Article
Clinical Neurology
Simon Akerman, Daniela Salvemini, Marcela Romero-Reyes
Summary: This study aimed to investigate the role of reactive nitroxidative species in the mechanisms of migraine and identified peroxynitrite as a potential effective target for migraine treatment. Targeting reactive nitroxidative species with drugs can alleviate migraine-related pain responses.
Article
Allergy
Briana N. James, Clement Oyeniran, Jamie L. Sturgill, Jason Newton, Rebecca K. Martin, Erhard Bieberich, Cynthia Weigel, Melissa A. Maczis, Elisa N. D. Palladino, Joseph C. Lownik, John B. Trudeau, Joan M. Cook-Mills, Sally Wenzel, Sheldon Milstien, Sarah Spiegel
Summary: Elevation of ceramide levels after allergen challenge contributes to features of severe asthma, including apoptosis, reactive oxygen species generation, and neutrophilic infiltrate. Ceramide may be a potential biomarker for monitoring disease progression and optimizing clinical outcomes in severe asthma patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Environmental Sciences
Sanghoon Lee, Hyo-Gu Kang, Pil-Soo Jeong, Min Ju Kim, Soo-Hyun Park, Bong-Seok Song, Bo-Woong Sim, Sun-Uk Kim
Summary: The study showed that inhibition of ceramide generation can attenuate the effects of heat stress-induced apoptosis in porcine cumulus-oocyte complexes (COCs).
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Xiaoqian Jia, Anqi Zhang, Zheng Li, Xiaoling Peng, Xuebi Tian, Feng Gao
Summary: This study found that spinal PDGFR beta in microglia promotes autophagy in GABA interneurons through activating the p38 MAPK pathway, which plays a significant role in the development of morphine tolerance.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Cell Biology
Terri Kagan, Gloria Stoyanova, Richard A. Lockshin, Zahra Zakeri
Summary: This study investigates the different functions of ceramide in cellular differentiation and dedifferentiation. The results suggest that the function of ceramide heavily depends on its intracellular location, and further understanding of its function requires resolving its location during cellular status changes.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Immunology
Kunli Zhang, Qiuyan Huang, Shoulong Deng, Yecheng Yang, Jianhao Li, Sutian Wang
Summary: Pathogenic infections have a significant impact on public health and the breeding industry, with immune cells generating reactive oxygen and nitrogen species to clear pathogens. Autophagy and nitroxidative stress are intertwined, with Toll-like receptor 4 playing a key role in regulating inflammation, autophagy, and nitroxidative stress during infectious diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Neurosciences
Zhong Yang, Feifei Zhang, Mannan Abdul, Jinhong Jiang, Yanqiang Li, Yeqi Li, Cui Yin, Yanhong Xing, Su Liu, Chen Lu
Summary: Chronic morphine tolerance is a barrier to pain treatment, but the molecular mechanisms are unknown. This study suggests that TIPE2 is a key control point in the progression of chronic morphine antinociceptive tolerance. Increased expression of spinal TIPE2 can attenuate morphine tolerance by downregulating neuronal ROS, inhibiting neuronal apoptosis, and suppressing MAPKs and NF-xB activation. TIPE2 may be a potential strategy for preventing morphine tolerance in future studies and clinical settings.
Article
Biochemistry & Molecular Biology
Yaswanth Kuthati, Prabhakar Busa, Srikrishna Tummala, Vaikar Navakanth Rao, Venkata Naga Goutham Davuluri, Yen-Peng Ho, Chih-Shung Wong
Summary: Research has shown that delivering morphine through an antioxidant nanocarrier may be an effective strategy to alleviate morphine antinociceptive tolerance, potentially playing a positive role in neuropathic pain management.
Article
Cell Biology
Fei-Yang Tzou, Tsu-Yi Su, Wan-Syuan Lin, Han-Chun Kuo, Yu-Lian Yu, Yu-Han Yeh, Chung-Chih Liu, Ching-Hua Kuo, Shu-Yi Huang, Chih-Chiang Chan
Summary: Disruption of sphingolipid homeostasis can lead to neurological disorders, with specific sphingolipid species modulating pathogenesis through mechanisms that remain unclear. DEGS1/ifc deficiency causes dihydroceramide accumulation, leading to Rac1 mislocalization and NOX-dependent neurodegeneration. The Rac1-NOX complex plays a crucial role in the accumulation of reactive oxygen species in the absence of DEGS1/ifc.
Article
Neurosciences
Ahmet Sevki Taskiran, Onur Avci
Summary: The study found that captopril has anti-nociceptive properties, increases the analgesic effect of morphine, and reduces the development of morphine tolerance. These effects may be achieved by suppressing inflammation and ER-stress pathways.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Dai Mizuno, Masahiro Kawahara, Keiko Konoha-Mizuno, Terumasa Ogawara, Ryoji Hama, Kentaro Yamazaki
Summary: This study compared the toxicities of Tl(I) and Tl(III) in a mouse neuronal cell line. Tl(III) was more toxic, leading to decreased cell viability and increased cytotoxicity. Both treatments induced oxidative stress-related apoptosis, but Tl(III) produced more MDA and showed stronger cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jae Ryong Lim, Chang Woo Chae, Ji Yong Park, Young Hyun Jung, Jee Hyeon Yoon, Min Jeong Kim, Hyun Jik Lee, Gee Euhn Choi, Ho Jae Han
Summary: Heavy alcohol consumption leads to neuronal cell death and cognitive impairment. The production of ceramide, a sphingolipid metabolite, may be responsible for the neuronal cell death induced by ethanol. However, the molecular mechanisms underlying this process have not been fully understood.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemical Research Methods
Stefano Bonciarelli, Bruna Neves, Pedro Domingues, Tania Melo, Laura Goracci, Maria Rosairio Domingues
Summary: Phosphatidylinositols (PIs) are complex lipids that can be modified by reactive oxygen and nitrogen species (RNS) to produce a variety of modified lipid products. This study used mass spectrometry to characterize the fragmentation signature of nitrated and nitroxidized PIs, allowing for the identification of these modified lipid products accurately. The findings of this study provide new opportunities to understand the pathophysiological roles of nitrated and nitroxidized PI derivatives at the cellular and tissue levels.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The study investigates the role of miR-26b in regulating morphine tolerance, showing that miR-26b alleviates morphine tolerance by inhibiting BDNF through the Wnt/beta-catenin pathway.
Article
Pharmacology & Pharmacy
Onur Avci, Ercan Ozdemir, Ahmet Sevki Taskiran, Zeynep Deniz Sahin Inan, Sinan Gursoy
Summary: The study found that metformin can alleviate the tolerance to morphine in diabetic rats and exhibit anti-apoptotic activity in DRG neurons.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rossella Basilotta, Marika Lanza, Alessia Filippone, Giovanna Casili, Deborah Mannino, Federica De Gaetano, Giulia Chisari, Lorenzo Colarossi, Gianmarco Motta, Michela Campolo, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
Summary: Oral squamous cell carcinoma (OSCC) is a common human tumor with a high mortality rate. Existing treatments for OSCC have poor survival outcomes, so there is a need for new therapeutic strategies. This study found that dimethyl fumarate (DMF) could reduce the expression of anti-apoptotic factors, modulate oxidative stress, and inhibit tumor cell migration, making it a promising strategy to counteract oral cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Maria Cristina Vinci, Ermes Carulli, Erica Rurali, Raffaella Rinaldi, Giulia Damiano, Angela Raucci, Giulio Pompilio, Stefano Genovese
Summary: Endothelial progenitor cells (EPCs) have been the subject of extensive research and clinical expectations, but their current status and potential in regenerative medicine remain uncertain. This review explores the past and recent literature on this diverse and intriguing cell population, taking the reader on a chronological journey from their initial discovery to subsequent efforts in understanding their biology and their recent applications in cardiovascular disease and regenerative medicine.
Article
Biochemistry & Molecular Biology
Alessia Filippone, Giovanna Casili, Marika Lanza, Sarah Adriana Scuderi, Alessio Ardizzone, Anna Paola Capra, Irene Paterniti, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito
Summary: Film-forming substances such as xyloglucan, pea protein, and Opuntia ficus-indica extract (XPO) have shown potential in restoring skin barrier integrity and may serve as alternative treatments for psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Marika Lanza, Salvatore Cuzzocrea, Salvatore Oddo, Emanuela Esposito, Giovanna Casili
Summary: Several neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, are characterized by the accumulation of misfolded proteins known as proteinopathies. Changes in gene expression, particularly in noncoding RNAs like miR-128, which is highly expressed in mammalian brains, may play a role in these diseases. Targeting miR-128 could potentially alleviate the behavioral phenotype associated with these diseases, as it is involved in neuronal plasticity, cytoskeletal organization, and neuronal death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anna Paola Capra, Alessio Ardizzone, Giuseppe Panto, Irene Paterniti, Michela Campolo, Lelio Crupi, Raffaele Squeri, Emanuela Esposito
Summary: Over the past three years, the global spread of COVID-19 has presented humanity with one of the most serious health emergencies. Identifying reliable biomarkers for COVID-19 mortality is a key objective, and pentraxin 3 (PTX3), a protein associated with innate immunity, appears to be linked to worse outcomes in the disease. This systematic review and meta-analysis evaluated the prognostic potential of PTX3 in COVID-19 and found increased levels of PTX3 in severe cases, particularly among ICU patients, suggesting it could be a reliable marker for poor outcomes and stratification of hospitalized patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Alessio Ardizzone, Deborah Mannino, Anna Paola Capra, Alberto Repici, Alessia Filippone, Emanuela Esposito, Michela Campolo
Summary: Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are characterized by abdominal pain, discomfort, and diarrhea. The immune system plays a crucial role in the development of IBD, with an inappropriate immune response leading to gut inflammation in UC patients. This study investigated the immunomodulatory and pain-relieving effects of Ulva pertusa, a marine green alga, in a murine model of colitis. Results showed that Ulva pertusa administration relieved abdominal pain and modulated innate and adaptive immune-inflammatory responses, specifically through the modulation of TLR4 and NLRP3 inflammasome. These findings suggest that Ulva pertusa could be a promising approach to alleviate immune dysregulation and abdominal discomfort in IBD.
Article
Oncology
Giovanna Casili, Sarah Adriana Scuderi, Marika Lanza, Alessia Filippone, Deborah Mannino, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Anna Paola Capra, Federica De Gaetano, Marco Portelli, Angela Militi, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
Summary: This study evaluated the effect of the selective NLRP3 inflammasome inhibitor, BAY-117082, in an in vivo model of oral squamous cell carcinoma (OSCC) and its role in invasion and metastasis in neighboring organs. The results showed that BAY-117082 treatment reduced tumor presence and nuclear pleomorphism in tongue tissues and inhibited NLRP3 inflammasome pathway activation in tongue, lung, and spleen tissues. Furthermore, BAY-117082 treatment modulated the epithelial-mesenchymal transition (EMT) process and reduced the expression of matrix metalloproteinases (MMPs), markers of cell invasion and migration. Overall, BAY-117082 effectively reduced tumor area and metastasis through NLRP3 inflammasome pathway inhibition.
Review
Cell Biology
Alessio Ardizzone, Rossella Basilotta, Alessia Filippone, Lelio Crupi, Marika Lanza, Sofia Paola Lombardo, Cristina Colarossi, Dorotea Sciacca, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo
Summary: Primary brain tumors are highly heterogeneous and invasive, leading to high mortality rates worldwide. Current therapies have improved survival rates, but new therapeutic strategies are needed. Immunotherapy approaches, targeting the immunosuppressive microenvironment, have shown promise in CNS tumors. Chemokines, a group of proteins that regulate immune cell recruitment and tumor growth, are examined as potential targets for immunotherapy in primary brain tumors.
Review
Cell Biology
Ermes Carulli, Giulio Pompilio, Maria Cristina Vinci
Summary: Type 1 diabetes mellitus (T1DM) is a common autoimmune disease causing the destruction of pancreatic islet beta-cells, resulting in insulin deficiency and reduced life quality. Cell therapy, particularly autologous nonmyeloablative hematopoietic stem cell transplantation (AHST), has shown promising results for restoring insulin independence, but the success rate varies. A comprehensive review of trials involving stem cells, specifically AHST, for T1DM treatment was conducted. Older patients had a significantly higher probability of achieving insulin independence, while patients with a history of ketoacidosis had a significantly lower probability. Further data is needed to determine the ideal candidate profile.
Review
Cell Biology
Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alberto Repici, Marika Lanza, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
Summary: Cancer, the leading cause of death worldwide, requires successful strategies for treatment. Growth factors like VEGF, bFGF, and TGF-beta play significant roles in tumor growth, activating essential signaling pathways and promoting cell proliferation, angiogenesis, and metastasis. Specifically, bFGF is secreted by tumor cells and interacts with its receptors (FGFRs), leading to tumor cell proliferation, invasion, and upregulation of pro-inflammatory and anti-apoptotic proteins. Studies have focused on developing therapeutic strategies targeting the bFGF/FGFR axis, considering its involvement in oncogenesis. This review comprehensively examines the biological mechanisms of bFGF in the tumor microenvironment, available anticancer therapies targeting FGFRs, and the prognostic value of bFGF.
Article
Biochemistry & Molecular Biology
Marika Lanza, Laura Cucinotta, Giovanna Casili, Alessia Filippone, Rossella Basilotta, Anna Paola Capra, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Summary: This study aimed to evaluate the inhibitory effect of Antrodia camphorata (AC) administration on neuroinflammation and oxidative stress in a murine model of Parkinson's disease (PD). The results showed that AC treatment significantly reduced PD-related pathological changes, increased tyrosine hydroxylase expression, reduced alpha-synuclein-positive neurons, restored the myelination process of neurons associated with PD, and attenuated neuroinflammation. Furthermore, AC was able to reduce oxidative stress induced by MPTP injection. This study highlights AC as a potential therapeutic agent for neurodegenerative disorders such as PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marika Lanza, Rossella Basilotta, Salvatore Cuzzocrea, Maria Bulzomi, Salvatore Oddo, Giovanna Casili, Emanuela Esposito
Summary: The prevalence of obesity worldwide is rapidly increasing and is considered a leading cause of death. Added sugar consumption is one of the main factors contributing to this, as it is associated with a higher risk of obesity, heart disease, diabetes, and brain illnesses such as Alzheimer's disease (AD). Excess sugar can worsen oxidative damage and brain inflammation, which are neuropathological signs of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anna Paola Capra, Lelio Crupi, Giuseppe Panto, Alberto Repici, Fabrizio Calapai, Raffaele Squeri, Alessio Ardizzone, Emanuela Esposito
Summary: According to this study, Pentraxin 3 (PTX3) may serve as a valuable biomarker for assessing the severity of COVID-19 and systemic inflammatory responses. The research found elevated levels of PTX3 and other inflammatory proteins in previously infected COVID-19-positive individuals. Gender was also found to influence the severity of the disease, with higher levels of PTX3 in males compared to females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Fabrizio Calapai, Ilaria Ammendolia, Luigi Cardia, Mariaconcetta Curro, Gioacchino Calapai, Emanuela Esposito, Carmen Mannucci
Summary: Risankizumab is a safe and effective treatment for moderate-to-severe plaque psoriasis and psoriatic arthritis, according to post-marketing analysis of real-world data. The most frequently reported serious adverse reactions to risankizumab include infections, cancer, nervous system and cardiac disorders. Despite the limitations of the study, the safety profile of risankizumab is consistent with previous clinical trials and further research is needed to explore the occurrence of malignancies and their sex distribution as adverse reactions.
Review
Biochemistry & Molecular Biology
Anna Paola Capra, Alessio Ardizzone, Lelio Crupi, Fabrizio Calapai, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito
Summary: Post-Covid Olfactory Dysfunction (PCOD) refers to the persistent olfactory abnormalities, hyposmia, and anosmia in individuals who have recovered from SARS-CoV-2 infection. Limited therapeutic strategies are available for PCOD, but emerging evidence suggests that CoUltraPEALut, a combination of micronized Palmitoylethanolamide (PEA) and Luteolin, may be a viable adjuvant treatment when combined with olfactory training. A systematic review and meta-analysis found that CoUltraPEALut demonstrated significant efficacy in improving olfactory function compared to conventional therapy, indicating its potential as a future treatment for PCOD when used as an adjuvant.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)