(2019)
Review
Genetics & Heredity
Kiyoshi Hayasaka, Chikahiko Numakura
APPLICATION OF CLINICAL GENETICS
(2018)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)