Article
Biochemistry & Molecular Biology
Felipe Salech, Carol D. SanMartin, Jorge Concha-Cerda, Esteban Romero-Hernandez, Daniela P. Ponce, Gianella Liabeuf, Nicole K. Rogers, Paola Murgas, Barbara Bruna, Jamileth More, Maria I. Behrens
Summary: Recent studies have shown that cellular senescence is involved in the development of Alzheimer's Disease (AD). By measuring senescence markers in peripheral blood mononuclear cells (PBMCs) of AD patients, this study found that several markers of cellular senescence can be measured in PBMCs of both aMCI and AD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carol D. SanMartin, Felipe Salech, Daniela Paz Ponce, Jorge Concha-Cerda, Esteban Romero-Hernandez, Gianella Liabeuf, Nicole K. Rogers, Paola Murgas, Barbara Bruna, Jamileth More, Maria I. Behrens
Summary: Epidemiological studies find that having a history of cancer or Alzheimer's Disease (AD) can protect against the development of the other. The underlying mechanism for this mutual protection is unknown. However, research suggests that PBMCs of individuals with aMCI and AD have increased susceptibility to oxidative cell death, while a history of cancer is associated with increased resistance to cell death caused by oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Ying-Ren Chen, Chih-Sung Liang, Hsin Chu, Joachim Voss, Xiao Linda Kang, Grant O'Connell, Hsiu-Ju Jen, Doresses Liu, Shu-Tai Shen Hsiao, Kuei-Ru Chou
Summary: Blood-based biomarkers have shown high diagnostic accuracy for detecting Alzheimer's disease, with plasma A beta 42, A beta oligomer, and plasma tau demonstrating good sensitivity and specificity. However, evidence for detecting amnestic mild cognitive impairment using blood-based biomarkers is still limited. Ultra-high sensitive technology can help explain the heterogeneity in diagnostic performance.
AGEING RESEARCH REVIEWS
(2021)
Review
Cell Biology
Alex Zabala-Findlay, Lewis K. Penny, Richard A. Lofthouse, Andrew J. Porter, Soumya Palliyil, Charles R. Harrington, Claude M. Wischik, Mohammad Arastoo
Summary: A meta-analysis of 48 studies found that blood-based total tau and phosphorylated tau proteins are associated with mild cognitive impairment and Alzheimer's disease. The levels of these proteins were significantly elevated in participants with AD compared to healthy controls. This study provides important evidence for the early diagnosis of Alzheimer's disease.
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Review
Behavioral Sciences
Yi Qu, Ya-Hui Ma, Yu-Yuan Huang, Ya-Nan Ou, Xue-Ning Shen, Shi-Dong Chen, Qiang Dong, Lan Tan, Jin-Tai Yu
Summary: Blood-based biomarkers of AD pathology show significant changes between AD, aMCI, and control groups, indicating their strong validity in identifying AD and aMCI, and providing a new prospect for early diagnosis and monitoring of AD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Immunology
Xiao-hang Qian, Xiao-li Liu, Sheng-di Chen, Hui-dong Tang
Summary: Immune system dysfunction is an early event in Alzheimer's disease, providing a new target for early diagnosis and treatment of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Rachel Heutz, Jurgen Claassen, Sanne Feiner, Aaron Davies, Dewakar Gurung, Ronney B. Panerai, Rianne de Heus, Lucy C. Beishon
Summary: Dynamic cerebral autoregulation (dCA) is a key mechanism that regulates cerebral blood flow in response to transient changes in blood pressure. The literature remains conflicted on whether dCA is altered in Alzheimer's disease (AD) and mild cognitive impairment (MCI). A qualitative synthesis of eight studies suggests no significant difference in dCA parameters for spontaneous fluctuations between AD, MCI, and healthy controls. Limited data on induced fluctuations indicate preserved or possibly better autoregulatory functioning in AD and MCI compared to controls. Further research is needed to investigate dCA in dementia with induced fluctuations controlling for changes in end-tidal carbon dioxide.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Cell Biology
Heng Zhang, Yan Wang, Diyang Lyu, Yan Li, Wenwen Li, Qi Wang, Qi Qin, Xuechu Wang, Min Gong, Haishan Jiao, Wenying Liu, Jianping Jia
Summary: The study found a spatial-temporal pattern of decreased cerebral blood flow in Alzheimer's disease progression, starting from specific regions and spreading to broader areas. Patients with Alzheimer's disease showed significant reductions in cerebral blood flow in the temporal, parietal, and hippocampal regions.
AGEING RESEARCH REVIEWS
(2021)
Article
Geriatrics & Gerontology
Michal S. Beeri, Sue E. Leugrans, Osvaldo Delbono, David A. Bennett, Aron S. Buchman
Summary: In this study, poor muscle function, rather than reduced lean muscle mass, was found to be associated with late-life cognitive impairment, including incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Further research is needed to identify muscle structure features that may enhance the specificity of sarcopenia in identifying older adults at risk for late-life cognitive impairment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Neurosciences
Marina Botello-Marabotto, M. Carmen Martinez-Bisbal, Miguel Calero, Andrea Bernardos, Ana B. Pastor, Miguel Medina, Ramon Martinez-Manez
Summary: This study employed 1H NMR spectroscopy to conduct a metabolomic study in serum samples from patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively healthy controls (HC). The aim was to search for potential metabolite biomarkers. The results highlight the potential of 1H NMR metabolomics to support the diagnosis of dementia in a less invasive way, and provide a starting point for the study of potential biomarkers to identify MCI or HC subjects at risk of developing AD in the future.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Allan I. Levey, Deqiang Qiu, Liping Zhao, William T. Hu, Duc M. Duong, Lenora Higginbotham, Eric B. Dammer, Nicholas T. Seyfried, Thomas S. Wingo, Chadwick M. Hales, Malu Gamez Tansey, David S. Goldstein, Anees Abrol, Vince D. Calhoun, Felicia C. Goldstein, Ihab Hajjar, Anne M. Fagan, Doug Galasko, Steven D. Edland, John Hanfelt, James J. Lah, David Weinshenker
Summary: The study demonstrated that atomoxetine, a clinically approved noradrenaline reuptake inhibitor, improved multiple Alzheimer's disease biomarkers in individuals with mild cognitive impairment. Treatment with atomoxetine significantly reduced CSF levels of Tau and pTau, normalized CSF protein biomarker panels linked to synaptic function, brain metabolism, and glial immunity, and increased brain activity and metabolism in key temporal lobe circuits.
Article
Oncology
Yan Wang, Ying Li, Yan Li, Tingting Li, Qi Wang, Qigeng Wang, Shuman Cao, Fangyu Li, Jianping Jia
Summary: This study selected four potential biomarkers and measured their plasma levels in patients with Alzheimer's disease and amnestic mild cognitive impairment, developing a composite panel for screening and diagnosing these two conditions.
BIOMARKER RESEARCH
(2023)
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Claudio Del Percio, Susanna Lopez, Giuseppe Noce, Roberta Lizio, Federico Tucci, Andrea Soricelli, Raffaele Ferri, Flavio Nobili, Dario Arnaldi, Francesco Fama, Carla Buttinelli, Franco Giubilei, Moira Marizzoni, Bahar Guntekin, Gorsev Yener, Fabrizio Stocchi, Laura Vacca, Giovanni B. Frisoni, Claudio Babiloni
Summary: Abnormalities in rsEEG rhythms can be used to monitor and evaluate the progression of Alzheimer's disease. This study suggests that these abnormalities can be observed using fewer scalp electrodes in patients with mild cognitive impairment due to AD. The findings show that specific bipolar channels exhibit power density changes in ADMCI patients, and these changes can accurately classify ADMCI individuals.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Review
Clinical Neurology
Andrew Lees, Eduardo Tolosa, Fabrizio Stocchi, Joaquim J. Ferreira, Olivier Rascol, Angelo Antonini, Werner Poewe
Summary: There is a resurgence of levodopa as the initial treatment for Parkinson's disease, while the addition of adjuvant treatments is an established strategy to reduce motor complications. Improving levodopa delivery to the brain and combining agents earlier in the disease course can leverage the full potential of this strategy.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Geriatrics & Gerontology
Susanna Lopez, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Alessandro Padovani, Flavio Nobili, Dario Arnaldi, Francesco Fama, Davide V. Moretti, Annachiara Cagnin, Giacomo Koch, Alberto Benussi, Marco Onofrj, Barbara Borroni, Andrea Soricelli, Raffaele Ferri, Carla Buttinelli, Franco Giubilei, Bahar Guntekin, Gorsev Yener, Fabrizio Stocchi, Laura Vacca, Laura Bonanni, Claudio Babiloni
Summary: This study compared the hubs of interdependencies in elderly individuals with and without Alzheimer's disease dementia (ADD) using rsEEG rhythms. The results showed that ADD patients have lower connectivity centrality and directionality compared to normal elderly individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Giovanni Mostile, Christian Geroin, Roberto Erro, Antonina Luca, Enrico Marcuzzo, Paolo Barone, Roberto Ceravolo, Sonia Mazzucchi, Andrea Pilotto, Alessandro Padovani, Luigi Michele Romito, Roberto Eleopra, Carlo Dallocchio, Carla Arbasino, Francesco Bono, Pietro Antonio Bruno, Benedetta Demartini, Orsola Gambini, Nicola Modugno, Enrica Olivola, Laura Bonanni, Alberto Albanese, Gina Ferrazzano, Rosa De Micco, Maurizio Zibetti, Giovanna Calandra-Buonaura, Martina Petracca, Francesca Morgante, Marcello Esposito, Antonio Pisani, Paolo Manganotti, Fabrizio Stocchi, Mario Coletti Moja, Ilaria Antonella Di Vico, Lucia Tesolin, Francesca De Bertoldi, Tommaso Ercoli, Giovanni Defazio, Mario Zappia, Alessandra Nicoletti, Michele Tinazzi
Summary: This study identified clinical subtypes of combined FMDs using a data-driven approach. Two distinct clusters were identified based on motor phenotype, and their characteristics were described in detail. This study provides valuable insights for further understanding and diagnosing FMD.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Stuart H. Isaacson, Alyssa Bowling, Ian Zhang, Eric Pappert, Fabrizio Stocchi
Summary: This study evaluated the timing of motor improvement in Parkinson's disease patients with OFF episodes using carbidopa/levodopa (CD/LD) and apomorphine sublingual film (SL-APO). Results showed that mean improvements in MDS-UPDRS-III scores were -6.7 and -16.3 at 15 and 30 minutes following the first daily CD/LD dose, and FULL ON was achieved by 6.5% and 41.8% of patients, respectively. With an optimized SL-APO dose, mean improvements in MDS-UPDRS-III scores were -13.9 and -22.9, and FULL ON was achieved by 34.7% and 81.0% of patients, respectively. In conclusion, concomitant administration of SL-APO with CD/LD may be beneficial for delayed ON.
NEURODEGENERATIVE DISEASE MANAGEMENT
(2023)
Review
Clinical Neurology
Valentina Leta, Lisa Klingelhoefer, Katherine Longardner, Marta Campagnolo, Hafize Cotur Levent, Federico Aureli, Vinod Metta, Roongroj Bhidayasiri, Guy Chung-Faye, Cristian Falup-Pecurariu, Fabrizio Stocchi, Peter Jenner, Tobias Warnecke, K. Ray Chaudhuri
Summary: Levodopa is the gold standard treatment for Parkinson's disease, but it often leads to motor and non-motor fluctuations. Gastrointestinal barriers, such as dysphagia, delayed gastric emptying, and gut dysbiosis, can affect levodopa absorption and response. Managing gastrointestinal dysfunction is crucial for optimizing levodopa therapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alessandra Feraco, Stefania Gorini, Caterina Mammi, Mauro Lombardo, Andrea Armani, Massimiliano Caprio
Summary: This study found that high-fat diet impairs glucose tolerance in mice and that the MR antagonist Spironolactone improves glucose tolerance. The expression of MR protein in skeletal muscle is downregulated by high-fat diet, but this effect can be partially reversed by Spironolactone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Stefanie Jost, Marie-Ann Kaldenbach, Angelo Antonini, Pablo Martinez-Martin, Lars Timmermann, Per Odin, Regina Katzenschlager, Rupam Borgohain, Alfonso Fasano, Fabrizio Stocchi, Nobutaka Hattori, Prashanth Lingappa Kukkle, Mayela Rodriguez-Violante, Cristian Falup-Pecurariu, Sebastian Schade, Jan Niklas Petry-Schmelzer, Vinod Metta, Daniel Weintraub, Guenther J. Deuschl, Alberto J. Espay, Eng-King Tan, Roongroj Bhidayasiri, Victor S. C. Fung, Francisco Cardoso, Claudia Trenkwalder, Peter Jenner, K. S. Ray Chaudhuri, Haidar Dafsari
Summary: This study reviewed the investigations on drug therapy for Parkinson's disease since 2010 and proposed a new drug conversion formula. These conversion formulas can help us compare drug regimens across different clinical trials. The results are important for studying the pharmacological efficacy of Parkinson's disease treatments as well as other non-pharmacological interventions.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Fabrizio Stocchi, Paolo Barone, Giuseppe Bellelli, Andrea Fagiolini, Luigi Ferini Strambi, Sandro Sorbi, Alessandro Padovani
Summary: The diagnosis of depression in Parkinson's disease is challenging due to overlapping symptoms. A panel of Italian specialists reached a consensus that depression is a risk factor for Parkinson's disease, with neuropathological abnormalities playing a role. Multimodal and SSRI antidepressants are confirmed as effective options for treating depression in Parkinson's disease.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Maria Francesca De Pandis, Margherita Torti, Rossella Rotondo, Lanfranco Iodice, Maria Levi Della Vida, Miriam Casali, Laura Vacca, Fabio Viselli, Valeria Servodidio, Stefania Proietti, Fabrizio Stocchi
Summary: This study evaluated the efficacy of an education program for Parkinson's disease patients. It found that the program significantly improved motor and non-motor symptoms, particularly in reducing daily OFF hours. The long-term efficacy of the program was also confirmed.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Manon Auffret, Daniel Weiss, Fabrizio Stocchi, Marc Verin, Wolfgang H. Jost
Summary: Device-aided therapies (DAT), including deep brain stimulation and pump-based continuous dopaminergic stimulation, have significantly improved the clinical management of Parkinson's disease (PD). However, there are disparities in access to DAT, raising concerns about the equal opportunity for advanced PD patients to receive these treatments. Factors such as access to care, referral patterns, physician biases, and patient preferences need to be considered in addressing these disparities.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Alessandro Padovani, Angelo Antonini, Paolo Barone, Giuseppe Bellelli, Andrea Fagiolini, Luigi Ferini Strambi, Sandro Sorbi, Fabrizio Stocchi
Summary: This Delphi study aims to reach a shared point of view among Italian specialists on depression in Alzheimer's disease (AD). Consensus was achieved in most cases (86%), with 80% of statements receiving positive consensus and 6% receiving negative consensus. The study also highlights the strong link between depression and AD, as well as specific features of depression in AD compared to major depressive disorder (MDD).
NEUROLOGICAL SCIENCES
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Francesco Fontanella, Sonia Pinelli, Claudio Babiloni, Roberta Lizio, Claudio Del Percio, Susanna Lopez, Giuseppe Noce, Franco Giubilei, Fabrizio Stocchi, Giovanni B. Frisoni, Flavio Nobili, Raffaele Ferri, Tiziana D'Alessandro, Nicole Dalia Cilia, Claudio De Stefano
Summary: Although there is currently no cure for Alzheimer's disease, predicting the cognitive decline of patients at an early stage of the disease can help alleviate its burden. This study used machine learning tools and EEG-based features to predict the cognitive decline of Alzheimer's patients, and found that at least three scores were effective in accurately predicting the decline.
IMAGE ANALYSIS AND PROCESSING, ICIAP 2022, PT I
(2022)
Meeting Abstract
Clinical Neurology
Gennaro Pagano, Stefano Zanigni, Annabelle Monnet, Kirsten I. Taylor, Andrea Hahn, Kenneth Marek, Ron Postuma, Nicola Pavese, Fabrizio Stocchi, Tanya Simuni, Giulia D'Urso, Nathalie Pross, Michael Lindemann, Hanno Svoboda, Paulo Fontoura, Rachelle Doody, Geoffrey A. Kerchner, Azad Bonni, Tania Nikolcheva
MOVEMENT DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Finn Gustafsson, Binyamin Ben Avraham, Ovidiu Chioncel, Tal Hasin, Avishai Grupper, Aviv Shaul, Sanemn Nalbantgil, Yoav Hammer, Wilfried Mullens, Laurens F. Tops, Jeremy Elliston, Steven Tsui, Davor Milicic, Johann Altenberger, Miriam Abuhazira, Stephan Winnik, Jacob Lavee, Massimo Francesco Piepoli, Lorrena Hill, Righab Hamdan, Arjang Ruhparwar, Stefan Anker, Marisa Generosa Crespo-Leiro, Andrew J. S. Coats, Gerasimos Filippatos, Marco Metra, Giuseppe Rosano, Petar Seferovic, Frank Ruschitzka, Stamatis Adamopoulos, Yaron Barac, Nicolaas De Jonge, Maria Frigerio, Eva Goncalvesova, Israel Gotsman, Osnat Itzhaki Ben Zadok, Piotr Ponikowski, Luciano Potena, Arsen Ristic, Tiny Jaarsma, Tuvia Ben Gal
Summary: This article provides details on the management of hospitalized LVAD-supported patients, including blood pressure assessment, medical therapy, challenges related to anesthesia and non-cardiac surgical interventions, as well as discharge and palliative care considerations.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
